NO20070334L - 4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorer - Google Patents

4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorer

Info

Publication number
NO20070334L
NO20070334L NO20070334A NO20070334A NO20070334L NO 20070334 L NO20070334 L NO 20070334L NO 20070334 A NO20070334 A NO 20070334A NO 20070334 A NO20070334 A NO 20070334A NO 20070334 L NO20070334 L NO 20070334L
Authority
NO
Norway
Prior art keywords
protein kinase
kinase inhibitors
disubstituted pyrimidines
pyrimidines
disubstituted
Prior art date
Application number
NO20070334A
Other languages
English (en)
Inventor
Thomas Beckers
Thomas Maier
Wolfgang Wirschun
Matthias Herdemann
Josef Stadlwieser
Thomas Baer
Thomas Ciossek
Armin Zuelch
Ulrich Graedler
Original Assignee
Nycomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Publication of NO20070334L publication Critical patent/NO20070334L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Oppfinnelsen vedrører nye pyrimidinderivater med formel (I), som er effektive proteinkinaserinhibitorer, spesielt av én eller flere isoformer av proteinkinasen B/Akt. ?? ?? ?? ??
NO20070334A 2004-06-28 2007-01-18 4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorer NO20070334L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04103011 2004-06-28
EP05102355 2005-03-23
PCT/EP2005/053019 WO2006000589A1 (en) 2004-06-28 2005-06-28 4,6-disubstituted pyrimidines and their use as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20070334L true NO20070334L (no) 2007-03-28

Family

ID=34973043

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070334A NO20070334L (no) 2004-06-28 2007-01-18 4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorer

Country Status (16)

Country Link
US (1) US7879853B2 (no)
EP (1) EP1763526B1 (no)
JP (1) JP5065017B2 (no)
KR (1) KR20070027723A (no)
CN (1) CN1972934A (no)
AT (1) ATE434614T1 (no)
AU (1) AU2005256659A1 (no)
BR (1) BRPI0512547A (no)
CA (1) CA2570552A1 (no)
DE (1) DE602005015110D1 (no)
ES (1) ES2328601T3 (no)
IL (1) IL179883A0 (no)
MX (1) MXPA06014747A (no)
NO (1) NO20070334L (no)
WO (1) WO2006000589A1 (no)
ZA (1) ZA200609637B (no)

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US6907921B2 (en) 1998-06-18 2005-06-21 3M Innovative Properties Company Microchanneled active fluid heat exchanger
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
MY147628A (en) 2006-07-06 2012-12-31 Array Biopharma Inc Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
US20090012434A1 (en) * 2007-07-03 2009-01-08 Anderson Robert S Apparatus, method, and system to treat a volume of skin
EP2214486A4 (en) * 2007-10-19 2011-03-09 Avila Therapeutics Inc HETEROARYL COMPOUNDS AND ITS USES
SG194048A1 (en) 2011-04-01 2013-11-29 Genentech Inc Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use
CN103841976A (zh) 2011-04-01 2014-06-04 基因泰克公司 Akt和mek抑制剂化合物的组合及其使用方法
AU2012321091B2 (en) * 2011-10-28 2016-05-12 Celgene Avilomics Research, Inc. Methods of treating a Bruton's Tyrosine Kinase disease or disorder
US9364476B2 (en) * 2011-10-28 2016-06-14 Celgene Avilomics Research, Inc. Methods of treating a Bruton's Tyrosine Kinase disease or disorder
MA37472A1 (fr) * 2012-04-04 2016-09-30 Amgen Inc Composés hétérocycliques et leurs utilisations
US9145387B2 (en) 2013-02-08 2015-09-29 Celgene Avilomics Research, Inc. ERK inhibitors and uses thereof
CN105764501A (zh) 2013-07-26 2016-07-13 现代化制药公司 改善比生群治疗效益的组合物
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
CN103601675B (zh) * 2013-10-08 2015-10-28 南京复兴生物科技有限公司 一种5-氨甲基烟酸的制备方法
CN103483250B (zh) * 2013-10-08 2015-07-22 南京复兴生物科技有限公司 一种5-氨甲基烟酸的制备方法
US10005760B2 (en) 2014-08-13 2018-06-26 Celgene Car Llc Forms and compositions of an ERK inhibitor
CN113509471B (zh) * 2021-07-19 2023-06-13 中国药科大学 Akt2抑制剂在制备治疗阿霉素引发心肌损伤药物中的应用

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TW321649B (no) * 1994-11-12 1997-12-01 Zeneca Ltd
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
CN1280580A (zh) 1997-11-11 2001-01-17 辉瑞产品公司 用作抗癌药的噻吩并嘧啶和噻吩并吡啶衍生物
GB9924092D0 (en) 1999-10-13 1999-12-15 Zeneca Ltd Pyrimidine derivatives
EP1246823A1 (en) * 1999-12-28 2002-10-09 Pharmacopeia, Inc. Pyrimidine and triazine kinase inhibitors
US20020065270A1 (en) * 1999-12-28 2002-05-30 Moriarty Kevin Joseph N-heterocyclic inhibitors of TNF-alpha expression
BR0113165A (pt) 2000-08-08 2003-07-15 Ortho Mcneil Pharm Inc Derivados de 4-pirimidinamina, composições farmacêuticas e métodos relacionados
AR035967A1 (es) * 2001-05-18 2004-07-28 Altana Pharma Ag Un compuesto de piridilmetilaminopirimidina, un medicamento que lo comprende y el uso del mismo
US7183288B2 (en) 2001-11-01 2007-02-27 Herwig Josephus Margareta Janssen, legal representative Amide derivatives as glycogen synthase kinase 3-β inhibitors
EP1448556A1 (en) * 2001-11-01 2004-08-25 Janssen Pharmaceutica N.V. Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors)
US20030187026A1 (en) * 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
US7910586B2 (en) 2002-01-04 2011-03-22 The Rockefeller University Compositions and methods for prevention and treatment of amyloid-β peptide-related disorders
AU2003295776B2 (en) 2002-11-21 2011-05-12 Novartis Vaccines And Diagnostics, Inc. 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (PI) 3-kinase inhibitors and their use in the treatment of cancer
EP1678147B1 (en) 2003-09-15 2012-08-08 Lead Discovery Center GmbH Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
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EP1901747A2 (en) * 2005-05-25 2008-03-26 Ingenium Pharmaceuticals AG Pyrimidine-based cdk inhibitors for treating pain

Also Published As

Publication number Publication date
DE602005015110D1 (de) 2009-08-06
EP1763526A1 (en) 2007-03-21
JP5065017B2 (ja) 2012-10-31
US20070208034A1 (en) 2007-09-06
MXPA06014747A (es) 2007-02-16
WO2006000589A8 (en) 2006-11-16
JP2008504251A (ja) 2008-02-14
BRPI0512547A (pt) 2008-03-25
ES2328601T3 (es) 2009-11-16
US7879853B2 (en) 2011-02-01
CN1972934A (zh) 2007-05-30
IL179883A0 (en) 2007-05-15
WO2006000589A1 (en) 2006-01-05
EP1763526B1 (en) 2009-06-24
KR20070027723A (ko) 2007-03-09
CA2570552A1 (en) 2006-01-05
AU2005256659A1 (en) 2006-01-05
ZA200609637B (en) 2008-08-27
ATE434614T1 (de) 2009-07-15

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