NO20045235L - Tetrahydropyranylsyklopentyltetrahydropyridopyridinmodulatorer med kjemokinreseptoraktivitet - Google Patents

Tetrahydropyranylsyklopentyltetrahydropyridopyridinmodulatorer med kjemokinreseptoraktivitet

Info

Publication number
NO20045235L
NO20045235L NO20045235A NO20045235A NO20045235L NO 20045235 L NO20045235 L NO 20045235L NO 20045235 A NO20045235 A NO 20045235A NO 20045235 A NO20045235 A NO 20045235A NO 20045235 L NO20045235 L NO 20045235L
Authority
NO
Norway
Prior art keywords
modulators
chemokine receptor
receptor activity
cyclopentyltetrahydropyridopyridine
tetrahydropyranyl
Prior art date
Application number
NO20045235A
Other languages
English (en)
Inventor
Gregori J Morriello
Lihu Yang
Richard Jiao
Christopher Moyes
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20045235L publication Critical patent/NO20045235L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Den foreliggende oppfirmelse er rettet mot forbindelser med formel (I) (I) hvor R^ er oksygen eller er fi-aværende, og R* er valgt fi-a hydrogen, ei.salkyl som er usubstituert eller substituert med 1-6 fluor, -O-e^alkyl, fluor og hydroksy, og farmasøytisk akseptable salter derav og individuelle diastereomerer derav, som er anvendbare som modulatorer for kjemokimeseptoraktivitet. Disse forbindelsene er særlig anvendbare som modulatorer for kjemokimeseptoren eeR-2.
NO20045235A 2002-04-29 2004-11-29 Tetrahydropyranylsyklopentyltetrahydropyridopyridinmodulatorer med kjemokinreseptoraktivitet NO20045235L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37629102P 2002-04-29 2002-04-29
PCT/US2003/013042 WO2003093266A1 (en) 2002-04-29 2003-04-25 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
NO20045235L true NO20045235L (no) 2004-11-29

Family

ID=29401326

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045235A NO20045235L (no) 2002-04-29 2004-11-29 Tetrahydropyranylsyklopentyltetrahydropyridopyridinmodulatorer med kjemokinreseptoraktivitet

Country Status (23)

Country Link
US (1) US7786305B2 (no)
KR (1) KR100754760B1 (no)
CN (1) CN1310917C (no)
AR (1) AR039489A1 (no)
AU (1) AU2003234251A1 (no)
BR (1) BR0309650A (no)
DO (1) DOP2003000638A (no)
EC (1) ECSP045392A (no)
HK (1) HK1081967A1 (no)
HR (1) HRP20041023A2 (no)
IL (1) IL164909A (no)
IS (1) IS7512A (no)
JO (1) JO2479B1 (no)
MA (1) MA27119A1 (no)
MX (1) MXPA04010702A (no)
MY (1) MY129850A (no)
NO (1) NO20045235L (no)
PE (1) PE20040598A1 (no)
PL (1) PL373401A1 (no)
RU (1) RU2285004C2 (no)
TW (1) TWI262077B (no)
UA (1) UA75828C2 (no)
WO (1) WO2003093266A1 (no)

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WO2005105092A2 (en) * 2004-04-28 2005-11-10 Merck & Co., Inc. 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity
JP2007537264A (ja) 2004-05-11 2007-12-20 インサイト コーポレイション ケモカインレセプタのモジュレータとしての３−（４−ヘテロアリールシクロヘキシルアミノ）シクロペンタンカルボキサミド
JP4116671B2 (ja) 2004-06-28 2008-07-09 インサイト コーポレイション ケモカイン受容体の調節剤としての３−アミノシクロペンタンカルボキサミド
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DK2370442T5 (da) * 2008-11-26 2013-09-23 Pfizer 3-aminocyclopentancarboxamider som chemokinreceptor modulatorer
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI540132B (zh) * 2009-06-08 2016-07-01 亞培公司 Ｂｃｌ-２族群抑制劑之口服醫藥劑型
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
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UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
KR101923364B1 (ko) 2010-11-23 2018-11-30 애브비 인코포레이티드 아폽토시스­유도제의 염 및 결정형
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US20130345254A1 (en) * 2011-03-17 2013-12-26 Anilkumar G. Nair Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
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Also Published As

Publication number Publication date
AU2003234251A8 (en) 2003-11-17
IL164909A0 (en) 2005-12-18
ECSP045392A (es) 2005-01-03
UA75828C2 (en) 2006-05-15
WO2003093266A1 (en) 2003-11-13
US7786305B2 (en) 2010-08-31
RU2004134604A (ru) 2005-05-27
US20050101628A1 (en) 2005-05-12
MY129850A (en) 2007-05-31
RU2285004C2 (ru) 2006-10-10
KR20050000413A (ko) 2005-01-03
BR0309650A (pt) 2005-04-26
CN1310917C (zh) 2007-04-18
IL164909A (en) 2010-04-15
JO2479B1 (en) 2009-01-20
TWI262077B (en) 2006-09-21
AU2003234251A1 (en) 2003-11-17
CN1662532A (zh) 2005-08-31
HK1081967A1 (en) 2006-05-26
PL373401A1 (en) 2005-08-22
TW200307543A (en) 2003-12-16
HRP20041023A2 (en) 2005-02-28
DOP2003000638A (es) 2003-11-30
AR039489A1 (es) 2005-02-23
MA27119A1 (fr) 2004-12-20
IS7512A (is) 2004-10-18
MXPA04010702A (es) 2005-02-17
KR100754760B1 (ko) 2007-09-04
PE20040598A1 (es) 2004-10-05

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