NO20032438L - Ortosubstituerte og metasubstituerte bisarylforbindelser, fremgangsmåte forfremstilling derav, deres anvendelse som et medikament samtfarmasöytiske preparater inneholdende forbindelsene - Google Patents

Ortosubstituerte og metasubstituerte bisarylforbindelser, fremgangsmåte forfremstilling derav, deres anvendelse som et medikament samtfarmasöytiske preparater inneholdende forbindelsene

Info

Publication number
NO20032438L
NO20032438L NO20032438A NO20032438A NO20032438L NO 20032438 L NO20032438 L NO 20032438L NO 20032438 A NO20032438 A NO 20032438A NO 20032438 A NO20032438 A NO 20032438A NO 20032438 L NO20032438 L NO 20032438L
Authority
NO
Norway
Prior art keywords
compounds
metasubstituted
orthosubstituted
drug
preparation
Prior art date
Application number
NO20032438A
Other languages
English (en)
Other versions
NO328599B1 (no
NO20032438D0 (no
Inventor
Stefan Peukert
Joachim Brendel
Horst Hemmerle
Heinz-Werner Kleemann
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20032438D0 publication Critical patent/NO20032438D0/no
Publication of NO20032438L publication Critical patent/NO20032438L/no
Publication of NO328599B1 publication Critical patent/NO328599B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20032438A 2000-11-30 2003-05-28 Ortosubstituerte og metasubstituerte bisarylforbindelser, deres anvendelse som et legemiddel, farmasoytiske preparater inneholdende forbindelsene, samt deres an-vendelse for fremstilling av medikamenter NO328599B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10059418A DE10059418A1 (de) 2000-11-30 2000-11-30 Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2001/013294 WO2002044137A1 (de) 2000-11-30 2001-11-17 Ortho, meta-substituierte bisarylverbindungen, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen

Publications (3)

Publication Number Publication Date
NO20032438D0 NO20032438D0 (no) 2003-05-28
NO20032438L true NO20032438L (no) 2003-07-09
NO328599B1 NO328599B1 (no) 2010-03-29

Family

ID=7665215

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032438A NO328599B1 (no) 2000-11-30 2003-05-28 Ortosubstituerte og metasubstituerte bisarylforbindelser, deres anvendelse som et legemiddel, farmasoytiske preparater inneholdende forbindelsene, samt deres an-vendelse for fremstilling av medikamenter

Country Status (29)

Country Link
US (2) US6605625B2 (no)
EP (1) EP1339675B1 (no)
JP (1) JP4051283B2 (no)
KR (1) KR100968056B1 (no)
CN (1) CN1290825C (no)
AR (1) AR031430A1 (no)
AT (1) ATE289292T1 (no)
AU (2) AU2793102A (no)
BR (1) BR0115769A (no)
CA (1) CA2430273C (no)
CZ (1) CZ301631B6 (no)
DE (2) DE10059418A1 (no)
EE (1) EE05240B1 (no)
ES (1) ES2236341T3 (no)
HK (1) HK1061231A1 (no)
HR (1) HRP20030436B1 (no)
HU (1) HUP0303317A3 (no)
IL (2) IL156097A0 (no)
MX (1) MXPA03004386A (no)
NO (1) NO328599B1 (no)
NZ (1) NZ526177A (no)
PL (1) PL206245B1 (no)
PT (1) PT1339675E (no)
RS (1) RS50403B (no)
RU (1) RU2278858C2 (no)
SK (1) SK286708B6 (no)
TW (1) TWI254039B (no)
WO (1) WO2002044137A1 (no)
ZA (1) ZA200303893B (no)

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GB0217757D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Novel compounds
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GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
EP1569907B1 (en) * 2002-12-13 2016-03-09 YM BioSciences Australia Pty Ltd Nicotinamide-based kinase inhibitors
AU2003291839B2 (en) * 2002-12-13 2009-01-22 Ym Biosciences Australia Pty Ltd Nicotinamide-based kinase inhibitors
SI1569907T1 (sl) 2002-12-13 2016-06-30 Ym Biosciences Australia Pty Ltd Na nikotinamidu osnovani kinazni inhibitorji
GB0308185D0 (en) * 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
DE10341233A1 (de) * 2003-09-08 2005-03-24 Aventis Pharma Deutschland Gmbh Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien
US20050054673A1 (en) * 2003-09-08 2005-03-10 Aventis Pharma Deutschland Gmbh Combination of phenylcarboxylic acid amides with beta-adrenoreceptor blockers and their use for the treatment of atrial arrhythmias
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US7569589B2 (en) 2004-07-29 2009-08-04 Merck & Co., Inc. Potassium channel inhibitors
US20080051416A1 (en) * 2004-10-05 2008-02-28 Smithkline Beecham Corporation Novel Compounds
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US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
GB0512429D0 (en) * 2005-06-17 2005-07-27 Smithkline Beecham Corp Novel compound
JP4943429B2 (ja) * 2005-07-22 2012-05-30 メルク・シャープ・エンド・ドーム・コーポレイション カリウムチャネル阻害剤
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
EP2012758A2 (en) * 2006-04-27 2009-01-14 Sanofi-Aventis Deutschland GmbH Inhibitors of the task-1 and task-3 ion channel
TW200845991A (en) 2007-01-12 2008-12-01 Smithkline Beecham Corp N-substituted glycine derivatives: hydroxylase inhibitors
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Also Published As

Publication number Publication date
US20030013719A1 (en) 2003-01-16
CN1290825C (zh) 2006-12-20
IL156097A (en) 2010-11-30
SK286708B6 (sk) 2009-03-05
RS37603A (en) 2006-12-15
DE50105386D1 (de) 2005-03-24
PT1339675E (pt) 2005-04-29
EE05240B1 (et) 2009-12-15
NO328599B1 (no) 2010-03-29
PL206245B1 (pl) 2010-07-30
HRP20030436B1 (en) 2006-04-30
EP1339675A1 (de) 2003-09-03
CA2430273A1 (en) 2002-06-06
KR100968056B1 (ko) 2010-07-08
US20030225099A1 (en) 2003-12-04
ATE289292T1 (de) 2005-03-15
RS50403B (sr) 2009-12-31
AU2002227931B2 (en) 2006-07-13
JP4051283B2 (ja) 2008-02-20
US6605625B2 (en) 2003-08-12
CN1494527A (zh) 2004-05-05
ES2236341T3 (es) 2005-07-16
DE10059418A1 (de) 2002-06-20
HK1061231A1 (en) 2004-09-10
RU2278858C2 (ru) 2006-06-27
EE200300183A (et) 2003-06-16
HUP0303317A2 (hu) 2004-01-28
ZA200303893B (en) 2004-04-15
CZ20031502A3 (cs) 2003-08-13
HUP0303317A3 (en) 2010-04-28
NO20032438D0 (no) 2003-05-28
WO2002044137A1 (de) 2002-06-06
EP1339675B1 (de) 2005-02-16
JP2004514707A (ja) 2004-05-20
KR20030062364A (ko) 2003-07-23
CZ301631B6 (cs) 2010-05-05
CA2430273C (en) 2010-02-09
HRP20030436A2 (en) 2005-04-30
BR0115769A (pt) 2004-01-13
PL362700A1 (en) 2004-11-02
SK6532003A3 (en) 2003-12-02
AU2793102A (en) 2002-06-11
NZ526177A (en) 2004-11-26
TWI254039B (en) 2006-05-01
MXPA03004386A (es) 2003-09-04
US6924392B2 (en) 2005-08-02
AR031430A1 (es) 2003-09-24
IL156097A0 (en) 2003-12-23

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