NO20022021L - Indeno-, nafto- og benzocyklohepta-dihydrotiazolderivater, fremstilling av de samme og deres anvendelse somanoreksilegemidler - Google Patents
Indeno-, nafto- og benzocyklohepta-dihydrotiazolderivater, fremstilling av de samme og deres anvendelse somanoreksilegemidlerInfo
- Publication number
- NO20022021L NO20022021L NO20022021A NO20022021A NO20022021L NO 20022021 L NO20022021 L NO 20022021L NO 20022021 A NO20022021 A NO 20022021A NO 20022021 A NO20022021 A NO 20022021A NO 20022021 L NO20022021 L NO 20022021L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- replaced
- preparation
- dihydrotiazole
- benzocyclohepta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Oppfinnelsen vedrører en forbindelse med formel (I). Y er en direkte binding, -CH-, -CH-CH-; X representerer CHCH(CH); CH(CH), CH(CH), CH(CH); R4 representerer (C-C)-cykloalkyl, hvori ett eller flere hydrogener kan substitueres i alkylgruppene med fluor eller et hydrogen kan erstattes med OH, OC(0)CH, OC(0)H, 0-CH-Ph eller 0-(C,-C)-alkyl;. (CH)-A-Rg, hvori n = 1 - 6, idet gruppen -CH-0-CH-fenyl, hvori fenyl er usubstituert, er utelatt; (CH)-B-R, hvori r = 1 - 6; A er O, S, SO, S0; B er NH, N-(C-C)-alkyl, NCHO, N(CO-CH); R8 representerer (C-C)-alkyl, (C-C)-cykloalkyl, idet i alkylgruppene ett eller flere hydrogener kan være erstattet med fluor eller et hydrogen kan være erstattet med OH, OC(0)CH, OC(0)H, 0-CH-Ph eller O-(C|-C)-alkyl; (CH)-aryl, hvor m = 0 - 6 og aryl er fenyl, naftyl, bifenyl, tienyl eller pyridyl og aryldelen kan være erstattet opp til to ganger og hvori gruppene Ri, R'i, Rog Rhar de angitte betydninger. Oppfinnelsen vedrører også fysiologisk tålbare salter av forbindelsene og fremgangsmåte for fremstilling av forbindelsene. Forbindelsene ifølge oppfinnelsen er f.eks. egnet for anvendelse som anorektiske midler.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19953205 | 1999-11-05 | ||
| DE2000113306 DE10013306A1 (de) | 2000-03-17 | 2000-03-17 | Polycyclische, in 2-Stellung mit substituierten Alkylresten versehene Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP2000/010396 WO2001032638A1 (de) | 1999-11-05 | 2000-10-21 | Indeno-, naphtho- und benzocyclohepta-dihydrothiazol derivate, deren herstellung und deren verwendung als anorektische arzneimittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20022021L true NO20022021L (no) | 2002-04-29 |
| NO20022021D0 NO20022021D0 (no) | 2002-04-29 |
| NO322309B1 NO322309B1 (no) | 2006-09-11 |
Family
ID=26004890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20022021A NO322309B1 (no) | 1999-11-05 | 2002-04-29 | Indenotiazolforbindelser, legemiddel som inneholder slike forbindelser, fremgangsmate for deres fremstilling og deres anvendelse som anoreksimidler. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6387935B1 (no) |
| EP (1) | EP1230230B1 (no) |
| JP (1) | JP2003524632A (no) |
| KR (1) | KR20020047331A (no) |
| CN (1) | CN1176080C (no) |
| AR (1) | AR026338A1 (no) |
| AT (1) | ATE250045T1 (no) |
| AU (1) | AU777569B2 (no) |
| BR (1) | BR0015322A (no) |
| CA (1) | CA2389703A1 (no) |
| CZ (1) | CZ20021528A3 (no) |
| DE (1) | DE50003761D1 (no) |
| DK (1) | DK1230230T3 (no) |
| EE (1) | EE200200235A (no) |
| ES (1) | ES2206320T3 (no) |
| HK (1) | HK1050524A1 (no) |
| HR (1) | HRP20020379A2 (no) |
| HU (1) | HUP0203290A3 (no) |
| IL (1) | IL149400A0 (no) |
| MX (1) | MXPA02003477A (no) |
| NO (1) | NO322309B1 (no) |
| NZ (1) | NZ518751A (no) |
| PL (1) | PL354533A1 (no) |
| PT (1) | PT1230230E (no) |
| SK (1) | SK6132002A3 (no) |
| WO (1) | WO2001032638A1 (no) |
| YU (1) | YU29602A (no) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EP2305352A1 (en) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| AU2008261102B2 (en) | 2007-06-04 | 2013-11-28 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| CA2930674A1 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| JP2011528375A (ja) | 2008-07-16 | 2011-11-17 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
| CN102264228A (zh) | 2008-10-22 | 2011-11-30 | 默沙东公司 | 用于抗糖尿病药的新的环状苯并咪唑衍生物 |
| AU2009309037A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| ES2652662T3 (es) | 2011-02-25 | 2018-02-05 | Merck Sharp & Dohme Corp. | Novedosos derivados de azabencimidazol cíclicos útiles como agentes antidiabéticos |
| CN108676076A (zh) | 2011-03-01 | 2018-10-19 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
| AU2013296470B2 (en) | 2012-08-02 | 2016-03-17 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| MX2015010935A (es) | 2013-02-22 | 2015-10-29 | Merck Sharp & Dohme | Compuestos biciclicos antidiabeticos. |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
| JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法 |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2018106518A1 (en) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| US10968232B2 (en) | 2016-12-20 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3507868A (en) * | 1968-10-21 | 1970-04-21 | Sandoz Ag | Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines |
| DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| DE19831878C2 (de) * | 1998-07-17 | 2001-05-17 | Aventis Pharma Gmbh | Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE19844547C2 (de) * | 1998-09-29 | 2002-11-07 | Aventis Pharma Gmbh | Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE19908539A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
-
2000
- 2000-10-21 PL PL00354533A patent/PL354533A1/xx not_active Application Discontinuation
- 2000-10-21 DK DK00974437T patent/DK1230230T3/da active
- 2000-10-21 CZ CZ20021528A patent/CZ20021528A3/cs unknown
- 2000-10-21 EE EEP200200235A patent/EE200200235A/xx unknown
- 2000-10-21 SK SK613-2002A patent/SK6132002A3/sk unknown
- 2000-10-21 YU YU29602A patent/YU29602A/sh unknown
- 2000-10-21 AT AT00974437T patent/ATE250045T1/de not_active IP Right Cessation
- 2000-10-21 HU HU0203290A patent/HUP0203290A3/hu unknown
- 2000-10-21 MX MXPA02003477A patent/MXPA02003477A/es active IP Right Grant
- 2000-10-21 NZ NZ518751A patent/NZ518751A/en unknown
- 2000-10-21 PT PT00974437T patent/PT1230230E/pt unknown
- 2000-10-21 AU AU12746/01A patent/AU777569B2/en not_active Ceased
- 2000-10-21 DE DE50003761T patent/DE50003761D1/de not_active Expired - Lifetime
- 2000-10-21 CA CA002389703A patent/CA2389703A1/en not_active Abandoned
- 2000-10-21 CN CNB008148899A patent/CN1176080C/zh not_active Expired - Fee Related
- 2000-10-21 KR KR1020027005768A patent/KR20020047331A/ko not_active Application Discontinuation
- 2000-10-21 ES ES00974437T patent/ES2206320T3/es not_active Expired - Lifetime
- 2000-10-21 EP EP00974437A patent/EP1230230B1/de not_active Expired - Lifetime
- 2000-10-21 WO PCT/EP2000/010396 patent/WO2001032638A1/de not_active Application Discontinuation
- 2000-10-21 JP JP2001534789A patent/JP2003524632A/ja not_active Withdrawn
- 2000-10-21 BR BR0015322-2A patent/BR0015322A/pt not_active IP Right Cessation
- 2000-10-21 IL IL14940000A patent/IL149400A0/xx unknown
- 2000-11-02 AR ARP000105782A patent/AR026338A1/es unknown
- 2000-11-06 US US09/706,351 patent/US6387935B1/en not_active Expired - Lifetime
-
2002
- 2002-04-29 NO NO20022021A patent/NO322309B1/no unknown
- 2002-04-30 HR HR20020379A patent/HRP20020379A2/hr not_active Application Discontinuation
-
2003
- 2003-04-10 HK HK03102611A patent/HK1050524A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2206320T3 (es) | 2004-05-16 |
| CA2389703A1 (en) | 2001-05-10 |
| PT1230230E (pt) | 2003-12-31 |
| KR20020047331A (ko) | 2002-06-21 |
| HUP0203290A3 (en) | 2004-12-28 |
| EP1230230A1 (de) | 2002-08-14 |
| JP2003524632A (ja) | 2003-08-19 |
| PL354533A1 (en) | 2004-01-26 |
| YU29602A (sh) | 2006-01-16 |
| AU1274601A (en) | 2001-05-14 |
| WO2001032638A1 (de) | 2001-05-10 |
| AU777569B2 (en) | 2004-10-21 |
| HUP0203290A2 (hu) | 2003-01-28 |
| CN1384827A (zh) | 2002-12-11 |
| NO20022021D0 (no) | 2002-04-29 |
| EP1230230B1 (de) | 2003-09-17 |
| CZ20021528A3 (cs) | 2002-07-17 |
| BR0015322A (pt) | 2002-07-09 |
| DK1230230T3 (da) | 2003-12-15 |
| EE200200235A (et) | 2003-06-16 |
| ATE250045T1 (de) | 2003-10-15 |
| NO322309B1 (no) | 2006-09-11 |
| IL149400A0 (en) | 2002-11-10 |
| US6387935B1 (en) | 2002-05-14 |
| NZ518751A (en) | 2004-06-25 |
| SK6132002A3 (en) | 2002-11-06 |
| CN1176080C (zh) | 2004-11-17 |
| DE50003761D1 (de) | 2003-10-23 |
| HK1050524A1 (en) | 2003-06-27 |
| MXPA02003477A (es) | 2002-08-20 |
| AR026338A1 (es) | 2003-02-05 |
| HRP20020379A2 (en) | 2004-02-29 |
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