NO20020665L - Streptomyces Avermitilis gen som bestemmer forholdet B2:B1 avermectiner - Google Patents

Streptomyces Avermitilis gen som bestemmer forholdet B2:B1 avermectiner

Info

Publication number
NO20020665L
NO20020665L NO20020665A NO20020665A NO20020665L NO 20020665 L NO20020665 L NO 20020665L NO 20020665 A NO20020665 A NO 20020665A NO 20020665 A NO20020665 A NO 20020665A NO 20020665 L NO20020665 L NO 20020665L
Authority
NO
Norway
Prior art keywords
ratio
avermectins
determines
streptomyces avermitilis
avermitilis gene
Prior art date
Application number
NO20020665A
Other languages
English (en)
Other versions
NO20020665D0 (no
Inventor
Kim Jonelle Stutzman-Engwall
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20020665D0 publication Critical patent/NO20020665D0/no
Publication of NO20020665L publication Critical patent/NO20020665L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det er beskrevet polynukleotidmolekyler omfattende nukleotidsekvenser kodende for et aveC genprodukt, idet polynukleotidmolekylene kan bli anvendt for å endre forholdet eller mengden til klasse 2:1 avermectiner produsert i fermenterings- kulturer av S. avermitilis. Det er videre beskrevet vektorer, vertsceller og mutante stammer av S. avermitilis hvor aveC genet er blitt inaktivert, eller mutert for å forandre forholdet eller mengden til klasse 2:1 avermectiner produsert.
NO20020665A 1999-08-12 2002-02-11 Streptomyces Avermitilis gen som bestemmer forholdet B2:B1 avermectiner NO20020665L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/372,934 US6248579B1 (en) 1998-02-13 1999-08-12 Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
PCT/IB2000/000996 WO2001012822A1 (en) 1999-08-12 2000-07-19 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Publications (2)

Publication Number Publication Date
NO20020665D0 NO20020665D0 (no) 2002-02-11
NO20020665L true NO20020665L (no) 2002-02-11

Family

ID=23470234

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020665A NO20020665L (no) 1999-08-12 2002-02-11 Streptomyces Avermitilis gen som bestemmer forholdet B2:B1 avermectiner

Country Status (37)

Country Link
US (8) US6248579B1 (no)
EP (1) EP1200605B1 (no)
JP (2) JP3688640B2 (no)
KR (1) KR100486006B1 (no)
CN (1) CN1186447C (no)
AP (2) AP2002002419A0 (no)
AR (1) AR021450A1 (no)
AT (1) ATE283363T1 (no)
AU (1) AU779756B2 (no)
BG (1) BG106478A (no)
BR (1) BR0013093A (no)
CA (1) CA2381427A1 (no)
CO (1) CO5290296A1 (no)
CZ (1) CZ2002297A3 (no)
DE (1) DE60016231T2 (no)
EA (1) EA004569B1 (no)
ES (1) ES2231214T3 (no)
GT (2) GT200000138CA (no)
HK (1) HK1046536B (no)
HR (1) HRP20020131A2 (no)
HU (1) HUP0202517A2 (no)
IL (1) IL147562A0 (no)
IS (1) IS6249A (no)
MA (1) MA26811A1 (no)
MX (1) MXPA02001514A (no)
NO (1) NO20020665L (no)
OA (1) OA11997A (no)
PA (1) PA8499201A1 (no)
PE (1) PE20010697A1 (no)
PL (1) PL353770A1 (no)
PT (1) PT1200605E (no)
SK (1) SK1382002A3 (no)
TN (1) TNSN00170A1 (no)
UY (1) UY26287A1 (no)
WO (1) WO2001012822A1 (no)
YU (1) YU8402A (no)
ZA (1) ZA200201071B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02001513A (es) * 1999-08-12 2002-07-02 Pfizer Prod Inc Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1.
AU2003210850A1 (en) 2002-02-05 2003-09-02 Bristol-Myers Squibb Company N-substituted3-hydroxy-4-pyridinones and pharmaceuticals containing thereof
ES2321827T3 (es) * 2002-02-12 2009-06-12 Pfizer Products Inc. Gen de streptomyces avermitilis que rige la relacion de avermectinas b2-b1.
US7943160B2 (en) * 2002-05-09 2011-05-17 Scimetrics Limited Corp. Pest control methods
US8440609B2 (en) * 2003-01-31 2013-05-14 Gerd Wallukat Peptides against autoantibodies causing intolerance to cold and use thereof
KR100759130B1 (ko) 2005-02-12 2007-09-19 휴메드 주식회사 항 인테그린 항체 코팅스텐트 및 그의 제조방법
CN106148216B (zh) * 2015-03-27 2019-06-04 浙江海正药业股份有限公司 一种链霉菌及其生产米尔贝霉素a3的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
EP0313297B1 (en) 1987-10-23 1993-05-19 Pfizer Inc. Process for production of avermectin aglycones and cultures therefor
EP0391594B1 (en) 1989-03-31 1995-10-18 Merck & Co. Inc. Cloning genes from streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
ES2204914T3 (es) 1993-07-30 2004-05-01 Pfizer Inc. Genes que codifican el complejo alfa cetoacido deshidrogenasa de cadena ramificada de streptomyces avermitilis.
ES2138090T3 (es) * 1993-10-05 2000-01-01 Pfizer Procedimiento e intermedios para doramectina.
FI942725A (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
CN1297485A (zh) * 1998-02-13 2001-05-30 辉瑞产品公司 介导除虫菌素b2:b1比例的除虫链霉菌基因

Also Published As

Publication number Publication date
NO20020665D0 (no) 2002-02-11
US20030129636A1 (en) 2003-07-10
PT1200605E (pt) 2005-04-29
KR100486006B1 (ko) 2005-05-03
MXPA02001514A (es) 2002-07-02
CO5290296A1 (es) 2003-06-27
AP2002002417A0 (en) 2002-03-31
ZA200201071B (en) 2003-06-25
PL353770A1 (en) 2003-12-01
US20010016350A1 (en) 2001-08-23
EP1200605B1 (en) 2004-11-24
EA004569B1 (ru) 2004-06-24
US6833263B2 (en) 2004-12-21
US7029887B2 (en) 2006-04-18
WO2001012822A1 (en) 2001-02-22
CZ2002297A3 (cs) 2002-08-14
AR021450A1 (es) 2002-07-17
ES2231214T3 (es) 2005-05-16
IL147562A0 (en) 2002-08-14
CN1370239A (zh) 2002-09-18
US20050196777A1 (en) 2005-09-08
KR20020022809A (ko) 2002-03-27
DE60016231T2 (de) 2005-12-08
HK1046536B (zh) 2005-05-13
CN1186447C (zh) 2005-01-26
US20010024818A1 (en) 2001-09-27
CA2381427A1 (en) 2001-02-22
US6248579B1 (en) 2001-06-19
BR0013093A (pt) 2002-08-13
AP2002002419A0 (en) 2002-03-31
GT200000138A (es) 2002-02-02
HRP20020131A2 (en) 2003-12-31
HK1046536A1 (en) 2003-01-17
JP3688640B2 (ja) 2005-08-31
UY26287A1 (es) 2001-03-16
JP2005198658A (ja) 2005-07-28
ATE283363T1 (de) 2004-12-15
DE60016231D1 (de) 2004-12-30
PE20010697A1 (es) 2001-07-05
HUP0202517A2 (hu) 2002-11-28
US20030124607A1 (en) 2003-07-03
GT200000138CA (es) 2002-02-02
TNSN00170A1 (fr) 2005-11-10
US7259241B2 (en) 2007-08-21
JP2003507018A (ja) 2003-02-25
YU8402A (sh) 2006-03-03
OA11997A (en) 2006-04-18
AU779756B2 (en) 2005-02-10
AU5702100A (en) 2001-03-13
EP1200605A1 (en) 2002-05-02
US20030134313A1 (en) 2003-07-17
IS6249A (is) 2002-01-25
PA8499201A1 (es) 2001-12-14
US6511841B2 (en) 2003-01-28
EA200200057A1 (ru) 2002-06-27
US20030129635A1 (en) 2003-07-10
MA26811A1 (fr) 2004-12-20
SK1382002A3 (en) 2002-11-06
BG106478A (bg) 2004-02-27
US6509159B2 (en) 2003-01-21

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