NO20000822L - Substituted 4-oxo-3-carboxamides as GABA Brain Receptor Ligands - Google Patents
Substituted 4-oxo-3-carboxamides as GABA Brain Receptor LigandsInfo
- Publication number
- NO20000822L NO20000822L NO20000822A NO20000822A NO20000822L NO 20000822 L NO20000822 L NO 20000822L NO 20000822 A NO20000822 A NO 20000822A NO 20000822 A NO20000822 A NO 20000822A NO 20000822 L NO20000822 L NO 20000822L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- agonists
- carboxamides
- oxo
- receptor ligands
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Foreliggende oppfinnelse omfatter strukturer med Formel (I) eller de farmasøytisk akseptable ikke-toksiske saltene derav, hvori: X er hydrogen, halogen, (u)substituert alkyl, (u)substituert alkoksy eller amino; og Y er (u)substituert alkyl, aryl eller heteroaryl, hvilke forbindelser er i høy grad selektive agonister, antagonister eller inverse agonister for GABAa hjernereseptorer eller pro-legemidler av agonister, antagonister eller inverse agonister for GABAa hjernereseptorer. Disse forbindelsene er nyttige for diagnose og behandling av angst, Down Syndrom, søvnforstyrrelse, kognitive forstyrrelser samt anfall og overdoser med benzodiazepin-legemidler og for forsterkning, av våkenhet.The present invention encompasses structures of Formula (I) or the pharmaceutically acceptable non-toxic salts thereof, wherein: X is hydrogen, halogen, (u) substituted alkyl, (u) substituted alkoxy or amino; and Y is (u) substituted alkyl, aryl or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or pro-drugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful for the diagnosis and treatment of anxiety, Down Syndrome, sleep disturbance, cognitive disorders as well as seizures and overdoses with benzodiazepine drugs and for the reinforcement, of wakefulness.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91818097A | 1997-08-25 | 1997-08-25 | |
PCT/US1998/017513 WO1999010347A1 (en) | 1997-08-25 | 1998-08-24 | Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20000822D0 NO20000822D0 (en) | 2000-02-18 |
NO20000822L true NO20000822L (en) | 2000-04-13 |
Family
ID=25439933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20000822A NO20000822L (en) | 1997-08-25 | 2000-02-18 | Substituted 4-oxo-3-carboxamides as GABA Brain Receptor Ligands |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1007526A1 (en) |
JP (1) | JP2001514181A (en) |
KR (1) | KR20010023313A (en) |
CN (1) | CN1268136A (en) |
AP (1) | AP2000001742A0 (en) |
AU (1) | AU753800B2 (en) |
BG (1) | BG104192A (en) |
BR (1) | BR9811362A (en) |
CA (1) | CA2301599C (en) |
EG (1) | EG21717A (en) |
HU (1) | HUP0003258A3 (en) |
IL (1) | IL134291A0 (en) |
IS (1) | IS5382A (en) |
LV (1) | LV12539B (en) |
NO (1) | NO20000822L (en) |
NZ (1) | NZ502548A (en) |
OA (1) | OA11293A (en) |
PE (1) | PE130999A1 (en) |
PL (1) | PL338783A1 (en) |
SI (1) | SI20270A (en) |
SK (1) | SK2162000A3 (en) |
TW (1) | TW574221B (en) |
WO (1) | WO1999010347A1 (en) |
YU (1) | YU10500A (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0010308A (en) * | 1999-05-06 | 2002-01-08 | Neurogen Corp | Compound, pharmaceutical composition, use of a compound, and, methods for treating a disease or disorder associated with pathogenic agonism, reverse agonism or antagonism of the gabaa receptor, to locate gabaa receptors in a tissue sample, to inhibit binding of a benzodiazepine compound to a gabaa receptor and to alter the signal transduction activity of gabaa receptors, and packaged pharmaceutical composition |
WO2000071528A1 (en) * | 1999-05-25 | 2000-11-30 | Neurogen Corporation | 4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands |
US6562822B2 (en) | 2000-07-12 | 2003-05-13 | Pharmacia & Upjohn Company | Heterocyle carboxamides as antiviral agents |
US6730682B2 (en) | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
ATE364385T1 (en) | 2000-10-12 | 2007-07-15 | Merck & Co Inc | AZA- AND POLYAZA-NAPHTHALENYL CARBONIC ACID AMIDES AS HIV INTEGRASE INHIBITORS |
IL155089A0 (en) | 2000-10-12 | 2003-10-31 | Merck & Co Inc | Aza and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
EP1326610B1 (en) | 2000-10-12 | 2006-11-15 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
US20020151591A1 (en) * | 2000-10-17 | 2002-10-17 | Anabella Villalobos | Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders |
KR20030076717A (en) * | 2001-03-01 | 2003-09-26 | 화이자 프로덕츠 인크. | Use of GABAA Inverse Agonists in Combination with Nicotine Receptor Partial Agonists, Estrogen, Selective Estrogen Modulators, or Vitamin E for the Treatment of Cognitive Disorders |
AR036256A1 (en) | 2001-08-17 | 2004-08-25 | Merck & Co Inc | SODIUM SALT OF AN HIV INTEGRAS INHIBITOR, PROCESSES FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING IT AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT |
ES2291642T3 (en) | 2002-01-17 | 2008-03-01 | MERCK & CO., INC. | USEFUL HYDROXINE FTIRIDINON CARBOXAMIDS AS INHIBITORS OF HIV INTEGRESS. |
JP4494020B2 (en) | 2002-03-15 | 2010-06-30 | メルク・シャープ・エンド・ドーム・コーポレイション | N- (substituted benzyl) -8-hydroxy-1,6-naphthyridine-7-carboxamide useful as an HIV integrase inhibitor |
WO2004106336A1 (en) * | 2003-05-27 | 2004-12-09 | Pfizer Products Inc. | Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides |
WO2004106334A2 (en) * | 2003-05-28 | 2004-12-09 | Pfizer Products Inc. | Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation |
WO2008046135A1 (en) * | 2006-10-16 | 2008-04-24 | Bionomics Limited | Novel anxiolytic compounds |
CA2670116C (en) * | 2006-11-22 | 2015-03-10 | Seaside Therapeutics, Llc | Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR204813A1 (en) * | 1972-05-08 | 1976-03-05 | Yamanouchi Pharma Co Ltd | PROCESS FOR THE PREPARATION OF AMPYLICIN DERIVATIVES |
GB1433774A (en) * | 1973-02-26 | 1976-04-28 | Allen & Hanburys Ltd | Heterocyclic compounds apparatus for conveying articles |
US4374138A (en) * | 1981-11-13 | 1983-02-15 | Warner-Lambert Company | Antibacterial amide compounds, compositions, and methods of use |
DD279875A1 (en) * | 1987-07-03 | 1990-06-20 | Inst Pharmakologische Forschun | PROCESS FOR PREPARING ACTIVATED CARBONIC ACID ESTERS |
DD279887A1 (en) * | 1987-07-03 | 1990-06-20 | Inst Pharmakologische Forschun | METHOD OF PREPARING D-ALPHA- (4 (1H) -1,5-NAPHTHYRIDONE-3-CARBOXAMIDO) -BENZYLPENICILLIN AND OTHER BETA LACTAMANTIBIOTICS |
DD295360A5 (en) * | 1987-07-03 | 1991-10-31 | Akad Wissenschaften | Process for the preparation of activated carboxylic acid esters |
JPS6461461A (en) * | 1987-09-01 | 1989-03-08 | Otsuka Pharma Co Ltd | Benzohetero ring derivative |
-
1998
- 1998-08-24 AU AU91173/98A patent/AU753800B2/en not_active Ceased
- 1998-08-24 WO PCT/US1998/017513 patent/WO1999010347A1/en not_active Application Discontinuation
- 1998-08-24 CN CN98808578A patent/CN1268136A/en active Pending
- 1998-08-24 PL PL98338783A patent/PL338783A1/en unknown
- 1998-08-24 BR BR9811362-3A patent/BR9811362A/en not_active Application Discontinuation
- 1998-08-24 EP EP98943352A patent/EP1007526A1/en not_active Withdrawn
- 1998-08-24 HU HU0003258A patent/HUP0003258A3/en unknown
- 1998-08-24 NZ NZ502548A patent/NZ502548A/en unknown
- 1998-08-24 CA CA002301599A patent/CA2301599C/en not_active Expired - Fee Related
- 1998-08-24 IL IL13429198A patent/IL134291A0/en unknown
- 1998-08-24 SK SK216-2000A patent/SK2162000A3/en unknown
- 1998-08-24 KR KR1020007001948A patent/KR20010023313A/en not_active Application Discontinuation
- 1998-08-24 SI SI9820055A patent/SI20270A/en unknown
- 1998-08-24 JP JP2000507675A patent/JP2001514181A/en active Pending
- 1998-08-24 YU YU10500A patent/YU10500A/en unknown
- 1998-09-29 EG EG118098A patent/EG21717A/en active
- 1998-10-23 TW TW87117597A patent/TW574221B/en active
- 1998-11-13 PE PE1998001100A patent/PE130999A1/en not_active Application Discontinuation
-
2000
- 2000-02-01 AP APAP/P/2000/001742A patent/AP2000001742A0/en unknown
- 2000-02-18 OA OA1200000044A patent/OA11293A/en unknown
- 2000-02-18 NO NO20000822A patent/NO20000822L/en not_active Application Discontinuation
- 2000-02-22 IS IS5382A patent/IS5382A/en unknown
- 2000-02-25 BG BG104192A patent/BG104192A/en unknown
- 2000-03-16 LV LVP-00-29A patent/LV12539B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1268136A (en) | 2000-09-27 |
CA2301599C (en) | 2003-03-25 |
JP2001514181A (en) | 2001-09-11 |
SK2162000A3 (en) | 2001-03-12 |
IS5382A (en) | 2000-02-22 |
PE130999A1 (en) | 1999-12-16 |
WO1999010347A1 (en) | 1999-03-04 |
BG104192A (en) | 2001-05-31 |
IL134291A0 (en) | 2001-04-30 |
EP1007526A1 (en) | 2000-06-14 |
NZ502548A (en) | 2002-06-28 |
AP2000001742A0 (en) | 2000-02-24 |
AU753800B2 (en) | 2002-10-31 |
AU9117398A (en) | 1999-03-16 |
TW574221B (en) | 2004-02-01 |
NO20000822D0 (en) | 2000-02-18 |
BR9811362A (en) | 2000-08-22 |
CA2301599A1 (en) | 1999-03-04 |
LV12539B (en) | 2001-01-20 |
SI20270A (en) | 2000-12-31 |
PL338783A1 (en) | 2000-11-20 |
OA11293A (en) | 2002-11-19 |
KR20010023313A (en) | 2001-03-26 |
YU10500A (en) | 2002-10-18 |
HUP0003258A3 (en) | 2001-05-28 |
EG21717A (en) | 2002-02-27 |
HUP0003258A2 (en) | 2001-03-28 |
LV12539A (en) | 2000-10-20 |
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Legal Events
Date | Code | Title | Description |
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |