CA2249562A1 - Certain fused pyrrolecarboxamides as gaba brain receptor ligands - Google Patents
Certain fused pyrrolecarboxamides as gaba brain receptor ligandsInfo
- Publication number
- CA2249562A1 CA2249562A1 CA002249562A CA2249562A CA2249562A1 CA 2249562 A1 CA2249562 A1 CA 2249562A1 CA 002249562 A CA002249562 A CA 002249562A CA 2249562 A CA2249562 A CA 2249562A CA 2249562 A1 CA2249562 A1 CA 2249562A1
- Authority
- CA
- Canada
- Prior art keywords
- compounds
- agonists
- receptor ligands
- antagonists
- brain receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004556 brain Anatomy 0.000 title abstract 3
- RLOQBKJCOAXOLR-UHFFFAOYSA-N 1h-pyrrole-2-carboxamide Chemical class NC(=O)C1=CC=CN1 RLOQBKJCOAXOLR-UHFFFAOYSA-N 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 239000000556 agonist Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Diclosed are compounds of formula (I), or the pharmaceutically acceptable non-toxic salts thereof, wherein W represents substituted or unsubstituted phenyl; T is hydrogen, halogen, hydroxyl, amino or alkyl; X is hydrogen, hydroxy, or lower alkyl; m is 0, 1, or 2; n is 0, 1, or 2; and R3 and R4 represent substituted or unsubstituted organic residues. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62093996A | 1996-03-22 | 1996-03-22 | |
| US08/620,939 | 1996-03-22 | ||
| PCT/US1997/004623 WO1997034870A1 (en) | 1996-03-22 | 1997-03-20 | Certain fused pyrrolecarboxamides as gaba brain receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2249562A1 true CA2249562A1 (en) | 1997-09-25 |
| CA2249562C CA2249562C (en) | 2006-06-13 |
Family
ID=36587576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002249562A Expired - Fee Related CA2249562C (en) | 1996-03-22 | 1997-03-20 | Certain fused pyrrolecarboxamides as gaba brain receptor ligands |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2249562C (en) |
-
1997
- 1997-03-20 CA CA002249562A patent/CA2249562C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2249562C (en) | 2006-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |