NO20000063L - Nye IL-5 inhiberende 6-azauracilderivater - Google Patents

Nye IL-5 inhiberende 6-azauracilderivater

Info

Publication number
NO20000063L
NO20000063L NO20000063A NO20000063A NO20000063L NO 20000063 L NO20000063 L NO 20000063L NO 20000063 A NO20000063 A NO 20000063A NO 20000063 A NO20000063 A NO 20000063A NO 20000063 L NO20000063 L NO 20000063L
Authority
NO
Norway
Prior art keywords
optionally substituted
alkyl
cycloalkyl
aryl
hydrogen
Prior art date
Application number
NO20000063A
Other languages
English (en)
Other versions
NO20000063D0 (no
Inventor
Jean Fernand Armand Lacrampe
Marc Gaston Venet
Eddy Jean Edgard Freyne
Gustaaf Maria Boeckx
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20000063D0 publication Critical patent/NO20000063D0/no
Publication of NO20000063L publication Critical patent/NO20000063L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Den foreliggende oppfinnelse vedrører forbindelser med for- mel (I), N-oksidene, de farmasøytisk akseptable addisjons- salter og de stereokjemisk isomere former derav, p og q er O, l, 2, 3 eller 4 og q er også 5; X er O, S, NR3 eller en direkte binding; R1 er hydrogen, hydroksy, halo, valgfritt substituert amino, valgfritt substituert d-6-alkyl, d-e~ alkyloksy, C3-7-cykloalkyl eller aryl; R2 er aryl, Het1, C3- -,-cykloalkyl, valgfritt substituert d-e-alkyl; og hvis X er O, S eller NR3, da kan R2 også være en karbonyl- eller tio- karbonyl-forbundet substituent; R3 er hydrogen eller d-<- alkyl; R4 og R5 er uavhengig valgfritt substituert d-e~ alkyl, halo, hydroksy, merkapto, d-6-alkyloksy, d-6~alkyl- tio, Ci-e-alkylkarbonyloksy, aryl, cyano, nitro, Het3, R6 eller NR7R8; R6 er substituert sulfonyl eller sulfonyl; R7 og R8 er hydrogen, valgfritt substituert d-4-alkyl, aryl, en karbonyl- eller tiokarbonyl-forbundet substituent, C3.7- cykloalkyl, Het3 og R6; R9 og R10 er hver uavhengig valgt fra hydrogen, valgfritt substituert d-4-alkyl, fenyl, en karbonyl- eller tiokarbonyl-forbundet substituent, C3.7- cykloalkyl, Het3 og R6, R11 er hydroksy, merkapto, cyano, nitro, halo, trihalometyl, d-4~alkyloksy, karboksyl, d-4~ alkyloksykarbonyl, trihalo-d-4-alkylsulfonyloksy, R6, NR7R8, C(=0)NR7R8, aryl, aryloksy, arylkarbonyl, C3-7-cykloalkyl, C3-7-cykloalkyloksy, ftalimid-2-yl, Het3 og C(=O)Het3; R12 og R13 er hver uavhengig valgt fra hydrogen, valgfritt substituert d-4-alkyl, fenyl, en karbonyl- eller tiokarbonyl-forbundet substituent, C3-7-cykloalkyl og R6; aryl er valgfritt substituert fenyl; Het1, Het2 og Het3 er valgfritt substituerte heterocykler; samt fremgangsmåter ved deres fremstilling og komposisjoner som inneholder dem. Den vedrører videre deres anvendelse som en medisin.
NO20000063A 1997-07-10 2000-01-06 Nye IL-5 inhiberende 6-azauracilderivater NO20000063L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202118 1997-07-10
PCT/EP1998/004191 WO1999002505A1 (en) 1997-07-10 1998-07-07 Il-5 inhibiting 6-azauracil derivatives

Publications (2)

Publication Number Publication Date
NO20000063D0 NO20000063D0 (no) 2000-01-06
NO20000063L true NO20000063L (no) 2000-03-10

Family

ID=8228531

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20000063A NO20000063L (no) 1997-07-10 2000-01-06 Nye IL-5 inhiberende 6-azauracilderivater

Country Status (23)

Country Link
EP (1) EP1000040B1 (no)
JP (1) JP2002511882A (no)
KR (1) KR20010014049A (no)
CN (1) CN1262679A (no)
AR (1) AR013360A1 (no)
AT (1) ATE364597T1 (no)
AU (1) AU742145B2 (no)
BR (1) BR9811678A (no)
CA (1) CA2294145A1 (no)
DE (1) DE69837922D1 (no)
EE (1) EE200000016A (no)
HR (1) HRP20000003A2 (no)
HU (1) HUP0004687A3 (no)
ID (1) ID24390A (no)
IL (1) IL133916A0 (no)
NO (1) NO20000063L (no)
NZ (1) NZ502180A (no)
PL (1) PL337947A1 (no)
SK (1) SK183999A3 (no)
TR (1) TR200000153T2 (no)
TW (1) TW496865B (no)
WO (1) WO1999002505A1 (no)
ZA (1) ZA986089B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006137A2 (en) * 1998-07-30 2000-02-10 Abbott Laboratories Glucocorticoid-selective anti-inflammatory agents
EP0987265A1 (en) 1998-09-18 2000-03-22 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives
UA73107C2 (en) * 1998-12-18 2005-06-15 Janssen Pharmaceutica Nv Derivatives of 6-azaurcyle inhibiting il-5
SK1642002A3 (en) * 1999-08-06 2003-03-04 Janssen Pharmaceutica Nv Interleukin-5 inhibiting 6-azauracil derivatives
US6743820B2 (en) 2000-07-07 2004-06-01 University Of Toledo Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor
US7183276B2 (en) 2002-02-28 2007-02-27 Takeda Pharmaceutical Company Limited Azole compounds
WO2004071448A2 (en) * 2003-02-12 2004-08-26 Transtech Pharma Inc. Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
GB0305575D0 (en) 2003-03-11 2003-04-16 Glaxo Group Ltd Novel compounds
WO2005116001A1 (en) * 2004-05-29 2005-12-08 7Tm Pharma A/S Substituted thiazoleacetic as crth2 ligands
DE102006049618A1 (de) * 2006-10-20 2008-05-08 Tschesche, Harald, Prof. Dr. Triazine und Ihre Verwendung als Metalloproteinase-Inhibitoren
CN101265238B (zh) * 2007-12-12 2010-06-16 重庆天极旅业有限公司 一种三嗪环衍生物的合成方法
CN101265216B (zh) * 2007-12-18 2012-06-27 重庆华邦胜凯制药有限公司 4-(取代乙氰基)-苯腙衍生物及其合成方法
EP2606045B1 (en) * 2010-08-16 2016-01-06 Boehringer Ingelheim International GmbH Oxadiazole inhibitors of leukotriene production
CN109963563A (zh) * 2016-07-13 2019-07-02 巴黎笛卡尔大学 用于预防和/或治疗与痤疮丙酸杆菌诱导的炎症相关的疾病的美克洛嗪衍生物和地克珠利衍生物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2149645A1 (de) * 1970-10-07 1972-09-14 Pfizer 2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose
US3912723A (en) * 1971-03-29 1975-10-14 Pfizer 2-Phenyl-as-triazine-3,5(2H,4H)diones
US3883528A (en) * 1974-04-19 1975-05-13 Pfizer Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats
CA1244024A (en) * 1984-08-01 1988-11-01 Gustaaf M. Boeckx .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES
GB8602342D0 (en) * 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
EP0476439A1 (de) * 1990-09-18 1992-03-25 Bayer Ag Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
TW403741B (en) * 1993-10-15 2000-09-01 Takeda Chemical Industries Ltd Triazine derivative, production and use thereof

Also Published As

Publication number Publication date
HRP20000003A2 (en) 2000-12-31
SK183999A3 (en) 2000-08-14
ID24390A (id) 2000-07-13
PL337947A1 (en) 2000-09-11
WO1999002505A1 (en) 1999-01-21
NO20000063D0 (no) 2000-01-06
NZ502180A (en) 2000-11-24
CA2294145A1 (en) 1999-01-21
CN1262679A (zh) 2000-08-09
AU8973898A (en) 1999-02-08
TW496865B (en) 2002-08-01
AU742145B2 (en) 2001-12-20
ZA986089B (en) 2000-01-10
IL133916A0 (en) 2001-04-30
EP1000040B1 (en) 2007-06-13
KR20010014049A (ko) 2001-02-26
ATE364597T1 (de) 2007-07-15
JP2002511882A (ja) 2002-04-16
EP1000040A1 (en) 2000-05-17
TR200000153T2 (tr) 2000-07-21
DE69837922D1 (de) 2007-07-26
AR013360A1 (es) 2000-12-27
BR9811678A (pt) 2000-09-19
HUP0004687A3 (en) 2002-03-28
EE200000016A (et) 2000-10-16
HUP0004687A2 (hu) 2002-02-28

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