ATE364597T1 - Il-5 hemmende 6-azauracilderivate - Google Patents

Il-5 hemmende 6-azauracilderivate

Info

Publication number
ATE364597T1
ATE364597T1 AT98941299T AT98941299T ATE364597T1 AT E364597 T1 ATE364597 T1 AT E364597T1 AT 98941299 T AT98941299 T AT 98941299T AT 98941299 T AT98941299 T AT 98941299T AT E364597 T1 ATE364597 T1 AT E364597T1
Authority
AT
Austria
Prior art keywords
inhibiting
azauracil derivatives
azauracil
derivatives
Prior art date
Application number
AT98941299T
Other languages
English (en)
Inventor
Jean Fernand Armand Lacrampe
Eddy Jean Edgard Freyne
Marc Gaston Venet
Gustaaf Maria Boeckx
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE364597T1 publication Critical patent/ATE364597T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
    • C07D253/0651,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/071,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075Two hetero atoms, in positions 3 and 5
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT98941299T 1997-07-10 1998-07-07 Il-5 hemmende 6-azauracilderivate ATE364597T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97202118 1997-07-10

Publications (1)

Publication Number Publication Date
ATE364597T1 true ATE364597T1 (de) 2007-07-15

Family

ID=8228531

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98941299T ATE364597T1 (de) 1997-07-10 1998-07-07 Il-5 hemmende 6-azauracilderivate

Country Status (23)

Country Link
EP (1) EP1000040B1 (de)
JP (1) JP2002511882A (de)
KR (1) KR20010014049A (de)
CN (1) CN1262679A (de)
AR (1) AR013360A1 (de)
AT (1) ATE364597T1 (de)
AU (1) AU742145B2 (de)
BR (1) BR9811678A (de)
CA (1) CA2294145A1 (de)
DE (1) DE69837922D1 (de)
EE (1) EE200000016A (de)
HR (1) HRP20000003A2 (de)
HU (1) HUP0004687A3 (de)
ID (1) ID24390A (de)
IL (1) IL133916A0 (de)
NO (1) NO20000063L (de)
NZ (1) NZ502180A (de)
PL (1) PL337947A1 (de)
SK (1) SK183999A3 (de)
TR (1) TR200000153T2 (de)
TW (1) TW496865B (de)
WO (1) WO1999002505A1 (de)
ZA (1) ZA986089B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1100483B1 (de) * 1998-07-30 2004-09-29 Abbott Laboratories Glucocorticoid selektive entzündungshemmende mittel
EP0987265A1 (de) * 1998-09-18 2000-03-22 Janssen Pharmaceutica N.V. Interleukin-5 hemmende 6-Azauracil Derivate
EE200100320A (et) * 1998-12-18 2002-10-15 Janssen Pharmaceutica N.V. 6-asauratsiili derivaadid, nende valmistamismeetod ja kasutamine, kompositsioon ja selle valmistamismeetod, retseptori märgistamismeetod ja organi visualiseerimismeetod
CZ2002356A3 (cs) 1999-08-06 2002-06-12 Janssen Pharmaceutica N. V. Deriváty 6-azauracilu inhibující interleukin-5
WO2002004411A1 (en) 2000-07-07 2002-01-17 The Administrators Of The Tulane Educational Fund Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor
US7183276B2 (en) 2002-02-28 2007-02-27 Takeda Pharmaceutical Company Limited Azole compounds
WO2004071448A2 (en) * 2003-02-12 2004-08-26 Transtech Pharma Inc. Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
GB0305575D0 (en) 2003-03-11 2003-04-16 Glaxo Group Ltd Novel compounds
WO2005116001A1 (en) * 2004-05-29 2005-12-08 7Tm Pharma A/S Substituted thiazoleacetic as crth2 ligands
DE102006049618A1 (de) * 2006-10-20 2008-05-08 Tschesche, Harald, Prof. Dr. Triazine und Ihre Verwendung als Metalloproteinase-Inhibitoren
CN101265238B (zh) * 2007-12-12 2010-06-16 重庆天极旅业有限公司 一种三嗪环衍生物的合成方法
CN101265216B (zh) * 2007-12-18 2012-06-27 重庆华邦胜凯制药有限公司 4-(取代乙氰基)-苯腙衍生物及其合成方法
NZ605690A (en) * 2010-08-16 2014-06-27 Boehringer Ingelheim Int Oxadiazole inhibitors of leukotriene production
AU2017297812A1 (en) * 2016-07-13 2019-02-07 Assistance Publique - Hopitaux De Paris Meclozine derivatives and diclazuril derivatives for use in the prevention and/or the treatment of disorders associated to the inflammation induced by P. acnes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2149645A1 (de) * 1970-10-07 1972-09-14 Pfizer 2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose
US3912723A (en) * 1971-03-29 1975-10-14 Pfizer 2-Phenyl-as-triazine-3,5(2H,4H)diones
US3883528A (en) * 1974-04-19 1975-05-13 Pfizer Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats
CA1244024A (en) * 1984-08-01 1988-11-01 Gustaaf M. Boeckx .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES
GB8602342D0 (en) * 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
EP0476439A1 (de) * 1990-09-18 1992-03-25 Bayer Ag Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
RU2146674C1 (ru) * 1993-10-15 2000-03-20 Такеда Кемикал Индастриз, Лтд. Производные триазина, способы их получения, антипротозойная композиция, добавка в пищу животных, способ ингибирования протозои у животных

Also Published As

Publication number Publication date
CN1262679A (zh) 2000-08-09
BR9811678A (pt) 2000-09-19
EP1000040A1 (de) 2000-05-17
EP1000040B1 (de) 2007-06-13
KR20010014049A (ko) 2001-02-26
HRP20000003A2 (en) 2000-12-31
AU8973898A (en) 1999-02-08
JP2002511882A (ja) 2002-04-16
EE200000016A (et) 2000-10-16
ID24390A (id) 2000-07-13
NZ502180A (en) 2000-11-24
TW496865B (en) 2002-08-01
IL133916A0 (en) 2001-04-30
ZA986089B (en) 2000-01-10
HUP0004687A2 (hu) 2002-02-28
DE69837922D1 (de) 2007-07-26
AU742145B2 (en) 2001-12-20
TR200000153T2 (tr) 2000-07-21
CA2294145A1 (en) 1999-01-21
AR013360A1 (es) 2000-12-27
NO20000063L (no) 2000-03-10
HUP0004687A3 (en) 2002-03-28
SK183999A3 (en) 2000-08-14
NO20000063D0 (no) 2000-01-06
PL337947A1 (en) 2000-09-11
WO1999002505A1 (en) 1999-01-21

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties