NO178401C - Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav

Info

Publication number: NO178401C
Authority: NO; Norway
Prior art keywords: triazines; preparation; triazolo; pyrazolo; heteroaryl
Prior art date: 1990-05-29

Application number

NO912051A

Other languages

English (en)

Other versions

NO178401B (no

NO912051D0 (no

NO912051L (no

Inventor

Peter William Rodney Caulkett

Geraint Jones

Michael George Collis

Simon Martin Poucher

Original Assignee

Zeneca Ltd

Ici Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-29

Filing date

1991-05-28

Publication date

1996-03-20

1990-05-29 Priority claimed from GB909011914A external-priority patent/GB9011914D0/en

1990-05-29 Priority claimed from GB909011913A external-priority patent/GB9011913D0/en

1991-01-22 Priority claimed from GB919101379A external-priority patent/GB9101379D0/en

1991-01-22 Priority claimed from GB919101380A external-priority patent/GB9101380D0/en

1991-02-27 Priority claimed from GB919104125A external-priority patent/GB9104125D0/en

1991-05-28 Application filed by Zeneca Ltd, Ici Plc filed Critical Zeneca Ltd

1991-05-28 Publication of NO912051D0 publication Critical patent/NO912051D0/no

1991-12-02 Publication of NO912051L publication Critical patent/NO912051L/no

1995-12-11 Publication of NO178401B publication Critical patent/NO178401B/no

1996-03-20 Publication of NO178401C publication Critical patent/NO178401C/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

NO912051A 1990-05-29 1991-05-28 Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav NO178401C (no)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB909011914A GB9011914D0 (en)	1990-05-29	1990-05-29	Heterocyclic compounds
GB909011913A GB9011913D0 (en)	1990-05-29	1990-05-29	Azole derivatives
GB919101379A GB9101379D0 (en)	1991-01-22	1991-01-22	Heterocyclic compounds
GB919101380A GB9101380D0 (en)	1991-01-22	1991-01-22	Azole derivatives
GB919104125A GB9104125D0 (en)	1991-02-27	1991-02-27	Azole derivatives

Publications (4)

Publication Number	Publication Date
NO912051D0 NO912051D0 (no)	1991-05-28
NO912051L NO912051L (no)	1991-12-02
NO178401B NO178401B (no)	1995-12-11
NO178401C true NO178401C (no)	1996-03-20

Family

ID=27516979

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO912051A NO178401C (no)	1990-05-29	1991-05-28	Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav

Country Status (20)

Country	Link
US (1)	US5270311A (no)
EP (1)	EP0459702A1 (no)
JP (1)	JP2504879B2 (no)
KR (1)	KR910020012A (no)
CN (1)	CN1056879A (no)
AP (1)	AP248A (no)
AU (1)	AU642494B2 (no)
CA (1)	CA2043424A1 (no)
CS (1)	CS159591A3 (no)
FI (1)	FI912563A (no)
GB (1)	GB2244487B (no)
HU (1)	HUT61311A (no)
IE (1)	IE911818A1 (no)
IL (1)	IL98316A (no)
NO (1)	NO178401C (no)
NZ (1)	NZ238288A (no)
OA (1)	OA09358A (no)
PT (1)	PT97776A (no)
RO (1)	RO109542B1 (no)
YU (1)	YU47812B (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5356894A (en) *	1990-05-29	1994-10-18	Rodney Peter W	Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
GB9226735D0 (en) *	1992-12-22	1993-02-17	Ici Plc	Azole derivatives
EP0459702A1 (en) *	1990-05-29	1991-12-04	Zeneca Limited	Azole Derivatives
GB9111130D0 (en) *	1991-05-23	1991-07-17	Ici Plc	Azole derivatives
GB9111131D0 (en) *	1991-05-23	1991-07-17	Ici Plc	Heterocyclic compounds
GB9125001D0 (en) *	1991-11-25	1992-01-22	Ici Plc	Heterocyclic compounds
GB9125002D0 (en) *	1991-11-25	1992-01-22	Ici Plc	Azole derivatives
GB9124968D0 (en) *	1991-11-25	1992-01-22	Ici Plc	Chemical process
WO1995003806A1 (fr) *	1993-07-27	1995-02-09	Kyowa Hakko Kogyo Co., Ltd.	Remede contre la maladie de parkinson
DE69426620T2 (de) *	1993-09-06	2001-06-21	Kyowa Hakko Kogyo Kk	Antidepressiva
AU743910B2 (en)	1997-03-24	2002-02-07	Kyowa Hakko Kirin Co., Ltd.	{1,2,4}triazolo{1,5-c}pyrimidine derivatives
US6060481A (en) *	1998-05-28	2000-05-09	The Penn State Research Foundation	Method for improving insulin sensitivity using an adenosine receptor antagonist
CN1328560A (zh) *	1998-09-22	2001-12-26	协和发酵工业株式会社	[1,2,4]***并[1,5－c]嘧啶衍生物
JPWO2004029056A1 (ja) *	2002-09-24	2006-01-26	協和醗酵工業株式会社	［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体
US7329658B2 (en) *	2003-02-06	2008-02-12	Pfizer Inc	Cannabinoid receptor ligands and uses thereof
WO2004092172A2 (en) *	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosin e receptor antagonists
WO2004092170A2 (en) *	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists
EP1615931A1 (en)	2003-04-09	2006-01-18	Biogen Idec MA Inc.	Triazolopyrazines and methods of making and using the same
US7834014B2 (en)	2003-04-09	2010-11-16	Biogen Idec Ma Inc.	A2a adenosine receptor antagonists
WO2004110454A1 (ja) *	2003-06-13	2004-12-23	Ishihara Sangyo Kaisha, Ltd.	アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
US7652041B2 (en)	2005-01-14	2010-01-26	Millennium Pharmaceuticals, Inc.	Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity
RU2015126797A (ru)	2012-12-06	2017-01-12	Сименс Акциенгезелльшафт	Система и способ введения тепла в геологическую формацию при помощи электромагнитной индукции
CN106916073A (zh) *	2017-01-20	2017-07-04	上海巧坤化工科技有限公司	一种大麦芽碱盐酸盐的合成方法
US20210032253A1 (en) *	2018-02-06	2021-02-04	Jiangsu Hengrui Medicine Co., Ltd.	Pyrazolo[1,5-a][1,3,5]triazine-2-amine derivative, preparation method therefor and medical use thereof
CA3103068A1 (en) *	2018-06-26	2020-01-02	Zhejiang Vimgreen Pharmaceuticals, Ltd	Triazolotriazine derivatives as a2a receptor antagonists
CN111051309B (zh) *	2018-06-26	2023-05-26	浙江春禾医药科技有限公司	可用作a2a受体拮抗剂的***并三嗪衍生物
BE1026602B1 (fr)	2018-09-27	2020-06-18	Iteos Therapeutics S A	Inhibiteurs d’a2a ne penetrant pas dans le cerveau et methodes d’utilisation dans le traitement de cancers
WO2020103939A1 (zh) *	2018-11-22	2020-05-28	上海科技大学	***并环类化合物、其制备方法、中间体和应用
CN112608316B (zh) *	2019-07-30	2022-10-21	厦门宝太生物科技股份有限公司	一种吡唑并三嗪类腺苷受体拮抗剂
CN114901665A (zh) *	2019-12-26	2022-08-12	浙江春禾医药科技有限公司	***并三嗪衍生物在治疗疾病中的用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3846423A (en) *	1972-06-08	1974-11-05	Icn Pharmaceuticals	Pyrazolo (1,5a) 1,3,5-triazines
BE815405A (en) *	1973-05-22	1974-11-22		Pyrazolo(1,5-a)-s-triazines - and their salts, with bronchospasmolytic activity
US3995039A (en) *	1975-05-27	1976-11-30	Merck & Co., Inc.	Pyrazolo [1,5-a] [1,3,5] triazines
GB1579932A (en) *	1976-05-12	1980-11-26	Ici Ltd	Herbicidal triazolotriazines
GB2016002B (en) *	1978-01-09	1982-05-06	Aron Sa	Amino derivatives of pyrazolo(1,5-a)s triazine
AU2192683A (en) *	1982-12-30	1984-07-05	Biomeasure Incorporated	Pyrazolo(1,5-alpha)-1,3,5-triazines
CA1267143A (en) *	1985-06-06	1990-03-27	Sun H. Kim	Anti-arthritic 7-phenylpyrazole[1,5-a]-1,3,5- triazine derivatives
US4824834A (en) *	1986-10-31	1989-04-25	Otsuka Pharmaceutical Company, Limited	Pyrazolotriazine compounds
US4734413A (en) *	1987-03-02	1988-03-29	Riker Laboratories, Inc.	Substituted 1,2,4-triazolo[1,5-A]triazines as bronchodilators
EP0297651B1 (en) *	1987-06-29	1993-11-03	Duphar International Research B.V	Anellated indole derivatives
US4970142A (en) *	1989-02-16	1990-11-13	Konica Corporation	Silver halide photographic light-sensitive material containing cyan coupler
EP0459702A1 (en) *	1990-05-29	1991-12-04	Zeneca Limited	Azole Derivatives

1991
- 1991-05-23 EP EP91304665A patent/EP0459702A1/en not_active Withdrawn
- 1991-05-23 GB GB9111132A patent/GB2244487B/en not_active Expired - Fee Related
- 1991-05-28 CS CS911595A patent/CS159591A3/cs unknown
- 1991-05-28 FI FI912563A patent/FI912563A/fi not_active Application Discontinuation
- 1991-05-28 AP APAP/P/1991/000266A patent/AP248A/en active
- 1991-05-28 AU AU77348/91A patent/AU642494B2/en not_active Ceased
- 1991-05-28 IE IE181891A patent/IE911818A1/en unknown
- 1991-05-28 NO NO912051A patent/NO178401C/no unknown
- 1991-05-28 YU YU94791A patent/YU47812B/sh unknown
- 1991-05-28 CA CA002043424A patent/CA2043424A1/en not_active Abandoned
- 1991-05-28 RO RO147639A patent/RO109542B1/ro unknown
- 1991-05-28 US US07/708,265 patent/US5270311A/en not_active Expired - Lifetime
- 1991-05-28 NZ NZ238288A patent/NZ238288A/xx unknown
- 1991-05-28 PT PT97776A patent/PT97776A/pt not_active Application Discontinuation
- 1991-05-28 KR KR1019910008926A patent/KR910020012A/ko not_active Application Discontinuation
- 1991-05-29 CN CN91103744A patent/CN1056879A/zh active Pending
- 1991-05-29 OA OA60010A patent/OA09358A/xx unknown
- 1991-05-29 JP JP3235332A patent/JP2504879B2/ja not_active Expired - Fee Related
- 1991-05-29 HU HU911789A patent/HUT61311A/hu unknown
- 1991-05-30 IL IL9831691A patent/IL98316A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR910020012A (ko)	1991-12-19
NO178401B (no)	1995-12-11
GB2244487A (en)	1991-12-04
FI912563A (fi)	1991-11-30
YU47812B (sr)	1996-01-09
NZ238288A (en)	1993-07-27
HUT61311A (en)	1992-12-28
JPH0597855A (ja)	1993-04-20
GB2244487B (en)	1994-02-02
FI912563A0 (fi)	1991-05-28
AP9100266A0 (en)	1991-07-31
RO109542B1 (ro)	1995-03-30
AU7734891A (en)	1991-12-05
IE911818A1 (en)	1991-12-04
AU642494B2 (en)	1993-10-21
HU911789D0 (en)	1991-12-30
US5270311A (en)	1993-12-14
GB9111132D0 (en)	1991-07-17
AP248A (en)	1993-03-16
YU94791A (sh)	1994-06-24
IL98316A0 (en)	1992-06-21
EP0459702A1 (en)	1991-12-04
NO912051D0 (no)	1991-05-28
OA09358A (fr)	1992-09-15
CA2043424A1 (en)	1991-11-30
CS159591A3 (en)	1992-01-15
JP2504879B2 (ja)	1996-06-05
CN1056879A (zh)	1991-12-11
NO912051L (no)	1991-12-02
PT97776A (pt)	1992-03-31
IL98316A (en)	1995-05-26

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