NO173870C - Analogifremgnagsmaate for fremstilling av terapeutisk aktive 3,5-dihydroimidazo(2,1-b)binazolin-2(1h)-on-derivater - Google Patents

Analogifremgnagsmaate for fremstilling av terapeutisk aktive 3,5-dihydroimidazo(2,1-b)binazolin-2(1h)-on-derivater

Info

Publication number: NO173870C
Authority: NO; Norway
Prior art keywords: 6alkyl; hydrogen; dihydroimidazo; derivatives; cooch2conr
Prior art date: 1989-07-07

Application number

NO903033A

Other languages

English (en)

Other versions

NO173870B (no

NO903033D0 (no

NO903033L (no

Inventor

Eddy Jean Freyne

Alfons Herman Marg Raeymaekers

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-07

Filing date

1990-07-06

Publication date

1994-02-16

1990-07-06 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1990-07-06 Publication of NO903033D0 publication Critical patent/NO903033D0/no

1991-01-08 Publication of NO903033L publication Critical patent/NO903033L/no

1993-11-08 Publication of NO173870B publication Critical patent/NO173870B/no

1994-02-16 Publication of NO173870C publication Critical patent/NO173870C/no

Links

125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical group 0.000 abstract 3
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
YLVVAWCDANPADI-UHFFFAOYSA-N 5,10-dihydro-3h-imidazo[2,1-b]quinazolin-2-one Chemical class C1C2=CC=CC=C2N=C2N1CC(=O)N2 YLVVAWCDANPADI-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
230000000297 inotrophic effect Effects 0.000 abstract 1
230000003295 lusitropic effect Effects 0.000 abstract 1
125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0834—Compounds having one or more O-Si linkage
- C07F7/0892—Compounds with a Si-O-N linkage

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cosmetics (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO903033A 1989-07-07 1990-07-06 Analogifremgnagsmaate for fremstilling av terapeutisk aktive 3,5-dihydroimidazo(2,1-b)binazolin-2(1h)-on-derivater NO173870C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP89201810		1989-07-07
US38133889A	1989-07-18	1989-07-18

Publications (4)

Publication Number	Publication Date
NO903033D0 NO903033D0 (no)	1990-07-06
NO903033L NO903033L (no)	1991-01-08
NO173870B NO173870B (no)	1993-11-08
NO173870C true NO173870C (no)	1994-02-16

Family

ID=26121192

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO903033A NO173870C (no)	1989-07-07	1990-07-06	Analogifremgnagsmaate for fremstilling av terapeutisk aktive 3,5-dihydroimidazo(2,1-b)binazolin-2(1h)-on-derivater

Country Status (18)

Country	Link
EP (1)	EP0406958B1 (no)
JP (1)	JPH0363277A (no)
KR (1)	KR910002857A (no)
AT (1)	ATE119902T1 (no)
AU (1)	AU623539B2 (no)
CA (1)	CA2020630A1 (no)
DE (1)	DE69017773T2 (no)
DK (1)	DK0406958T3 (no)
ES (1)	ES2072373T3 (no)
FI (1)	FI93361C (no)
HU (1)	HUT55395A (no)
IE (1)	IE65781B1 (no)
IL (1)	IL94978A (no)
NO (1)	NO173870C (no)
NZ (1)	NZ234186A (no)
PH (1)	PH27111A (no)
PT (1)	PT94616B (no)
RU (1)	RU2057753C1 (no)

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US5120845A (en) *	1989-07-18	1992-06-09	Janssen Pharmaceutica N.V.	Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives
JPH05271200A (ja) *	1991-05-22	1993-10-19	Egyt Gyogyszervegyeszeti Gyar	６，７−ジクロロ−１，５−ジヒドロ−イミダゾ〔２，１−ｂ〕キナゾリン−２〔３Ｈ〕−オンの製造方法
PH31245A (en) *	1991-10-30	1998-06-18	Janssen Pharmaceutica Nv	1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
FR2689012A1 (fr) *	1992-03-27	1993-10-01	Beecham Laboratoires	Utilisation de composés aryliques dans le traitement d'affections cardio-vasculaires.
TW593317B (en)	1993-06-21	2004-06-21	Janssen Pharmaceutica Nv	Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
KR100347215B1 (ko) *	1994-03-07	2002-10-31	주식회사 삼영건설기술공사	고강도구조보강나선관
US6451807B1 (en)	1999-04-30	2002-09-17	Lilly Icos, Llc.	Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
CA2374215C (en)	1999-05-28	2011-05-24	Virco N.V.	New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance
BR0115132A (pt)	2000-10-20	2004-06-15	Virco Bvba	Perfis mutacionais em transcriptase reversa de hiv-1 correlacionados com resistência à droga fenotìpica
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
US7700608B2 (en)	2004-08-04	2010-04-20	Shire Holdings Ag	Quinazoline derivatives and their use in the treatment of thrombocythemia
US8383637B2 (en)	2004-08-06	2013-02-26	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8426429B2 (en)	2004-08-06	2013-04-23	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en)	2004-08-06	2013-05-07	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
WO2007050612A1 (en)	2005-10-25	2007-05-03	Janssen Pharmaceutica N.V.	2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of beta-secretase (bace)
EP2218442A1 (en)	2005-11-09	2010-08-18	CombinatoRx, Inc.	Methods, compositions, and kits for the treatment of ophthalmic disorders
US7932261B2 (en)	2006-02-06	2011-04-26	Janssen Pharmaceutica Nv	Macrocycle derivatives useful as inhibitors of β-secretase (BACE)
US7776882B2 (en)	2006-02-06	2010-08-17	Baxter Ellen W	2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of β-secretase (BACE)
WO2007092854A2 (en)	2006-02-06	2007-08-16	Janssen Pharmaceutica N.V.	2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)
US8304420B2 (en)	2006-11-28	2012-11-06	Shire Llc	Substituted quinazolines for reducing platelet count
US7910597B2 (en)	2006-11-28	2011-03-22	Shire Llc	Substituted quinazolines
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP5546451B2 (ja)	2007-06-04	2014-07-09	シナジーファーマシューティカルズインコーポレイテッド	胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
US8076358B2 (en)	2008-01-28	2011-12-13	Janssen Pharmaceutica Nv	6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)
WO2009097401A1 (en)	2008-01-29	2009-08-06	Janssen Pharmaceutica N.V.	2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)
GB0808950D0 (en) *	2008-05-16	2008-06-25	Shire Llc	Substituted quinazolines
GB0808953D0 (en) *	2008-05-16	2008-06-25	Shire Llc	substituted quinazolines
GB0808944D0 (en) *	2008-05-16	2008-06-25	Shire Llc	Substituted quinazolines
AU2009256157B2 (en)	2008-06-04	2014-12-18	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en)	2008-07-16	2010-01-21	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
CN103764672A (zh)	2011-03-01	2014-04-30	辛纳吉制药公司	制备鸟苷酸环化酶c激动剂的方法
US20150119399A1 (en)	2012-01-10	2015-04-30	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
WO2014131024A2 (en)	2013-02-25	2014-08-28	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
CA2905435A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
US10011637B2 (en)	2013-06-05	2018-07-03	Synergy Pharmaceuticals, Inc.	Ultra-pure agonists of guanylate cyclase C, method of making and using same
US20160184387A1 (en)	2013-08-09	2016-06-30	Dominique Charmot	Compounds and methods for inhibiting phosphate transport
WO2020237096A1 (en)	2019-05-21	2020-11-26	Ardelyx, Inc.	Combination for lowering serum phosphate in a patient

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4490371A (en) *	1983-02-16	1984-12-25	Syntex (U.S.A.) Inc.	N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides

1990
- 1990-06-21 NZ NZ234186A patent/NZ234186A/xx unknown
- 1990-06-26 PH PH40730A patent/PH27111A/en unknown
- 1990-07-02 DE DE69017773T patent/DE69017773T2/de not_active Expired - Fee Related
- 1990-07-02 AT AT90201745T patent/ATE119902T1/de not_active IP Right Cessation
- 1990-07-02 EP EP90201745A patent/EP0406958B1/en not_active Expired - Lifetime
- 1990-07-02 ES ES90201745T patent/ES2072373T3/es not_active Expired - Lifetime
- 1990-07-02 KR KR1019900009910A patent/KR910002857A/ko not_active Application Discontinuation
- 1990-07-02 DK DK90201745.8T patent/DK0406958T3/da active
- 1990-07-05 IL IL9497890A patent/IL94978A/en not_active IP Right Cessation
- 1990-07-05 JP JP2176486A patent/JPH0363277A/ja active Pending
- 1990-07-06 FI FI903428A patent/FI93361C/fi not_active IP Right Cessation
- 1990-07-06 CA CA002020630A patent/CA2020630A1/en not_active Abandoned
- 1990-07-06 AU AU58798/90A patent/AU623539B2/en not_active Ceased
- 1990-07-06 RU SU904830347A patent/RU2057753C1/ru active
- 1990-07-06 IE IE246990A patent/IE65781B1/en not_active IP Right Cessation
- 1990-07-06 HU HU904118A patent/HUT55395A/hu unknown
- 1990-07-06 PT PT94616A patent/PT94616B/pt not_active IP Right Cessation
- 1990-07-06 NO NO903033A patent/NO173870C/no unknown

Also Published As

Publication number	Publication date
CA2020630A1 (en)	1991-01-08
NZ234186A (en)	1991-10-25
EP0406958B1 (en)	1995-03-15
KR910002857A (ko)	1991-02-26
PH27111A (en)	1993-03-16
EP0406958A2 (en)	1991-01-09
PT94616A (pt)	1991-03-20
DE69017773T2 (de)	1995-07-13
DE69017773D1 (de)	1995-04-20
NO173870B (no)	1993-11-08
EP0406958A3 (en)	1991-09-25
ES2072373T3 (es)	1995-07-16
IE65781B1 (en)	1995-11-15
IL94978A (en)	1994-06-24
DK0406958T3 (da)	1995-04-03
HU904118D0 (en)	1990-12-28
HUT55395A (en)	1991-05-28
ATE119902T1 (de)	1995-04-15
FI903428A0 (fi)	1990-07-06
RU2057753C1 (ru)	1996-04-10
AU5879890A (en)	1991-01-10
FI93361B (fi)	1994-12-15
IL94978A0 (en)	1991-06-10
AU623539B2 (en)	1992-05-14
NO903033D0 (no)	1990-07-06
JPH0363277A (ja)	1991-03-19
IE902469A1 (en)	1991-02-13
PT94616B (pt)	1997-02-28
FI93361C (fi)	1995-03-27
NO903033L (no)	1991-01-08

Publication	Publication Date	Title
NO173870C (no)	1994-02-16	Analogifremgnagsmaate for fremstilling av terapeutisk aktive 3,5-dihydroimidazo(2,1-b)binazolin-2(1h)-on-derivater
AU588890B2 (en)	1989-09-28	(4-Piperidinylmethyl and - hetero) Purines
FI900085A (fi)	1990-07-10	Menetelmä terapeuttisesti käyttökelpoisten N-(pyrimidin- ja kondensoitu pyrimidin-4-oni)etyyli-piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
AU593736B2 (en)	1990-02-15	Novel intermediates
AU1398892A (en)	1992-10-15	Pyrazolopyridine compound and processes for preparation thereof
AU630575B2 (en)	1992-10-29	Benzodiazepine derivatives
FI894125A0 (fi)	1989-09-01	Analogiamenetelmä terapeuttisesti käyttökelpoisen 3-piperidinyyli-indatsolin valmistamiseksi