NO171633C - Analogifremgangsmaate for fremstilling av terapeutisk aktive cykloalkano(1.2-b)indol-sulfonamider - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive cykloalkano(1.2-b)indol-sulfonamider

Info

Publication number: NO171633C
Authority: NO; Norway
Prior art keywords: cycloal; sulphonamides; indol; preparation; change
Prior art date: 1986-02-21

Application number

NO870437A

Other languages

English (en)

Other versions

NO870437D0 (no

NO171633B (no

NO870437L (no

Inventor

Horst Boeshagen

Ulrich Rosentreter

Folker Lieb

Hermann Oediger

Friedel Seuter

Elisabeth Perzborn

Volker-Bernd Fiedler

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-02-21

Filing date

1987-02-04

Publication date

1993-04-14

1987-02-04 Application filed by Bayer Ag filed Critical Bayer Ag

1987-02-04 Publication of NO870437D0 publication Critical patent/NO870437D0/no

1987-08-24 Publication of NO870437L publication Critical patent/NO870437L/no

1993-01-04 Publication of NO171633B publication Critical patent/NO171633B/no

1993-04-14 Publication of NO171633C publication Critical patent/NO171633C/no

Links

-1 INDOL SULPHONAMIDES Chemical class 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pulmonology (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO870437A 1986-02-21 1987-02-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive cykloalkano(1.2-b)indol-sulfonamider NO171633C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3605566		1986-02-21
DE19863631824 DE3631824A1 (de)	1986-02-21	1986-09-19	Cycloalkano(1.2-b)indol-sulfonamide

Publications (4)

Publication Number	Publication Date
NO870437D0 NO870437D0 (no)	1987-02-04
NO870437L NO870437L (no)	1987-08-24
NO171633B NO171633B (no)	1993-01-04
NO171633C true NO171633C (no)	1993-04-14

Family

ID=25841196

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO870437A NO171633C (no)	1986-02-21	1987-02-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive cykloalkano(1.2-b)indol-sulfonamider

Country Status (19)

Country	Link
US (3)	US4827032A (no)
EP (1)	EP0242518B1 (no)
JP (1)	JPH075552B2 (no)
KR (2)	KR940007302B1 (no)
AU (1)	AU595855B2 (no)
CA (1)	CA1309414C (no)
CS (1)	CS275837B6 (no)
DE (2)	DE3631824A1 (no)
DK (1)	DK167009B1 (no)
ES (1)	ES2028801T3 (no)
FI (1)	FI86544C (no)
GR (1)	GR3001763T3 (no)
HU (1)	HU198686B (no)
IE (1)	IE59470B1 (no)
IL (1)	IL81611A (no)
NO (1)	NO171633C (no)
NZ (1)	NZ219319A (no)
PH (1)	PH24491A (no)
PT (1)	PT84316B (no)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3826371A1 (de) *	1988-08-03	1990-02-08	Bayer Ag	Tetrahydro-1-benz-(c,d)-indolpropionsaeure-sulfonamide
DE3829455A1 (de) *	1988-08-31	1990-03-15	Boehringer Mannheim Gmbh	Sulfonamidoalkyl-cyclohexan-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel
US4959383A (en) *	1988-10-31	1990-09-25	E. R. Squibb & Sons, Inc.	Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use
US5070099A (en) *	1988-10-31	1991-12-03	E. R. Squibb & Sons, Inc.	Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
US5006542A (en) *	1988-10-31	1991-04-09	E. R. Squibb & Sons, Inc.	Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
GB8924392D0 (en) *	1989-10-30	1989-12-20	Bayer Ag	Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
GB9008108D0 (en) *	1990-04-10	1990-06-06	Bayer Ag	Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles
DE4027278A1 (de) *	1990-08-29	1992-03-05	Bayer Ag	Heterocyclisch substituierte indolsulfonamide
US5827871A (en) *	1991-06-26	1998-10-27	Smithkline Beecham Plc	Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof
DE4131346A1 (de) *	1991-09-20	1993-03-25	Bayer Ag	Indolsulfonamid substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
EP0603432B1 (en) *	1992-12-18	1998-10-21	Smithkline Beecham Plc	Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated
DE19507751A1 (de) *	1995-03-06	1996-09-12	Bayer Ag	Verfahren zur Herstellung von substituierten 1,2,3,4-Tetrahydrocarbazolen
US5708187A (en) *	1996-06-27	1998-01-13	Eli Lilly And Company	6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
DE19757983A1 (de) *	1997-12-24	1999-07-01	Bayer Yakuhin Ltd	Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban)
CA2618550C (en) *	2005-08-12	2013-12-17	Merck Frosst Canada Ltd.	Indole derivatives as crth2 receptor antagonists
US7662831B2 (en) *	2006-07-27	2010-02-16	Wyeth Llc	Tetracyclic indoles as potassium channel modulators
US7601856B2 (en) *	2006-07-27	2009-10-13	Wyeth	Benzofurans as potassium ion channel modulators
NZ574705A (en)	2006-08-07	2011-12-22	Actelion Pharmaceuticals Ltd	(3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
GB0624084D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril amino acid salts
GB0624090D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril amine salts
GB0624087D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril combination salt
CA2673214A1 (en) *	2006-12-20	2008-06-26	Cardoz Ab	New combination for use in the treatment of inflammatory disorders
US20100099693A1 (en) *	2007-01-16	2010-04-22	Johan Raud	New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) *	2007-07-11	2009-01-15	Cardoz Ab	Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
WO2010008864A2 (en) *	2008-06-24	2010-01-21	Amira Pharmaceuticals, Inc.	Cycloalkane[b]indole angtagonists of prostaglandin d2 receptors
WO2010006939A1 (en) *	2008-07-15	2010-01-21	F. Hoffmann-La Roche Ag	Aminotetrahydroindazoloacetic acids
NZ591914A (en)	2008-11-17	2013-04-26	Hoffmann La Roche	Naphthylacetic acids
CA2740864A1 (en)	2008-11-17	2010-05-20	F. Hoffmann-La Roche Ag	Naphthylacetic acids
EP2358677B1 (en)	2008-11-17	2014-01-08	F. Hoffmann-La Roche AG	Naphthylacetic acids used as crth2 antagonists or partial agonists
BR112012024114B1 (pt)	2010-03-22	2021-02-09	Idorsia Pharmaceuticals Ltd	Compostos derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9h-carbazol, uso dos mesmos, e, composição farmacêutica
UA110245C2 (en)	2011-04-14	2015-12-10	Actelion Pharmaceuticals Ltd	7-(heleroaryl-amino)-6,7,8,9-letrahydropyrido[1,2-a]indol acetic acid derivatives and their application as prostaglandin d2 receptor modulators
US8470884B2 (en)	2011-11-09	2013-06-25	Hoffmann-La Roche Inc.	Alkenyl naphthylacetic acids
BR112016021471B1 (pt)	2014-03-17	2022-10-11	Idorsia Pharmaceuticals Ltd	Compostos derivados de ácido acético azaindol, composição farmacêutica, e, uso de um composto
US9850241B2 (en)	2014-03-18	2017-12-26	Idorsia Pharmaceuticals Ltd	Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators
AU2016323262B2 (en)	2015-09-15	2020-11-19	Idorsia Pharmaceuticals Ltd	Crystalline forms

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1415322A (fr) *	1963-12-09	1965-10-22	Eastman Kodak Co	Nouveaux composés de 3-sulfamidocyclobutanone et de 3-sulfamidocyclobutanol
US3642816A (en) *	1967-08-10	1972-02-15	Sterling Drug Inc	3-acetamido-1 2 3 4-tetrahydrocarbazole
JPS4713658Y1 (no) *	1969-12-18	1972-05-18
CH586678A5 (no) *	1970-05-25	1977-04-15	Hoffmann La Roche
DE2226702A1 (de) *	1972-05-25	1973-12-13	Schering Ag	Neue mittel zur behandlung des diabetes mellitus
JPS5186117A (en) *	1975-01-27	1976-07-28	Tanabe Seiyaku Co	Johoseibiryushiseizainoseiho
US4235901A (en) *	1978-05-08	1980-11-25	American Home Products Corporation	1-Hydroxyalkanamine pyrano(3,4-b)indole compositions and use thereof

1986
- 1986-09-19 DE DE19863631824 patent/DE3631824A1/de not_active Withdrawn
1987
- 1987-02-04 NO NO870437A patent/NO171633C/no unknown
- 1987-02-11 ES ES198787101901T patent/ES2028801T3/es not_active Expired - Lifetime
- 1987-02-11 EP EP87101901A patent/EP0242518B1/de not_active Expired - Lifetime
- 1987-02-11 DE DE8787101901T patent/DE3769191D1/de not_active Expired - Lifetime
- 1987-02-13 AU AU68808/87A patent/AU595855B2/en not_active Expired
- 1987-02-18 NZ NZ219319A patent/NZ219319A/en unknown
- 1987-02-18 IL IL81611A patent/IL81611A/xx not_active IP Right Cessation
- 1987-02-19 PT PT84316A patent/PT84316B/pt not_active IP Right Cessation
- 1987-02-19 CA CA000530077A patent/CA1309414C/en not_active Expired - Lifetime
- 1987-02-19 HU HU87650A patent/HU198686B/hu unknown
- 1987-02-19 FI FI870693A patent/FI86544C/fi not_active IP Right Cessation
- 1987-02-19 CS CS871093A patent/CS275837B6/cs unknown
- 1987-02-19 PH PH34883A patent/PH24491A/en unknown
- 1987-02-20 KR KR1019870001410A patent/KR940007302B1/ko not_active IP Right Cessation
- 1987-02-20 DK DK087187A patent/DK167009B1/da not_active IP Right Cessation
- 1987-02-20 IE IE43987A patent/IE59470B1/en not_active IP Right Cessation
- 1987-07-31 KR KR87008383A patent/KR960001914B1/ko not_active IP Right Cessation
1988
- 1988-06-29 US US07/212,840 patent/US4827032A/en not_active Expired - Lifetime
1989
- 1989-02-08 US US07/308,152 patent/US4904797A/en not_active Expired - Lifetime
- 1989-11-28 US US07/442,043 patent/US4965258A/en not_active Expired - Lifetime
1991
- 1991-04-11 GR GR91400361T patent/GR3001763T3/el unknown
1992
- 1992-02-27 JP JP4076232A patent/JPH075552B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HU198686B (en)	1989-11-28
JPH075552B2 (ja)	1995-01-25
NO870437D0 (no)	1987-02-04
DE3631824A1 (de)	1988-03-31
GR3001763T3 (en)	1992-11-23
FI86544C (fi)	1992-09-10
KR890001982A (ko)	1989-04-07
ES2028801T3 (es)	1992-07-16
PH24491A (en)	1990-07-18
US4965258A (en)	1990-10-23
IE59470B1 (en)	1994-03-09
EP0242518B1 (de)	1991-04-10
PT84316A (en)	1987-03-01
AU6880887A (en)	1987-08-27
CS8701093A2 (en)	1990-11-14
DK167009B1 (da)	1993-08-16
NO171633B (no)	1993-01-04
KR940007302B1 (ko)	1994-08-12
PT84316B (pt)	1989-09-14
HUT44493A (en)	1988-03-28
KR870007885A (ko)	1987-09-22
FI86544B (fi)	1992-05-29
CS275837B6 (en)	1992-03-18
IE870439L (en)	1987-08-21
KR960001914B1 (en)	1996-02-06
NO870437L (no)	1987-08-24
IL81611A (en)	1991-03-10
DE3769191D1 (de)	1991-05-16
NZ219319A (en)	1990-12-21
EP0242518A1 (de)	1987-10-28
DK87187D0 (da)	1987-02-20
FI870693A0 (fi)	1987-02-19
CA1309414C (en)	1992-10-27
JPH0592954A (ja)	1993-04-16
AU595855B2 (en)	1990-04-12
US4827032A (en)	1989-05-02
FI870693A (fi)	1987-08-22
US4904797A (en)	1990-02-27
DK87187A (da)	1987-08-22

Publication	Publication Date	Title
NO171633C (no)	1993-04-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive cykloalkano(1.2-b)indol-sulfonamider
NO165344C (no)	1991-01-30	Analogifremgangsmaate for fremstilling av teraputisk aktive indolizin-derivater.
NO870075L (no)	1987-07-09	Fremgangsmaate for fremstilling av terapeutisk aktive indol-derivater.
NO166639C (no)	1991-08-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte, basiske 2-aminotetraliner.
NO171787C (no)	1993-05-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive 8-azabicyclo(3.2.1)oct-2-en-forbindelser
NO167384C (no)	1991-10-30	Analogifremgangsmaate for fremstilling av terapeutisk aktive n-aralkylpiperidinmethanolderivater.
NO871267D0 (no)	1987-03-26	Fremgangsmaate for fremstilling av terapeutisk aktive tiazepinforbindelser.
NO871266D0 (no)	1987-03-26	Fremgangsmaate for fremstilling av terapeutisk aktive kinazolin-derivater.
NO902411D0 (no)	1990-05-31	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-hydroksy-n-propylaminer.
NO874869L (no)	1988-05-25	Fremgangsmaate for fremstilling av terapeutisk aktive forbindelser.
NO870526L (no)	1987-08-13	Fremgangsmaate for fremstilling av terapeutisk aktive dikloranilin-derivater.
NO880182D0 (no)	1988-01-18	Fremgangsmaate for fremstilling av terapeutisk aktive 1, 2-dihydro-3h-indazol-3h-indazol-3-on-derivater.
NO162238C (no)	1989-12-06	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,4-dihydro-4-oksonaftyridinderivater.
NO166080C (no)	1991-05-29	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5,6,8-trifluorkinoliner.
NO871588D0 (no)	1987-04-14	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske karboksamider.
NO863671L (no)	1987-03-17	Fremgangsmaate for fremstilling av terapeutisk aktive tetrahydro-2-heterocykloalkylpyrido(4,3)indoler.
NO171412C (no)	1993-03-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksatiolan- eller 1,3-ditiolanderivater
NO166130C (no)	1991-06-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-pyridonderivater.
NO873108D0 (no)	1987-07-24	Fremgangsmaate for fremstilling av terapeutisk aktive 1,4-benzodiazepiner.
NO167802C (no)	1991-12-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzotiazepinderivater.
NO871766D0 (no)	1987-04-28	Fremgangsmaate for fremstilling av terapeutisk aktive benzo(de)isokinolin-1,3-dioner.
NO171211C (no)	1993-02-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-dioksaner
NO168247C (no)	1992-01-29	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5-metoksy-alkyl-ammonium-tetrahydrofuraner.
NO893768D0 (no)	1989-09-22	Fremgangsmaate for fremstilling av terapeutisk aktive 2,7-diamino-1,2,3,4-tetrahydronaftalenderivater.
NO882281D0 (no)	1988-05-25	Fremgangsmaate for fremstilling av terapeutisk aktive pyrazinamider.