NO166267C - Konjugat av et maalsoekende biologisk aktivt molekyl og en forbindelse inneholdende spormerkende metall, samt diagnostisk preparat inneholdende konjugatet. - Google Patents

Konjugat av et maalsoekende biologisk aktivt molekyl og en forbindelse inneholdende spormerkende metall, samt diagnostisk preparat inneholdende konjugatet.

Info

Publication number: NO166267C
Authority: NO; Norway
Prior art keywords: conjugate; metal; biologically active; targesting; sporable
Prior art date: 1983-10-06

Application number

NO844017A

Other languages

English (en)

Other versions

NO844017L (no

NO166267B (no

Inventor

Glen Lewis Tolman

Original Assignee

Du Pont Merck Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-10-06

Filing date

1984-10-05

Publication date

1991-06-26

1984-10-05 Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma

1985-04-09 Publication of NO844017L publication Critical patent/NO844017L/no

1988-11-04 Priority to NO884941A priority Critical patent/NO173874C/no

1991-03-18 Publication of NO166267B publication Critical patent/NO166267B/no

1991-06-26 Publication of NO166267C publication Critical patent/NO166267C/no

Links

150000001875 compounds Chemical class 0.000 title 1
DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 abstract 2
102000003792 Metallothionein Human genes 0.000 abstract 2
108090000157 Metallothionein Proteins 0.000 abstract 2
239000002184 metal Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Optics & Photonics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)

NO844017A 1983-10-06 1984-10-05 Konjugat av et maalsoekende biologisk aktivt molekyl og en forbindelse inneholdende spormerkende metall, samt diagnostisk preparat inneholdende konjugatet. NO166267C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO884941A NO173874C (no)	1983-10-06	1988-11-04	Konjugat til bruk ved fremstilling av spormerkede konjugater, bestaaende av et maalsoekende, biologisk aktivt molekyl og en forbindelse inneholdende et ikke-radioaktivt metall

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/539,733 US4732864A (en)	1983-10-06	1983-10-06	Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules

Publications (3)

Publication Number	Publication Date
NO844017L NO844017L (no)	1985-04-09
NO166267B NO166267B (no)	1991-03-18
NO166267C true NO166267C (no)	1991-06-26

Family

ID=24152436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO844017A NO166267C (no)	1983-10-06	1984-10-05	Konjugat av et maalsoekende biologisk aktivt molekyl og en forbindelse inneholdende spormerkende metall, samt diagnostisk preparat inneholdende konjugatet.

Country Status (17)

Country	Link
US (1)	US4732864A (no)
EP (1)	EP0137457B1 (no)
JP (2)	JPS60166625A (no)
KR (1)	KR860001151B1 (no)
AT (1)	ATE32730T1 (no)
AU (1)	AU578428B2 (no)
CA (1)	CA1248090A (no)
DE (1)	DE3469536D1 (no)
DK (1)	DK162105C (no)
ES (1)	ES8605105A1 (no)
FI (1)	FI81263C (no)
GR (1)	GR80560B (no)
IE (1)	IE55709B1 (no)
IL (1)	IL73183A (no)
NO (1)	NO166267C (no)
NZ (1)	NZ209788A (no)
ZA (1)	ZA847797B (no)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4707352A (en) *	1984-01-30	1987-11-17	Enzo Biochem, Inc.	Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US4880626A (en) *	1985-01-18	1989-11-14	Mcmichael John	Immunotherapeutic methods and compositions for the treatment of diseases of viral origin, including acquired immune deficiency syndrome
NO167124C (no) *	1985-04-03	1991-10-09	Du Pont Merck Pharma	Fremgangsmaate for fremstilling av et spormerket konjugat av metallthionein og biologisk aktivt molekyl.
US5776093A (en) *	1985-07-05	1998-07-07	Immunomedics, Inc.	Method for imaging and treating organs and tissues
AU597032B2 (en) *	1986-01-16	1990-05-24	General Hospital Corporation, The	Method for the diagnosis and treatment of inflammation
US6165729A (en) *	1986-04-30	2000-12-26	Hyperion Catalysis International, Inc.	Electrochemiluminescent reaction utilizing amine-derived reductant
US6451225B1 (en)	1986-04-30	2002-09-17	Igen International, Inc.	Electrochemiluminescent reaction utilizing amine-derived reductant
US5591581A (en)	1986-04-30	1997-01-07	Igen, Inc.	Electrochemiluminescent rhenium moieties and methods for their use
US4877599A (en) *	1986-11-10	1989-10-31	New England Deaconess Hospital Corporation	Detection of vascular disease with labelled antibodies
US5672334A (en) *	1991-01-16	1997-09-30	Access Pharmaceuticals, Inc.	Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
WO1989004302A1 (en) *	1987-11-04	1989-05-18	Igen, Inc.	Electrochemiluminescent rhenium moieties and methods
US5202451A (en) *	1988-02-17	1993-04-13	Neorx Corporation	Anchimeric radiometal chelating compounds
USH735H (en)	1988-03-30	1990-02-06	The United States Of America As Represented By The United States Department Of Energy	Lead-203 as a label for radioimaging
US5061641A (en) *	1988-04-01	1991-10-29	Immunomedics, Inc.	Method for radiolabeling proteins
US5057301A (en) *	1988-04-06	1991-10-15	Neorx Corporation	Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents
US6702986B1 (en)	1988-04-29	2004-03-09	Igen International, Inc.	Electrochemiluminescent reaction utilizing amine-derived reductant
US5059541A (en) *	1988-04-29	1991-10-22	Neorx Corporation	Minimal derivatization of proteins
US5972890A (en) *	1988-05-02	1999-10-26	New England Deaconess Hospital Corporation	Synthetic peptides for arterial imaging
US5726153A (en) *	1988-05-02	1998-03-10	New England Deaconess Hospital Corporation	Synthetic peptides for arterial imaging
US5218128A (en) *	1988-06-15	1993-06-08	Centocor, Inc.	Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
WO1990006323A2 (en) *	1988-11-29	1990-06-14	Centocor, Inc.	Chimeric proteins incorporating a metal binding protein
US5759515A (en) *	1989-08-09	1998-06-02	Rhomed Incorporated	Polyvalent peptide pharmaceutical applications
US5102990A (en) *	1989-08-09	1992-04-07	Rhomed Incorporated	Direct radiolabeling of antibodies and other proteins with technetium or rhenium
US5078985A (en) *	1989-08-09	1992-01-07	Rhomed, Incorporated	Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction
US5443816A (en) *	1990-08-08	1995-08-22	Rhomed Incorporated	Peptide-metal ion pharmaceutical preparation and method
US5985240A (en) *	1989-08-09	1999-11-16	Rhomed Incorporated	Peptide radiopharmaceutical applications
US5700444A (en) *	1992-02-20	1997-12-23	Rhomed Incorporated	Chemotactic peptide pharmaceutical applications
CA2075974C (en) *	1990-02-15	2001-02-06	Dana M. Fowlkes	Totally synthetic affinity reagents
US5747334A (en) *	1990-02-15	1998-05-05	The University Of North Carolina At Chapel Hill	Random peptide library
US5498538A (en) *	1990-02-15	1996-03-12	The University Of North Carolina At Chapel Hill	Totally synthetic affinity reagents
US6019958A (en) *	1991-02-08	2000-02-01	Diatide, Inc.	Technetium-99m labeled peptides for imaging inflammation
US7238340B1 (en)	1991-11-27	2007-07-03	Cis Bio International	Monoamine, diamide, thiol-containing metal chelating agents
US5645815A (en)	1991-02-08	1997-07-08	Diatide, Inc.	Radiolabled compounds for thrombus imaging
DK0570493T3 (da) *	1991-02-08	2000-06-26	Diatide Inc	Technetium-99m-mærkede polypeptider til billeddannelse.
US6403771B1 (en)	1991-02-19	2002-06-11	Actinium Pharmaceuticals, Limited	Method and means for site directed therapy
US6391590B1 (en) *	1991-10-21	2002-05-21	The Regents Of The University Of California	Recombinant streptavidin-metallothionein chimeric protein having biological recognition specificity
US5556609A (en) *	1992-02-20	1996-09-17	Rhomed Incorporated	YIGSR peptide radiopharmaceutical applications
US5738838A (en) *	1992-02-20	1998-04-14	Rhomed Incorporated	IKVAV peptide radiopharmaceutical applications
US5643549A (en) *	1992-02-20	1997-07-01	Rhomed Incorporated	Leukostimulatory agent for in vivo leukocyte tagging
US5326856A (en) *	1992-04-09	1994-07-05	Cytogen Corporation	Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
US5338686A (en) *	1992-04-29	1994-08-16	Hellerstein Marc K	Method for measuring in vivo synthesis of biopolymers
CA2100709C (en) *	1992-07-27	2004-03-16	Maurits W. Geerlings	Method and means for site directed therapy
US6203775B1 (en) *	1993-03-19	2001-03-20	The General Hospital Corporation	Chelating polymers for labeling of proteins
JPH08510250A (ja) *	1993-05-17	1996-10-29	イムノメディクス，インコーポレイテッド	ビオチンまたはアビジンと金属キレート化タンパク質との複合体による病変の検出および治療法の改善
US6120768A (en) *	1993-05-17	2000-09-19	Immunomedics, Inc.	Dota-biotin derivatives
WO1995003280A1 (en) *	1993-07-19	1995-02-02	Resolution Pharmaceuticals Inc.	Hydrazino-type radionuclide chelators having an n3s configuration
WO1995004753A1 (en) *	1993-08-11	1995-02-16	University Of New Mexico	Compositions of fusion proteins containing metallothionein and targeting-protein structural components
US5449761A (en) *	1993-09-28	1995-09-12	Cytogen Corporation	Metal-binding targeted polypeptide constructs
US5942210A (en) *	1994-11-15	1999-08-24	Cytogen Corporation	Methods for lyoprotecting a macromolecule using tricine
US5891418A (en) *	1995-06-07	1999-04-06	Rhomed Incorporated	Peptide-metal ion pharmaceutical constructs and applications
US6331285B1 (en)	1996-06-05	2001-12-18	Palatin Technologies, Inc.	Structurally determined cyclic metallo-constructs and applications
US7745142B2 (en)	1997-09-15	2010-06-29	Molecular Devices Corporation	Molecular modification assays
JP2002524108A (ja)	1998-07-28	2002-08-06	インナーダイン，インコーポレイテッド	吸収性近接照射療法および化学療法送達デバイスならびに方法
BR9914519A (pt) *	1998-10-13	2001-07-03	Univ Georgia Res Found	Peptìdios bioativos estabilizados e métodos de identificação, sìntese e uso
US20030190740A1 (en)	1998-10-13	2003-10-09	The University Of Georgia Research Foundation, Inc	Stabilized bioactive peptides and methods of identification, synthesis, and use
US7666609B1 (en)	1998-12-01	2010-02-23	Shanghai Cp Guojian Pharmaceutical Co. Ltd.	Method and composition for diagnosis of melanocytic lesions
AU2591800A (en) *	1998-12-23	2000-07-31	Bert L. Vallee	Synthetic and therapeutic methods for the alpha and beta domains of metallothionein
CA2359234C (en) *	1999-01-22	2011-11-15	Martek Biosciences Corporation	A method for labeled conjugate production
ES2198171B1 (es) *	2000-09-06	2005-04-16	Provital, S.A.	Composicion cosmetica y/o farmaceutica conteniendo metalotioneina.
US7385025B2 (en)	2000-12-19	2008-06-10	Palatin Technologies, Inc.	Metallopeptide compounds
US20020117169A1 (en) *	2001-02-27	2002-08-29	Kurz Daniel R.	Cover and applicator for a portion of a mammalian body
CA2449941A1 (en) *	2001-06-11	2002-12-19	University Of Miami	Use of radiopharmaceutical complexes in achieving transplantation tolerance
AU2003241024A1 (en) *	2002-05-29	2003-12-19	Immunomedics, Inc.	Methods and compositions for radioimmunotherapy of brain and cns tumors
US20060246415A1 (en) *	2002-10-11	2006-11-02	Krepinsky Jiri J	Methods for detection of breast cancer
US20050232926A1 (en) *	2003-06-06	2005-10-20	Oncomax Acquisition Corp.	Antibodies specific for cancer associated antigen SM5-1 and uses thereof
CN1279056C (zh) *	2003-06-06	2006-10-11	马菁	肿瘤相关抗原sm5－1的特异性抗体及其应用
CA2539384C (en)	2003-09-17	2012-08-28	Board Of Regents, The University Of Texas System	Mechanism-based targeted pancreatic beta cell imaging and therapy
DE602004028513D1 (de)	2003-12-23	2010-09-16	Mount Sinai Hospital Corp	Verfahren zum nachweis von mit endometrialer krankheit oder phase assoziierten markern
EP2267034A3 (en) *	2004-03-31	2011-06-22	Canon Kabushiki Kaisha	Gold-binding protein and use thereof
WO2006118615A2 (en) *	2004-12-16	2006-11-09	Brandeis University	Clonable tag for purification and electron microscopy labeling
US8258181B2 (en) *	2005-03-23	2012-09-04	Florida Atlantic University	Treatment or prevention of cancer and precancerous disorders
US8765808B2 (en) *	2005-03-23	2014-07-01	Chs Pharma, Inc.	Treatment or prevention of cancer and precancerous disorders
US8357720B2 (en) *	2005-03-23	2013-01-22	Florida Atlantic University	Treatment or prevention of cancer and precancerous disorders
WO2007130575A2 (en) *	2006-05-03	2007-11-15	Florida Atlantic University	Protection against oxidative damage in cells
GB0621894D0 (en) *	2006-11-02	2006-12-13	Iti Scotland Ltd	Magnetic recognition system
US20080269065A1 (en) *	2007-04-30	2008-10-30	Syntrix Biosystems, Inc.	Conformationally Constrained Analytical Probes
US20100256464A1 (en) *	2007-05-14	2010-10-07	Dr. Susan Love Research Foundation	Device for determining risk of developing breast cancer and method thereof
CA2618163A1 (en)	2008-02-07	2009-08-07	K. W. Michael Siu	Head and neck cancer biomarkers
GB0808086D0 (en) *	2008-05-02	2008-06-11	Iti Scotland Ltd	Magnetic proteins for in vivo imaging
KR20140001257A (ko)	2008-05-13	2014-01-06	유니버시티 오브 캔사스	금속 추출 펩타이드(ｍａｐ) 태그 및 관련된 방법
JP5985392B2 (ja)	2009-07-22	2016-09-06	アクティニウムファーマシューティカルズインコーポレイテッド	放射性免疫複合体を生成するための方法
EP2486049A1 (en)	2009-10-06	2012-08-15	The Board Of Trustees Of The UniversityOf Illinois	Human single-chain t cell receptors
EP2606165B1 (en)	2010-08-16	2016-10-12	Sinai Health System	Markers of the male urogenital tract
US9187735B2 (en)	2012-06-01	2015-11-17	University Of Kansas	Metal abstraction peptide with superoxide dismutase activity
EP3409297A1 (en)	2017-05-30	2018-12-05	AlfaRim Medial Holding B.V.	The optimal 225actinium--213bismuth generator for alpha-particle radioimmunotherapy
US20200230266A1 (en)	2017-09-20	2020-07-23	Alfarim Medical Holding B.V.	The optimal 225actinium--213bismuth generator for alpha-particle radioimmunotherapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS56125317A (en) *	1980-03-08	1981-10-01	Nippon Mejifuijitsukusu Kk	Stable radioactive diagnosticum with radioactive metallic mark
NL8204108A (nl) *	1981-10-27	1983-05-16	Hybritech Inc	In beeld brengen van tumor met radioactief gemerkte monoclonale antilichamen.
CA1222691A (en) *	1981-12-29	1987-06-09	Wilhelmus T. Goedemans	Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4472509A (en) *	1982-06-07	1984-09-18	Gansow Otto A	Metal chelate conjugated monoclonal antibodies

1983
- 1983-10-06 US US06/539,733 patent/US4732864A/en not_active Expired - Lifetime
1984
- 1984-09-28 AU AU33629/84A patent/AU578428B2/en not_active Ceased
- 1984-10-04 ZA ZA847797A patent/ZA847797B/xx unknown
- 1984-10-04 GR GR80560A patent/GR80560B/el unknown
- 1984-10-04 CA CA000464746A patent/CA1248090A/en not_active Expired
- 1984-10-04 DE DE8484111913T patent/DE3469536D1/de not_active Expired
- 1984-10-04 AT AT84111913T patent/ATE32730T1/de not_active IP Right Cessation
- 1984-10-04 EP EP84111913A patent/EP0137457B1/en not_active Expired
- 1984-10-05 NO NO844017A patent/NO166267C/no unknown
- 1984-10-05 DK DK480284A patent/DK162105C/da not_active IP Right Cessation
- 1984-10-05 IL IL73183A patent/IL73183A/xx not_active IP Right Cessation
- 1984-10-05 IE IE2539/84A patent/IE55709B1/en not_active IP Right Cessation
- 1984-10-05 FI FI843930A patent/FI81263C/fi not_active IP Right Cessation
- 1984-10-05 NZ NZ209788A patent/NZ209788A/xx unknown
- 1984-10-05 ES ES536547A patent/ES8605105A1/es not_active Expired
- 1984-10-05 JP JP59208413A patent/JPS60166625A/ja active Granted
- 1984-10-06 KR KR1019840006193A patent/KR860001151B1/ko not_active IP Right Cessation
1989
- 1989-04-04 JP JP1084174A patent/JPH01294700A/ja active Pending

Also Published As

Publication number	Publication date
DK480284D0 (da)	1984-10-05
NO844017L (no)	1985-04-09
FI843930L (fi)	1985-04-07
NZ209788A (en)	1988-10-28
JPH0470320B2 (no)	1992-11-10
ATE32730T1 (de)	1988-03-15
IL73183A (en)	1991-09-16
KR860001151B1 (ko)	1986-08-18
FI81263C (fi)	1990-10-10
AU578428B2 (en)	1988-10-27
IL73183A0 (en)	1985-01-31
AU3362984A (en)	1985-04-18
JPH01294700A (ja)	1989-11-28
KR850002961A (ko)	1985-05-28
DE3469536D1 (en)	1988-04-07
ES536547A0 (es)	1986-02-16
ZA847797B (en)	1986-05-28
IE55709B1 (en)	1990-12-19
FI843930A0 (fi)	1984-10-05
DK162105B (da)	1991-09-16
GR80560B (en)	1985-02-06
EP0137457A2 (en)	1985-04-17
EP0137457B1 (en)	1988-03-02
EP0137457A3 (en)	1985-08-14
DK480284A (da)	1985-04-07
NO166267B (no)	1991-03-18
FI81263B (fi)	1990-06-29
US4732864A (en)	1988-03-22
IE842539L (en)	1985-04-06
CA1248090A (en)	1989-01-03
JPS60166625A (ja)	1985-08-29
ES8605105A1 (es)	1986-02-16
DK162105C (da)	1992-02-17

Publication	Publication Date	Title
NO166267C (no)	1991-06-26	Konjugat av et maalsoekende biologisk aktivt molekyl og en forbindelse inneholdende spormerkende metall, samt diagnostisk preparat inneholdende konjugatet.
TR199801180T2 (xx)	1998-10-21	Aneljestik etkiye sahip yeni bile�ikler.
NO304552B1 (no)	1999-01-11	Kompleksforbindelser, konjugater, farmas°ytiske preparater inneholdende slike og forbindelser
EA200000427A1 (ru)	2001-02-26	Терапевтические применения хинолиновых производных
DE3766157D1 (de)	1990-12-20	Kupplungsmittel zum radiomarkieren von proteinen.
KR950700749A (ko)	1995-02-20	2'-할로메틸리덴 유도체와 S-기 또는 M-기 특이성 항종양제를 사용하는 결합치료에 의한 암치료 방법(Method of treating cancer by conjunctive therapy with 2'-halomethylidene derivatives and a S-phase or M phase specific antineoplastic agent)
IT1212778B (it)	1989-11-30	Composizioni farmaceutiche adattivita' antiinfiammatoria e/o analgesica, non ulcerogene.
CA2093928A1 (en)	1992-04-13	Monoclonal antibodies for detection and treatment of cancer
DK465488D0 (da)	1988-08-19	Farmaceutisk praeparat indeholdende en triazol-forbindelse
GR851767B (no)	1985-11-26
AU628095B2 (en)	1992-09-10	Chelants possessing ortho ligating functionality and complexes thereof
FR2707638B1 (fr)	1995-08-18	Nouveaux dérivés d'amino-acides, leurs procédés de préparation et leur application thérapeutique.
TR199801184T2 (xx)	1998-09-21	Analjezik tesirli yeni bile�ikler.
OA07270A (fr)	1984-04-30	Dérivés N-(vinblastinoyl-23) d'acide aminés, leur préparation et leur application thérapeutique.
ATE106732T1 (de)	1994-06-15	Arzneimittelzubereitung, enthaltend stigmasta-4- en-3-on sowie deren verwendung.
OA08067A (fr)	1987-03-31	Application thérapeutique d'aminométhylènes-2 indanediones-1,3 substituées sur l'azote.
TR200000728T2 (tr)	2000-09-21	Kronik hepatit C' nin tedavisinde IFN-alfa ve amantadin kullanımı.
GR880100401A (el)	1989-03-08	8α-ακυλαμινεργολινη,παρασκευη της και φαρμακευτικες συνθεσεις που την περιεχουν.
NO173874C (no)	1994-02-16	Konjugat til bruk ved fremstilling av spormerkede konjugater, bestaaende av et maalsoekende, biologisk aktivt molekyl og en forbindelse inneholdende et ikke-radioaktivt metall
IT8223733A0 (it)	1982-10-13	Preparazione e composizione derivato terapeutica che lo contiene. dell'isopropilamino-pirimidina, sua
IT1233861B (it)	1992-04-21	Composizione di composti che migliorano l'attivita' analgesica, antipiretica e antiinfiammatoria
ATE70840T1 (de)	1992-01-15	Benzothiepino(5,4-c>pyridazin-verbindungen und ihre pharmazeutischen wirkungen.