NO165543C - Analogifremgangsmaate for fremst av terapeutisk aktiv (4r,5s,6s,8r,2's,-4's)-3- 4-(dimethylamino-carbonyl)-pyrrolidinhylthio -4-methyl-6-(1-hydroxyethyl)-1-azabicyclo- 3,2,0 hept-2-en-7-on-2-carboxylsyre i krystallinsk form. - Google Patents

Analogifremgangsmaate for fremst av terapeutisk aktiv (4r,5s,6s,8r,2's,-4's)-3- 4-(dimethylamino-carbonyl)-pyrrolidinhylthio -4-methyl-6-(1-hydroxyethyl)-1-azabicyclo- 3,2,0 hept-2-en-7-on-2-carboxylsyre i krystallinsk form.

Info

Publication number
NO165543C
NO165543C NO873205A NO873205A NO165543C NO 165543 C NO165543 C NO 165543C NO 873205 A NO873205 A NO 873205A NO 873205 A NO873205 A NO 873205A NO 165543 C NO165543 C NO 165543C
Authority
NO
Norway
Prior art keywords
pyrrolidinhylthio
hept
dimethylamino
promotion
hydroxyethyl
Prior art date
Application number
NO873205A
Other languages
English (en)
Other versions
NO873205D0 (no
NO873205L (no
NO165543B (no
Inventor
Makoto Sunagawa
Yutaka Isobe
Yutaka Takeuchi
Haruki Matsumura
Tetsuo Noguchi
Yukio Ozaki
Original Assignee
Sumitomo Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharma filed Critical Sumitomo Pharma
Publication of NO873205D0 publication Critical patent/NO873205D0/no
Publication of NO873205L publication Critical patent/NO873205L/no
Publication of NO165543B publication Critical patent/NO165543B/no
Publication of NO165543C publication Critical patent/NO165543C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO873205A 1986-07-30 1987-07-30 Analogifremgangsmaate for fremst av terapeutisk aktiv (4r,5s,6s,8r,2's,-4's)-3- 4-(dimethylamino-carbonyl)-pyrrolidinhylthio -4-methyl-6-(1-hydroxyethyl)-1-azabicyclo- 3,2,0 hept-2-en-7-on-2-carboxylsyre i krystallinsk form. NO165543C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17932186 1986-07-30
JP15776987 1987-06-26

Publications (4)

Publication Number Publication Date
NO873205D0 NO873205D0 (no) 1987-07-30
NO873205L NO873205L (no) 1988-02-01
NO165543B NO165543B (no) 1990-11-19
NO165543C true NO165543C (no) 1991-02-27

Family

ID=26485103

Family Applications (2)

Application Number Title Priority Date Filing Date
NO873205A NO165543C (no) 1986-07-30 1987-07-30 Analogifremgangsmaate for fremst av terapeutisk aktiv (4r,5s,6s,8r,2's,-4's)-3- 4-(dimethylamino-carbonyl)-pyrrolidinhylthio -4-methyl-6-(1-hydroxyethyl)-1-azabicyclo- 3,2,0 hept-2-en-7-on-2-carboxylsyre i krystallinsk form.
NO1997013C NO1997013I1 (no) 1986-07-30 1997-10-17 Meropenem

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1997013C NO1997013I1 (no) 1986-07-30 1997-10-17 Meropenem

Country Status (20)

Country Link
US (1) US4888344A (no)
EP (1) EP0256377B1 (no)
JP (1) JP2665767B2 (no)
AR (1) AR243189A1 (no)
AU (1) AU596857B2 (no)
CA (1) CA1322371C (no)
DE (1) DE3781980T2 (no)
DK (1) DK172666B1 (no)
ES (1) ES2052524T3 (no)
FI (1) FI88037C (no)
GR (1) GR3006254T3 (no)
HK (1) HK169595A (no)
HU (1) HU199473B (no)
IE (1) IE60588B1 (no)
IL (1) IL83372A (no)
LU (1) LU88635I2 (no)
MX (1) MX173359B (no)
NO (2) NO165543C (no)
NZ (1) NZ221224A (no)
PH (1) PH24710A (no)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
KR880006244A (ko) * 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
EP0406863B1 (en) * 1989-07-06 1995-05-24 Banyu Pharmaceutical Co., Ltd. Cyclic amidinylthiocarbapenem derivatives
US5112818A (en) * 1989-12-29 1992-05-12 Banyu Pharmaceutical Co., Ltd. 2-(2-cyclopropylpyrrolidin-4-ylthio)carbapenhem derivatives
TW264475B (no) * 1991-09-20 1995-12-01 Takeda Pharm Industry Co Ltd
JP2696807B2 (ja) * 1992-08-06 1998-01-14 田辺製薬株式会社 カルバペネム誘導体の製法
GB9503717D0 (en) * 1995-02-24 1995-04-12 Smithkline Beecham Plc Novel compounds
FR2735474B1 (fr) * 1995-06-13 1997-08-08 Roussel Uclaf Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre
TR199901887T2 (xx) * 1997-02-07 1999-12-21 Kyoto Pharmaceutical Industries, Ltd. Karbapenem bile�i�i, bu bile�i�in kullan�m� ve bu bile�ik i�in ara bile�ik.
BR9910098A (pt) 1998-05-01 2000-12-26 Kyoto Pharma Ind Derivados de carbapenem, utilização dos mesmos e compostos intermediários dos mesmos
CA2375601C (en) * 1999-06-03 2008-07-29 Eisai Co., Ltd. Carbapenem compound crystals and injection preparations
TWI250160B (en) * 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
US7041660B2 (en) 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
CA2408417C (en) * 2000-05-12 2009-09-15 Novalar Pharmaceuticals, Inc. Local anesthetic methods and kits
JP5079190B2 (ja) * 2001-04-27 2012-11-21 大日本住友製薬株式会社 アゼチジノン誘導体およびその製造方法
SK15822003A3 (sk) * 2001-05-21 2004-06-08 Kyoto Pharmaceutical Industries, Ltd. Karbapenémový derivát
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
EP1426376A4 (en) * 2001-08-13 2004-12-22 Eisai Co Ltd PROCESS FOR THE PREPARATION OF CARBAPENEM-BASED ANTIBIOTICS
CA2457642C (en) * 2001-09-26 2009-01-06 Merck & Co., Inc. Crystalline forms of ertapenem sodium
KR100628676B1 (ko) * 2001-09-26 2006-09-27 머크 앤드 캄파니 인코포레이티드 카바페넴 화합물의 제조방법
ITMI20012364A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Processo di sintesi della cefixima via alchil-o arilsolfonati
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
US20030236306A1 (en) * 2002-06-20 2003-12-25 Chen Andrew X. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
US7229630B2 (en) * 2002-06-20 2007-06-12 Novalar Pharmaceuticals, Inc. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
EP1950563A3 (en) 2002-09-11 2008-08-06 Michio Ishibashi Method for screening for a substance for promoting regeneration of macrophages
JP2008501657A (ja) * 2004-06-02 2008-01-24 サンド・アクチエンゲゼルシヤフト 結晶形態のメロペネム中間体
WO2006035300A2 (en) * 2004-09-30 2006-04-06 Ranbaxy Laboratories Limited A process for the preparation of meropenem
JP4547245B2 (ja) * 2004-12-16 2010-09-22 株式会社パーマケム・アジア ペリンドプリルエルブミンのi型結晶、及びその製造方法
US8501818B2 (en) * 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US7872050B2 (en) * 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
US20110039943A1 (en) * 2005-03-14 2011-02-17 Robert Alonso Methods for treating skin disorders with topical nitrogen mustard compositions
US20070197781A1 (en) * 2005-07-29 2007-08-23 Neera Tewari Processes for the preparation of carbapenems
EP1926732B1 (en) 2005-09-05 2013-11-06 Ranbaxy Laboratories Limited A process for the preparation of carbapenem compounds
US8148520B2 (en) 2005-09-15 2012-04-03 Orchid Chemicals And Pharmaceuticals Limited Process for the preparation of beta-lactam antibiotic meropenem trihydrate
CN100497338C (zh) * 2006-01-05 2009-06-10 上海医药工业研究院 4-甲基-7-氧-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸类衍生物的制备方法
KR100781821B1 (ko) * 2006-02-16 2007-12-03 문순구 카르바페넴계 화합물의 제조방법
EP2006290A4 (en) * 2006-03-28 2011-01-05 Kaneka Corp IMPROVED PROCESS FOR PRODUCING CARBAPENEM COMPOUND
CN101432289B (zh) * 2006-04-28 2013-07-10 株式会社钟化 碳青霉素烯抗生素中间体的改良结晶析出方法
EP2229944A1 (en) * 2007-12-12 2010-09-22 Dainippon Sumitomo Pharma Co., Ltd. Preparation composition
US20090216010A1 (en) * 2008-02-22 2009-08-27 Wei-Hong Tseng Crystalline carbapenem compound and produced method thereof
EP2098525A1 (en) 2008-02-26 2009-09-09 Savior Lifetec Corporation Crystalline carbapenem compound and produced method thereof
HUE053482T2 (hu) * 2008-03-27 2021-06-28 Helsinn Healthcare Sa Alkilezõszerek stabilizált készítményei és alkalmazási eljárásaik
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
KR20110049823A (ko) * 2008-07-30 2011-05-12 랜박시 래보러터리스 리미티드 카르바페넴 화합물의 제조 방법
RU2490270C2 (ru) * 2009-03-13 2013-08-20 Даевунг Фармасьютикал Ко., Лтд. Улучшенный способ получения меропенема с применением цинкового порошка
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
WO2011141847A1 (en) * 2010-05-10 2011-11-17 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of meropenem
CA2815167A1 (en) 2010-10-22 2012-04-26 Ranbaxy Laboratories Limited A process for the preparation of pure meropenem trihydrate
CN101962383A (zh) * 2010-11-12 2011-02-02 上海巴迪生物医药科技有限公司 一种美罗培南的合成方法
WO2012081033A2 (en) * 2010-12-06 2012-06-21 Sequent Scientific Limited A process for preparation of imipenem
CN102532140B (zh) * 2010-12-21 2015-03-11 北大方正集团有限公司 一种美罗培南三水合物的制备方法
CN102250096B (zh) * 2011-09-05 2016-04-06 江西华邦药业有限公司 一种美罗培南的制备方法
CN103570718B (zh) * 2012-07-31 2016-06-29 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570720B (zh) * 2012-07-31 2016-02-10 新乡海滨药业有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570719B (zh) * 2012-07-31 2016-03-02 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
KR101331762B1 (ko) 2012-12-28 2013-11-20 주식회사 대웅제약 메로페넴의 삼수화물의 제조방법
CN103044429B (zh) * 2013-01-28 2015-04-01 苏州二叶制药有限公司 一种美罗培南的制备方法
EP2950648B1 (en) 2013-02-01 2019-09-18 Ocuphire Pharma, Inc. Aqueous ophthalmic solutions of phentolamine and medical uses thereof
EP2950800B1 (en) 2013-02-01 2020-09-09 Ocuphire Pharma, Inc. Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
KR102144777B1 (ko) 2013-06-19 2020-08-18 제이더블유중외제약 주식회사 결정형 메로페넴 삼수화물의 제조방법
KR102360512B1 (ko) * 2014-03-27 2022-02-10 존슨 맛쎄이 퍼블릭 리미티드 컴파니 카바페넴 항생물질의 제조 방법
WO2020087021A1 (en) 2018-10-26 2020-04-30 Ocuphire Pharma, Inc. Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK153486C (da) * 1978-07-03 1988-11-28 Merck & Co Inc Analogifremgangsmaade til fremstilling af krystallinsk n-formimidoyl-thienamycin-monohydrat
EP0113101A1 (en) * 1982-12-30 1984-07-11 Merck & Co. Inc. 6-(1-Hydroxyethyl)-2-SR8-1-methyl-1-carbadethiapen-2-em-3-carboxylic acid esters
JPS60104088A (ja) * 1983-11-11 1985-06-08 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
US4748238A (en) * 1984-03-14 1988-05-31 Merck & Co., Inc. Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid
US4713451A (en) * 1984-04-09 1987-12-15 Merck & Co., Inc. Crystalline dimethyliminothienamycin
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
NZ214691A (en) * 1984-12-27 1988-08-30 Sumitomo Pharma The preparation of carbapenem derivatives and beta-lactam intermediates
US4788282A (en) * 1985-06-07 1988-11-29 Bristol-Myers Company Deprotection of allylic esters and ethers

Also Published As

Publication number Publication date
NO1997013I1 (no) 1997-10-17
AR243189A1 (es) 1993-07-30
IL83372A (en) 1992-05-25
DK399087D0 (da) 1987-07-30
IE60588B1 (en) 1994-07-27
DK172666B1 (da) 1999-05-10
DE3781980T2 (de) 1993-02-18
US4888344A (en) 1989-12-19
NZ221224A (en) 1989-10-27
FI873299A (fi) 1988-01-31
NO873205D0 (no) 1987-07-30
IE871959L (en) 1988-01-30
HK169595A (en) 1995-11-10
NO873205L (no) 1988-02-01
EP0256377B1 (en) 1992-09-30
JPS6434986A (en) 1989-02-06
JP2665767B2 (ja) 1997-10-22
CA1322371C (en) 1993-09-21
AU7619687A (en) 1988-03-03
HU199473B (en) 1990-02-28
GR3006254T3 (no) 1993-06-21
HUT44553A (en) 1988-03-28
MX7534A (es) 1993-10-01
NO165543B (no) 1990-11-19
FI873299A0 (fi) 1987-07-29
LU88635I2 (fr) 1995-12-01
EP0256377A1 (en) 1988-02-24
IL83372A0 (en) 1987-12-31
ES2052524T3 (es) 1994-07-16
DE3781980D1 (de) 1992-11-05
MX173359B (es) 1994-02-23
PH24710A (en) 1990-10-01
AU596857B2 (en) 1990-05-17
FI88037C (fi) 1993-03-25
FI88037B (fi) 1992-12-15
DK399087A (da) 1988-01-31

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