NO133088B - - Google Patents

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Info

Publication number: NO133088B
Authority: NO; Norway
Prior art keywords: spores; mycelium; soc; chem; steroids
Prior art date: 1970-11-18

Application number

NO4243/71A

Other languages

English (en)

Norwegian (no)

Other versions

NO133088C (sv

Inventor

S Baxter

P D Changani

Original Assignee

Monsanto Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1970-11-18

Filing date

1971-11-17

Publication date

1975-12-01

1971-11-17 Application filed by Monsanto Ltd filed Critical Monsanto Ltd

1975-12-01 Publication of NO133088B publication Critical patent/NO133088B/no

1976-03-10 Publication of NO133088C publication Critical patent/NO133088C/no

Links

150000003431 steroids Chemical class 0.000 claims description 23
238000000034 method Methods 0.000 claims description 22
230000033444 hydroxylation Effects 0.000 claims description 9
238000005805 hydroxylation reaction Methods 0.000 claims description 9
230000002906 microbiologic effect Effects 0.000 claims description 8
230000009466 transformation Effects 0.000 claims description 5
238000003776 cleavage reaction Methods 0.000 claims description 4
230000018044 dehydration Effects 0.000 claims description 4
238000006297 dehydration reaction Methods 0.000 claims description 4
230000036571 hydration Effects 0.000 claims description 4
238000006703 hydration reaction Methods 0.000 claims description 4
230000007017 scission Effects 0.000 claims description 4
239000007788 liquid Substances 0.000 claims description 2
230000001939 inductive effect Effects 0.000 claims 1
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 20
235000015097 nutrients Nutrition 0.000 description 19
239000000758 substrate Substances 0.000 description 15
238000000855 fermentation Methods 0.000 description 13
230000004151 fermentation Effects 0.000 description 13
238000006243 chemical reaction Methods 0.000 description 11
239000002609 medium Substances 0.000 description 11
239000000186 progesterone Substances 0.000 description 11
229960003387 progesterone Drugs 0.000 description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
239000000725 suspension Substances 0.000 description 8
230000009105 vegetative growth Effects 0.000 description 8
150000001875 compounds Chemical class 0.000 description 7
230000008569 process Effects 0.000 description 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
238000004519 manufacturing process Methods 0.000 description 6
239000000463 material Substances 0.000 description 6
239000012153 distilled water Substances 0.000 description 5
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
241000233866 Fungi Species 0.000 description 4
238000000605 extraction Methods 0.000 description 4
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 4
238000011084 recovery Methods 0.000 description 4
239000000243 solution Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
241000122824 Aspergillus ochraceus Species 0.000 description 3
208000005156 Dehydration Diseases 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
241000187389 Streptomyces lavendulae Species 0.000 description 3
239000012736 aqueous medium Substances 0.000 description 3
239000006227 byproduct Substances 0.000 description 3
238000006356 dehydrogenation reaction Methods 0.000 description 3
238000001914 filtration Methods 0.000 description 3
239000008103 glucose Substances 0.000 description 3
239000002054 inoculum Substances 0.000 description 3
239000000203 mixture Substances 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
239000000126 substance Substances 0.000 description 3
WHBHBVVOGNECLV-OBQKJFGGSA-N 11-deoxycortisol Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 WHBHBVVOGNECLV-OBQKJFGGSA-N 0.000 description 2
BFZHCUBIASXHPK-QJSKAATBSA-N 11alpha-hydroxyprogesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)C[C@H]2O BFZHCUBIASXHPK-QJSKAATBSA-N 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
241000228143 Penicillium Species 0.000 description 2
240000005384 Rhizopus oryzae Species 0.000 description 2
235000013752 Rhizopus oryzae Nutrition 0.000 description 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
240000008042 Zea mays Species 0.000 description 2
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
235000002017 Zea mays subsp mays Nutrition 0.000 description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
235000005822 corn Nutrition 0.000 description 2
239000011491 glass wool Substances 0.000 description 2
229960000890 hydrocortisone Drugs 0.000 description 2
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
230000006872 improvement Effects 0.000 description 2
239000000543 intermediate Substances 0.000 description 2
238000011835 investigation Methods 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
244000005700 microbiome Species 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
239000008363 phosphate buffer Substances 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
241000894007 species Species 0.000 description 2
ZESRJSPZRDMNHY-YFWFAHHUSA-N 11-deoxycorticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 ZESRJSPZRDMNHY-YFWFAHHUSA-N 0.000 description 1
NVUUMOOKVFONOM-GPBSYSOESA-N 19-Norprogesterone Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 NVUUMOOKVFONOM-GPBSYSOESA-N 0.000 description 1
-1 A-1 compound Chemical class 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
241001558165 Alternaria sp. Species 0.000 description 1
241000228212 Aspergillus Species 0.000 description 1
241000228245 Aspergillus niger Species 0.000 description 1
241001312183 Coniothyrium Species 0.000 description 1
241000010216 Cunninghamella blakesleeana Species 0.000 description 1
241000223211 Curvularia lunata Species 0.000 description 1
241000555695 Didymella Species 0.000 description 1
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
241000733421 Epipactis Species 0.000 description 1
241000186984 Kitasatospora aureofaciens Species 0.000 description 1
241000235388 Mucorales Species 0.000 description 1
240000000064 Penicillium roqueforti Species 0.000 description 1
241000123526 Peziza Species 0.000 description 1
241000235400 Phycomyces Species 0.000 description 1
241000235527 Rhizopus Species 0.000 description 1
241000235546 Rhizopus stolonifer Species 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
235000019764 Soybean Meal Nutrition 0.000 description 1
241000187180 Streptomyces sp. Species 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
241000215410 Trichothecium roseum Species 0.000 description 1
239000008272 agar Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
150000001491 aromatic compounds Chemical class 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
238000006757 chemical reactions by type Methods 0.000 description 1
239000000470 constituent Substances 0.000 description 1
ZESRJSPZRDMNHY-UHFFFAOYSA-N de-oxy corticosterone Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 ZESRJSPZRDMNHY-UHFFFAOYSA-N 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
229940119740 deoxycorticosterone Drugs 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
230000000694 effects Effects 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
230000002538 fungal effect Effects 0.000 description 1
239000007789 gas Substances 0.000 description 1
230000035784 germination Effects 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
230000012010 growth Effects 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
238000002955 isolation Methods 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000008101 lactose Substances 0.000 description 1
238000009630 liquid culture Methods 0.000 description 1
235000021243 milk fat Nutrition 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
230000035772 mutation Effects 0.000 description 1
239000006916 nutrient agar Substances 0.000 description 1
239000012476 oxidizable substance Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
150000003333 secondary alcohols Chemical class 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000004455 soybean meal Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
238000000844 transformation Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
- C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/08—Use of materials for tobacco smoke filters of organic materials as carrier or major constituent
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment

Landscapes

Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Extrusion Moulding Of Plastics Or The Like (AREA)
Filtering Materials (AREA)
Cigarettes, Filters, And Manufacturing Of Filters (AREA)
Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO4243/71A 1970-11-18 1971-11-17 NO133088C (sv)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB5480670		1970-11-18
GB5870070		1970-12-10
GB964671		1971-04-16

Publications (2)

Publication Number	Publication Date
NO133088B true NO133088B (sv)	1975-12-01
NO133088C NO133088C (sv)	1976-03-10

Family

ID=27255404

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO4243/71A NO133088C (sv)	1970-11-18	1971-11-17

Country Status (13)

Country	Link
JP (2)	JPS577172B1 (sv)
AT (1)	AT315709B (sv)
BE (1)	BE775476A (sv)
CH (1)	CH546543A (sv)
DE (1)	DE2156375C3 (sv)
DK (1)	DK133125C (sv)
FR (1)	FR2114696A5 (sv)
IE (1)	IE36798B1 (sv)
IL (1)	IL38123A (sv)
IT (1)	IT950514B (sv)
NL (1)	NL170916C (sv)
NO (1)	NO133088C (sv)
SE (1)	SE400457B (sv)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1482216A (en) *	1974-04-11	1977-08-10	Monsanto Ltd	Cigarette filters
MXPA02008938A (es) *	2000-03-17	2003-06-17	Dow Global Technologies Inc	Espuma de poliolefina util para aislamiento acustico y termico.
WO2020153490A1 (ja) *	2019-01-25	2020-07-30	日本たばこ産業株式会社	喫煙物品用フィルター

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2972554A (en) *	1955-05-23	1961-02-21	Fiber Bond Corp	Pad and method of making same

1971
- 1971-11-04 AT AT949971A patent/AT315709B/de not_active IP Right Cessation
- 1971-11-09 NL NLAANVRAGE7115391,A patent/NL170916C/xx not_active IP Right Cessation
- 1971-11-10 SE SE7114391A patent/SE400457B/sv unknown
- 1971-11-11 IL IL38123A patent/IL38123A/en unknown
- 1971-11-12 DE DE2156375A patent/DE2156375C3/de not_active Expired
- 1971-11-12 IE IE1429/71A patent/IE36798B1/xx unknown
- 1971-11-12 CH CH1643371A patent/CH546543A/xx not_active IP Right Cessation
- 1971-11-15 FR FR7140766A patent/FR2114696A5/fr not_active Expired
- 1971-11-17 DK DK565571A patent/DK133125C/da active
- 1971-11-17 NO NO4243/71A patent/NO133088C/no unknown
- 1971-11-17 BE BE775476A patent/BE775476A/xx unknown
- 1971-11-17 IT IT54140/71A patent/IT950514B/it active
- 1971-11-18 JP JP9270871A patent/JPS577172B1/ja active Pending
1977
- 1977-11-09 JP JP13453277A patent/JPS5411299A/ja active Pending

Also Published As

Publication number	Publication date
FR2114696A5 (en)	1972-06-30
DE2156375C3 (de)	1981-02-19
AU3563971A (en)	1973-05-17
NL170916B (nl)	1982-08-16
CH546543A (de)	1974-03-15
JPS5411299A (en)	1979-01-27
AT315709B (de)	1974-06-10
IL38123A0 (en)	1972-01-27
DK133125B (da)	1976-03-29
NL7115391A (sv)	1972-05-23
DE2156375A1 (de)	1972-05-31
IL38123A (en)	1975-03-13
IE36798B1 (en)	1977-03-02
JPS577172B1 (sv)	1982-02-09
DE2156375B2 (de)	1980-05-29
DK133125C (da)	1976-08-30
BE775476A (fr)	1972-05-17
SE400457B (sv)	1978-04-03
IT950514B (it)	1973-06-20
NL170916C (nl)	1983-01-17
NO133088C (sv)	1976-03-10
IE36798L (en)	1972-05-18

Publication	Publication Date	Title
US2649402A (en)	1953-08-18	Steroids
US2649400A (en)	1953-08-18	Steroids
Vézina et al.	1963	Transformation of Steroids by Spores of Microorganisms: I. Hydroxylation of Progesterone by Conidia of Aspergillus ochraceus
US5166055A (en)	1992-11-24	Microbiological preparation of 9-alpha-hydroxy-17-keto steroids
GB2123833A (en)	1984-02-08	Steroid 1,2-dehydrogenation using dried microbial cells
EP0127294B1 (en)	1986-12-17	Steroid dehydrogenation
NO133088B (sv)	1975-12-01
EP0425001B1 (en)	1996-01-17	Natural delta-lactones and process of the production thereof
US2802775A (en)	1957-08-13	11 alpha-hydroxylation of steroids by aspergillus ochraceus
US4397947A (en)	1983-08-09	Microbial process for 9α-hydroxylation of steroids
US2831798A (en)	1958-04-22	Mgsox
US3031379A (en)	1962-04-24	Conversion of steroids with mold spores
US2721828A (en)	1955-10-25	Process for production of 17-ketosteroids
US3360439A (en)	1967-12-26	Process for preparing 1-dehydro steroids
US3031382A (en)	1962-04-24	Fermentation process using spore forming fungi
US3047470A (en)	1962-07-31	Microbiological 11alpha-hydroxylation of 16alpha, 17alpha-epoxy pregnenes
US3340278A (en)	1967-09-05	5(10), 7-estradiene-3, 17-dione and the process for the production thereof
EP0217840B1 (de)	1989-12-13	Verfahren zur herstellung von 1-methyl-1,4-androstadien-3,17-dion
US2823171A (en)	1958-02-11	Synthesis of steroids of the 1-dehydrotestololactone series
US2762747A (en)	1956-09-11	Preparation of 17-keto steroid by penicillium
US2863806A (en)	1958-12-09	17alpha hydroxylation of steroids by trichoderma viride
US3010878A (en)	1961-11-28	Process for the production of eburicoic acid
US2902411A (en)	1959-09-01	Use of second steroid to accelerate 1-dehydrogenation of substrate steroid
US3243355A (en)	1966-03-29	Method of hydroxylating 19-nor-androstenedione
US3037914A (en)	1962-06-05	Bacterial production of triamcinolone by bacterial formulations