NL184418B - Werkwijze voor de bereiding van bis-indool-alkaloiden. - Google Patents

Werkwijze voor de bereiding van bis-indool-alkaloiden.

Info

Publication number
NL184418B
NL184418B NLAANVRAGE7515193,A NL7515193A NL184418B NL 184418 B NL184418 B NL 184418B NL 7515193 A NL7515193 A NL 7515193A NL 184418 B NL184418 B NL 184418B
Authority
NL
Netherlands
Prior art keywords
indool
alkaloids
bis
preparation
indool alkaloids
Prior art date
Application number
NLAANVRAGE7515193,A
Other languages
English (en)
Other versions
NL184418C (nl
NL7515193A (nl
Inventor
Pierre Potier
Nicole Langlois-Petit
Yves Langlois
Francoise Gueritte
Original Assignee
Anvar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9146736&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL184418(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Anvar filed Critical Anvar
Publication of NL7515193A publication Critical patent/NL7515193A/nl
Publication of NL184418B publication Critical patent/NL184418B/nl
Application granted granted Critical
Publication of NL184418C publication Critical patent/NL184418C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
NLAANVRAGE7515193,A 1974-12-30 1975-12-30 Werkwijze voor de bereiding van bis-indool-alkaloiden. NL184418C (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7443221A FR2296418B1 (nl) 1974-12-30 1974-12-30

Publications (3)

Publication Number Publication Date
NL7515193A NL7515193A (nl) 1976-07-02
NL184418B true NL184418B (nl) 1989-02-16
NL184418C NL184418C (nl) 1989-07-17

Family

ID=9146736

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7515193,A NL184418C (nl) 1974-12-30 1975-12-30 Werkwijze voor de bereiding van bis-indool-alkaloiden.

Country Status (10)

Country Link
US (2) US4769453A (nl)
JP (1) JPS6056719B2 (nl)
BE (1) BE837073A (nl)
CA (1) CA1132544A (nl)
CH (1) CH606023A5 (nl)
DE (1) DE2558124A1 (nl)
FR (1) FR2296418B1 (nl)
GB (1) GB1536407A (nl)
HU (1) HU177154B (nl)
NL (1) NL184418C (nl)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2296418B1 (nl) * 1974-12-30 1978-07-21 Anvar
GB1593231A (en) * 1977-01-19 1981-07-15 Lilly Co Eli Vincristine derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds
HU180924B (en) 1977-05-20 1983-05-30 Richter Gedeon Vegyeszet Process for producing leurosine-type alkaloides
HU181874B (en) * 1977-08-08 1983-11-28 Lilly Co Eli Process for preparing amides of deacetyl-leurosine and deacetyl-leuroformine
US4191688A (en) 1977-08-08 1980-03-04 Eli Lilly And Company Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine
US4195022A (en) 1978-03-27 1980-03-25 Eli Lilly And Company 4-Desacetoxy-4α-hydroxyvinblastine and related compounds
FR2443470A1 (fr) * 1978-12-08 1980-07-04 Anvar Nouveau procede de synthese de la vinblastine et de la leurosidine
AU590873B2 (en) * 1985-03-12 1989-11-23 University Of Vermont And State Agricultural College, The Synthesis of vinblastine and vincristine type compounds
US4897477A (en) * 1985-03-12 1990-01-30 University Of Vermont & State Agricultural College Synthesis of vinblastine and vincristine type compounds
US4841045A (en) * 1985-03-12 1989-06-20 University Of Vermont & State Agricultural College Synthesis of vinblastine and vincristine type compounds
US4778885A (en) * 1986-09-18 1988-10-18 Allelix Inc. Production of alkaloid dimers using ferric ion
AU1066888A (en) * 1987-01-22 1988-08-04 University Of British Columbia, The Process for the synthesis of vinblastine and vincristine
CA1341261C (en) * 1987-01-22 2001-06-26 James P. Kutney Process for the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine
US5047528A (en) * 1987-01-22 1991-09-10 University Of Bristish Columbia Process of synthesis of vinblastine and vincristine
USRE37449E1 (en) 1987-02-06 2001-11-13 University Of British Columbia Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine
US5037977A (en) * 1988-08-11 1991-08-06 Mitsui Petrochemical Industries Ltd. Method for production of dimeric alkaloids
FR2707988B1 (fr) * 1993-07-21 1995-10-13 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
ATE315389T1 (de) 1995-08-08 2006-02-15 Albany Medical College Ibogamin verwandte verbindungen
FR2779146B1 (fr) 1998-06-02 2002-01-18 Roowin Nouveaux derives de vinca-alcaloides et procedes de preparation
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US7238704B2 (en) * 2003-12-04 2007-07-03 Amr Technology, Inc. Vinca derivatives
EP1694330A4 (en) * 2003-12-04 2009-06-24 Amr Technology Inc DERIVATIVES OF VINORELBINE
US20080125451A1 (en) * 2006-09-12 2008-05-29 Amr Technology, Inc. Vinorelbine derivatives
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
RU2586296C2 (ru) 2010-07-23 2016-06-10 Демеркс, Инк. Композиции норибогаина
EP2481740B1 (en) * 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US8742096B2 (en) * 2011-03-28 2014-06-03 Demerx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
EP2788003A4 (en) 2011-12-09 2015-05-27 Demerx Inc PHOSPHATESTER OF NORIBOGAIN
US20130178618A1 (en) 2012-01-10 2013-07-11 William Allen Boulanger Novel pharmaceutical intermediates and methods for preparing the same
US8877921B2 (en) 2012-01-25 2014-11-04 Demerx, Inc. Synthetic voacangine
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
US9783535B2 (en) 2012-12-20 2017-10-10 Demerx, Inc. Substituted noribogaine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH77A (de) * 1889-01-09 Christian Herren Wurzelschneidmaschine
FR2210393B1 (nl) * 1972-12-19 1976-07-02 Richter Gedeon Vegyeszet
HU165986B (nl) * 1973-02-16 1974-12-28
FR2296418B1 (nl) * 1974-12-30 1978-07-21 Anvar
US4279817A (en) * 1975-05-30 1981-07-21 The United States Of America As Represented By The Department Of Health & Human Services Method for producing dimer alkaloids
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4143041A (en) * 1977-01-19 1979-03-06 Eli Lilly And Company 4'-Deoxyvincristine and related compounds
HU180924B (en) * 1977-05-20 1983-05-30 Richter Gedeon Vegyeszet Process for producing leurosine-type alkaloides
HU178084B (en) * 1977-05-31 1982-03-28 Richter Gedeon Vegyeszet New process for the extraction of native vindoline,catharantine,3',4'-anhydrovinblastine,leurosine and,if desired,of other diinodle alkaloids from vinca rosea l.drogue

Also Published As

Publication number Publication date
US4737586A (en) 1988-04-12
FR2296418A1 (nl) 1976-07-30
NL184418C (nl) 1989-07-17
BE837073A (fr) 1976-06-24
CH606023A5 (nl) 1978-10-13
FR2296418B1 (nl) 1978-07-21
HU177154B (en) 1981-08-28
DE2558124A1 (de) 1976-07-01
US4769453A (en) 1988-09-06
GB1536407A (en) 1978-12-20
JPS6056719B2 (ja) 1985-12-11
NL7515193A (nl) 1976-07-02
CA1132544A (en) 1982-09-28
JPS5188999A (en) 1976-08-04
DE2558124C2 (nl) 1991-04-18

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Legal Events

Date Code Title Description
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
A85 Still pending on 85-01-01
SNR Assignments of patents or rights arising from examined patent applications

Owner name: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS

V4 Discontinued because of reaching the maximum lifetime of a patent

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