NL1003284C2 - Werkwijze voor het vergroten van de elektrotransport-flux van polypeptiden. - Google Patents

Werkwijze voor het vergroten van de elektrotransport-flux van polypeptiden. Download PDF

Info

Publication number: NL1003284C2
Authority: NL; Netherlands
Prior art keywords: polypeptide; amino acid; electrotransport; helix; analog
Prior art date: 1995-06-06

Application number

NL1003284A

Other languages

English (en)

Dutch (nl)

Other versions

NL1003284A1 (nl

Inventor

Kevin Ray Oldenburg

Original Assignee

Alza Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-06

Filing date

1996-06-06

Publication date

1997-03-20

1996-06-06 Application filed by Alza Corp filed Critical Alza Corp

1996-12-09 Publication of NL1003284A1 publication Critical patent/NL1003284A1/xx

1997-03-20 Application granted granted Critical

1997-03-20 Publication of NL1003284C2 publication Critical patent/NL1003284C2/nl

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HOWHQWFXSLOJEF-MGZLOUMQSA-N systemin Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)OC(=O)[C@@H]1CCCN1C(=O)[C@H]1N(C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]2N(CCC2)C(=O)[C@H]2N(CCC2)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)CCC1 HOWHQWFXSLOJEF-MGZLOUMQSA-N 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
229960004072 thrombin Drugs 0.000 description 1
239000003868 thrombin inhibitor Substances 0.000 description 1
LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
229940034199 thyrotropin-releasing hormone Drugs 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000011282 treatment Methods 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
229960003726 vasopressin Drugs 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Analytical Chemistry (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Radiology & Medical Imaging (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Toxicology (AREA)
Zoology (AREA)
Pharmacology & Pharmacy (AREA)
Tropical Medicine & Parasitology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NL1003284A 1995-06-06 1996-06-06 Werkwijze voor het vergroten van de elektrotransport-flux van polypeptiden. NL1003284C2 (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/468,275 US5747453A (en)	1995-06-06	1995-06-06	Method for increasing the electrotransport flux of polypeptides
US46827595		1995-06-06

Publications (2)

Publication Number	Publication Date
NL1003284A1 NL1003284A1 (nl)	1996-12-09
NL1003284C2 true NL1003284C2 (nl)	1997-03-20

Family

ID=23859150

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL1003284A NL1003284C2 (nl)	1995-06-06	1996-06-06	Werkwijze voor het vergroten van de elektrotransport-flux van polypeptiden.

Country Status (13)

Country	Link
US (2)	US5747453A (it)
JP (1)	JPH11507634A (it)
AU (1)	AU6264296A (it)
BE (1)	BE1009752A5 (it)
BR (1)	BR9609148A (it)
CA (1)	CA2220060A1 (it)
DE (1)	DE19681438B4 (it)
FR (1)	FR2735133B1 (it)
GB (1)	GB2316083B (it)
IE (1)	IE960414A1 (it)
IT (1)	IT1285404B1 (it)
NL (1)	NL1003284C2 (it)
WO (1)	WO1996039423A2 (it)

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US6333189B1 (en)	1996-06-06	2001-12-25	Alza Corporation	Method of making an electrotransport device
EP0922467A3 (en) *	1997-12-12	2000-05-24	Takeda Chemical Industries, Ltd.	Iontophoretic drug delivery
US8480580B2 (en)	1998-04-30	2013-07-09	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US8465425B2 (en)	1998-04-30	2013-06-18	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US6949816B2 (en) *	2003-04-21	2005-09-27	Motorola, Inc.	Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US9066695B2 (en)	1998-04-30	2015-06-30	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US8688188B2 (en)	1998-04-30	2014-04-01	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US8346337B2 (en)	1998-04-30	2013-01-01	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US6175752B1 (en)	1998-04-30	2001-01-16	Therasense, Inc.	Analyte monitoring device and methods of use
US8974386B2 (en)	1998-04-30	2015-03-10	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US6560471B1 (en)	2001-01-02	2003-05-06	Therasense, Inc.	Analyte monitoring device and methods of use
DE60331226D1 (de)	2002-05-24	2010-03-25	Medtronic Inc	Verfahren und dna-konstrukte zur produktion von polypeptiden mit hoher ausbeute
EP1554302A4 (en) *	2002-05-24	2006-05-03	Restoragen Inc	DNA RECOMBINATION METHODS AND PRODUCTS FOR HIGH-YIELD PRODUCTION OF POLYPEPTIDES
WO2003099854A2 (en) *	2002-05-24	2003-12-04	Nps Allelix Corp.	Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
ME01366B (me) *	2003-11-21	2013-12-20	Nps Allelix Corp	POSTUPAK ZA PROIZVODNJU PEPTIDA 2 NALIK NA GLUKAGON l NJIHOVIH ANALOGA
WO2006045503A1 (en)	2004-10-19	2006-05-04	Lonza Ag	Method for solid phase peptide synthesis
ES2551305T3 (es) *	2005-12-28	2015-11-17	Alza Corporation	Formulaciones terapéuticas estables

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DE3703321A1 (de) *	1986-09-01	1988-03-10	Transcutan Gmbh	Therapievorrichtung zur anwendung von elektrischem strom
WO1993025197A1 (en) *	1992-06-12	1993-12-23	Affymax Technologies N.V.	Compositions and methods for enhanced drug delivery
EP0643981A1 (en) *	1993-09-22	1995-03-22	Takeda Chemical Industries, Ltd.	A matrix for iontophoreses
WO1995011988A1 (en) *	1993-10-25	1995-05-04	Affymax Technologies N.V.	Compounds with pth activity and recombinant dna vectors encoding same
EP0667355A1 (de) *	1994-02-10	1995-08-16	Hoechst Aktiengesellschaft	Hirudinderivate und Verfahren zu deren Herstellung

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1995
- 1995-06-06 US US08/468,275 patent/US5747453A/en not_active Expired - Lifetime
1996
- 1996-06-05 IE IE960414A patent/IE960414A1/en not_active IP Right Cessation
- 1996-06-05 IT IT96TO000495A patent/IT1285404B1/it active IP Right Grant
- 1996-06-06 BR BR9609148A patent/BR9609148A/pt not_active Application Discontinuation
- 1996-06-06 AU AU62642/96A patent/AU6264296A/en not_active Abandoned
- 1996-06-06 DE DE19681438T patent/DE19681438B4/de not_active Expired - Fee Related
- 1996-06-06 WO PCT/US1996/009647 patent/WO1996039423A2/en active Application Filing
- 1996-06-06 FR FR9607003A patent/FR2735133B1/fr not_active Expired - Fee Related
- 1996-06-06 JP JP9501922A patent/JPH11507634A/ja active Pending
- 1996-06-06 NL NL1003284A patent/NL1003284C2/nl not_active IP Right Cessation
- 1996-06-06 CA CA002220060A patent/CA2220060A1/en not_active Abandoned
- 1996-06-06 GB GB9725980A patent/GB2316083B/en not_active Expired - Fee Related
- 1996-06-06 BE BE9600518A patent/BE1009752A5/fr not_active IP Right Cessation
1998
- 1998-01-15 US US09/007,466 patent/US6313092B1/en not_active Expired - Lifetime

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3703321A1 (de) *	1986-09-01	1988-03-10	Transcutan Gmbh	Therapievorrichtung zur anwendung von elektrischem strom
WO1993025197A1 (en) *	1992-06-12	1993-12-23	Affymax Technologies N.V.	Compositions and methods for enhanced drug delivery
EP0643981A1 (en) *	1993-09-22	1995-03-22	Takeda Chemical Industries, Ltd.	A matrix for iontophoreses
WO1995011988A1 (en) *	1993-10-25	1995-05-04	Affymax Technologies N.V.	Compounds with pth activity and recombinant dna vectors encoding same
EP0667355A1 (de) *	1994-02-10	1995-08-16	Hoechst Aktiengesellschaft	Hirudinderivate und Verfahren zu deren Herstellung

Also Published As

Publication number	Publication date
IT1285404B1 (it)	1998-06-03
US5747453A (en)	1998-05-05
DE19681438B4 (de)	2010-02-04
ITTO960495A1 (it)	1997-12-05
WO1996039423A2 (en)	1996-12-12
ITTO960495A0 (it)	1996-06-05
GB9725980D0 (en)	1998-02-04
GB2316083A (en)	1998-02-18
CA2220060A1 (en)	1996-12-12
US6313092B1 (en)	2001-11-06
WO1996039423A3 (en)	1997-01-30
DE19681438T1 (de)	1998-07-23
JPH11507634A (ja)	1999-07-06
BR9609148A (pt)	1999-02-23
FR2735133B1 (fr)	1998-02-13
GB2316083B (en)	2000-01-19
AU6264296A (en)	1996-12-24
FR2735133A1 (fr)	1996-12-13
IE960414A1 (en)	1996-12-11
BE1009752A5 (fr)	1997-07-01
NL1003284A1 (nl)	1996-12-09

Legal Events

Date	Code	Title	Description
1997-02-03	AD1A	A request for search or an international type search has been filed
1997-03-03	RD2N	Patents in respect of which a decision has been taken or a report has been made (novelty report)	Effective date: 19970115
1997-05-01	PD2B	A search report has been drawn up
2011-01-12	V1	Lapsed because of non-payment of the annual fee	Effective date: 20110101

Publication	Publication Date	Title
NL1003284C2 (nl)	1997-03-20	Werkwijze voor het vergroten van de elektrotransport-flux van polypeptiden.
ES2202910T3 (es)	2004-04-01	Composiciones de farmacos regulados para la administracion transdermica por electrotranporte.
US5814603A (en)	1998-09-29	Compounds with PTH activity
US20090275877A1 (en)	2009-11-05	Method of Enhancing Electrotransport Polypeptide Flux By Amino Acid Substitution with Histidine
US6333189B1 (en)	2001-12-25	Method of making an electrotransport device
EP0929576A1 (en)	1999-07-21	Glp-2 derivatives
JP2008542364A (ja)	2008-11-27	副甲状腺ホルモン、緩衝液、および安定剤を含んでなる安定化された副甲状腺ホルモン組成物
US20070014735A1 (en)	2007-01-18	Buccal delivery system
JP3737832B2 (ja)	2006-01-25	イオントフォレシス用マトリックス
US6323178B1 (en)	2001-11-27	Beta-lipotropin methods
JP4686780B2 (ja)	2011-05-25	細胞死抑制活性強化タンパク質ｆｎｋを用いた脱毛の防止
JP3638316B2 (ja)	2005-04-13	イオントフォレシス用マトリックス
IE83528B1 (en)	2004-07-14	Modification of polypeptide drugs to increase electrotransport flux