DE19681438T1 - Verfahren zum Erhöhen des Elektrotransportflusses von Polypeptiden - Google Patents

Verfahren zum Erhöhen des Elektrotransportflusses von Polypeptiden

Info

Publication number
DE19681438T1
DE19681438T1 DE19681438T DE19681438T DE19681438T1 DE 19681438 T1 DE19681438 T1 DE 19681438T1 DE 19681438 T DE19681438 T DE 19681438T DE 19681438 T DE19681438 T DE 19681438T DE 19681438 T1 DE19681438 T1 DE 19681438T1
Authority
DE
Germany
Prior art keywords
polypeptides
increasing
electrotransport flow
electrotransport
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19681438T
Other languages
English (en)
Other versions
DE19681438B4 (de
Inventor
Leslie A Holladay
Kevin R Oldenburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of DE19681438T1 publication Critical patent/DE19681438T1/de
Application granted granted Critical
Publication of DE19681438B4 publication Critical patent/DE19681438B4/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE19681438T 1995-06-06 1996-06-06 Verwendung von Polypeptidanaloga mit erhöhter Elektrotransportierbarkeit und Parathormon (PTH) - Analog Expired - Fee Related DE19681438B4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/468,275 US5747453A (en) 1995-06-06 1995-06-06 Method for increasing the electrotransport flux of polypeptides
US08/468,275 1995-06-06
PCT/US1996/009647 WO1996039423A2 (en) 1995-06-06 1996-06-06 A method for increasing the electrotransport flux of polypeptides

Publications (2)

Publication Number Publication Date
DE19681438T1 true DE19681438T1 (de) 1998-07-23
DE19681438B4 DE19681438B4 (de) 2010-02-04

Family

ID=23859150

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19681438T Expired - Fee Related DE19681438B4 (de) 1995-06-06 1996-06-06 Verwendung von Polypeptidanaloga mit erhöhter Elektrotransportierbarkeit und Parathormon (PTH) - Analog

Country Status (13)

Country Link
US (2) US5747453A (de)
JP (1) JPH11507634A (de)
AU (1) AU6264296A (de)
BE (1) BE1009752A5 (de)
BR (1) BR9609148A (de)
CA (1) CA2220060A1 (de)
DE (1) DE19681438B4 (de)
FR (1) FR2735133B1 (de)
GB (1) GB2316083B (de)
IE (1) IE960414A1 (de)
IT (1) IT1285404B1 (de)
NL (1) NL1003284C2 (de)
WO (1) WO1996039423A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6333189B1 (en) 1996-06-06 2001-12-25 Alza Corporation Method of making an electrotransport device
EP0922467A3 (de) * 1997-12-12 2000-05-24 Takeda Chemical Industries, Ltd. Iontophoretische Verabreichung von Medikamenten
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) * 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) * 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US6175752B1 (en) * 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
EP1572720A4 (de) * 2002-05-24 2008-12-24 Nps Allelix Corp Verfahren zur enzymatischen herstellung von glp-2-(1-33)- und glp-2-(1-34)-peptiden
CA2485835C (en) 2002-05-24 2018-03-06 Restoragen, Inc. Methods and dna constructs for high yield production of polypeptides
WO2003100022A2 (en) * 2002-05-24 2003-12-04 Restoragen, Inc. Methods and dna constructs for high yield production of polypeptides
US7829307B2 (en) * 2003-11-21 2010-11-09 Nps Pharmaceuticals, Inc. Production of glucagon-like peptide 2
ES2352204T3 (es) 2004-10-19 2011-02-16 Lonza Ag Método de síntesis peptídica en fase sólida.
WO2007084247A2 (en) * 2005-12-28 2007-07-26 Alza Corporation Stable therapeutic formulations

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4382529A (en) * 1980-12-15 1983-05-10 Drdlik Frank J Sanitary dispensing closure
CA1231306A (en) * 1983-03-03 1988-01-12 Erich Hochuli Purification of interferon
US4631211A (en) * 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4722726A (en) * 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
DE3703321A1 (de) * 1986-09-01 1988-03-10 Transcutan Gmbh Therapievorrichtung zur anwendung von elektrischem strom
AU609769B2 (en) * 1987-02-10 1991-05-09 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
EP0482124B1 (de) * 1989-07-10 1993-12-22 The Upjohn Company Somatotropinanaloge
US5516512A (en) * 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
NZ237202A (en) * 1990-02-23 1994-01-26 Bristol Myers Squibb Co Composition containing beta-lactam antibiotic and cationic oligopeptide
USH1160H (en) * 1990-11-26 1993-04-06 Iontophoretic delivery of peptides
DK10191D0 (da) * 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
CA2087087C (en) * 1992-01-22 2000-07-18 Burton H. Sage, Jr. Molecules for iontophoretic delivery
US5312326A (en) * 1992-06-02 1994-05-17 Alza Corporation Iontophoretic drug delivery apparatus
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
AU4534593A (en) * 1992-06-12 1994-01-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
WO1993025579A1 (en) * 1992-06-15 1993-12-23 Pfizer Inc. Glucagon-like peptide and insulinotropin derivatives
EP1138345A3 (de) * 1993-09-22 2003-06-04 Hisamitsu Pharmaceutical Co., Inc. Eine Matrix für die Iontophorese
US5387189A (en) * 1993-12-02 1995-02-07 Alza Corporation Electrotransport delivery device and method of making same
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
ITTO960495A0 (it) 1996-06-05
FR2735133B1 (fr) 1998-02-13
BR9609148A (pt) 1999-02-23
JPH11507634A (ja) 1999-07-06
US5747453A (en) 1998-05-05
IE960414A1 (en) 1996-12-11
NL1003284C2 (nl) 1997-03-20
ITTO960495A1 (it) 1997-12-05
DE19681438B4 (de) 2010-02-04
GB2316083B (en) 2000-01-19
NL1003284A1 (nl) 1996-12-09
AU6264296A (en) 1996-12-24
GB2316083A (en) 1998-02-18
FR2735133A1 (fr) 1996-12-13
IT1285404B1 (it) 1998-06-03
CA2220060A1 (en) 1996-12-12
WO1996039423A2 (en) 1996-12-12
US6313092B1 (en) 2001-11-06
WO1996039423A3 (en) 1997-01-30
GB9725980D0 (en) 1998-02-04
BE1009752A5 (fr) 1997-07-01

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee