NI201000063A - AMINAS UNIDAS A LOS MODULADORES DE LA y-SECRETASA. - Google Patents
AMINAS UNIDAS A LOS MODULADORES DE LA y-SECRETASA.Info
- Publication number
- NI201000063A NI201000063A NI201000063A NI201000063A NI201000063A NI 201000063 A NI201000063 A NI 201000063A NI 201000063 A NI201000063 A NI 201000063A NI 201000063 A NI201000063 A NI 201000063A NI 201000063 A NI201000063 A NI 201000063A
- Authority
- NI
- Nicaragua
- Prior art keywords
- secretase modulators
- amines attached
- amines
- attached
- compounds
- Prior art date
Links
- VHNYOQKVZQVBLC-RTCGXNAVSA-N (4r,7e,9as)-7-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-(3,4,5-trifluorophenyl)-1,3,4,8,9,9a-hexahydropyrido[2,1-c][1,4]oxazin-6-one Chemical group C1([C@@H]2COC[C@@H]3CC\C(C(N32)=O)=C/C=2C=C(C(=CC=2)N2C=C(C)N=C2)OC)=CC(F)=C(F)C(F)=C1 VHNYOQKVZQVBLC-RTCGXNAVSA-N 0.000 title 1
- 150000001412 amines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se relaciona a compuestos de la Fórmula I como se muestran abajo , en donde las definiciones de A, R1, R2, R3, R4, R5, R6, R7, y R8 se proporcionan en la especificación. Los compuestos de la Fórmula I son útiles para el tratamiento de enfermedades asociadas a la actividad de la y-secretasa, incluyendo la enfermedad de Alzheimer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98117007P | 2007-10-19 | 2007-10-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NI201000063A true NI201000063A (es) | 2010-09-13 |
Family
ID=40091367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NI201000063A NI201000063A (es) | 2007-10-19 | 2010-04-16 | AMINAS UNIDAS A LOS MODULADORES DE LA y-SECRETASA. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7951843B2 (es) |
| EP (1) | EP2212280B1 (es) |
| JP (1) | JP5543353B2 (es) |
| KR (1) | KR20100090265A (es) |
| CN (1) | CN101888990B (es) |
| AU (1) | AU2008312653B2 (es) |
| BR (1) | BRPI0817425A2 (es) |
| CA (1) | CA2702835A1 (es) |
| CO (1) | CO6280529A2 (es) |
| CR (1) | CR11436A (es) |
| EA (1) | EA017907B1 (es) |
| ES (1) | ES2447842T3 (es) |
| IL (1) | IL205044A (es) |
| MX (1) | MX2010004308A (es) |
| NI (1) | NI201000063A (es) |
| NZ (1) | NZ584721A (es) |
| WO (1) | WO2009052079A1 (es) |
| ZA (1) | ZA201003518B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101903335A (zh) * | 2007-10-19 | 2010-12-01 | 詹森药业有限公司 | 连接有胺的γ-分泌酶调节剂 |
| MX2010004309A (es) * | 2007-10-19 | 2010-05-03 | Janssen Pharmaceutica Nv | Moduladores de piperidinil y piperazinil de gamma-secretasa. |
| EP2215043B1 (en) * | 2007-10-19 | 2013-03-06 | Janssen Pharmaceutica, N.V. | Carbon linked modulators of y-secretase |
| US20120129189A1 (en) * | 2009-07-17 | 2012-05-24 | Chulan Kwon | Methods of Controlling Cell Proliferation |
| WO2011057214A2 (en) * | 2009-11-09 | 2011-05-12 | Neurogenetic Pharmaceuticals, Inc. | Gamma-secretase modulatory compounds, methods for identifying same, and uses therefor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877399A (en) * | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
| EP1284729A4 (en) * | 2000-04-13 | 2007-12-19 | Mayo Foundation | REDUCTION AGENTS OF A (BETA) 42 |
| DE10131899A1 (de) | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
| EP2489659B1 (en) * | 2004-06-24 | 2017-12-13 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| GB0416508D0 (en) * | 2004-07-23 | 2004-08-25 | Merck Sharp & Dohme | Therapeutic agents |
| EP1650183A1 (en) | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
| EP2044044A2 (en) * | 2006-06-09 | 2009-04-08 | Icos Corporation | Substituted phenyl acetic acids as dp-2 antagonists |
-
2008
- 2008-10-14 CA CA2702835A patent/CA2702835A1/en not_active Abandoned
- 2008-10-14 BR BRPI0817425-3A patent/BRPI0817425A2/pt not_active IP Right Cessation
- 2008-10-14 EA EA201070494A patent/EA017907B1/ru not_active IP Right Cessation
- 2008-10-14 AU AU2008312653A patent/AU2008312653B2/en not_active Ceased
- 2008-10-14 US US12/250,622 patent/US7951843B2/en not_active Expired - Fee Related
- 2008-10-14 EP EP08838993.7A patent/EP2212280B1/en active Active
- 2008-10-14 JP JP2010530057A patent/JP5543353B2/ja not_active Expired - Fee Related
- 2008-10-14 WO PCT/US2008/079782 patent/WO2009052079A1/en active Application Filing
- 2008-10-14 MX MX2010004308A patent/MX2010004308A/es active IP Right Grant
- 2008-10-14 ES ES08838993.7T patent/ES2447842T3/es active Active
- 2008-10-14 NZ NZ584721A patent/NZ584721A/en not_active IP Right Cessation
- 2008-10-14 CN CN200880119162.XA patent/CN101888990B/zh not_active Expired - Fee Related
- 2008-10-14 KR KR1020107010765A patent/KR20100090265A/ko active IP Right Grant
-
2010
- 2010-04-13 IL IL205044A patent/IL205044A/en not_active IP Right Cessation
- 2010-04-16 NI NI201000063A patent/NI201000063A/es unknown
- 2010-04-26 CO CO10048723A patent/CO6280529A2/es not_active Application Discontinuation
- 2010-05-17 CR CR11436A patent/CR11436A/es not_active Application Discontinuation
- 2010-05-18 ZA ZA2010/03518A patent/ZA201003518B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0817425A2 (pt) | 2015-06-16 |
| CA2702835A1 (en) | 2009-04-23 |
| EP2212280B1 (en) | 2013-12-04 |
| CN101888990A (zh) | 2010-11-17 |
| US7951843B2 (en) | 2011-05-31 |
| IL205044A (en) | 2015-02-26 |
| ES2447842T3 (es) | 2014-03-13 |
| NZ584721A (en) | 2011-11-25 |
| KR20100090265A (ko) | 2010-08-13 |
| US20090105345A1 (en) | 2009-04-23 |
| JP5543353B2 (ja) | 2014-07-09 |
| EA017907B1 (ru) | 2013-04-30 |
| WO2009052079A1 (en) | 2009-04-23 |
| EA201070494A1 (ru) | 2010-12-30 |
| JP2011500699A (ja) | 2011-01-06 |
| EP2212280A1 (en) | 2010-08-04 |
| AU2008312653B2 (en) | 2013-03-07 |
| CR11436A (es) | 2011-01-14 |
| AU2008312653A1 (en) | 2009-04-23 |
| ZA201003518B (en) | 2012-07-25 |
| IL205044A0 (en) | 2010-11-30 |
| CO6280529A2 (es) | 2011-05-20 |
| CN101888990B (zh) | 2014-01-29 |
| MX2010004308A (es) | 2010-05-03 |
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