EA201070494A1 - МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ С АМИДНЫМИ СВЯЗЯМИ - Google Patents

МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ С АМИДНЫМИ СВЯЗЯМИ

Info

Publication number
EA201070494A1
EA201070494A1 EA201070494A EA201070494A EA201070494A1 EA 201070494 A1 EA201070494 A1 EA 201070494A1 EA 201070494 A EA201070494 A EA 201070494A EA 201070494 A EA201070494 A EA 201070494A EA 201070494 A1 EA201070494 A1 EA 201070494A1
Authority
EA
Eurasian Patent Office
Prior art keywords
secretase
ties
modulators
amide
compounds
Prior art date
Application number
EA201070494A
Other languages
English (en)
Other versions
EA017907B1 (ru
Inventor
Чих Юнг Хо
Original Assignee
Янссен Фармацевтика, Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика, Н.В. filed Critical Янссен Фармацевтика, Н.В.
Publication of EA201070494A1 publication Critical patent/EA201070494A1/ru
Publication of EA017907B1 publication Critical patent/EA017907B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к соединениям с общей формулой I, как показано ниже, определения A, RR, R, R, R, R, Rи Rуказаны в спецификации. Соединения формулы I могут применяться для лечения заболеваний, связанных с активностью γ-секретазы, включая болезнь Альцгеймера.
EA201070494A 2007-10-19 2008-10-14 МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ С АМИДНЫМИ СВЯЗЯМИ EA017907B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98117007P 2007-10-19 2007-10-19
PCT/US2008/079782 WO2009052079A1 (en) 2007-10-19 2008-10-14 Amide linked modulators of y-secretase

Publications (2)

Publication Number Publication Date
EA201070494A1 true EA201070494A1 (ru) 2010-12-30
EA017907B1 EA017907B1 (ru) 2013-04-30

Family

ID=40091367

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070494A EA017907B1 (ru) 2007-10-19 2008-10-14 МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ С АМИДНЫМИ СВЯЗЯМИ

Country Status (18)

Country Link
US (1) US7951843B2 (ru)
EP (1) EP2212280B1 (ru)
JP (1) JP5543353B2 (ru)
KR (1) KR20100090265A (ru)
CN (1) CN101888990B (ru)
AU (1) AU2008312653B2 (ru)
BR (1) BRPI0817425A2 (ru)
CA (1) CA2702835A1 (ru)
CO (1) CO6280529A2 (ru)
CR (1) CR11436A (ru)
EA (1) EA017907B1 (ru)
ES (1) ES2447842T3 (ru)
IL (1) IL205044A (ru)
MX (1) MX2010004308A (ru)
NI (1) NI201000063A (ru)
NZ (1) NZ584721A (ru)
WO (1) WO2009052079A1 (ru)
ZA (1) ZA201003518B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101903335A (zh) * 2007-10-19 2010-12-01 詹森药业有限公司 连接有胺的γ-分泌酶调节剂
MX2010004309A (es) * 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Moduladores de piperidinil y piperazinil de gamma-secretasa.
EP2215043B1 (en) * 2007-10-19 2013-03-06 Janssen Pharmaceutica, N.V. Carbon linked modulators of y-secretase
US20120129189A1 (en) * 2009-07-17 2012-05-24 Chulan Kwon Methods of Controlling Cell Proliferation
WO2011057214A2 (en) * 2009-11-09 2011-05-12 Neurogenetic Pharmaceuticals, Inc. Gamma-secretase modulatory compounds, methods for identifying same, and uses therefor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) * 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
EP1284729A4 (en) * 2000-04-13 2007-12-19 Mayo Foundation REDUCTION AGENTS OF A (BETA) 42
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
EP2489659B1 (en) * 2004-06-24 2017-12-13 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
EP1650183A1 (en) 2004-10-21 2006-04-26 Cellzome Ag (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy
EP2044044A2 (en) * 2006-06-09 2009-04-08 Icos Corporation Substituted phenyl acetic acids as dp-2 antagonists

Also Published As

Publication number Publication date
BRPI0817425A2 (pt) 2015-06-16
CA2702835A1 (en) 2009-04-23
EP2212280B1 (en) 2013-12-04
CN101888990A (zh) 2010-11-17
US7951843B2 (en) 2011-05-31
IL205044A (en) 2015-02-26
ES2447842T3 (es) 2014-03-13
NZ584721A (en) 2011-11-25
KR20100090265A (ko) 2010-08-13
US20090105345A1 (en) 2009-04-23
JP5543353B2 (ja) 2014-07-09
NI201000063A (es) 2010-09-13
EA017907B1 (ru) 2013-04-30
WO2009052079A1 (en) 2009-04-23
JP2011500699A (ja) 2011-01-06
EP2212280A1 (en) 2010-08-04
AU2008312653B2 (en) 2013-03-07
CR11436A (es) 2011-01-14
AU2008312653A1 (en) 2009-04-23
ZA201003518B (en) 2012-07-25
IL205044A0 (en) 2010-11-30
CO6280529A2 (es) 2011-05-20
CN101888990B (zh) 2014-01-29
MX2010004308A (es) 2010-05-03

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU