NI200700242A - Derivados de cumarina sustituidos con tiadiazol y sus usos como inhibidores de la biosíntesis de leucotrienos. - Google Patents

Derivados de cumarina sustituidos con tiadiazol y sus usos como inhibidores de la biosíntesis de leucotrienos.

Info

Publication number
NI200700242A
NI200700242A NI200700242A NI200700242A NI200700242A NI 200700242 A NI200700242 A NI 200700242A NI 200700242 A NI200700242 A NI 200700242A NI 200700242 A NI200700242 A NI 200700242A NI 200700242 A NI200700242 A NI 200700242A
Authority
NI
Nicaragua
Prior art keywords
inhibitors
biosynthesis
leucotriens
tiadiazol
aromatic ring
Prior art date
Application number
NI200700242A
Other languages
English (en)
Inventor
Marc Blouin
Erich L Grimm
Yves Gareau
Marc Gagnon
Helene Juteau
Sebastien Laliberte
Bruce Mackay
Richard Friesen
Original Assignee
Merck Frosst Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37023348&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NI200700242(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Frosst Canada Ltd filed Critical Merck Frosst Canada Ltd
Publication of NI200700242A publication Critical patent/NI200700242A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
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  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)

Abstract

La presente invención provee compuestos de la fórmula (Ia) los cuales son inhibidores de biosíntesis de leucotrienos, donde X es O ó S, Y es O, S, -NR6, -CHR7- ó -NR8-C(O)- y A se selecciona de un anillo aromático heterocíclico de 5 miembros, un anillo aromático heterocíclico de 6 miembros, un sistema de anillo aromático naftelenílico o heterobicíclico, fenilo y bencilo. A está opcionalmente mono-o-di-sustituida. Los compuestos de la fórmula (Ia) son útiles como agentes antiatereosclerótico, antiasmáticos, antialérgicos, antiinflamatorios y citoprotectores.
NI200700242A 2005-03-23 2007-09-20 Derivados de cumarina sustituidos con tiadiazol y sus usos como inhibidores de la biosíntesis de leucotrienos. NI200700242A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66431705P 2005-03-23 2005-03-23

Publications (1)

Publication Number Publication Date
NI200700242A true NI200700242A (es) 2008-05-13

Family

ID=37023348

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Application Number Title Priority Date Filing Date
NI200700242A NI200700242A (es) 2005-03-23 2007-09-20 Derivados de cumarina sustituidos con tiadiazol y sus usos como inhibidores de la biosíntesis de leucotrienos.

Country Status (26)

Country Link
US (3) US20090227638A1 (es)
EP (1) EP1869031B1 (es)
JP (2) JP4109316B1 (es)
KR (1) KR20070113259A (es)
CN (2) CN101146802A (es)
AR (1) AR055041A1 (es)
AU (1) AU2006227524B2 (es)
BR (1) BRPI0609687A2 (es)
CA (1) CA2600727C (es)
CR (1) CR9442A (es)
DO (1) DOP2006000069A (es)
EA (1) EA012704B1 (es)
ES (1) ES2394179T3 (es)
GT (1) GT200600117A (es)
IL (1) IL185724A0 (es)
MA (1) MA29398B1 (es)
MX (1) MX2007011638A (es)
MY (1) MY142105A (es)
NI (1) NI200700242A (es)
NO (1) NO20075384L (es)
PA (1) PA8667201A1 (es)
PE (1) PE20061328A1 (es)
TN (1) TNSN07348A1 (es)
TW (1) TWI321130B (es)
WO (1) WO2006099735A1 (es)
ZA (1) ZA200707385B (es)

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AR055041A1 (es) * 2005-03-23 2007-08-01 Merck Frosst Canada Ltd Tiadiazoles y oxadiazoles como inhibidores de la sintesis de leucotrienos. composiciones farmaceuticas.
JP2009510132A (ja) * 2005-10-05 2009-03-12 メルク フロスト カナダ リミテツド ロイコトリエン生合成の阻害剤としての置換キノリン
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GB2474120B (en) 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
SG190417A1 (en) 2010-12-07 2013-07-31 Amira Pharmaceuticals Inc Lysophosphatidic acid receptor antagonists and their use in the treatment of fibrosis
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US8541587B2 (en) 2011-04-05 2013-09-24 Amira Pharmaceuticals, Inc. Lysophosphatidic acid receptor antagonists
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CN103304556B (zh) * 2013-06-21 2016-06-01 天津药物研究院有限公司 含有苯并吡喃的希夫碱类化合物、其制备方法和用途
EP3795568A1 (en) 2015-03-06 2021-03-24 Pharmakea, Inc. Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
WO2017049871A1 (zh) * 2015-09-24 2017-03-30 四川大学 4位取代的香豆素衍生物及其制备方法和用途
KR102615565B1 (ko) 2016-09-07 2023-12-18 파마케아, 인크. 리실 옥시다제 유사 2 억제제의 용도
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CN108658962B (zh) * 2017-03-30 2021-10-01 复旦大学 3-取代香豆素呋咱衍生物及其在制备抗多药耐药肿瘤药物中的用途
CN111116506B (zh) * 2019-12-31 2024-03-08 浙江大学衢州研究院 一种芳巯基二唑类衍生物的合成方法
CN113149979B (zh) * 2021-03-05 2022-11-25 朗捷睿(苏州)生物科技有限公司 一种8-(苯并噻唑酰胺)取代香豆素类化合物及其制备方法和应用

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BRPI0609687A2 (pt) 2010-04-20
EP1869031B1 (en) 2012-08-08
MA29398B1 (fr) 2008-04-01
TW200700414A (en) 2007-01-01
CN102627638A (zh) 2012-08-08
US20090227638A1 (en) 2009-09-10
EP1869031A4 (en) 2011-02-09
US20090030048A1 (en) 2009-01-29
TWI321130B (en) 2010-03-01
IL185724A0 (en) 2008-01-06
TNSN07348A1 (en) 2008-12-31
US20070149579A1 (en) 2007-06-28
NO20075384L (no) 2007-11-30
CA2600727C (en) 2011-06-14
EA200702058A1 (ru) 2008-02-28
CR9442A (es) 2008-01-21
DOP2006000069A (es) 2006-09-30
PA8667201A1 (es) 2006-10-13
AU2006227524A1 (en) 2006-09-28
AR055041A1 (es) 2007-08-01
MX2007011638A (es) 2007-11-14
EA012704B1 (ru) 2009-12-30
JP4109316B1 (ja) 2008-07-02
CA2600727A1 (en) 2006-09-28
EP1869031A1 (en) 2007-12-26
GT200600117A (es) 2007-01-19
MY142105A (en) 2010-09-15
ES2394179T3 (es) 2013-01-23
WO2006099735A1 (en) 2006-09-28
JP2008533179A (ja) 2008-08-21
CN101146802A (zh) 2008-03-19
KR20070113259A (ko) 2007-11-28
PE20061328A1 (es) 2007-01-13
AU2006227524B2 (en) 2011-06-30
JP2008101010A (ja) 2008-05-01
ZA200707385B (en) 2010-01-27
US7553973B2 (en) 2009-06-30
JP5207711B2 (ja) 2013-06-12

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