MXPA05011496A - Derivados de azabiciclononeno. - Google Patents
Derivados de azabiciclononeno.Info
- Publication number
- MXPA05011496A MXPA05011496A MXPA05011496A MXPA05011496A MXPA05011496A MX PA05011496 A MXPA05011496 A MX PA05011496A MX PA05011496 A MXPA05011496 A MX PA05011496A MX PA05011496 A MXPA05011496 A MX PA05011496A MX PA05011496 A MXPA05011496 A MX PA05011496A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- azabicyclononene
- compounds
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invencion se refiere a los nuevos derivados del 9-azabiciclo[3.3.1]noneno y a los compuestos relacionados y a su uso como ingredientes activos en la preparacion de composiciones farmaceuticas. La invencion tambien se refiere a los aspectos relacionados que incluyen los procesos para la preparacion de los compuestos, las composiciones farmaceuticas que contienen uno o mas de estos compuestos y especialmente su uso como inhibidores de la renina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP0304488 | 2003-04-30 | ||
PCT/EP2004/004369 WO2004096803A1 (en) | 2003-04-30 | 2004-04-26 | Azabicyclononene derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05011496A true MXPA05011496A (es) | 2005-12-15 |
Family
ID=33395687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05011496A MXPA05011496A (es) | 2003-04-30 | 2004-04-26 | Derivados de azabiciclononeno. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20060235044A1 (es) |
EP (1) | EP1622907A1 (es) |
JP (1) | JP2006524654A (es) |
KR (1) | KR20060006069A (es) |
CN (1) | CN1780837A (es) |
AU (1) | AU2004234038A1 (es) |
BR (1) | BRPI0409818A (es) |
CA (1) | CA2521924A1 (es) |
MX (1) | MXPA05011496A (es) |
NO (1) | NO20055623L (es) |
RU (1) | RU2005137174A (es) |
WO (1) | WO2004096803A1 (es) |
ZA (1) | ZA200509667B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005040173A1 (en) * | 2003-10-23 | 2005-05-06 | Actelion Pharmaceuticals Ltd | Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors |
JP2007513107A (ja) * | 2003-12-05 | 2007-05-24 | アクテリオン ファマシューティカルズ リミテッド | ジアザビシクロノネンおよび新側鎖を有するテトラヒドロピリジン誘導体 |
ATE462703T1 (de) | 2004-08-25 | 2010-04-15 | Actelion Pharmaceuticals Ltd | Bicyclononen-derivate als renin-inhibitoren |
WO2006021403A1 (en) * | 2004-08-25 | 2006-03-02 | Actelion Pharmaceuticals Ltd | Bicyclononene derivatives |
WO2006058546A1 (en) * | 2004-12-01 | 2006-06-08 | Actelion Pharmaceuticals Ltd | Novel lactame derivatives as renin inhibitors |
WO2006063610A1 (en) * | 2004-12-17 | 2006-06-22 | Actelion Pharmaceuticals Ltd | Heteroaryl substituted diazabicyclononene derivatives |
GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
WO2006092268A1 (en) * | 2005-03-02 | 2006-09-08 | Actelion Pharmaceuticals Ltd | Bicyclic five-membered heteroaryl derivatives and their use as renin inhibitors |
GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
JP5306821B2 (ja) | 2005-12-30 | 2013-10-02 | ノバルティス アーゲー | レニン阻害剤としての3,5−置換ピペリジン化合物 |
EP1981847A1 (en) | 2006-02-02 | 2008-10-22 | Actelion Pharmaceuticals Ltd. | Secondary amines as renin inhibitors |
US20100166839A1 (en) * | 2006-03-16 | 2010-07-01 | Nicox S.A | Non peptidic renin inhibitors nitroderivatives |
AU2008253519A1 (en) | 2007-05-24 | 2008-11-27 | Merck Frosst Canada Ltd | Novel case of renin inhibitors |
CA2689109A1 (en) | 2007-06-25 | 2008-12-31 | Novartis Ag | N5-(2-ethoxyethyl)-n3-(2-pyridinyl) -3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
WO2009023964A1 (en) | 2007-08-20 | 2009-02-26 | Merck Frosst Canada Ltd. | Renin inhibitors |
ES2548134T3 (es) | 2008-05-05 | 2015-10-14 | Actelion Pharmaceuticals Ltd. | Derivados de piperidina 3,4-sustituida como inhibidores de renina |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3509161A (en) * | 1967-07-10 | 1970-04-28 | Boehringer & Soehne Gmbh | 3-phenyl-granatene-(2)-derivatives |
US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
PL294866A1 (en) * | 1991-06-21 | 1993-05-31 | Hoechst Ag | Method of obtaining novel rennin redtarding heterocyclic compounds |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
CN1256326C (zh) * | 1995-09-07 | 2006-05-17 | 弗·哈夫曼-拉罗切有限公司 | 治疗心脏和肾功能不全的新型4-(氧烷氧基苯基)-3-氧哌啶化合物 |
KR20080059687A (ko) * | 2000-03-06 | 2008-06-30 | 아카디아 파마슈티칼스 인코포레이티드 | 세로토닌 관련 질병의 치료에 사용되는 아자시클릭 화합물 |
US20030013883A1 (en) * | 2000-06-16 | 2003-01-16 | Tamagnan Gilles D. | Tropane analogs binding to monoamine transporters |
US7427613B2 (en) * | 2002-04-29 | 2008-09-23 | Actelion Pharmaceuticals Ltd. | 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases |
WO2005040173A1 (en) * | 2003-10-23 | 2005-05-06 | Actelion Pharmaceuticals Ltd | Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors |
JP2007513107A (ja) * | 2003-12-05 | 2007-05-24 | アクテリオン ファマシューティカルズ リミテッド | ジアザビシクロノネンおよび新側鎖を有するテトラヒドロピリジン誘導体 |
-
2004
- 2004-04-26 JP JP2006505258A patent/JP2006524654A/ja active Pending
- 2004-04-26 WO PCT/EP2004/004369 patent/WO2004096803A1/en not_active Application Discontinuation
- 2004-04-26 CN CNA2004800114435A patent/CN1780837A/zh active Pending
- 2004-04-26 AU AU2004234038A patent/AU2004234038A1/en not_active Abandoned
- 2004-04-26 EP EP04729428A patent/EP1622907A1/en not_active Withdrawn
- 2004-04-26 US US10/554,879 patent/US20060235044A1/en not_active Abandoned
- 2004-04-26 BR BRPI0409818-8A patent/BRPI0409818A/pt not_active Application Discontinuation
- 2004-04-26 RU RU2005137174/04A patent/RU2005137174A/ru not_active Application Discontinuation
- 2004-04-26 CA CA002521924A patent/CA2521924A1/en not_active Abandoned
- 2004-04-26 KR KR1020057020482A patent/KR20060006069A/ko not_active Application Discontinuation
- 2004-04-26 MX MXPA05011496A patent/MXPA05011496A/es not_active Application Discontinuation
-
2005
- 2005-11-29 NO NO20055623A patent/NO20055623L/no not_active Application Discontinuation
- 2005-11-29 ZA ZA200509667A patent/ZA200509667B/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2005137174A (ru) | 2006-03-27 |
CA2521924A1 (en) | 2004-11-11 |
ZA200509667B (en) | 2006-10-25 |
EP1622907A1 (en) | 2006-02-08 |
US20060235044A1 (en) | 2006-10-19 |
AU2004234038A1 (en) | 2004-11-11 |
JP2006524654A (ja) | 2006-11-02 |
CN1780837A (zh) | 2006-05-31 |
KR20060006069A (ko) | 2006-01-18 |
WO2004096803A1 (en) | 2004-11-11 |
BRPI0409818A (pt) | 2006-05-09 |
NO20055623L (no) | 2005-11-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW200514786A (en) | Novel diazabicyclononene derivatives | |
TW200514772A (en) | Novel tetrahydropyridine derivatives | |
MXPA05010137A (es) | Derivados de tetrahidroisoquinolil acetamida para usarse como antagonistas del receptor de orexina. | |
IL150986A0 (en) | 1,2,3,4,- tetrahydroisoquinoline derivatives | |
WO2004033418A3 (en) | Sulfonylamino-acetic derivatives and their use as orexin receptor antagonists | |
IL155806A0 (en) | Novel benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists | |
MXPA05011711A (es) | Derivados de diazabiciclononeno. | |
WO2004026836A8 (en) | 1-pyridin-4-yl-urea derivatives | |
TW200621773A (en) | Bicyclononene derivatives | |
TW200637861A (en) | Novel diazabicyclononene derivative | |
MXPA05011496A (es) | Derivados de azabiciclononeno. | |
MXPA05011498A (es) | Derivados de 9-azabiciclo[3.3.1]non-6-eno con un heteroatomo en la posicion 3 como inhibidores de renina. | |
WO2007102127A3 (en) | New amines | |
TNSN07435A1 (en) | Novel piperidine carboxylic acid amide derivatives | |
TW200628468A (en) | Bicyclononene derivatives | |
MXPA05011497A (es) | Derivados de tropano y su uso como inhibidores de la enzima de conversion de angiotensina (ace). | |
WO2005030209A8 (en) | Pyridine derivatives and use thereof as urotensin ii antagonists | |
WO2002070464A3 (en) | Hydrazones and their therapeutic use | |
WO2005054244A3 (en) | Azabicyclooctene and other tetrahydropyridine derivatives with a new side-chain | |
MXPA04001773A (es) | Derivados de 6,7-dihidroxitetrahidroisquinolinas 3-sustituidas parta uso como agentes antibacterianos. | |
MXPA03000606A (es) | Derivados de benzofurano y su uso como agentes antibacterianos. | |
TW200621774A (en) | Bicyclononene derivatives | |
TW200634014A (en) | Novel diazabicyclononene derivative | |
WO2006021399A3 (en) | Azabicyclononene derivatives as renin inhibitors | |
WO2006059304A3 (en) | Novel lactame derivatives as renin inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |