WO2006059304A3 - Novel lactame derivatives as renin inhibitors - Google Patents

Novel lactame derivatives as renin inhibitors Download PDF

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Publication number
WO2006059304A3
WO2006059304A3 PCT/IB2005/054008 IB2005054008W WO2006059304A3 WO 2006059304 A3 WO2006059304 A3 WO 2006059304A3 IB 2005054008 W IB2005054008 W IB 2005054008W WO 2006059304 A3 WO2006059304 A3 WO 2006059304A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel
renin inhibitors
derivatives
lactame
lactame derivatives
Prior art date
Application number
PCT/IB2005/054008
Other languages
French (fr)
Other versions
WO2006059304A2 (en
Inventor
Olivier Bezencon
Christoph Boss
Daniel Bur
Olivier Corminboeuf
Walter Fischli
Corinna Grisostomi
Lubos Remen
Sylvia Richard-Bildstein
Thierry Sifferlen
Thomas Weller
Dwight Macdonald
Daniel Mckay
David A Powell
Original Assignee
Actelion Pharmaceuticals Ltd
Olivier Bezencon
Christoph Boss
Daniel Bur
Olivier Corminboeuf
Walter Fischli
Corinna Grisostomi
Lubos Remen
Sylvia Richard-Bildstein
Thierry Sifferlen
Thomas Weller
Dwight Macdonald
Daniel Mckay
David A Powell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Olivier Bezencon, Christoph Boss, Daniel Bur, Olivier Corminboeuf, Walter Fischli, Corinna Grisostomi, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Thomas Weller, Dwight Macdonald, Daniel Mckay, David A Powell filed Critical Actelion Pharmaceuticals Ltd
Publication of WO2006059304A2 publication Critical patent/WO2006059304A2/en
Publication of WO2006059304A3 publication Critical patent/WO2006059304A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention relates to novel bicyclic derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
PCT/IB2005/054008 2004-12-01 2005-12-01 Novel lactame derivatives as renin inhibitors WO2006059304A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EPPCT/EP2004/013610 2004-12-01
PCT/EP2004/013610 WO2006058546A1 (en) 2004-12-01 2004-12-01 Novel lactame derivatives as renin inhibitors

Publications (2)

Publication Number Publication Date
WO2006059304A2 WO2006059304A2 (en) 2006-06-08
WO2006059304A3 true WO2006059304A3 (en) 2006-10-12

Family

ID=34959363

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2004/013610 WO2006058546A1 (en) 2004-12-01 2004-12-01 Novel lactame derivatives as renin inhibitors
PCT/IB2005/054008 WO2006059304A2 (en) 2004-12-01 2005-12-01 Novel lactame derivatives as renin inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/013610 WO2006058546A1 (en) 2004-12-01 2004-12-01 Novel lactame derivatives as renin inhibitors

Country Status (1)

Country Link
WO (2) WO2006058546A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8129538B1 (en) 2007-03-28 2012-03-06 Takeda Pharmaceutical Company Limited Renin inhibitors
AU2008253519A1 (en) 2007-05-24 2008-11-27 Merck Frosst Canada Ltd Novel case of renin inhibitors
AU2008288648A1 (en) 2007-08-20 2009-02-26 Merck Frosst Canada Ltd. Renin inhibitors
JP4790871B2 (en) 2008-05-05 2011-10-12 メルク フロスト カナダ リミテツド 3,4-Substituted piperidine derivatives as renin inhibitors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004096366A1 (en) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd 9-azabicyclo’3.3.1!non-6-ee derivatives with a heteroatom at the 3-position as renin inhibitors
WO2004096116A2 (en) * 2003-05-02 2004-11-11 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives
WO2004096803A1 (en) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Azabicyclononene derivatives
WO2005040173A1 (en) * 2003-10-23 2005-05-06 Actelion Pharmaceuticals Ltd Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors
WO2005040165A1 (en) * 2003-10-13 2005-05-06 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives and their use as renin inhibitors
WO2005054244A2 (en) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Azabicyclooctene and other tetrahydropyridine derivatives with a new side-chain

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004096366A1 (en) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd 9-azabicyclo’3.3.1!non-6-ee derivatives with a heteroatom at the 3-position as renin inhibitors
WO2004096803A1 (en) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Azabicyclononene derivatives
WO2004096116A2 (en) * 2003-05-02 2004-11-11 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives
WO2005040165A1 (en) * 2003-10-13 2005-05-06 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives and their use as renin inhibitors
WO2005040173A1 (en) * 2003-10-23 2005-05-06 Actelion Pharmaceuticals Ltd Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors
WO2005054244A2 (en) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Azabicyclooctene and other tetrahydropyridine derivatives with a new side-chain

Also Published As

Publication number Publication date
WO2006059304A2 (en) 2006-06-08
WO2006058546A1 (en) 2006-06-08

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