MXPA05008570A - Metodos para la prevencion y tratamiento de danos tisulares asociados con una lesion por isquemia-reperfusion. - Google Patents
Metodos para la prevencion y tratamiento de danos tisulares asociados con una lesion por isquemia-reperfusion.Info
- Publication number
- MXPA05008570A MXPA05008570A MXPA05008570A MXPA05008570A MXPA05008570A MX PA05008570 A MXPA05008570 A MX PA05008570A MX PA05008570 A MXPA05008570 A MX PA05008570A MX PA05008570 A MXPA05008570 A MX PA05008570A MX PA05008570 A MXPA05008570 A MX PA05008570A
- Authority
- MX
- Mexico
- Prior art keywords
- tissue damage
- ischemia
- reperfusion injury
- damage associated
- preventing
- Prior art date
Links
- 230000000451 tissue damage Effects 0.000 title abstract 5
- 231100000827 tissue damage Toxicity 0.000 title abstract 5
- 206010063837 Reperfusion injury Diseases 0.000 title abstract 4
- 208000012947 ischemia reperfusion injury Diseases 0.000 title abstract 4
- 201000008982 Thoracic Aortic Aneurysm Diseases 0.000 abstract 4
- 208000007474 aortic aneurysm Diseases 0.000 abstract 4
- 239000004074 complement inhibitor Substances 0.000 abstract 3
- 108010069112 Complement System Proteins Proteins 0.000 abstract 1
- 102000000989 Complement System Proteins Human genes 0.000 abstract 1
- 229940124073 Complement inhibitor Drugs 0.000 abstract 1
- 101001055956 Homo sapiens Mannan-binding lectin serine protease 1 Proteins 0.000 abstract 1
- 101001056015 Homo sapiens Mannan-binding lectin serine protease 2 Proteins 0.000 abstract 1
- 102000004856 Lectins Human genes 0.000 abstract 1
- 108090001090 Lectins Proteins 0.000 abstract 1
- 101150104297 MASP1 gene Proteins 0.000 abstract 1
- 102100026061 Mannan-binding lectin serine protease 1 Human genes 0.000 abstract 1
- 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 abstract 1
- 102100026553 Mannose-binding protein C Human genes 0.000 abstract 1
- 101710110798 Mannose-binding protein C Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000002523 lectin Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un metodo para prevenir o tratar el dano tisular asociado con la lesion por isquemia-reperfusion y reparacion de aneurisma aortica toracica-abdominal (TAAA) al administrar una cantidad suficiente para la prevencion o tratamiento del dano tisular de un inhibidor de complemento a un paciente que sufriria probablemente o sufre del dano tisular asociado con el dano por reperfusion-isquemia o con la reparacion de TAAA. Los inhibidores de complemento son de preferencia anticuerpos que se unen e inhiben a las proteinas de complemento involucradas en la formacion del complejo de ataque de membrana, de preferencia anticuerpos que inhiben MBL, MASP1, MASP2 y MASP3 en la ruta de lectina. Los inhibidores de complemento pueden emplearse solos o en combinacion para disminuir la morbididad y mortalidad causada por el dano tisular asociado con la lesion por isquemia-reperfusion y reparacion de TAAA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44906903P | 2003-02-21 | 2003-02-21 | |
PCT/US2004/005136 WO2004075837A2 (en) | 2003-02-21 | 2004-02-20 | Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05008570A true MXPA05008570A (es) | 2005-11-04 |
Family
ID=32927493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05008570A MXPA05008570A (es) | 2003-02-21 | 2004-02-20 | Metodos para la prevencion y tratamiento de danos tisulares asociados con una lesion por isquemia-reperfusion. |
Country Status (9)
Country | Link |
---|---|
US (2) | US20060140939A1 (es) |
EP (2) | EP1601377A4 (es) |
JP (1) | JP2006518749A (es) |
CN (2) | CN1750844B (es) |
AU (1) | AU2004216176B2 (es) |
CA (1) | CA2515453C (es) |
HK (2) | HK1084603A1 (es) |
MX (1) | MXPA05008570A (es) |
WO (1) | WO2004075837A2 (es) |
Cited By (1)
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---|---|---|---|---|
CN109908352A (zh) * | 2012-06-18 | 2019-06-21 | 奥默罗斯公司 | 抑制masp-1和/或masp-2和/或masp-3的组合物和方法 |
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US6969601B2 (en) | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
US20070160645A1 (en) * | 2001-10-25 | 2007-07-12 | Jakob Vinten-Johansen | PostConditioning System And Method For The Reduction Of Ischemic-Reperfusion Injury In The Heart And Other Organs |
DE60229416D1 (de) | 2001-10-25 | 2008-11-27 | Univ Emory | Katheter für modifizierte Perfusion |
US7827077B2 (en) | 2003-05-02 | 2010-11-02 | Visa U.S.A. Inc. | Method and apparatus for management of electronic receipts on portable devices |
EP1625166B1 (en) | 2003-05-12 | 2015-04-08 | Helion Biotech ApS | Antibodies to masp-2 |
CA2524534C (en) * | 2003-05-15 | 2012-12-11 | Sek Chung Fung | Methods and compositions for the prevention and treatment of sepsis |
US7919094B2 (en) * | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
AU2011265532B2 (en) * | 2004-06-10 | 2014-04-24 | Omeros Corporation | Methods for treating conditions associated with MASP-2-dependent complement activation |
PT1753456T (pt) * | 2004-06-10 | 2016-11-04 | Univ Leicester | Métodos para tratar condições associadas com a ativação do complemento dependente de masp-2 |
AU2013201565B2 (en) * | 2004-06-10 | 2016-03-31 | Omeros Corporation | Methods for treating conditions associated with MASP-2-dependent complement activation |
GB0412966D0 (en) * | 2004-06-10 | 2004-07-14 | Univ Leicester | Genetically modified non-human mammals and cells |
US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
US20080097385A1 (en) * | 2004-12-22 | 2008-04-24 | Jakob Vinten-Johansen | Therapeutic Adjuncts to Enhance the Organ Protective Effects of Postconditioning |
US8168584B2 (en) * | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
ES2551202T5 (es) * | 2005-11-04 | 2018-11-30 | Genentech, Inc. | Uso de inhibidores de la vía del complemento para tratar enfermedades oculares |
DK1965831T3 (da) * | 2005-12-21 | 2011-10-24 | Pharming Intellectual Pty Bv | Anvendelse af C1-inhibitor til forebyggelse af iskæmi-reperfusionsskade |
US8524453B2 (en) | 2006-02-10 | 2013-09-03 | The Brigham And Woman's Hospital, Inc. | Lectin complement pathway assays and related compositions and methods |
PL3028716T3 (pl) | 2006-10-10 | 2021-03-08 | Regenesance B.V. | Hamowanie układu dopełniacza służące do lepszej regeneracji nerwów |
WO2009085475A1 (en) * | 2007-12-21 | 2009-07-09 | Sevrain Lionel C | Method for detection and treatment of aneurysms |
HUP0900319A2 (en) * | 2009-05-25 | 2011-01-28 | Eotvos Lorand Tudomanyegyetem | New peptides, method of producing therof and use thereof |
HUE030897T2 (en) * | 2009-10-16 | 2017-06-28 | Omeros Corp | Procedures for Treatment of Disseminated Intravascular Coagulation by Inhibition of MASP-Dependent Complement Activation |
CA2811091C (en) * | 2010-03-02 | 2017-07-25 | Novelmed Therapeutics, Inc. | A method for inhibiting alternative pathway mediated disorders with anti-properdin antibodies that inhibit c5 interactions with properdin |
WO2011112575A1 (en) * | 2010-03-08 | 2011-09-15 | Wake Forest University Health Sciences | Keratin biomaterials for treatment of ischemia |
CA2797856C (en) | 2010-04-30 | 2018-09-18 | Alexion Pharmaceuticals, Inc. | Anti-c5a antibodies and methods for using the antibodies |
WO2012006599A2 (en) * | 2010-07-09 | 2012-01-12 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of rhinosinusitis and nasal polyposis |
US9644035B2 (en) * | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
EP3287142B1 (en) | 2011-04-08 | 2021-08-04 | University Of Leicester | Methods for treating conditions associated with masp-2 dependent complement activation |
CN102304158B (zh) * | 2011-05-20 | 2014-07-30 | 中国人民解放军第二军医大学 | 酰化黄酮苷化合物及其在制备补体抑制剂药物中的应用 |
KR20140064768A (ko) | 2011-07-01 | 2014-05-28 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 항-프로퍼딘 항체 및 그의 용도 |
WO2013025941A1 (en) | 2011-08-17 | 2013-02-21 | Keranetics Llc | Low protein percentage gelling compositions |
WO2013025928A2 (en) | 2011-08-17 | 2013-02-21 | Keranetics Llc | Methods for extracting keratin proteins |
CA2848510A1 (en) * | 2011-09-24 | 2013-03-28 | Csl Behring Gmbh | Combination therapy using immunoglobulin and c1-inhibitor |
US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
CN104114576B (zh) | 2011-12-21 | 2017-04-05 | 诺华股份有限公司 | 用于抗体靶定p因子的组合物和方法 |
HUE036930T2 (hu) * | 2012-04-06 | 2018-08-28 | Omeros Corp | Készítmények és eljárások MASP-1 és/vagy MASP-3 gátlására paroxymalis nocturnalis hemoglobinürítés kezelésére |
EP2904014A4 (en) | 2012-10-04 | 2016-09-28 | Novelmed Therapeutics Inc | FOR ALTERNATIVE PATHS, SPECIFIC ANTIBODIES FOR THE TREATMENT OF HEMOLYTIC DISEASES |
RS62243B9 (sr) | 2012-11-15 | 2022-11-30 | Apellis Pharmaceuticals Inc | Analozi kompstatina sa produženim trajanjem dejstva i njihove kompozicije i postupci |
US10286047B2 (en) | 2013-03-08 | 2019-05-14 | Csl Behring Gmbh | Treatment and prevention of remote ischemia-reperfusion injury |
US9827245B2 (en) | 2013-03-15 | 2017-11-28 | KeraNetics, LLC | Keratin compositions comprising halofuginone |
US10308687B2 (en) | 2013-03-15 | 2019-06-04 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
BR112016002845A2 (pt) | 2013-08-12 | 2017-09-12 | Genentech Inc | composições e métodos para tratar condições associadas ao complemento |
CN103788157B (zh) * | 2014-02-14 | 2016-04-06 | 天津科技大学 | 绒毛白蜡中一种香豆素衍生物及其制备工艺和应用 |
JP2017515811A (ja) | 2014-05-01 | 2017-06-15 | ジェネンテック, インコーポレイテッド | 抗d因子抗体変異体及びその使用法 |
KR20180090785A (ko) | 2015-10-07 | 2018-08-13 | 아펠리스 파마슈티컬스 인코포레이티드 | 투여 요법 |
WO2017075173A2 (en) | 2015-10-30 | 2017-05-04 | Genentech, Inc. | Anti-factor d antibodies and conjugates |
US10654932B2 (en) | 2015-10-30 | 2020-05-19 | Genentech, Inc. | Anti-factor D antibody variant conjugates and uses thereof |
JOP20170154B1 (ar) | 2016-08-01 | 2023-03-28 | Omeros Corp | تركيبات وطرق لتثبيط masp-3 لعلاج أمراض واضطرابات مختلفة |
US11007254B2 (en) | 2016-10-17 | 2021-05-18 | Musc Foundation For Research Development | Compositions and methods for treating central nervous system injury |
JP2020516607A (ja) | 2017-04-07 | 2020-06-11 | アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals,Inc. | 投与レジメンならびに関連組成物および方法 |
GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
WO2019246367A1 (en) * | 2018-06-22 | 2019-12-26 | Omeros Corporation | Compositions and methods of inhibiting masp-2 for the treatment of various thrombotic diseases and disorders |
WO2020115095A2 (en) * | 2018-12-05 | 2020-06-11 | Glycardial Diagnostics, S.L. | Methods and compositions for the prevention and/or treatment of ischemia and of ischemia/reperfusion injury |
GB2583560A (en) | 2018-12-11 | 2020-11-04 | Admirx Inc | Fusion protein constructs for complement associated disease |
CA3139209A1 (en) | 2019-05-07 | 2020-11-12 | Bayer Aktiengesellschaft | Masp inhibitory compounds and uses thereof |
EP4011904A1 (en) | 2020-12-14 | 2022-06-15 | Bayer Aktiengesellschaft | Masp inhibitory compounds and uses thereof |
WO2022096394A1 (en) | 2020-11-04 | 2022-05-12 | Bayer Aktiengesellschaft | Masp inhibitory compounds and uses thereof |
JP2024518724A (ja) * | 2021-04-25 | 2024-05-02 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | 抗masp2抗体、その抗原結合断片および医薬用途 |
Family Cites Families (13)
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US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US6458360B1 (en) * | 1990-04-25 | 2002-10-01 | The Johns Hopkins University | Soluble complement regulatory molecules |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US6086868A (en) * | 1997-04-30 | 2000-07-11 | Schering Corporation | Method for treating or preventing ischemia-reperfusion injury |
US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
US7273925B1 (en) * | 1998-12-15 | 2007-09-25 | Brigham And Women's Hospital, Inc. | Methods and products for regulating lectin complement pathway associated complement activation |
EP1140171A4 (en) * | 1998-12-15 | 2002-03-13 | Brigham & Womens Hospital | METHODS AND PRODUCTS FOR REGULATING THE COMPLEMENT ACTIVATION ASSOCIATED WITH THE LECTIN COMPLEMENT SYSTEM |
WO2000047194A2 (en) | 1999-02-09 | 2000-08-17 | 3-Dimensional Pharmaceuticals, Inc. | METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR |
CA2380979A1 (en) * | 1999-08-13 | 2001-02-22 | Brigham And Women's Hospital, Inc. | Inhibitors of the lectin complement pathway (lcp) and their use |
CA2391402A1 (en) * | 1999-12-02 | 2001-06-07 | Jens Christian Jensenius | Masp-3, a complement-fixing enzyme, and uses for it |
CA2887012A1 (en) * | 2000-07-13 | 2002-01-24 | Helion Biotech Aps | Masp-2, a complement-fixing enzyme, and uses for it |
CA2433353C (en) | 2000-12-28 | 2017-03-21 | Altus Biologics, Inc. | Crystals of whole antibodies and fragments thereof and methods for making and using them |
US7361339B2 (en) | 2003-01-09 | 2008-04-22 | Alexion Pharmaceuticals, Inc. | Methods for reducing morality associated with acute myocardial infarction |
-
2004
- 2004-02-20 AU AU2004216176A patent/AU2004216176B2/en not_active Ceased
- 2004-02-20 CA CA2515453A patent/CA2515453C/en not_active Expired - Fee Related
- 2004-02-20 MX MXPA05008570A patent/MXPA05008570A/es active IP Right Grant
- 2004-02-20 CN CN2004800045401A patent/CN1750844B/zh not_active Expired - Fee Related
- 2004-02-20 EP EP04713419A patent/EP1601377A4/en not_active Withdrawn
- 2004-02-20 US US10/545,700 patent/US20060140939A1/en not_active Abandoned
- 2004-02-20 CN CN201010221441.6A patent/CN101897969B/zh not_active Expired - Fee Related
- 2004-02-20 WO PCT/US2004/005136 patent/WO2004075837A2/en active Search and Examination
- 2004-02-20 JP JP2006503762A patent/JP2006518749A/ja active Pending
- 2004-02-20 EP EP11183631A patent/EP2422812A1/en not_active Withdrawn
-
2006
- 2006-06-20 HK HK06106987.6A patent/HK1084603A1/xx not_active IP Right Cessation
-
2008
- 2008-06-13 US US12/139,192 patent/US20090017031A1/en not_active Abandoned
-
2011
- 2011-05-16 HK HK11104750.9A patent/HK1150751A1/xx not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109908352A (zh) * | 2012-06-18 | 2019-06-21 | 奥默罗斯公司 | 抑制masp-1和/或masp-2和/或masp-3的组合物和方法 |
Also Published As
Publication number | Publication date |
---|---|
HK1150751A1 (en) | 2012-01-13 |
CA2515453A1 (en) | 2004-09-10 |
US20060140939A1 (en) | 2006-06-29 |
CA2515453C (en) | 2013-09-24 |
WO2004075837A3 (en) | 2005-06-02 |
EP1601377A2 (en) | 2005-12-07 |
EP2422812A1 (en) | 2012-02-29 |
WO2004075837A2 (en) | 2004-09-10 |
AU2004216176B2 (en) | 2008-04-03 |
EP1601377A4 (en) | 2009-07-15 |
CN101897969A (zh) | 2010-12-01 |
US20090017031A1 (en) | 2009-01-15 |
AU2004216176A1 (en) | 2004-09-10 |
CN101897969B (zh) | 2014-04-02 |
CN1750844B (zh) | 2010-09-08 |
HK1084603A1 (en) | 2006-08-04 |
CN1750844A (zh) | 2006-03-22 |
JP2006518749A (ja) | 2006-08-17 |
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