MXPA04005139A - Derivados de 2 pirrolidin-2-il-iii-indol sustituidos para el tratamiento de migrana. - Google Patents

Derivados de 2 pirrolidin-2-il-iii-indol sustituidos para el tratamiento de migrana.

Info

Publication number
MXPA04005139A
MXPA04005139A MXPA04005139A MXPA04005139A MXPA04005139A MX PA04005139 A MXPA04005139 A MX PA04005139A MX PA04005139 A MXPA04005139 A MX PA04005139A MX PA04005139 A MXPA04005139 A MX PA04005139A MX PA04005139 A MXPA04005139 A MX PA04005139A
Authority
MX
Mexico
Prior art keywords
pyrrolidine
indole derivatives
substituted
migraine
disease
Prior art date
Application number
MXPA04005139A
Other languages
English (en)
Inventor
Sundermann Corinna
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of MXPA04005139A publication Critical patent/MXPA04005139A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

Abstract

La invencion se relaciona con derivados de 2-pirrolidin-2-il-III-indol sustituidos de la formula I, con metodos para su produccion, con farmacos conteniendo estos compuestos y con el uso de derivados de 2-pirrolidin-2-il-III-indol para la produccion de un farmaco para ka inhibicion de la NO cintaza y para el tratamiento de migrana, choque septicemico, esclerosis multiple, enfermedad de Parkinson, enfermedad de Alzheimer, enfermedad de Huntington, inflamaciones, dolores inflamatorios, isquemia cerebral, diabetes, meningitis, arteriosclerosis y/o curacion de heridas.
MXPA04005139A 2001-12-06 2002-12-02 Derivados de 2 pirrolidin-2-il-iii-indol sustituidos para el tratamiento de migrana. MXPA04005139A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10159922A DE10159922A1 (de) 2001-12-06 2001-12-06 Substituierte 2-Pyrrolidin-2-yl-1H-indol-Derivate
PCT/EP2002/013613 WO2003048156A1 (de) 2001-12-06 2002-12-02 Substituierte 2-pyrrolidin-2-yl-1h-indol-derivative für die behandlung von migräne

Publications (1)

Publication Number Publication Date
MXPA04005139A true MXPA04005139A (es) 2004-08-11

Family

ID=7708242

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04005139A MXPA04005139A (es) 2001-12-06 2002-12-02 Derivados de 2 pirrolidin-2-il-iii-indol sustituidos para el tratamiento de migrana.

Country Status (18)

Country Link
US (1) US7271192B2 (es)
EP (1) EP1451177B1 (es)
JP (1) JP4663982B2 (es)
AR (1) AR037707A1 (es)
AT (1) ATE357441T1 (es)
AU (1) AU2002363859B2 (es)
CA (1) CA2469346C (es)
CY (1) CY1106576T1 (es)
DE (2) DE10159922A1 (es)
DK (1) DK1451177T3 (es)
ES (1) ES2284973T3 (es)
HU (1) HUP0402283A3 (es)
MX (1) MXPA04005139A (es)
PE (1) PE20030748A1 (es)
PL (1) PL371270A1 (es)
PT (1) PT1451177E (es)
SI (1) SI1451177T1 (es)
WO (1) WO2003048156A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE556712T1 (de) 2005-06-07 2012-05-15 Kyowa Hakko Kirin Co Ltd A2a antagonisten zur behandlung von motorischen störungen
SG181797A1 (en) 2009-12-18 2012-07-30 Idenix Pharmaceuticals Inc 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors
US10092574B2 (en) 2012-09-26 2018-10-09 Valorisation-Recherche, Limited Partnership Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
CN112010841A (zh) * 2020-08-20 2020-12-01 上海体育学院 一种基于吲哚骨架的吡咯烷衍生物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506683A (en) * 1963-10-07 1970-04-14 Upjohn Co 3-(2-pyrrolidinylidene)-3h-indoles
US5639752A (en) * 1991-11-25 1997-06-17 Pfizer Inc Indole derivatives
GB9201038D0 (en) * 1992-01-16 1992-03-11 Glaxo Group Ltd Chemical compounds
BR9407402A (pt) * 1993-08-31 1996-11-05 Pfizer Derivados do 5-arilindol
GB9523999D0 (en) * 1995-11-23 1996-01-24 Lilly Co Eli Indolyl neuropeptide y receptor antagonists
HN1998000118A (es) * 1997-08-27 1999-02-09 Pfizer Prod Inc 2 - aminopiridinas que contienen sustituyentes de anillos condensados.
CA2425185A1 (en) * 2000-10-06 2002-04-11 Stephane De Lombaert Benzimidazole and indole derivatives as crf receptor modulators

Also Published As

Publication number Publication date
HUP0402283A2 (hu) 2005-02-28
CA2469346A1 (en) 2003-06-12
CY1106576T1 (el) 2012-01-25
AR037707A1 (es) 2004-12-01
JP2005511694A (ja) 2005-04-28
PT1451177E (pt) 2007-04-30
US7271192B2 (en) 2007-09-18
HUP0402283A3 (en) 2009-07-28
PL371270A1 (en) 2005-06-13
EP1451177A1 (de) 2004-09-01
WO2003048156A1 (de) 2003-06-12
AU2002363859B2 (en) 2008-09-18
CA2469346C (en) 2010-10-19
EP1451177B1 (de) 2007-03-21
JP4663982B2 (ja) 2011-04-06
US20050014815A1 (en) 2005-01-20
DK1451177T3 (da) 2007-07-02
PE20030748A1 (es) 2003-09-05
DE50209798D1 (de) 2007-05-03
ATE357441T1 (de) 2007-04-15
DE10159922A1 (de) 2003-06-26
AU2002363859A1 (en) 2003-06-17
SI1451177T1 (sl) 2007-08-31
ES2284973T3 (es) 2007-11-16

Similar Documents

Publication Publication Date Title
WO2001078711A3 (en) Pde-v inhibitors for treatment of parkinson's disease
TR200401545T4 (tr) NOSS inhibitörü ilaçların amalatı için ikame imidazo [1,2-a]piridin-,-pirimidin- ve-pirazin-3-amin-türevlerinin kullanımı
NO20063275L (no) Anvendelse av substituerte 2-aminotetraliner for forebyggende behandling av Parkinsons sykdom
ATE440603T1 (de) 8-hydroxychinolinderivate
TW200635599A (en) Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
MXPA04001500A (es) Compuestos que tienen un efecto sobre la glucocinasa.
GB0318447D0 (en) Therapeutic agents
GB0225475D0 (en) Therapeutic agents
TWI265928B (en) A61k 31/4025 200601 a i htw a61p 25/00 200601 a n htw
HUP0401086A2 (hu) 4-[(Fenil-piperazinil)-metil]-benzamid-származékok és alkalmazásuk fájdalom, szorongás vagy gasztrointesztinális zavarok kezelésére szolgáló gyógyszerkészítmények előállítására és eljárás a vegyületek előállítására
YU23202A (sh) Lekovi za tretman malignih tumora
DE60034240D1 (de) Drogen zur behandlung maligner tumoren
ATE253918T1 (de) Verwendung von hymenialdisin und dessen derivaten zur herstellung therapeutischer mittel
MXPA04006184A (es) Compuestos derivados de 1h-pirazolilo, para el uso en enfermedades asociadas con el receptor 5-ht2c.
UA83233C2 (ru) Замещенный 2-аминотетралин для лечения депрессии
TW200502221A (en) Novel lactams and uses thereof
BR0316723A (pt) Derivados de anilinopirazol úteis para o tratamento de diabetes
TW200509933A (en) Therapeutic agents
MXPA02001813A (es) Hidroxialcanoilaminolactamas y estructuras relacionas como inhibidores de la produccion de la proteina abeta.
DE60104697D1 (de) Sulfonamid-derivate
HUP0300562A2 (hu) [(Hidroxi-fenil)-piperazinil-metil]-benzamid-származékok fájdalom kezelésére, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
SE0101082D0 (sv) Novel use
YU12003A (sh) Novi derivati aminocikloheksana
MXPA04005139A (es) Derivados de 2 pirrolidin-2-il-iii-indol sustituidos para el tratamiento de migrana.
MXPA04005907A (es) Derivados de aminociclohexano heteroarilsustituidos.

Legal Events

Date Code Title Description
FG Grant or registration