MXPA02002901A - Enzimas de ruta de enfocado lisosomal. - Google Patents

Enzimas de ruta de enfocado lisosomal.

Info

Publication number
MXPA02002901A
MXPA02002901A MXPA02002901A MXPA02002901A MXPA02002901A MX PA02002901 A MXPA02002901 A MX PA02002901A MX PA02002901 A MXPA02002901 A MX PA02002901A MX PA02002901 A MXPA02002901 A MX PA02002901A MX PA02002901 A MXPA02002901 A MX PA02002901A
Authority
MX
Mexico
Prior art keywords
lysosomal targeting
pathway enzymes
targeting pathway
methods
enzyme
Prior art date
Application number
MXPA02002901A
Other languages
English (en)
Inventor
William M Canfield
Original Assignee
William M Canfield
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William M Canfield filed Critical William M Canfield
Publication of MXPA02002901A publication Critical patent/MXPA02002901A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1223—Phosphotransferases with a nitrogenous group as acceptor (2.7.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/04—Phosphoric diester hydrolases (3.1.4)
    • C12Y301/04045—N-Acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (3.1.4.45)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MXPA02002901A 1999-09-14 2000-09-14 Enzimas de ruta de enfocado lisosomal. MXPA02002901A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15383199P 1999-09-14 1999-09-14
PCT/US2000/021970 WO2001019955A2 (en) 1999-09-14 2000-09-14 Lysosomal targeting pathway enzymes

Publications (1)

Publication Number Publication Date
MXPA02002901A true MXPA02002901A (es) 2003-10-14

Family

ID=22548927

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02002901A MXPA02002901A (es) 1999-09-14 2000-09-14 Enzimas de ruta de enfocado lisosomal.

Country Status (10)

Country Link
US (8) US6537785B1 (es)
EP (1) EP1224266B1 (es)
JP (1) JP2003509043A (es)
AT (1) ATE373086T1 (es)
AU (1) AU783224B2 (es)
BR (1) BR0014514A (es)
CA (1) CA2383217C (es)
DE (1) DE60036395T2 (es)
MX (1) MXPA02002901A (es)
WO (1) WO2001019955A2 (es)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545553A (en) * 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
US6537785B1 (en) * 1999-09-14 2003-03-25 Genzyme Glycobiology Research Institute, Inc. Methods of treating lysosomal storage diseases
DE60138535D1 (de) 2000-02-04 2009-06-10 Children S Hospital Res Founda Verwendung von lysosomal acid lipase zur behandlung von atherosklerose und ähnlichen krankheiten
EP2767291B1 (en) 2000-07-18 2016-09-14 Duke University Treatment of glycogen storage disease type II
EP1782825B1 (en) * 2000-07-18 2014-09-10 Duke University Treatment of glycogen storage diseases type II
AU2012200674B2 (en) * 2000-08-18 2014-04-24 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
US7138262B1 (en) * 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
US7001994B2 (en) * 2001-01-18 2006-02-21 Genzyme Corporation Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins
US7723296B2 (en) 2001-01-18 2010-05-25 Genzyme Corporation Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
EP1368039A4 (en) * 2001-02-20 2006-03-29 Uab Research Foundation AMINOGLYCOSIDE TREATMENT FOR LYSOSOMAL STORAGE DISEASES
US20040005309A1 (en) * 2002-05-29 2004-01-08 Symbiontics, Inc. Targeted therapeutic proteins
JP4641705B2 (ja) * 2001-04-30 2011-03-02 ザイストール セラピューティクス， インコーポレイテッド 治療的タンパク質の亜細胞標的化
US7560424B2 (en) * 2001-04-30 2009-07-14 Zystor Therapeutics, Inc. Targeted therapeutic proteins
US7629309B2 (en) * 2002-05-29 2009-12-08 Zystor Therapeutics, Inc. Targeted therapeutic proteins
FR2825268B1 (fr) * 2001-05-31 2004-09-17 Oreal Composition cosmetique comprenant des particules de carbonate de calcium et des agents de conditionnement
AU2002317700A1 (en) * 2001-06-07 2002-12-16 Hemebiotech A/S Production of recombinant human arylsulfatase a
JP4742191B2 (ja) * 2001-06-14 2011-08-10 独立行政法人産業技術総合研究所 糖蛋白質およびその製造方法
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7399613B2 (en) * 2001-10-10 2008-07-15 Neose Technologies, Inc. Sialic acid nucleotide sugars
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7179617B2 (en) * 2001-10-10 2007-02-20 Neose Technologies, Inc. Factor IX: remolding and glycoconjugation of Factor IX
US8008252B2 (en) * 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7696163B2 (en) 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7214660B2 (en) * 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US20030072761A1 (en) * 2001-10-16 2003-04-17 Lebowitz Jonathan Methods and compositions for targeting proteins across the blood brain barrier
AU2002340256B2 (en) * 2001-10-19 2007-04-05 Merck Sharp & Dohme Corp. Androgen receptor modulators and methods of use thereof
AU2002351197A1 (en) * 2001-11-28 2003-06-10 Neose Technologies, Inc. Glycopeptide remodeling using amidases
US6800472B2 (en) * 2001-12-21 2004-10-05 Genzyme Glycobiology Research Institute, Inc. Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase
US6905856B2 (en) * 2001-12-21 2005-06-14 Genzyme Glycobiology Research Institute, Inc. Soluble GlcNAc phosphotransferase
US20030133924A1 (en) * 2001-12-21 2003-07-17 Novazyme Pharmaceuticals, Inc. Highly phosphorylated acid beta-glucocerebrosidase and methods of treating gaucher's disease
US20050158296A1 (en) 2002-01-11 2005-07-21 Starr Christopher M. Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
EP1336411A1 (en) * 2002-02-14 2003-08-20 Academisch Medisch Centrum bij de Universiteit van Amsterdam Compositions and methods for improving enzyme replacement therapy of lysosomal storage diseases
MXPA04012496A (es) 2002-06-21 2005-09-12 Novo Nordisk Healthcare Ag Glicoformos del factor vii pegilados.
JP2006523211A (ja) 2003-03-14 2006-10-12 ネオス テクノロジーズ インコーポレイテッド 分岐水溶性ポリマーとその複合物
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
SG155777A1 (en) 2003-04-09 2009-10-29 Neose Technologies Inc Glycopegylation methods and proteins/peptides produced by the methods
WO2004091499A2 (en) * 2003-04-09 2004-10-28 Neose Technologies, Inc. Intracellular formation of peptide conjugates
AU2004240553A1 (en) 2003-05-09 2004-12-02 Neose Technologies, Inc. Compositions and methods for the preparation of human growth hormone glycosylation mutants
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US7842661B2 (en) 2003-11-24 2010-11-30 Novo Nordisk A/S Glycopegylated erythropoietin formulations
US20080318850A1 (en) * 2003-12-03 2008-12-25 Neose Technologies, Inc. Glycopegylated Factor Ix
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US7956032B2 (en) * 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
JP5743368B2 (ja) 2004-01-08 2015-07-01 ラショファーム ゲーエムベーハー ペプチドのｏ結合型グリコシル化
EP1720405A4 (en) * 2004-02-06 2008-08-27 Biomarin Pharm Inc MANUFACTURE OF HIGHLY PHOSPHORYLATED LYSOSOMAL ENZYMES AND USES THEREOF
JP4914224B2 (ja) * 2004-02-10 2012-04-11 バイオマリン ファーマシューティカル インコーポレイテッド 酸性αグルコシダーゼおよびそのフラグメント
US20050208090A1 (en) * 2004-03-18 2005-09-22 Medtronic, Inc. Methods and systems for treatment of neurological diseases of the central nervous system
EP1773401B1 (en) * 2004-06-21 2013-01-02 Medtronic, Inc. Medical systems and methods for delivering compositions to cells
WO2006007560A2 (en) * 2004-07-01 2006-01-19 University Of Pennsylvania Targeted protein replacement for the treatment of lysosomal storage disorders
EP1771066A2 (en) 2004-07-13 2007-04-11 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1
WO2006031811A2 (en) 2004-09-10 2006-03-23 Neose Technologies, Inc. Glycopegylated interferon alpha
DK2586456T3 (en) 2004-10-29 2016-03-21 Ratiopharm Gmbh Conversion and glycopegylation of fibroblast growth factor (FGF)
ES2449195T3 (es) 2005-01-10 2014-03-18 Ratiopharm Gmbh Factor estimulante de colonias de granulocitos glicopegilado
CA2601797A1 (en) * 2005-03-16 2006-09-21 University Of Oxford Mannose immunogens for hiv-1
JP2008538181A (ja) * 2005-03-30 2008-10-16 ネオス テクノロジーズ インコーポレイテッド 昆虫細胞系において増殖させたペプチドを生産するための製造方法
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
BRPI0612928A2 (pt) * 2005-05-17 2010-12-07 Amicus Therapeutics Inc Método para aumentar a atividade de uma enzima de (alfa)-glucosidade em uma célula e método para tratar doença de pompe
US20080255026A1 (en) * 2005-05-25 2008-10-16 Glycopegylated Factor 1X Glycopegylated Factor Ix
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090297496A1 (en) * 2005-09-08 2009-12-03 Childrens Hospital Medical Center Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases
JP5583908B2 (ja) * 2005-10-21 2014-09-03 ジェンザイム・コーポレーション 増強されたａｄｃｃ活性を伴う抗体に基づく治療薬
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
PL1986612T3 (pl) 2006-02-07 2013-02-28 Shire Human Genetic Therapies Stabilizowana kompozycja glukocerebrozydazy
US20080248959A1 (en) * 2006-07-21 2008-10-09 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
US20100075375A1 (en) 2006-10-03 2010-03-25 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
US20080207487A1 (en) * 2006-11-02 2008-08-28 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
CA2669347A1 (en) * 2006-11-13 2008-05-29 Zystor Therapeutics, Inc. Methods for treating pompe disease
DK2457920T3 (en) 2007-01-18 2018-01-22 Genzyme Corp Oligosaccharides comprising an amino oxy group and conjugates thereof
KR20090103939A (ko) * 2007-01-29 2009-10-01 유나이티드 세러퓨틱스 코오포레이션 당 면역원
WO2008112525A2 (en) * 2007-03-09 2008-09-18 Link Medicine Corporation Treatment of lysosomal storage diseases
WO2008124406A2 (en) 2007-04-03 2008-10-16 Neose Technologies, Inc. Methods of treatment using glycopegylated g-csf
US20090053167A1 (en) * 2007-05-14 2009-02-26 Neose Technologies, Inc. C-, S- and N-glycosylation of peptides
EP2170919B8 (en) 2007-06-12 2016-01-20 ratiopharm GmbH Improved process for the production of nucleotide sugars
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
US7722865B2 (en) 2008-01-18 2010-05-25 Biomarin Pharmaceutical Inc. Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
CA3112632A1 (en) 2008-01-18 2009-07-23 Biomarin Pharmaceutical Inc. Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
AU2009219232B2 (en) 2008-02-27 2014-02-27 Novo Nordisk A/S Conjugated Factor VIII molecules
EP3778652A1 (en) * 2008-05-07 2021-02-17 BioMarin Pharmaceutical Inc. Lysosomal targeting peptides and uses thereof
SI2889043T1 (sl) 2008-12-16 2019-08-30 Genzyme Corporation Sintetične vmesne spojine za pripravo konjugatov oligosaharid-protein
EP3075386B1 (en) 2009-06-17 2019-10-16 BioMarin Pharmaceutical Inc. Formulations for lysosomal enzymes
CN105126086B (zh) * 2009-07-28 2019-05-14 夏尔人类遗传性治疗公司 用于治疗戈谢病的组合物和方法
WO2011019620A1 (en) 2009-08-10 2011-02-17 Genentech, Inc. Antibodies with enhanced adcc function
KR20200034828A (ko) 2009-08-28 2020-03-31 이칸 스쿨 오브 메디슨 엣 마운트 시나이 산성 스핑고미엘리나제 결핍을 치료하기 위한 투여량 단계적 증가 효소 대체 요법
US8536148B2 (en) 2009-09-04 2013-09-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Disabling autophagy as a treatment for lysosomal storage diseases
US9889182B2 (en) 2009-09-15 2018-02-13 The Regents Of The University Of California Assisted enzyme replacement therapy
ES2950358T3 (es) 2010-04-23 2023-10-09 Alexion Pharma Inc Enzima de la enfermedad de almacenamiento lisosomal
AU2011270667B2 (en) 2010-06-25 2017-01-05 Shire Human Genetic Therapies, Inc. Methods and compositions for CNS delivery of heparan N-sulfatase
JP6063380B2 (ja) 2010-06-25 2017-01-18 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド サンフィリポ症候群ｂ型の処置
EP3875107A1 (en) 2010-06-25 2021-09-08 Shire Human Genetic Therapies, Inc. Pharmaceutical formulation comprising a replacement enzyme for a lysosomal enzyme for use in treating lysosomal storage disease intrathecally
US8545837B2 (en) 2010-06-25 2013-10-01 Shire Human Genetic Therapies, Inc. Methods and compositions for CNS delivery of iduronate-2-sulfatase
DK2585104T3 (da) 2010-06-25 2019-10-14 Shire Human Genetic Therapies Fremgangsmåder og sammensætninger tilcns-levering af arylsulfatase a
SI3626258T1 (sl) 2010-06-25 2021-11-30 Shire Human Genetic Therapies, Inc. Postopki in sestavki za dovajanje idunorat-2-sulfataze v cžs
EP2595651B1 (en) 2010-07-19 2017-03-29 Shire Human Genetic Therapies, Inc. Mannose receptor c type 1 (mrc1) codon optimized cell line and uses thereof
AR082319A1 (es) 2010-07-22 2012-11-28 Biomarin Pharm Inc Produccion de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos
JP5693728B2 (ja) 2010-09-09 2015-04-01 シナジーバ バイオファーマ コープ 患者のリソソーム酸リパーゼ欠乏症を治療するためのリソソーム酸リパーゼの使用
WO2012101671A1 (en) * 2011-01-25 2012-08-02 Jcr Pharmaceuticals Co., Ltd. Method for production of human recombinant iduronate 2-sulfatase
KR20140006037A (ko) 2011-02-15 2014-01-15 시나게바 바이오파르마, 코포레이션 리소좀의 산 리파제 결핍을 치료하는 방법들
US9138465B2 (en) 2011-04-28 2015-09-22 Osaka University Pharmaceutical composition for treating lysosomal storage disease
US9150846B2 (en) 2011-07-05 2015-10-06 Bioasis Technologies, Inc. P97-antibody conjugates and methods of use
ES2791760T3 (es) 2011-09-07 2020-11-05 Sinai School Medicine Ceramidasa y diferenciación celular
WO2013055888A2 (en) * 2011-10-12 2013-04-18 Synageva Biopharma Corp. Recombinant human naglu protein and uses thereof
CA2859988A1 (en) 2011-12-23 2013-06-27 Shire Human Genetic Therapies, Inc. Treatment of cognitive impairment of hunter syndrome by intrathecal delivery of iduronate-2-sulfatase
US20140377244A1 (en) 2011-12-23 2014-12-25 Shire Human Genetic Therapies, Inc. Stable formulations for cns delivery of arylsulfatase a
AU2013225816B2 (en) 2012-03-02 2017-10-26 Takeda Pharmaceutical Company Limited Compositions and methods for treating Type III Gaucher Disease
KR20230066482A (ko) 2012-03-07 2023-05-15 아미쿠스 세라퓨틱스, 인코포레이티드 폼페병의 치료를 위한 고농도 알파-글루코시다제 조성물
EA201491578A1 (ru) 2012-03-30 2015-04-30 Шир Хьюман Дженетик Терапис, Инк. Подкожное введение идуронат-2-сульфатазы
HUE053565T2 (hu) 2012-05-03 2021-07-28 Amicus Therapeutics Inc Adagolási rendek Pompe betegség kezelésére
LT2854910T (lt) 2012-06-01 2020-05-25 Icahn School Of Medicine At Mount Sinai Ceramido lygiai infekcijos gydymo ir prevencijos metu
EP2880156B1 (en) * 2012-07-31 2017-08-23 biOasis Technologies Inc Dephosphorylated lysosomal storage disease proteins and methods of use thereof
AU2013355046A1 (en) 2012-12-07 2015-05-14 Shire Human Genetic Therapies, Inc. Methods and compositions for intrathecally administered treatment of mucupolysaccharidosis Type IIIA
CN105189542A (zh) 2013-02-20 2015-12-23 瓦莱里昂治疗有限责任公司 用于治疗庞贝氏症的方法和组合物
ES2774549T3 (es) 2013-03-13 2020-07-21 Bioasis Technologies Inc Fragmentos de P97 y usos de los mismos
PT2968479T (pt) 2013-03-14 2019-08-07 Icahn School Med Mount Sinai Composições terapêuticas de ceramidase ácida e métodos de fabrico e utilização
US10751283B2 (en) 2014-01-14 2020-08-25 Capability Building, Inc. Liposomal rehydration salt formulation and associated methods of use
AR094658A1 (es) * 2014-01-14 2015-08-19 Fast Rehydration Llc Formulación de sales de rehidratación liposomal
AU2015210612B2 (en) 2014-02-03 2020-04-09 Bioasis Technologies Inc. P97 fusion proteins
WO2015126729A1 (en) 2014-02-19 2015-08-27 Bioasis Technologies, Inc. P97-ids fusion proteins
US10058619B2 (en) 2014-05-01 2018-08-28 Bioasis Technologies, Inc. P97-polynucleotide conjugates
AU2015323966A1 (en) 2014-09-29 2017-03-16 Alexion Pharmaceuticals, Inc. Methods of treating mucopolysaccharidosis IIIB (MPSIIIB)
KR102455814B1 (ko) 2014-09-30 2022-10-18 아미쿠스 세라퓨틱스, 인코포레이티드 개선된 탄수화물을 가지는 고도로 강력한 산성 알파-글루코시다제
WO2017015375A1 (en) 2015-07-20 2017-01-26 Shire Human Genetic Therapies, Inc. Treatment of cognitive impairment of mucopolysaccharidosis type iiia by intrathecal delivery of heparan n-sulfatase
MX2018006613A (es) 2015-12-02 2019-01-30 Stcube & Co Inc Anticuerpos y moleculas que se unen inmunoespecificamente a btn1a1 y los usos terapeuticos de los mismos.
WO2017106313A1 (en) * 2015-12-15 2017-06-22 Genzyme Corporation Adeno-associated viral vectors for treating mucolipidosis type ii
KR102272399B1 (ko) * 2015-12-30 2021-07-05 주식회사 녹십자 헌터증후군을 치료하기 위한 방법 및 조성물
MX2018008185A (es) 2015-12-30 2018-08-28 Amicus Therapeutics Inc Alfa-glucosidasa con mayor cantidad de acido para el tratamiento de la enfermedad de pompe.
MX2018009937A (es) 2016-02-17 2018-11-29 Shire Human Genetic Therapies Metodos y composiciones para administración de arisulfatasa a en el sistema nervioso central (cns).
US11345904B2 (en) 2016-02-24 2022-05-31 Biomarin Pharmaceutical Inc. Targeted therapeutic lysosomal enzyme fusion proteins, associated formulations and uses thereof
WO2017173059A1 (en) 2016-03-30 2017-10-05 Amicus Therapeutics, Inc. Method for selection of high m6p recombinant proteins
AU2017239641A1 (en) 2016-03-30 2018-10-18 Amicus Therapeutics, Inc. Formulations comprising recombinant acid alpha-glucosidase
NL2017294B1 (en) 2016-08-05 2018-02-14 Univ Erasmus Med Ct Rotterdam Natural cryptic exon removal by pairs of antisense oligonucleotides.
US10449230B2 (en) 2016-10-06 2019-10-22 The Regents Of The University Of California Polymyxin derived cell penetrating scaffolds
WO2018071898A1 (en) 2016-10-14 2018-04-19 Children's Medical Center Corporation Compositions and methods for treating diseases and disorders of the central nervous system
JP2020503900A (ja) * 2017-01-10 2020-02-06 アミカス セラピューティックス インコーポレイテッド ファブリー病の処置のための組換えアルファ−ガラクトシダーゼａ
US11548936B2 (en) 2017-01-17 2023-01-10 Children's Medical Center Corporation Compositions and methods for treating lysosomal storage diseases and disorders
EP3357489A1 (en) 2017-02-03 2018-08-08 Rheinische Friedrich-Wilhelms-Universität Bonn Mutated arylsulfatase a
EP3624831B1 (en) 2017-05-15 2023-03-29 Amicus Therapeutics, Inc. Recombinant human acid alpha-glucosidase
US20200131266A1 (en) 2017-05-31 2020-04-30 Stcube & Co., Inc. Methods of treating cancer using antibodies and molecules that immunospecifically bind to btn1a1
CA3065301A1 (en) 2017-05-31 2018-12-06 Stcube & Co., Inc. Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
WO2018226671A1 (en) 2017-06-06 2018-12-13 Stcube & Co., Inc. Methods of treating cancer using antibodies and molecules that bind to btn1a1 or btn1a1-ligands
KR101942093B1 (ko) * 2018-01-05 2019-01-24 인하대학교 산학협력단 만노시다제 억제제를 포함하는 고만노즈 타입 n-당쇄를 갖는 인간 리소좀 효소 생산용 조성물
WO2020046132A1 (en) 2018-08-31 2020-03-05 Leiden University Pharmacological chaperones for enzyme treatment therapy
EP4043562A1 (en) 2021-02-16 2022-08-17 Rheinische Friedrich-Wilhelms-Universität Bonn Mutated arylsulfatase a with increased stability
WO2023196863A1 (en) * 2022-04-05 2023-10-12 Astellas Gene Therapies, Inc. Adeno-associated virus potency assay and uses thereof
TW202400212A (zh) 2022-05-05 2024-01-01 美商阿米庫斯醫療股份有限公司 用於治療龐貝氏病之方法
WO2023220649A2 (en) * 2022-05-10 2023-11-16 Mammoth Biosciences, Inc. Effector protein compositions and methods of use thereof

Family Cites Families (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US583711A (en) * 1897-06-01 Detergent and process of producing same
US4140107A (en) 1972-12-28 1979-02-20 Erasmus University Rotterdam Echoscope for examination of objects
CH585793A5 (es) 1974-02-01 1977-03-15 Nestle Sa
JPS5322158B2 (es) 1974-05-02 1978-07-06
US3957578A (en) 1975-01-03 1976-05-18 Hokkaido Sugar Co., Ltd. Method for manufacture of α-galactosidase by microorganism
US4328215A (en) 1977-05-09 1982-05-04 The Johns Hopkins University Method of reducing or avoiding the mutagenic activity of drugs
NL7706429A (nl) 1977-06-10 1978-12-12 Univ Erasmus Werkwijze voor de bereiding van een geneesmid- del met angst en angstequivalenten opheffende werking en gevormd geneesmiddel met een derge- lijke werking.
US4195126A (en) 1977-10-04 1980-03-25 The Board Of Trustees Of The University Of Alabama Albumin-dye complex for fatty acid determination
USRE35770E (en) 1978-11-06 1998-04-14 Choay, S.A. Oligosaccharides having anti-Xa activity and pharmaceutical compositions containing them
IL61201A (en) 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4332894A (en) 1980-08-15 1982-06-01 Purdue Research Foundation Conversion of guar gum to gel-forming polysaccharides by the action of α-galactosidase
US4496722A (en) 1981-05-01 1985-01-29 The Children's Medical Center Corporation Reporter compounds
US4659817A (en) 1981-05-01 1987-04-21 The Children's Medical Center Corporation Reporter compounds containing boron
DE3122216A1 (de) 1981-06-04 1982-12-23 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung eines mikroorganismus, welcher (alpha)-galactosidase, aber keine invertase bildet, so erhaltener mikroorganismus und seine verwendung
US4433946A (en) 1981-07-21 1984-02-28 Christianson Systems, Inc. Discharge system for grain handling apparatus
IT1140312B (it) 1981-12-03 1986-09-24 Anic Spa Procedimento per la produzione di alfa-galattosidasi e impieghi dell'enzima cosi' ottenuto
NL8105635A (nl) 1981-12-15 1983-07-01 Univ Erasmus Geneesmiddel met transplantaatafstotings- en/of immunologische ontstekingsremmende werking, alsmede werkwijze voor de remming van transplantaatafstoting en/of immunologische ontsteking.
US4987223A (en) 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
US4749570A (en) 1981-12-31 1988-06-07 The Governors Of The University Of Alberta Targeting conjugates of albumin and therapeutic agents
US4492761A (en) 1982-04-05 1985-01-08 Duke University Complement assay method
NL189547C (nl) 1983-04-12 1993-05-17 Univ Erasmus Stelsel voor het bepalen van de stroomsterkte van het hart van een patient.
SE440973B (sv) 1984-02-02 1985-09-02 Trelleborg Ab Anleggning for fiskodling i oppen sjo med flytkroppar ledbart forbundna med varandra och stabiliserade med en tyngdbelastad kjol anleggning for fiskodling i oppen sjo med flytkroppar ledbart forbundna med varandra och stabiliserade med en tyngdbelastad kjol
JPS60241884A (ja) 1984-05-15 1985-11-30 Tokyo Daigaku 自動サイクリング反応装置およびこれを用いる自動分析装置
US5001072A (en) 1984-05-23 1991-03-19 Icn Biomedicals Inc. Compositions and methods for multiple simultaneous immunoradiometric assay (IRMA) of analytes using radioisotope chelate labels
US5691181A (en) 1984-08-21 1997-11-25 Celltech Limited DNA encoding lipase from human gastric mucosal tissue
US4986274A (en) 1984-10-19 1991-01-22 Stephens John D Fetal anatomic sex assignment by ultrasonography during early pregnancy
US4639420A (en) 1984-11-21 1987-01-27 Schaffner Carl P Method for the immunoanalysis of cholesterol epoxides
US4615884A (en) 1985-04-09 1986-10-07 Vanderbilt University Method and vaccine for treatment of demyelinating diseases
JPH0669953B2 (ja) 1985-08-16 1994-09-07 日産化学工業株式会社 脳脊髄系神経栄養剤
CA1339101C (en) 1986-06-03 1997-07-29 Nicolaas Overbeeke Production of guar alpha-galactosidase and immunologically related alpha-galactosidases by host organisms transformed with recombinant dna methods
US5217865A (en) 1986-07-25 1993-06-08 The United States Of America As Represented By The Department Of Health And Human Services Screening for Tay-Sachs disease with cloned DNA for beta-hexosaminidase
FR2603804B1 (fr) 1986-09-17 1989-10-27 Jouveinal Sa Lipases et extraits lipasiques, leur procede de preparation et leur application en therapeutique
GB8630721D0 (en) 1986-12-23 1987-02-04 Unilever Plc Cosmetic compositions
EP0279582A3 (en) 1987-02-17 1989-10-18 Pharming B.V. Dna sequences to target proteins to the mammary gland for efficient secretion
US5055401A (en) 1987-04-10 1991-10-08 Alko Ltd. Construction of new α-galactosidase producing yeast strains and the industrial application of these strains
US5166320A (en) 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
US5750172A (en) 1987-06-23 1998-05-12 Pharming B.V. Transgenic non human mammal milk
JPS6460379A (en) 1987-08-28 1989-03-07 Toyo Jozo Kk Novel ganglioside ceramidase and production thereof
US5143841A (en) 1987-08-28 1992-09-01 Toyo Jozo Company, Ltd. Ganglioside ceramidase and process for producing same
DE3732871A1 (de) 1987-09-30 1989-04-20 Behringwerke Ag Chromogene substrate
US4866042A (en) 1987-11-18 1989-09-12 Neuwelt Edward A Method for the delivery of genetic material across the blood brain barrier
US4868042A (en) 1987-12-09 1989-09-19 Pall Corporation Antiwicking compositions and fabrics treated therewith
US5639939A (en) 1987-12-23 1997-06-17 The Board Of Trustees For The Leland Stanford Junior University Chimeric immunocompromised mammal comprosing vascularized fetal organ tissue
US5126247A (en) 1988-02-26 1992-06-30 Enzymatics, Inc. Method, system and devices for the assay and detection of biochemical molecules
GB8806892D0 (en) 1988-03-23 1988-04-27 Unilever Plc Lactams their synthesis & use in cosmetic compositions
US5310646A (en) 1988-05-13 1994-05-10 Regents Of The University Of Minnesota Method for the detection of mucopolysaccharide storage diseases
US5202253A (en) 1988-12-30 1993-04-13 Oklahoma Medical Research Foundation Monoclonal antibody specific for protein C and antibody purification method
US5583160A (en) 1989-02-03 1996-12-10 The Biomembrane Institute Methylsphingosine used to treat apoptosis
US5929036A (en) 1989-03-08 1999-07-27 The Board Of Regents Of The University Of Oklahoma Ligand or GMP-140 selectin and methods of use thereof
US5693622A (en) 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
US5179023A (en) 1989-03-24 1993-01-12 Research Corporation Technologies, Inc. Recombinant α-galactosidase a therapy for Fabry disease
DE3916729A1 (de) 1989-05-23 1990-12-06 Behringwerke Ag Fluorogene verbindungen und ihre verwendung
US5281394A (en) 1989-07-21 1994-01-25 Icn Biomedicals, Inc. Data collection and sample handling apparatus
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US5060428A (en) 1990-02-09 1991-10-29 Resco Products, Inc. Prefabricated walls
US5089392A (en) 1990-03-30 1992-02-18 The United States Of America As Represented By Of The Department Of Health And Human Services Fluorogenic substrates for measurement of lysosomal enzyme activities within intact cells
US5061025A (en) 1990-04-13 1991-10-29 Eastman Kodak Company Hologon scanner with beam shaping stationary diffraction grating
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5316908A (en) 1990-07-13 1994-05-31 Life Technologies, Inc. Size markers for electrophoretic analysis of DNA
US5612205A (en) 1990-08-29 1997-03-18 Genpharm International, Incorporated Homologous recombination in mammalian cells
US5401650A (en) 1990-10-24 1995-03-28 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-galactosidase A
US5356804A (en) 1990-10-24 1994-10-18 Mount Sinai School Of Medicine Of The City Of New York Cloning and expression of biologically active human α-galactosidase A
US5382524A (en) 1990-10-24 1995-01-17 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-n-acetylgalactosaminidase
US5208148A (en) 1990-12-07 1993-05-04 Molecular Probes, Inc. Lipophilic fluorescent glycosidase substrates
US5260447A (en) 1991-02-15 1993-11-09 Sankyo Company, Limited Polyhydroxycyclopentane derivatives, their preparation and their therapeutic use
US5773278A (en) 1991-05-03 1998-06-30 Mount Sinai Medical Center Acid sphingomyelinase gene
US5205917A (en) 1991-05-07 1993-04-27 Glyko, Inc. Fluorophore assisted carbohydrate electrophoresis diagnosis
JPH06509711A (ja) 1991-08-07 1994-11-02 マウント　シナイ　スクール　オブ　メディスン　オブ　ザ　シティー　ユニバーシティー　オブ　ニューヨーク 鉛中毒に対する感受性を測定する方法
US5242805A (en) 1991-08-23 1993-09-07 Molecular Probes, Inc. Long wavelength lipophilic fluorogenic glycosidase substrates
US5316906A (en) 1991-08-23 1994-05-31 Molecular Probes, Inc. Enzymatic analysis using substrates that yield fluorescent precipitates
DE69229174T2 (de) 1991-08-23 1999-09-16 Molecular Probes Inc Verwendung von haloalkylderivaten von reportermolekülen zur analyse der metabolischen aktivität in zellen
US5576424A (en) 1991-08-23 1996-11-19 Molecular Probes, Inc. Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
NL9101680A (nl) 1991-10-04 1993-05-03 Tno Werkwijze voor het genetisch modificeren van beenmergcellen van primaten, alsmede daarbij bruikbare cellen die recombinante retrovirale vectoren produceren.
US5433946A (en) 1991-10-11 1995-07-18 Health Research Inc. Synthesis and utilization of therapeutic agents for the treatment of lysosomal storage diseases
US5968502A (en) 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
EP0613478A1 (en) 1991-11-06 1994-09-07 Toronto Research Chemicals Inc. Immunostimulating swainsonine analogs
US5932211A (en) 1991-11-12 1999-08-03 Women's And Children's Hospital Glycosylation variants of iduronate 2-sulfatase
DE69312142T2 (de) 1992-04-02 1998-02-05 Philips Electronics Nv Verfahren zum Herstellen einer zugespitzten Elektrode
GB9207288D0 (en) 1992-04-02 1992-05-13 Unilever Plc Cosmetic composition
GB9207280D0 (en) 1992-04-02 1992-05-13 Unilever Plc Skin care method and composition
US5366883A (en) 1992-06-09 1994-11-22 Takara Shuzo Co., Ltd. α-amylase gene
US5578479A (en) 1992-06-09 1996-11-26 The Johns Hopkins University Alpha-amylase from hyperthermophilic archaebacterium
US5420112A (en) 1992-06-12 1995-05-30 Lewis; Michael E. Prevention and treatment of peripheral neuropathy
PT659083E (pt) 1992-06-12 2000-05-31 Cephalon Inc Prevencao e tratamento de neuropatia periferica
EP0665883A1 (en) 1992-08-26 1995-08-09 Dnx Corporation Tetracycline repressor-mediated binary regulation system for control of gene expression in transgenic animals
US5449604A (en) 1992-10-21 1995-09-12 University Of Washington Chromosome 14 and familial Alzheimers disease genetic markers and assays
WO1994010340A1 (en) 1992-10-30 1994-05-11 Mt. Sinai Hospital Corporation Method for measuring glycosyltransferase activity
US5512471A (en) 1992-12-23 1996-04-30 The Curators Of The University Of Missouri Process for purifying an α-D-galactosidase isozyme from Coffea beans
US5667839A (en) 1993-01-28 1997-09-16 Collagen Corporation Human recombinant collagen in the milk of transgenic animals
DK38893D0 (da) 1993-03-31 1993-03-31 Novo Nordisk As Dna
DE69431295T2 (de) 1993-04-21 2003-05-15 Pasteur Institut Biokompatibles implantat zur in vivo expression und sekretion von therapeutischer verbindung
US5798366A (en) 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
US5736360A (en) 1993-09-10 1998-04-07 The Trustees Of The University Of Pennsylvania Endothelial cell tropic compositions and methods of making and using the same
NZ273329A (en) 1993-09-15 1996-09-25 Unilever Plc Skin care preparation containing stratum corneum trypsin-like enzymes
GB9319104D0 (en) 1993-09-15 1993-11-03 Unilever Plc Skin care method & composition
US5491076A (en) 1993-11-01 1996-02-13 The Texas A&M University System Expression of foreign genes using a replicating polyprotein producing virus vector
US5405751A (en) 1994-01-12 1995-04-11 Schering Corporation Prenatal diagnosis by cytokine-induced proliferation of fetal T-cells
CA2183459A1 (en) 1994-02-16 1995-08-24 Jan H. Nuijens Isolation of lactoferrin from milk
US5627171A (en) 1994-04-11 1997-05-06 Oncomembrane, Inc. Sphingosine-1-phosphate/trimethylsphingosine composition
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
JP3906314B2 (ja) 1994-04-25 2007-04-18 ジェネンテク・インコーポレイテッド カルジオトロフィンおよびその使用
US5716614A (en) 1994-08-05 1998-02-10 Molecular/Structural Biotechnologies, Inc. Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier
PT781343E (pt) 1994-09-08 2003-11-28 Vision 7 Gmbh Hibridos de vectores retrovirais e sua utilizacao para transferencia genetica
US5759775A (en) 1994-10-27 1998-06-02 Genetech, Inc. Methods for detecting nucleic acids encoding AL--1 neurotrophic factor
US5707865A (en) 1994-12-21 1998-01-13 Kohn; Donald B. Retroviral vectors for expression in embryonic cells
US5792647A (en) 1995-02-13 1998-08-11 The Johns Hopkins University Bacterial catabolism of chitin
JPH08271784A (ja) 1995-03-30 1996-10-18 Canon Inc 視線検出機能付き光学機器
US5871946A (en) 1995-05-18 1999-02-16 Coulter Corporation Method for determining activity of enzymes in metabolically active whole cells
US5663254A (en) 1995-05-22 1997-09-02 The Johns Hopkins University Synthesis of high mannose glycopolymers
US5704910A (en) 1995-06-05 1998-01-06 Nephros Therapeutics, Inc. Implantable device and use therefor
US5928928A (en) 1995-06-07 1999-07-27 Universiteit Van Amsterdam Human chitinase, its recombinant production, its use for decomposing chitin, its use in therapy or prophylaxis against infection diseases
US6118045A (en) 1995-08-02 2000-09-12 Pharming B.V. Lysosomal proteins produced in the milk of transgenic animals
US5663076A (en) 1995-08-08 1997-09-02 Lsi Logic Corporation Automating photolithography in the fabrication of integrated circuits
AU6671496A (en) 1995-08-17 1997-03-12 Introgene B.V. Poly(organo)phosphazenes for use in synthetic transfection systems
EP0865499B1 (en) 1995-09-14 2009-03-18 Virginia Tech Intellectual Properties, Inc. Production of lysosomal enzymes in plant-based expression systems
WO1997010817A1 (en) 1995-09-20 1997-03-27 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
US6048964A (en) 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US5858351A (en) 1996-01-18 1999-01-12 Avigen, Inc. Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors
US5830916A (en) 1996-05-23 1998-11-03 Duke University Inhibitor of ceramidase
US5719031A (en) 1996-08-14 1998-02-17 Molecular Probes, Inc. Dye labeled polymers as reagents for measuring polymer degradation
US5830850A (en) 1996-08-28 1998-11-03 Mount Sinai School Of Medicine Of The City Of New York Methods for the treatment of bone resorption disorders, including osteoporosis
JPH1080280A (ja) 1996-09-09 1998-03-31 Shimadzu Corp 核酸合成法
WO1999031117A1 (en) * 1997-12-18 1999-06-24 Human Genome Sciences, Inc. 110 human secreted proteins
US5773236A (en) 1997-04-25 1998-06-30 Molecule Probes, Inc. Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules
US5939279A (en) 1997-09-18 1999-08-17 The Board Of Trustees Of The University Of Arkansas Inhibition of bacterial binding by high-mannose oligosaccharides
US6537785B1 (en) * 1999-09-14 2003-03-25 Genzyme Glycobiology Research Institute, Inc. Methods of treating lysosomal storage diseases
US6800472B2 (en) * 2001-12-21 2004-10-05 Genzyme Glycobiology Research Institute, Inc. Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase

Also Published As

Publication number Publication date
CA2383217A1 (en) 2001-03-22
US6534300B1 (en) 2003-03-18
JP2003509043A (ja) 2003-03-11
US20050089869A1 (en) 2005-04-28
EP1224266B1 (en) 2007-09-12
AU7330300A (en) 2001-04-17
DE60036395D1 (de) 2007-10-25
US20020150981A1 (en) 2002-10-17
US6861242B2 (en) 2005-03-01
US6537785B1 (en) 2003-03-25
US20080176285A1 (en) 2008-07-24
US20020025550A1 (en) 2002-02-28
US7371366B2 (en) 2008-05-13
BR0014514A (pt) 2002-07-23
CA2383217C (en) 2013-11-19
US6642038B1 (en) 2003-11-04
WO2001019955A2 (en) 2001-03-22
WO2001019955A3 (en) 2001-10-04
US20060073498A1 (en) 2006-04-06
EP1224266A2 (en) 2002-07-24
EP1224266A4 (en) 2003-05-28
US7067127B2 (en) 2006-06-27
AU783224B2 (en) 2005-10-06
ATE373086T1 (de) 2007-09-15
US6670165B2 (en) 2003-12-30
DE60036395T2 (de) 2008-06-12

Similar Documents

Publication Publication Date Title
EP1224266A4 (en) ENZYMES WITH LYSOSOMIAL TARGETING
WO1999057325A3 (en) Enzymes mixture
WO2001097829A3 (en) Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
EP1463512A4 (en) USE OF P97 AS AN ENZYME DELIVERY SYSTEM FOR THE DELIVERY OF THERAPEUTIC LYSOSOMAL ENZYMES
DE60021160D1 (de) Protein-deamiderendes Enzym, dafür kodierendes Gen, enzym-produzierendes Mikroorganismus, Verfahren zur Herstellung und Verwendung davon
EP2333097A3 (en) Enzymes having alpha amylase activity and methods of use thereof
WO1997026270A3 (en) Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
AU2002366285A8 (en) Ides, an igg-degrading enzyme of streptococcus pyogenes
MXPA03005960A (es) Nuevas mezclas de enzimas microbianas.
AU5630999A (en) Endofucanases and method using same for preparing fuco-oligosaccharides from fucanes, bacterium producing endofucanases and uses of fuco-oligosaccharides for plant protection
DK0976829T3 (da) Protein-deamiderende enzym, gen kodende for dette, fremgangsmåde til fremstilling heraf same anvendelse heraf
WO2001047944A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
HK1154623A1 (en) Isolated luciferases and the use thereof
WO2006063055A3 (en) Enzyme conjugates for use as detoxifying agents
WO2000029623A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
GB0020331D0 (en) Enzyme
AU2003235506A8 (en) Targeted enzymes and methods of making and using targeted enzymes.
ES2171136A1 (es) Enzima con actividad proteolitica construccion de adn que comprende una secuencia de adn que codifica dicha enzima y sus aplicaciones.
WO2001048245A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2001040521A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
ATE356212T1 (de) O-fukosyltransferase
WO2001060986A3 (en) Esterase enzymes having selective activity
WO2002103032A3 (en) Catalases, nucleic acids encoding them and methods for making and using them
WO2000029622A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
ES2164545A1 (es) Enzimas con actividad beta-(1,6)-endoglucanasa.