MX9800411A - Compuestos quimicos. - Google Patents

Compuestos quimicos.

Info

Publication number
MX9800411A
MX9800411A MX9800411A MX9800411A MX9800411A MX 9800411 A MX9800411 A MX 9800411A MX 9800411 A MX9800411 A MX 9800411A MX 9800411 A MX9800411 A MX 9800411A MX 9800411 A MX9800411 A MX 9800411A
Authority
MX
Mexico
Prior art keywords
phosphodiesterase inhibitors
cyclic gmp
specific phosphodiesterase
represents hydrogen
3alkyl
Prior art date
Application number
MX9800411A
Other languages
English (en)
Other versions
MXPA98000411A (es
Inventor
Alain Claude-Marie Daugan
Francoise Gellibert
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of MXPA98000411A publication Critical patent/MXPA98000411A/es
Publication of MX9800411A publication Critical patent/MX9800411A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invencion se refiere a un compuesto de la formula (I), y los solvatos (por ej., hidratos) de éstos, en los cuales: R0 representa hidrogeno, halogeno o alquilo de C1-C6; R1 representa hidrogeno o alquilo de C1-C6; R2 representa el anillo bicíclico, que puede ser opcionalmente sustituido por uno o más grupos que se seleccionan de halogeno y alquilo de C1-C3; y R3 representa hidrogeno o alquilo de C1-C3. Un compuesto de la presente invencion es un inhibidor potente y selectivo de la PDE específica de GMPc que tiene utilidad en una variedad de áreas terapéuticas en donde dicha inhibicion es benéfica.
MX9800411A 1995-07-14 1996-07-11 Compuestos quimicos. MX9800411A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9514465.5A GB9514465D0 (en) 1995-07-14 1995-07-14 Chemical compounds
GB9514465.5 1995-07-14
PCT/EP1996/003025 WO1997003985A1 (en) 1995-07-14 1996-07-11 Cyclic gmp-specific phosphodiesterase inhibitors

Publications (2)

Publication Number Publication Date
MXPA98000411A MXPA98000411A (es) 1998-04-01
MX9800411A true MX9800411A (es) 1998-04-30

Family

ID=10777696

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9800411A MX9800411A (es) 1995-07-14 1996-07-11 Compuestos quimicos.

Country Status (24)

Country Link
US (1) US5981527A (es)
EP (1) EP0846118B1 (es)
JP (1) JP4150818B2 (es)
CN (1) CN1069318C (es)
AR (1) AR003455A1 (es)
AT (1) ATE216997T1 (es)
AU (1) AU702324B2 (es)
BR (1) BR9609780A (es)
CA (1) CA2226761A1 (es)
CO (1) CO4700455A1 (es)
CZ (1) CZ3298A3 (es)
DE (1) DE69621026T2 (es)
ES (1) ES2176471T3 (es)
GB (1) GB9514465D0 (es)
HR (1) HRP960321B1 (es)
HU (1) HUP9900006A3 (es)
IL (1) IL122923A0 (es)
MX (1) MX9800411A (es)
NO (1) NO980154L (es)
PL (1) PL324527A1 (es)
SK (1) SK3898A3 (es)
WO (1) WO1997003985A1 (es)
YU (1) YU42296A (es)
ZA (1) ZA965934B (es)

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Also Published As

Publication number Publication date
EP0846118A1 (en) 1998-06-10
HUP9900006A2 (hu) 1999-04-28
ES2176471T3 (es) 2002-12-01
IL122923A0 (en) 1998-08-16
PL324527A1 (en) 1998-06-08
CN1195349A (zh) 1998-10-07
AU702324B2 (en) 1999-02-18
WO1997003985A1 (en) 1997-02-06
ATE216997T1 (de) 2002-05-15
ZA965934B (en) 1997-02-03
HRP960321B1 (en) 2003-06-30
GB9514465D0 (en) 1995-09-13
AU6419296A (en) 1997-02-18
HUP9900006A3 (en) 1999-11-29
JP4150818B2 (ja) 2008-09-17
DE69621026D1 (de) 2002-06-06
JPH11509535A (ja) 1999-08-24
YU42296A (sh) 1998-12-23
NO980154L (no) 1998-03-10
CO4700455A1 (es) 1998-12-29
AR003455A1 (es) 1998-08-05
US5981527A (en) 1999-11-09
BR9609780A (pt) 1999-03-09
HRP960321A2 (en) 1998-08-31
CZ3298A3 (cs) 1998-06-17
CN1069318C (zh) 2001-08-08
SK3898A3 (en) 1998-11-04
CA2226761A1 (en) 1997-02-06
NO980154D0 (no) 1998-01-13
DE69621026T2 (de) 2002-08-22
EP0846118B1 (en) 2002-05-02

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