MX9709647A - Derivados de estirilbencimidazol como inhibidores de proliferacion de celulas de musculo liso. - Google Patents
Derivados de estirilbencimidazol como inhibidores de proliferacion de celulas de musculo liso.Info
- Publication number
- MX9709647A MX9709647A MX9709647A MX9709647A MX9709647A MX 9709647 A MX9709647 A MX 9709647A MX 9709647 A MX9709647 A MX 9709647A MX 9709647 A MX9709647 A MX 9709647A MX 9709647 A MX9709647 A MX 9709647A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- cell proliferation
- smooth muscle
- muscle cell
- benzimidazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describe en la presente compuestos de formula (I) o (II), en los que R es fenilo o fenilo sustituido; o R es furilo, piridilo o quinolinilo; R y R son hidrogeno, halogeno, alquilo, alcoxi, nitro, carboxilo, alcoxiarbonilo o ariloxicarbonilo; R es hidrogeno, alquilo; o una sal farmacéuticamente aceptable de los mismos, los cuales son utiles como inhidibores de proliferacion de células de musculo liso.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US468271 | 1995-06-06 | ||
| US08/468,271 US6444694B1 (en) | 1995-06-06 | 1995-06-06 | Styryl benzimidazole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9709647A true MX9709647A (es) | 1998-07-31 |
| MXPA97009647A MXPA97009647A (es) | 1998-11-09 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9900914A2 (hu) | 1999-07-28 |
| BR9609153A (pt) | 1999-05-04 |
| DE69615023T2 (de) | 2002-06-06 |
| PT830345E (pt) | 2002-01-30 |
| AU5968496A (en) | 1996-12-24 |
| CA2223585A1 (en) | 1996-12-12 |
| DK0830345T3 (da) | 2001-11-19 |
| AR002749A1 (es) | 1998-04-29 |
| EP0830345A1 (en) | 1998-03-25 |
| DE69615023D1 (de) | 2001-10-11 |
| HUP9900679A3 (en) | 2001-07-30 |
| HUP9900679A2 (hu) | 1999-09-28 |
| EP0830345B1 (en) | 2001-09-05 |
| ZA964693B (en) | 1997-12-05 |
| WO1996039391A1 (en) | 1996-12-12 |
| KR19990022266A (ko) | 1999-03-25 |
| ES2162063T3 (es) | 2001-12-16 |
| AU711965B2 (en) | 1999-10-28 |
| IL118385A0 (en) | 1996-09-12 |
| CN1192206A (zh) | 1998-09-02 |
| ATE205196T1 (de) | 2001-09-15 |
| JPH11506753A (ja) | 1999-06-15 |
| NZ309499A (en) | 2000-08-25 |
| US6444694B1 (en) | 2002-09-03 |
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