ATE205196T1 - Styrylbenzimidazolderivate als inhibitoren der glatten muskelzellenproliferation - Google Patents

Styrylbenzimidazolderivate als inhibitoren der glatten muskelzellenproliferation

Info

Publication number
ATE205196T1
ATE205196T1 AT96916978T AT96916978T ATE205196T1 AT E205196 T1 ATE205196 T1 AT E205196T1 AT 96916978 T AT96916978 T AT 96916978T AT 96916978 T AT96916978 T AT 96916978T AT E205196 T1 ATE205196 T1 AT E205196T1
Authority
AT
Austria
Prior art keywords
styrylbenzimidazole
inhibitors
derivatives
cell proliferation
smooth muscle
Prior art date
Application number
AT96916978T
Other languages
English (en)
Inventor
Sie-Yearl Chai
Hassan Mahmoud Elokdah
Theodore Sylvester Sulkowski
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of ATE205196T1 publication Critical patent/ATE205196T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT96916978T 1995-06-06 1996-06-03 Styrylbenzimidazolderivate als inhibitoren der glatten muskelzellenproliferation ATE205196T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/468,271 US6444694B1 (en) 1995-06-06 1995-06-06 Styryl benzimidazole derivatives
PCT/US1996/008375 WO1996039391A1 (en) 1995-06-06 1996-06-03 Styryl benzimidazole derivatives as inhibitors of smooth muscle cell proliferation

Publications (1)

Publication Number Publication Date
ATE205196T1 true ATE205196T1 (de) 2001-09-15

Family

ID=23859136

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96916978T ATE205196T1 (de) 1995-06-06 1996-06-03 Styrylbenzimidazolderivate als inhibitoren der glatten muskelzellenproliferation

Country Status (19)

Country Link
US (1) US6444694B1 (de)
EP (1) EP0830345B1 (de)
JP (1) JPH11506753A (de)
KR (1) KR19990022266A (de)
CN (1) CN1192206A (de)
AR (1) AR002749A1 (de)
AT (1) ATE205196T1 (de)
AU (1) AU711965B2 (de)
BR (1) BR9609153A (de)
CA (1) CA2223585A1 (de)
DE (1) DE69615023T2 (de)
DK (1) DK0830345T3 (de)
ES (1) ES2162063T3 (de)
HU (2) HUP9900914A2 (de)
IL (1) IL118385A0 (de)
NZ (1) NZ309499A (de)
PT (1) PT830345E (de)
WO (1) WO1996039391A1 (de)
ZA (1) ZA964693B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
EP2335700A1 (de) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
DK1718608T3 (da) 2004-02-20 2013-10-14 Boehringer Ingelheim Int Virale polymeraseinhibitorer
CA2618682C (en) 2005-08-12 2011-06-21 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
EP2035369B1 (de) 2006-07-05 2014-06-25 Fibrotech Therapeutics PTY LTD Therapeutische verbindungen
WO2011047432A1 (en) * 2009-10-22 2011-04-28 Fibrotech Therapeutics Pty Ltd Fused ring analogues of anti-fibrotic agents
WO2018144620A1 (en) 2017-02-03 2018-08-09 Shire Human Genetic Therapies, Inc. Anti-fibrotic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3575956A (en) * 1967-07-24 1971-04-20 Sterling Drug Inc 2-substituted-benz-x-azol-6-ylazo-aminonaphthalene compounds
DE1670908A1 (de) * 1967-08-16 1971-04-29 Hoechst Ag Neue Benzimidazolverbindungen,Verfahren zu ihrer Herstellung und ihre Verwendung als optische Aufhellungsmittel
FR2104717A1 (en) * 1970-09-28 1972-04-21 Dynachim Sarl Organophosphorus pesticides stabilised with benzimidazole derivs - - for controlling insects and internal parasites of animals
DE3505609A1 (de) 1985-02-19 1986-08-21 Merck Patent Gmbh, 6100 Darmstadt Benzimidazolyl-pyridazinone
JPH05507072A (ja) 1990-04-16 1993-10-14 イッスム　リサーチ　ディヴェロプメント　カンパニー　オブ　ザ　ヒーブルー　ユニヴァーシティ　オブ　エルサレム Ｅｇｆレセプタチロシンキナーゼを阻害する複素環式エテンジイル化合物
US5196446A (en) 1990-04-16 1993-03-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Certain indole compounds which inhibit EGF receptor tyrosine kinase
DE4212748A1 (de) 1992-04-16 1993-10-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5387600A (en) 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions

Also Published As

Publication number Publication date
MX9709647A (es) 1998-07-31
HUP9900914A2 (hu) 1999-07-28
BR9609153A (pt) 1999-05-04
DE69615023T2 (de) 2002-06-06
PT830345E (pt) 2002-01-30
AU5968496A (en) 1996-12-24
CA2223585A1 (en) 1996-12-12
DK0830345T3 (da) 2001-11-19
AR002749A1 (es) 1998-04-29
EP0830345A1 (de) 1998-03-25
DE69615023D1 (de) 2001-10-11
HUP9900679A3 (en) 2001-07-30
HUP9900679A2 (hu) 1999-09-28
EP0830345B1 (de) 2001-09-05
ZA964693B (en) 1997-12-05
WO1996039391A1 (en) 1996-12-12
KR19990022266A (ko) 1999-03-25
ES2162063T3 (es) 2001-12-16
AU711965B2 (en) 1999-10-28
IL118385A0 (en) 1996-09-12
CN1192206A (zh) 1998-09-02
JPH11506753A (ja) 1999-06-15
NZ309499A (en) 2000-08-25
US6444694B1 (en) 2002-09-03

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee