MX9709646A - Derivados de bencimidazol como inhibidores de proliferacion de celulas de musculo liso. - Google Patents

Derivados de bencimidazol como inhibidores de proliferacion de celulas de musculo liso.

Info

Publication number
MX9709646A
MX9709646A MX9709646A MX9709646A MX9709646A MX 9709646 A MX9709646 A MX 9709646A MX 9709646 A MX9709646 A MX 9709646A MX 9709646 A MX9709646 A MX 9709646A MX 9709646 A MX9709646 A MX 9709646A
Authority
MX
Mexico
Prior art keywords
inhibitors
cell proliferation
smooth muscle
muscle cell
benzimidazole derivatives
Prior art date
Application number
MX9709646A
Other languages
English (en)
Other versions
MXPA97009646A (es
Inventor
Hassan Mahmoud Elokdah
Chai Sie-Yearl
Theodore Sylvester Sulkowski
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of MX9709646A publication Critical patent/MX9709646A/es
Publication of MXPA97009646A publication Critical patent/MXPA97009646A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En la presente se describen compuestos y sales farmacéuticamente aceptables de compuestos de formula (I) o (II), en las qur R es alquilo, fenilo o fenilo sustituido; R2 es hidrogeno, hologeno, alcoxi o alquilo; R1 es hidrogeno, alquilo, arilo, arilalquilo o bencilo sustituido; los cuales son utiles como inhibidores de proliferacion de células de musculo liso.
MXPA/A/1997/009646A 1995-06-06 1997-12-05 Derivados de bencimidazol como inhibidores de proliferacion de celulas de musculo liso MXPA97009646A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/468,482 US6288100B1 (en) 1995-06-06 1995-06-06 Benzimidazole derivatives
US08468482 1995-06-06

Publications (2)

Publication Number Publication Date
MX9709646A true MX9709646A (es) 1998-07-31
MXPA97009646A MXPA97009646A (es) 1998-11-09

Family

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Also Published As

Publication number Publication date
IL118384A0 (en) 1996-09-12
AR002748A1 (es) 1998-04-29
US6288100B1 (en) 2001-09-11
AU5967396A (en) 1996-12-24
JPH11506749A (ja) 1999-06-15
ZA964692B (en) 1997-12-05
BR9609365A (pt) 1999-05-18
NZ309490A (en) 1999-09-29
AU713043B2 (en) 1999-11-25
WO1996039390A1 (en) 1996-12-12
KR19990022372A (ko) 1999-03-25
CA2223393A1 (en) 1996-12-12
EP0830343A1 (en) 1998-03-25
CN1192205A (zh) 1998-09-02

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