MX9703622A - Una nueva forma solida fisicamente estable en una fluoroquinolona. - Google Patents

Una nueva forma solida fisicamente estable en una fluoroquinolona.

Info

Publication number
MX9703622A
MX9703622A MX9703622A MX9703622A MX9703622A MX 9703622 A MX9703622 A MX 9703622A MX 9703622 A MX9703622 A MX 9703622A MX 9703622 A MX9703622 A MX 9703622A MX 9703622 A MX9703622 A MX 9703622A
Authority
MX
Mexico
Prior art keywords
fluoroquinolone
solid form
physically stable
stable solid
forms
Prior art date
Application number
MX9703622A
Other languages
English (en)
Other versions
MXPA97003622A (es
Inventor
William C Schinzer
Michael J Dunn
Roberth Shih-Liang Chao
Dale S Aldrich
Azhwarsamy Jeganathan
Xuanoiang Yu
Michael S Bergren
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MXPA97003622A publication Critical patent/MXPA97003622A/es
Publication of MX9703622A publication Critical patent/MX9703622A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen las nuevas formas de cristal de la fluoroquinolona, del ácido [S-(R*, S*)]-1-ciclopropil-6-fluoro-1,4-dihidro-8-metoxi-7 -[3-[1-(metilamino)etil]-1-pirrolidinil]1-4-oxo-3- quinolonacarboxilica. Las formas son caracterizadas por medio de una forma de solvato de metanol, y tres formas de anhídridos polimorfos, de las cuales, la Forma III exhibe la más importante estabilidad y disminucion de la higroscopicidad.
MX9703622A 1994-11-18 1995-11-08 Una nueva forma solida fisicamente estable en una fluoroquinolona. MX9703622A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US342,202 1989-04-21
US34220294A 1994-11-18 1994-11-18
US342202 1994-11-18
PCT/US1995/013481 WO1996016055A1 (en) 1994-11-18 1995-11-08 A new physically stable solid form of a fluoroquinolone

Publications (2)

Publication Number Publication Date
MXPA97003622A MXPA97003622A (es) 1997-08-01
MX9703622A true MX9703622A (es) 1997-08-30

Family

ID=23340805

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9703622A MX9703622A (es) 1994-11-18 1995-11-08 Una nueva forma solida fisicamente estable en una fluoroquinolona.

Country Status (15)

Country Link
US (1) US5985893A (es)
EP (1) EP0790992A1 (es)
JP (1) JPH10509169A (es)
KR (1) KR970707115A (es)
AU (1) AU709057B2 (es)
BR (1) BR9509688A (es)
CA (1) CA2201735A1 (es)
CZ (1) CZ138297A3 (es)
FI (1) FI972103A0 (es)
HU (1) HUT77946A (es)
MX (1) MX9703622A (es)
NO (1) NO972273L (es)
NZ (1) NZ297590A (es)
PL (1) PL320190A1 (es)
WO (1) WO1996016055A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43932E1 (en) 1997-07-18 2013-01-15 Novartis Ag Crystal modification of a N-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
DE19854355A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854356A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908448A1 (de) * 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure
DE19908449A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US8084445B2 (en) 2004-08-13 2011-12-27 Schering-Plough Animal Health Corporation Pharmaceutical formulation
US9481777B2 (en) 2012-03-30 2016-11-01 The Procter & Gamble Company Method of dewatering in a continuous high internal phase emulsion foam forming process

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
JP2676521B2 (ja) * 1988-03-22 1997-11-17 北陸製薬株式会社 キノロンカルボン酸化合物ｉ型結晶の製造法
US5258528A (en) * 1990-11-30 1993-11-02 Warner-Lambert Company Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group
WO1992009596A1 (en) * 1990-11-30 1992-06-11 Warner-Lambert Company Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents
EP0629621B1 (en) * 1992-01-31 2001-10-24 Chugai Seiyaku Kabushiki Kaisha Crystal of quinolonecarboxylic acid derivative hydrate

Also Published As

Publication number Publication date
JPH10509169A (ja) 1998-09-08
AU709057B2 (en) 1999-08-19
FI972103A (fi) 1997-05-16
HUT77946A (hu) 1998-12-28
NO972273D0 (no) 1997-05-16
NZ297590A (en) 1999-06-29
BR9509688A (pt) 1997-09-30
WO1996016055A1 (en) 1996-05-30
CA2201735A1 (en) 1996-05-30
PL320190A1 (en) 1997-09-15
CZ138297A3 (en) 1997-10-15
NO972273L (no) 1997-05-16
US5985893A (en) 1999-11-16
FI972103A0 (fi) 1997-05-16
AU4278096A (en) 1996-06-17
KR970707115A (ko) 1997-12-01
EP0790992A1 (en) 1997-08-27

Similar Documents

Publication Publication Date Title
MX9703622A (es) Una nueva forma solida fisicamente estable en una fluoroquinolona.
MX9703564A (es) Inhibidores de proteasa multicatalitica.
FR2733244B1 (fr) Systeme de stabilisants a base de derives de polyalkylpiperidine
RS49688B (sr) Novi derivat 3-aril-2- hidroksipropionske kiseline (i)
BG102474A (en) (-)-cis-6(s)-phenyl-5(r)-[4-(2-pyrrolidine-1-yletoxi)phenyl)-5,6,7 ,8-tetrahydronaphthalen-2-ol-d-tartarate
HK1051500A1 (en) Cell adhesion inhibitors
AU2178895A (en) Heterocyclic-cyclic amine derivatives
DE69606721D1 (de) 1-(5-isochinolinsulfonyl)homopiperazin hydrochlorid
WO1996013259A3 (en) Method and compositions for inhibiting protein kinases
CA2511255A1 (en) 2-piperidone derivatives as prostaglandin agonists
NZ507076A (en) Substituted pyrrolidine derivatives useful as metalloprotease inhibitors
YU41199A (sh) Hinoksalindioni
EA200200510A1 (ru) 4-карбоксиамино-2-этил-1,2,3,4-тетрагидрохинолин в кристаллической форме как ингибитор сетр
EP1031573A4 (en) BENZOYLPYRAZOLE COMPOUNDS, INTERMEDIATE PRODUCTS AND HERBICIDES
EP0310072A3 (en) Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents
KR20000005379A (en) Isatin derivatives as acetylcholinesterase inhibitors and analgesics
AU4156397A (en) Stable non-hygroscopic crystalline form of N-(N-N-(4-(piperidin-4-yl)butanoyl)-N-ethylglycyl) compounds
EP0313847A3 (en) Non-peptidyl alpha-succinamidoacyl aminodiols as anti-hypertensive agents
HU9503270D0 (en) Nipecotic acid derivatives as antithrombic compounds
AU7087991A (en) Tricyclic-cyclic amines as novel cholinesterase inhibitors
WO1998003508A3 (de) Substituierte triazoloazinsulfonamide und ihre verwendung als planzenbehandlungsmittel
IN187760B (es)
ES2128031T3 (es) Forma cristalina y polimorfica de (s,s,s)-n-(1-(2-carboxi-3-(n2-mesilisilamino)propil)-1-ciclopentilcarbonil)tirosina.
DE69827614D1 (de) Chinoxalindionen
EP0310071A3 (en) Non-peptidyl alpha-aminoacyl aminodiol carbamates as anti-hypertensive agents

Legal Events

Date Code Title Description
FA Abandonment or withdrawal