MX9303710A - Proceso a baja temperatura para preparar sulfonatos de 2-desoxi-2,2-difluoro-d-riboforanosilo enriquecidos con alfa-anomero. - Google Patents

Proceso a baja temperatura para preparar sulfonatos de 2-desoxi-2,2-difluoro-d-riboforanosilo enriquecidos con alfa-anomero.

Info

Publication number
MX9303710A
MX9303710A MX9303710A MX9303710A MX9303710A MX 9303710 A MX9303710 A MX 9303710A MX 9303710 A MX9303710 A MX 9303710A MX 9303710 A MX9303710 A MX 9303710A MX 9303710 A MX9303710 A MX 9303710A
Authority
MX
Mexico
Prior art keywords
difluoro
enriched
alpha
ribophoranosil
anomerous
Prior art date
Application number
MX9303710A
Other languages
English (en)
Inventor
Ta-Sen Chou
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25415642&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9303710(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX9303710A publication Critical patent/MX9303710A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un proceso estereoselectivo para preparar sulfonatos de 2-deoxi-2,2-difluoro-D-ribofuranosilo enriquecidos con anómero poniendo en contacto con lactol con una base en un disolvente inerte, ajustando la temperatura y añadiendo un reactivo de sulfonación.
MX9303710A 1992-06-22 1993-06-21 Proceso a baja temperatura para preparar sulfonatos de 2-desoxi-2,2-difluoro-d-riboforanosilo enriquecidos con alfa-anomero. MX9303710A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,301 US5401861A (en) 1992-06-22 1992-06-22 Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Publications (1)

Publication Number Publication Date
MX9303710A true MX9303710A (es) 1994-01-31

Family

ID=25415642

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9303710A MX9303710A (es) 1992-06-22 1993-06-21 Proceso a baja temperatura para preparar sulfonatos de 2-desoxi-2,2-difluoro-d-riboforanosilo enriquecidos con alfa-anomero.

Country Status (15)

Country Link
US (1) US5401861A (es)
EP (1) EP0576229B1 (es)
JP (1) JP3379994B2 (es)
KR (1) KR100312389B1 (es)
AT (1) ATE161264T1 (es)
BR (1) BR9302428A (es)
CA (1) CA2098886C (es)
DE (1) DE69315752T2 (es)
DK (1) DK0576229T3 (es)
ES (1) ES2112389T3 (es)
GR (1) GR3026210T3 (es)
HU (1) HU216840B (es)
IL (1) IL106076A (es)
MX (1) MX9303710A (es)
TW (1) TW233299B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
JP5230052B2 (ja) * 2000-05-26 2013-07-10 イデニクス（ケイマン）リミテツド フラビウイルスおよびペスチウイルス治療のための方法および組成物
WO2004002422A2 (en) * 2002-06-28 2004-01-08 Idenix (Cayman) Limited 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
NZ537662A (en) * 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
SI1576138T1 (sl) 2002-11-15 2017-07-31 Idenix Pharmaceuticals Llc 2'-metil nukleozidi v kombinaciji z interferon in flaviviridae mutacijo
AU2003300901A1 (en) * 2002-12-12 2004-06-30 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
EP1912643A2 (en) * 2004-06-23 2008-04-23 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
KR100578616B1 (ko) * 2004-07-23 2006-05-10 한미약품 주식회사 Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
BRPI0513783A (pt) 2004-07-29 2008-05-13 Hanmi Pharm Ind Co Ltd derivados 1-(alfa)-halo-2, 2-diflúor-2-desóxi-d-ribofuranose e processo para a sua preparação
AU2005320374B2 (en) * 2004-12-30 2009-01-08 Hanmi Science Co., Ltd. Method for the preparation of 2'-deoxy-2',2'-difluorocytidine
WO2006070985A1 (en) 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
ATE458743T1 (de) * 2005-03-04 2010-03-15 Fresenius Kabi Oncology Ltd Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'- difluor-d-ribufuranosylnukleosiden
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
KR101171087B1 (ko) * 2005-06-03 2012-08-06 조오지 슐로에머 알파-아노머가 풍부한 2-데옥시-2,2-디플루오로-ｄ-리보푸라노실 설포네이트 및 베타 뉴클레오시드 제조를 위한 이들의 용도
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
CA2634749C (en) * 2005-12-23 2014-08-19 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
KR101357409B1 (ko) 2006-11-03 2014-02-03 에스티팜 주식회사 2′-데옥시-2′,2′-디플루오로시티딘의 제조방법
WO2008117955A1 (en) * 2007-03-23 2008-10-02 Dongwoo Syntech Co., Ltd. Process for preparing of 2'-deoxy-2'2'-difluorocytidine
KR100858842B1 (ko) 2007-03-23 2008-09-22 동우신테크 주식회사 키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
CN109796506A (zh) * 2019-01-28 2019-05-24 江苏八巨药业有限公司 一种吉西他滨关键中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
ATE217009T1 (de) * 1987-08-28 2002-05-15 Lilly Co Eli Stereoselektives verfahren zur herstellung von geschützten 2',2'-difluorlactonen
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides

Also Published As

Publication number Publication date
EP0576229B1 (en) 1997-12-17
TW233299B (es) 1994-11-01
KR100312389B1 (ko) 2002-06-20
DE69315752T2 (de) 1998-04-23
EP0576229A1 (en) 1993-12-29
US5401861A (en) 1995-03-28
HUT64552A (en) 1994-01-28
IL106076A0 (en) 1993-10-20
ATE161264T1 (de) 1998-01-15
JPH0656866A (ja) 1994-03-01
DK0576229T3 (da) 1998-01-19
CA2098886A1 (en) 1993-12-23
DE69315752D1 (de) 1998-01-29
BR9302428A (pt) 1994-01-11
CA2098886C (en) 2005-08-09
HU9301827D0 (en) 1993-09-28
IL106076A (en) 2002-02-10
KR940005655A (ko) 1994-03-22
ES2112389T3 (es) 1998-04-01
GR3026210T3 (en) 1998-05-29
HU216840B (hu) 1999-09-28
JP3379994B2 (ja) 2003-02-24

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