MX9303710A - Proceso a baja temperatura para preparar sulfonatos de 2-desoxi-2,2-difluoro-d-riboforanosilo enriquecidos con alfa-anomero. - Google Patents
Proceso a baja temperatura para preparar sulfonatos de 2-desoxi-2,2-difluoro-d-riboforanosilo enriquecidos con alfa-anomero.Info
- Publication number
- MX9303710A MX9303710A MX9303710A MX9303710A MX9303710A MX 9303710 A MX9303710 A MX 9303710A MX 9303710 A MX9303710 A MX 9303710A MX 9303710 A MX9303710 A MX 9303710A MX 9303710 A MX9303710 A MX 9303710A
- Authority
- MX
- Mexico
- Prior art keywords
- difluoro
- enriched
- alpha
- ribophoranosil
- anomerous
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un proceso estereoselectivo para preparar sulfonatos de 2-deoxi-2,2-difluoro-D-ribofuranosilo enriquecidos con anómero poniendo en contacto con lactol con una base en un disolvente inerte, ajustando la temperatura y añadiendo un reactivo de sulfonación.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/902,301 US5401861A (en) | 1992-06-22 | 1992-06-22 | Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9303710A true MX9303710A (es) | 1994-01-31 |
Family
ID=25415642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9303710A MX9303710A (es) | 1992-06-22 | 1993-06-21 | Proceso a baja temperatura para preparar sulfonatos de 2-desoxi-2,2-difluoro-d-riboforanosilo enriquecidos con alfa-anomero. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5401861A (es) |
EP (1) | EP0576229B1 (es) |
JP (1) | JP3379994B2 (es) |
KR (1) | KR100312389B1 (es) |
AT (1) | ATE161264T1 (es) |
BR (1) | BR9302428A (es) |
CA (1) | CA2098886C (es) |
DE (1) | DE69315752T2 (es) |
DK (1) | DK0576229T3 (es) |
ES (1) | ES2112389T3 (es) |
GR (1) | GR3026210T3 (es) |
HU (1) | HU216840B (es) |
IL (1) | IL106076A (es) |
MX (1) | MX9303710A (es) |
TW (1) | TW233299B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3485225D1 (de) * | 1983-08-18 | 1991-12-05 | Beecham Group Plc | Antivirale guanin-derivate. |
US5424416A (en) * | 1993-08-25 | 1995-06-13 | Eli Lilly And Company | Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides |
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
JP5230052B2 (ja) * | 2000-05-26 | 2013-07-10 | イデニクス(ケイマン)リミテツド | フラビウイルスおよびペスチウイルス治療のための方法および組成物 |
WO2004002422A2 (en) * | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
US7608600B2 (en) * | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
NZ537662A (en) * | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
SI1576138T1 (sl) | 2002-11-15 | 2017-07-31 | Idenix Pharmaceuticals Llc | 2'-metil nukleozidi v kombinaciji z interferon in flaviviridae mutacijo |
AU2003300901A1 (en) * | 2002-12-12 | 2004-06-30 | Idenix (Cayman) Limited | Process for the production of 2'-branched nucleosides |
EP1912643A2 (en) * | 2004-06-23 | 2008-04-23 | Idenix (Cayman) Limited | 5-aza-7-deazapurine derivatives for treating infections with flaviviridae |
US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
KR100578616B1 (ko) * | 2004-07-23 | 2006-05-10 | 한미약품 주식회사 | D-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법 |
BRPI0513783A (pt) | 2004-07-29 | 2008-05-13 | Hanmi Pharm Ind Co Ltd | derivados 1-(alfa)-halo-2, 2-diflúor-2-desóxi-d-ribofuranose e processo para a sua preparação |
AU2005320374B2 (en) * | 2004-12-30 | 2009-01-08 | Hanmi Science Co., Ltd. | Method for the preparation of 2'-deoxy-2',2'-difluorocytidine |
WO2006070985A1 (en) | 2004-12-30 | 2006-07-06 | Hanmi Pharm. Co., Ltd. | METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE |
ATE458743T1 (de) * | 2005-03-04 | 2010-03-15 | Fresenius Kabi Oncology Ltd | Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'- difluor-d-ribufuranosylnukleosiden |
JP4516863B2 (ja) * | 2005-03-11 | 2010-08-04 | 株式会社ケンウッド | 音声合成装置、音声合成方法及びプログラム |
KR101171087B1 (ko) * | 2005-06-03 | 2012-08-06 | 조오지 슐로에머 | 알파-아노머가 풍부한 2-데옥시-2,2-디플루오로-d-리보푸라노실 설포네이트 및 베타 뉴클레오시드 제조를 위한 이들의 용도 |
AU2011202539B2 (en) * | 2005-06-03 | 2012-07-05 | Scinopharm Taiwan, Ltd. | Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside |
AT502221A1 (de) * | 2005-07-20 | 2007-02-15 | Pharmacon Forschung & Beratung Gmbh | Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung |
CA2634749C (en) * | 2005-12-23 | 2014-08-19 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
KR101357409B1 (ko) | 2006-11-03 | 2014-02-03 | 에스티팜 주식회사 | 2′-데옥시-2′,2′-디플루오로시티딘의 제조방법 |
WO2008117955A1 (en) * | 2007-03-23 | 2008-10-02 | Dongwoo Syntech Co., Ltd. | Process for preparing of 2'-deoxy-2'2'-difluorocytidine |
KR100858842B1 (ko) | 2007-03-23 | 2008-09-22 | 동우신테크 주식회사 | 키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법 |
CN100475832C (zh) * | 2007-05-31 | 2009-04-08 | 南京卡文迪许生物工程技术有限公司 | 一种新颖的高立体选择性合成吉西他滨工艺及中间体 |
CN109796506A (zh) * | 2019-01-28 | 2019-05-24 | 江苏八巨药业有限公司 | 一种吉西他滨关键中间体的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
ATE217009T1 (de) * | 1987-08-28 | 2002-05-15 | Lilly Co Eli | Stereoselektives verfahren zur herstellung von geschützten 2',2'-difluorlactonen |
US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
-
1992
- 1992-06-22 US US07/902,301 patent/US5401861A/en not_active Expired - Lifetime
-
1993
- 1993-06-21 EP EP93304818A patent/EP0576229B1/en not_active Expired - Lifetime
- 1993-06-21 AT AT93304818T patent/ATE161264T1/de active
- 1993-06-21 ES ES93304818T patent/ES2112389T3/es not_active Expired - Lifetime
- 1993-06-21 HU HU9301827A patent/HU216840B/hu unknown
- 1993-06-21 DE DE69315752T patent/DE69315752T2/de not_active Expired - Lifetime
- 1993-06-21 BR BR9302428A patent/BR9302428A/pt not_active Application Discontinuation
- 1993-06-21 KR KR1019930011307A patent/KR100312389B1/ko not_active IP Right Cessation
- 1993-06-21 DK DK93304818.3T patent/DK0576229T3/da active
- 1993-06-21 JP JP14916693A patent/JP3379994B2/ja not_active Expired - Fee Related
- 1993-06-21 MX MX9303710A patent/MX9303710A/es unknown
- 1993-06-21 IL IL10607693A patent/IL106076A/en not_active IP Right Cessation
- 1993-06-21 CA CA002098886A patent/CA2098886C/en not_active Expired - Lifetime
- 1993-06-22 TW TW082104966A patent/TW233299B/zh not_active IP Right Cessation
-
1998
- 1998-02-25 GR GR980400387T patent/GR3026210T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0576229B1 (en) | 1997-12-17 |
TW233299B (es) | 1994-11-01 |
KR100312389B1 (ko) | 2002-06-20 |
DE69315752T2 (de) | 1998-04-23 |
EP0576229A1 (en) | 1993-12-29 |
US5401861A (en) | 1995-03-28 |
HUT64552A (en) | 1994-01-28 |
IL106076A0 (en) | 1993-10-20 |
ATE161264T1 (de) | 1998-01-15 |
JPH0656866A (ja) | 1994-03-01 |
DK0576229T3 (da) | 1998-01-19 |
CA2098886A1 (en) | 1993-12-23 |
DE69315752D1 (de) | 1998-01-29 |
BR9302428A (pt) | 1994-01-11 |
CA2098886C (en) | 2005-08-09 |
HU9301827D0 (en) | 1993-09-28 |
IL106076A (en) | 2002-02-10 |
KR940005655A (ko) | 1994-03-22 |
ES2112389T3 (es) | 1998-04-01 |
GR3026210T3 (en) | 1998-05-29 |
HU216840B (hu) | 1999-09-28 |
JP3379994B2 (ja) | 2003-02-24 |
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