ES2112389T3 - Procedimiento a baja temperatura para preparar 2-desoxi-2,2-difluoro-d-ribofuranosil sulfonatos enriquecidos en anomero alfa. - Google Patents
Procedimiento a baja temperatura para preparar 2-desoxi-2,2-difluoro-d-ribofuranosil sulfonatos enriquecidos en anomero alfa.Info
- Publication number
- ES2112389T3 ES2112389T3 ES93304818T ES93304818T ES2112389T3 ES 2112389 T3 ES2112389 T3 ES 2112389T3 ES 93304818 T ES93304818 T ES 93304818T ES 93304818 T ES93304818 T ES 93304818T ES 2112389 T3 ES2112389 T3 ES 2112389T3
- Authority
- ES
- Spain
- Prior art keywords
- difluoro
- enriched
- alpha
- anomerous
- ribofuranosil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
UN PROCESO ESTEREOSELECTIVO PARA LA PREPARACION DE 2-DESOXI-2,2-DIFLUORO-DRIBOFURANOSIL-SULFONATOS ENRIQUECIDOS CON ALFA-ANOMEROS QUE CONSISTE EN HACER PONER EN CONTACTO UN LACTOL CON UNA BASE EN UN SOLVENTE INERTE, AJUSTAR LA TEMPERATURA Y AÑADIR UN REACTIVO DE SULFONACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/902,301 US5401861A (en) | 1992-06-22 | 1992-06-22 | Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2112389T3 true ES2112389T3 (es) | 1998-04-01 |
Family
ID=25415642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93304818T Expired - Lifetime ES2112389T3 (es) | 1992-06-22 | 1993-06-21 | Procedimiento a baja temperatura para preparar 2-desoxi-2,2-difluoro-d-ribofuranosil sulfonatos enriquecidos en anomero alfa. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5401861A (es) |
EP (1) | EP0576229B1 (es) |
JP (1) | JP3379994B2 (es) |
KR (1) | KR100312389B1 (es) |
AT (1) | ATE161264T1 (es) |
BR (1) | BR9302428A (es) |
CA (1) | CA2098886C (es) |
DE (1) | DE69315752T2 (es) |
DK (1) | DK0576229T3 (es) |
ES (1) | ES2112389T3 (es) |
GR (1) | GR3026210T3 (es) |
HU (1) | HU216840B (es) |
IL (1) | IL106076A (es) |
MX (1) | MX9303710A (es) |
TW (1) | TW233299B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3485225D1 (de) * | 1983-08-18 | 1991-12-05 | Beecham Group Plc | Antivirale guanin-derivate. |
US5424416A (en) * | 1993-08-25 | 1995-06-13 | Eli Lilly And Company | Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
NZ547204A (en) * | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
JP2005533824A (ja) * | 2002-06-28 | 2005-11-10 | イデニクス(ケイマン)リミテツド | フラビウイルス科感染の治療のための2’−c−メチル−3’−o−l−バリンエステルリボフラノシルシチジン |
US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
NZ537662A (en) * | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
WO2004046331A2 (en) * | 2002-11-15 | 2004-06-03 | Idenix (Cayman) Limited | 2’-branched nucleosides and flaviviridae mutation |
WO2004052899A2 (en) * | 2002-12-12 | 2004-06-24 | Idenix (Cayman) Limited | Process for the production of 2'-branched nucleosides |
WO2006000922A2 (en) * | 2004-06-23 | 2006-01-05 | Idenix (Cayman) Limited | 5-aza-7-deazapurine derivatives for treating infections with flaviviridae |
US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
KR100578616B1 (ko) * | 2004-07-23 | 2006-05-10 | 한미약품 주식회사 | D-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법 |
EP1781678A4 (en) | 2004-07-29 | 2012-04-25 | Hanmi Holdings Co Ltd | 1 -? - HALOGEN-2,2-DIFLUOR-2-DESOXY-D-RIBOFURANOSEDERIVATE AND PROCESS FOR THE PRODUCTION THEREOF |
BRPI0514718A (pt) * | 2004-12-30 | 2008-07-01 | Hanmi Pharm Ind Co Ltd | método para a preparação de 2'-desoxi-2', 2'-diflúor-citidina |
WO2006070985A1 (en) * | 2004-12-30 | 2006-07-06 | Hanmi Pharm. Co., Ltd. | METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE |
JP2008531680A (ja) * | 2005-03-04 | 2008-08-14 | ダブール・ファーマ・リミテッド | βアノマーが富化された21−デオキシ−21,21−ジフルオロ−D−リボフラノシルヌクレオシドの調製のための中間体と方法 |
JP4516863B2 (ja) * | 2005-03-11 | 2010-08-04 | 株式会社ケンウッド | 音声合成装置、音声合成方法及びプログラム |
AU2011202539B2 (en) * | 2005-06-03 | 2012-07-05 | Scinopharm Taiwan, Ltd. | Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside |
US7572898B2 (en) * | 2005-06-03 | 2009-08-11 | Scinopharm Taiwan, Ltd. | Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonate and use thereof for making a beta nucleoside |
AT502221A1 (de) * | 2005-07-20 | 2007-02-15 | Pharmacon Forschung & Beratung Gmbh | Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung |
US7781576B2 (en) * | 2005-12-23 | 2010-08-24 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
KR101357409B1 (ko) | 2006-11-03 | 2014-02-03 | 에스티팜 주식회사 | 2′-데옥시-2′,2′-디플루오로시티딘의 제조방법 |
JP5349342B2 (ja) * | 2007-03-23 | 2013-11-20 | ドンウ シンテック カンパニー リミテッド | 2’−デオキシ−2’,2’−ジフルオロシチジンの製造方法 |
KR100858842B1 (ko) | 2007-03-23 | 2008-09-22 | 동우신테크 주식회사 | 키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법 |
CN100475832C (zh) | 2007-05-31 | 2009-04-08 | 南京卡文迪许生物工程技术有限公司 | 一种新颖的高立体选择性合成吉西他滨工艺及中间体 |
CN109796506A (zh) * | 2019-01-28 | 2019-05-24 | 江苏八巨药业有限公司 | 一种吉西他滨关键中间体的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
EP0688783B1 (en) * | 1987-08-28 | 2001-06-13 | Eli Lilly And Company | Method for preparing 2'-deoxy-2',2'-difluornucleosides |
US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
-
1992
- 1992-06-22 US US07/902,301 patent/US5401861A/en not_active Expired - Lifetime
-
1993
- 1993-06-21 MX MX9303710A patent/MX9303710A/es unknown
- 1993-06-21 AT AT93304818T patent/ATE161264T1/de active
- 1993-06-21 IL IL10607693A patent/IL106076A/en not_active IP Right Cessation
- 1993-06-21 CA CA002098886A patent/CA2098886C/en not_active Expired - Lifetime
- 1993-06-21 EP EP93304818A patent/EP0576229B1/en not_active Expired - Lifetime
- 1993-06-21 BR BR9302428A patent/BR9302428A/pt not_active Application Discontinuation
- 1993-06-21 HU HU9301827A patent/HU216840B/hu unknown
- 1993-06-21 ES ES93304818T patent/ES2112389T3/es not_active Expired - Lifetime
- 1993-06-21 DE DE69315752T patent/DE69315752T2/de not_active Expired - Lifetime
- 1993-06-21 KR KR1019930011307A patent/KR100312389B1/ko not_active IP Right Cessation
- 1993-06-21 DK DK93304818.3T patent/DK0576229T3/da active
- 1993-06-21 JP JP14916693A patent/JP3379994B2/ja not_active Expired - Fee Related
- 1993-06-22 TW TW082104966A patent/TW233299B/zh not_active IP Right Cessation
-
1998
- 1998-02-25 GR GR980400387T patent/GR3026210T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
MX9303710A (es) | 1994-01-31 |
KR940005655A (ko) | 1994-03-22 |
DE69315752T2 (de) | 1998-04-23 |
EP0576229A1 (en) | 1993-12-29 |
CA2098886A1 (en) | 1993-12-23 |
DE69315752D1 (de) | 1998-01-29 |
BR9302428A (pt) | 1994-01-11 |
TW233299B (es) | 1994-11-01 |
IL106076A0 (en) | 1993-10-20 |
GR3026210T3 (en) | 1998-05-29 |
DK0576229T3 (da) | 1998-01-19 |
ATE161264T1 (de) | 1998-01-15 |
JPH0656866A (ja) | 1994-03-01 |
JP3379994B2 (ja) | 2003-02-24 |
KR100312389B1 (ko) | 2002-06-20 |
HUT64552A (en) | 1994-01-28 |
US5401861A (en) | 1995-03-28 |
IL106076A (en) | 2002-02-10 |
EP0576229B1 (en) | 1997-12-17 |
HU216840B (hu) | 1999-09-28 |
CA2098886C (en) | 2005-08-09 |
HU9301827D0 (en) | 1993-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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