MX9206169A - Derivados de quinoleina, su preparacion y su aplicacion en terapeutica. - Google Patents

Derivados de quinoleina, su preparacion y su aplicacion en terapeutica.

Info

Publication number
MX9206169A
MX9206169A MX9206169A MX9206169A MX9206169A MX 9206169 A MX9206169 A MX 9206169A MX 9206169 A MX9206169 A MX 9206169A MX 9206169 A MX9206169 A MX 9206169A MX 9206169 A MX9206169 A MX 9206169A
Authority
MX
Mexico
Prior art keywords
group
alkoxy
therapeutics
application
aryl
Prior art date
Application number
MX9206169A
Other languages
English (en)
Inventor
Gerard Cremer Pascale G Muller
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9418349&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9206169(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthelabo filed Critical Synthelabo
Publication of MX9206169A publication Critical patent/MX9206169A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Communication Cables (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

Los compuestos derivados de la quinoleína en el cual R1 representa, ya sea un grupo 1H-tetrazol-5-ilo, ya sea un grupo CO2H, R2 representa, ya sea un grupo (C1-7) alquilo, ya sea un grupo (C2-6) alcenilo, R3 y R4 representan, cada uno independientemente uno del otro, ya sea un átomo de hidrógeno, ya sea un átomo de halógeno, ya sea un grupo ciano, ya sea un grupo (C1-7) alquilo, ya sea un grupo (C3-7)cicloalquil (C1-4) alquilo, ya sea un grupo arilo, ya sea un grupo aril (C2-6) alcenilo, ya sea un grupo -(CH2)mCOR5 en el cual m0 a 4 y R5 representa un átomo de hidrógeno, un grupo OH, un grupo (C1-6) alcoxi o un grupo NR7R8, en donde R7 y R8 representan, cada uno independientemente uno del otro, un átomo de hidrógeno o un grupo (C1-4) alquilo, ya sea un grupo -(CH2)n-R6 en el cual n1 a 4 y R6 representa un grupo OH, un grupo (C1-6) alcoxi, un grupo (C1-4) alcoxi (C1-4) alcoxi o un grupo (C3-7) cicloalquil (C1-4) alcoxi, así como sus sales orgánicas farmacéuticamente aceptables. Se aplica en terapéutica.
MX9206169A 1991-10-28 1992-10-27 Derivados de quinoleina, su preparacion y su aplicacion en terapeutica. MX9206169A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9113240A FR2683819B1 (fr) 1991-10-28 1991-10-28 Derives de quinoleine, leur procede de preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
MX9206169A true MX9206169A (es) 1993-07-01

Family

ID=9418349

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9206169A MX9206169A (es) 1991-10-28 1992-10-27 Derivados de quinoleina, su preparacion y su aplicacion en terapeutica.

Country Status (18)

Country Link
EP (1) EP0540400B1 (es)
JP (1) JPH05239053A (es)
KR (1) KR930007935A (es)
CN (1) CN1073171A (es)
AT (1) ATE126798T1 (es)
AU (1) AU651740B2 (es)
CA (1) CA2081537A1 (es)
CZ (1) CZ324292A3 (es)
DE (1) DE69204252T2 (es)
FI (1) FI924869A (es)
FR (1) FR2683819B1 (es)
HU (1) HUT62883A (es)
IL (1) IL103568A0 (es)
MX (1) MX9206169A (es)
NO (1) NO924138L (es)
NZ (1) NZ244892A (es)
PL (1) PL296369A1 (es)
ZA (1) ZA928297B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478832A (en) * 1992-05-08 1995-12-26 The Green Cross Corporation Quinoline compounds
IT1255461B (it) * 1992-07-28 1995-11-02 Luso Farmaco Inst Eteri di imidazoli ad attivita' a ii antagonista
FR2699174B1 (fr) * 1992-12-14 1995-01-20 Synthelabo Dérivés de 3-(quinoléin-6-yl-méthyl)-4H-imidazol-4-one, leur préparation et leur application en thérapeutique.
FR2710914B1 (fr) * 1993-10-04 1995-11-24 Synthelabo Dérivés de 2-[2-(tétrazol-5-yl)phényl]-1,2-dihydroquinoléine, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2716196B1 (fr) * 1994-02-16 1996-04-05 Synthelabo Dérivés de 8-[2-(1H-tétrazol-5-yl) phényl] quinoléine, leur préparation et leur application en thérapeutique.
JPH09202774A (ja) 1996-01-25 1997-08-05 Green Cross Corp:The ２−アリールキノリン類およびその製造方法
DE19706161A1 (de) * 1997-02-17 1998-08-20 Oswald Hartmut Prof Dr Med Verwendung von Cyaninen, Isocyaninen und Pseudoisocyaninen als Diuretika
KR100744826B1 (ko) * 2006-04-05 2007-08-01 한국화학연구원 이미다졸기가 치환된 퀴놀리논 유도체
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103804349A (zh) * 2012-11-01 2014-05-21 杨子娇 一类治疗青光眼的化合物及其用途
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
CN108558750B (zh) * 2018-07-11 2021-01-05 武汉工程大学 无溶剂法合成3-硝基喹啉衍生物的工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
MX9200299A (es) * 1991-02-07 1992-12-01 Roussel Uclaf Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
DE4117750A1 (de) * 1991-05-30 1992-12-24 Bayer Ag Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
ATE152718T1 (de) * 1991-08-15 1997-05-15 Ciba Geigy Ag N-acyl-n-heterocyclyl- oder naphthylalkyl- aminosäuren als angiotensin ii antagonisten

Also Published As

Publication number Publication date
CA2081537A1 (en) 1993-04-29
FI924869A0 (fi) 1992-10-27
IL103568A0 (en) 1993-03-15
FR2683819B1 (fr) 1994-02-11
JPH05239053A (ja) 1993-09-17
ZA928297B (en) 1993-05-07
EP0540400B1 (fr) 1995-08-23
EP0540400A1 (fr) 1993-05-05
CZ324292A3 (en) 1993-09-15
KR930007935A (ko) 1993-05-20
ATE126798T1 (de) 1995-09-15
NO924138L (no) 1993-04-29
HU9203374D0 (en) 1993-01-28
AU651740B2 (en) 1994-07-28
AU2734892A (en) 1993-04-29
DE69204252T2 (de) 1996-04-18
FR2683819A1 (fr) 1993-05-21
HUT62883A (en) 1993-06-28
CN1073171A (zh) 1993-06-16
PL296369A1 (en) 1993-05-31
DE69204252D1 (de) 1995-09-28
NZ244892A (en) 1994-06-27
NO924138D0 (no) 1992-10-27
FI924869A (fi) 1993-04-29

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