MX370579B - Arreglos de microagujas cargadas en la punta para insercion transdermica. - Google Patents
Arreglos de microagujas cargadas en la punta para insercion transdermica.Info
- Publication number
- MX370579B MX370579B MX2014013234A MX2014013234A MX370579B MX 370579 B MX370579 B MX 370579B MX 2014013234 A MX2014013234 A MX 2014013234A MX 2014013234 A MX2014013234 A MX 2014013234A MX 370579 B MX370579 B MX 370579B
- Authority
- MX
- Mexico
- Prior art keywords
- tip
- microneedle arrays
- loaded microneedle
- transdermal insertion
- base portion
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C67/00—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23C—MILLING
- B23C3/00—Milling particular work; Special milling operations; Machines therefor
- B23C3/16—Working surfaces curved in two directions
- B23C3/20—Working surfaces curved in two directions for shaping dies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
- B29L2031/7544—Injection needles, syringes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a un arreglo de microagujas disolubles para la inserción transdérmica en un paciente, caracterizado porque comprende: un componente bioactivo; una porción de base; y una pluralidad de microagujas que se extienden desde la porción de base, en donde el componente bioactivo está presente en una concentración mayor en la pluralidad de microagujas que en la porción de base, en donde el componente bioactivo comprende doxorubicina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261641209P | 2012-05-01 | 2012-05-01 | |
PCT/US2013/039084 WO2013166162A1 (en) | 2012-05-01 | 2013-05-01 | Tip-loaded microneedle arrays for transdermal insertion |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014013234A MX2014013234A (es) | 2015-10-29 |
MX370579B true MX370579B (es) | 2019-12-17 |
Family
ID=49514855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014013234A MX370579B (es) | 2012-05-01 | 2013-05-01 | Arreglos de microagujas cargadas en la punta para insercion transdermica. |
Country Status (11)
Country | Link |
---|---|
US (3) | US9944019B2 (es) |
EP (2) | EP2841147A4 (es) |
JP (7) | JP2015515886A (es) |
CN (2) | CN104703651A (es) |
AU (5) | AU2013256348B2 (es) |
BR (1) | BR112014027242A2 (es) |
CA (2) | CA3077452C (es) |
HK (1) | HK1209658A1 (es) |
IN (1) | IN2014DN10161A (es) |
MX (1) | MX370579B (es) |
WO (1) | WO2013166162A1 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
CA3077452C (en) | 2012-05-01 | 2022-08-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Tip-loaded microneedle arrays for transdermal insertion |
JP2015157072A (ja) * | 2014-01-27 | 2015-09-03 | コスメディ製薬株式会社 | 3dプリンターによるマイクロニードルの製造 |
EP3134149A4 (en) * | 2014-04-24 | 2017-12-27 | Georgia Tech Research Corporation | Microneedles and methods of manufacture thereof |
SG10202004900TA (en) * | 2014-11-06 | 2020-06-29 | Univ Pittsburgh Commonwealth Sys Higher Education | Microneedle arrays for cancer therapy applications |
US10441768B2 (en) | 2015-03-18 | 2019-10-15 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
US10894151B2 (en) | 2015-04-23 | 2021-01-19 | Carnegie Mellon University | Biosensor tattoos and uses therefor for biomarker monitoring |
KR20180035210A (ko) * | 2015-07-24 | 2018-04-05 | 킴벌리-클라크 월드와이드, 인크. | 활성제의 류마티즘 전달 방법 |
US11684763B2 (en) | 2015-10-16 | 2023-06-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices |
KR101811513B1 (ko) * | 2015-11-25 | 2017-12-20 | 주식회사 파이안에스테틱스 | 마이크로 스피큘과 이의 제조용 몰드 및 이의 제조방법 |
WO2017120322A1 (en) * | 2016-01-05 | 2017-07-13 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
US20170209553A1 (en) * | 2016-01-22 | 2017-07-27 | Transderm, Inc. | Delivery of botulinum with microneedle arrays |
EP3434314B1 (en) * | 2016-03-25 | 2022-11-09 | Toppan Printing Co., Ltd. | Transdermal delivery device |
KR101719319B1 (ko) * | 2016-04-05 | 2017-03-23 | 주식회사 엘지생활건강 | 효율적인 피부 천공을 위한 마이크로니들 구조 |
US20200230846A1 (en) * | 2016-04-12 | 2020-07-23 | Juvic Inc. | Rotating assembly and apparatus for manufacturing microstructure comprising same |
KR101692266B1 (ko) * | 2016-08-01 | 2017-01-03 | 부산대학교 산학협력단 | 마이크로니들 패치 및 이의 제조 방법 |
JP6700144B2 (ja) * | 2016-09-06 | 2020-05-27 | 富士フイルム株式会社 | マイクロニードルアレイ撮像方法及びマイクロニードルアレイ検査方法 |
US10913776B2 (en) | 2016-09-30 | 2021-02-09 | University of Pittsburgh—of the Commonwealth System of Higher Education | Zika virus vaccines |
CN107913460B (zh) * | 2016-10-10 | 2021-06-22 | 苏州纳通生物纳米技术有限公司 | 一种液体定量输送*** |
CN107913459A (zh) * | 2016-10-10 | 2018-04-17 | 苏州纳通生物纳米技术有限公司 | 一种液体定量输送装置 |
CA3053641A1 (en) * | 2017-02-17 | 2018-08-23 | Allergan, Inc. | Microneedle array with active ingredient |
CN106727273A (zh) * | 2017-03-02 | 2017-05-31 | 李成国 | 可溶性微针的制造方法 |
WO2018208222A1 (en) * | 2017-05-10 | 2018-11-15 | Chee Yen Lim | Pyramidal microneedles with enhanced drug loading capacity and method for manufacturing |
EP3624751A4 (en) * | 2017-05-17 | 2021-03-03 | Massachusetts Institute of Technology | SELF-ALIGNING SYSTEMS, PROCEDURES AND ASSOCIATED COMPONENTS |
US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
US20210128897A1 (en) * | 2017-08-17 | 2021-05-06 | New York University | Bone growth stimulator and methods of use |
WO2019064653A1 (ja) * | 2017-09-29 | 2019-04-04 | 凸版印刷株式会社 | 細胞移植装置、および、細胞移植用ユニット |
WO2019094349A1 (en) * | 2017-11-07 | 2019-05-16 | NanoCav, LLC | Microneedle array device, methods of manufacture and use thereof |
US20200131483A1 (en) * | 2018-10-29 | 2020-04-30 | University Of South Carolina | Culture System and Media for Skin Explants Providing Enhanced Viability and Enabling Molecular Studies |
EP3772329A1 (fr) * | 2019-08-08 | 2021-02-10 | PKvitality | Systeme de surveillance corporelle comprenant une microaiguille |
CN110368576A (zh) * | 2019-08-23 | 2019-10-25 | 苏州纳生微电子有限公司 | 定量液体供给装置 |
US11213482B1 (en) | 2020-03-05 | 2022-01-04 | University of Pittsburgh—Of the Commonwealth System of Higher Educat | SARS-CoV-2 subunit vaccine and microneedle array delivery system |
US11202753B1 (en) | 2020-03-06 | 2021-12-21 | Aquavit Pharmaceuticals, Inc. | Systems and methods for generating immune responses in subjects using microchannel delivery devices |
CN115734798A (zh) * | 2020-04-28 | 2023-03-03 | 提克纳有限责任公司 | 微针组件 |
US20220008007A1 (en) * | 2020-07-13 | 2022-01-13 | Icreate Technology (Zhuhai) Co., Ltd. | Microneedle array and sensor including the same |
CN112569465B (zh) * | 2020-12-29 | 2022-07-19 | 华东理工大学 | 一种微针贴片的制备方法 |
TW202300514A (zh) * | 2021-05-21 | 2023-01-01 | 高端疫苗生物製劑股份有限公司 | 抗新型冠狀病毒之微針疫苗 |
GB2607115B (en) * | 2021-06-25 | 2023-10-04 | Cipherx Tech Ltd | Method of producing a microneedle array |
Family Cites Families (151)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5246783A (en) | 1991-08-15 | 1993-09-21 | Exxon Chemical Patents Inc. | Electrical devices comprising polymeric insulating or semiconducting members |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US7422574B2 (en) | 1995-05-19 | 2008-09-09 | Applied Tissue Technologies, Llc | Microseeding device for gene delivery by microneedle injection |
US5658515A (en) | 1995-09-25 | 1997-08-19 | Lee; Abraham P. | Polymer micromold and fabrication process |
US6234990B1 (en) * | 1996-06-28 | 2001-05-22 | Sontra Medical, Inc. | Ultrasound enhancement of transdermal transport |
CA2276312C (en) * | 1996-12-31 | 2012-11-27 | Jonathan A. Eppstein | Microporation of tissue for delivery of bioactive agents |
US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6496629B2 (en) | 1999-05-28 | 2002-12-17 | Tycom (Us) Inc. | Undersea telecommunications cable |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US6331266B1 (en) | 1999-09-29 | 2001-12-18 | Becton Dickinson And Company | Process of making a molded device |
US6511463B1 (en) | 1999-11-18 | 2003-01-28 | Jds Uniphase Corporation | Methods of fabricating microneedle arrays using sacrificial molds |
IL134997A0 (en) | 2000-03-09 | 2001-05-20 | Yehoshua Yeshurun | Health care system based on micro device |
US6595947B1 (en) | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
US6607513B1 (en) | 2000-06-08 | 2003-08-19 | Becton, Dickinson And Company | Device for withdrawing or administering a substance and method of manufacturing a device |
US6623707B1 (en) | 2000-06-19 | 2003-09-23 | Corning Incorporated | Monolithic catalyst dehydrogenation reactor |
US20050008683A1 (en) * | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
US6656147B1 (en) | 2000-07-17 | 2003-12-02 | Becton, Dickinson And Company | Method and delivery device for the transdermal administration of a substance |
US6533949B1 (en) | 2000-08-28 | 2003-03-18 | Nanopass Ltd. | Microneedle structure and production method therefor |
AU9682801A (en) * | 2000-10-13 | 2002-04-22 | Alza Corp | Apparatus and method for piercing skin with microprotrusions |
US7108681B2 (en) | 2000-10-16 | 2006-09-19 | Corium International, Inc. | Microstructures for delivering a composition cutaneously to skin |
US9302903B2 (en) * | 2000-12-14 | 2016-04-05 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
US6767211B2 (en) | 2001-03-13 | 2004-07-27 | Carolyn W. Hall | Method and apparatus for behaviorally reinforced training with guided practice |
US6663820B2 (en) | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
US20020193729A1 (en) * | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
JP2004531578A (ja) * | 2001-06-29 | 2004-10-14 | ベクトン・ディキンソン・アンド・カンパニー | ワクチンおよび遺伝子治療剤のマイクロカニューレによる皮内送達 |
US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
WO2003024507A2 (en) | 2001-09-19 | 2003-03-27 | Biovalve Technologies, Inc. | Microneedles, microneedle arrays, and systems and methods relating to same |
US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
US6908453B2 (en) | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
US6714707B2 (en) | 2002-01-24 | 2004-03-30 | Alcatel | Optical cable housing an optical unit surrounded by a plurality of gel layers |
WO2003074102A2 (en) | 2002-03-04 | 2003-09-12 | Nano Pass Technologies Ltd. | Devices and methods for transporting fluid across a biological barrier |
US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
US6899838B2 (en) | 2002-07-12 | 2005-05-31 | Becton, Dickinson And Company | Method of forming a mold and molding a micro-device |
WO2004024224A1 (en) * | 2002-09-16 | 2004-03-25 | Sung-Yun Kwon | Solid micro-perforators and methods of use |
AU2003277306A1 (en) | 2002-10-07 | 2004-05-04 | Biovalve Technologies, Inc. | Microneedle array patch |
IL152271A (en) | 2002-10-13 | 2006-04-10 | Meir Hefetz | Structures of micro needles and manufacturing methods |
US7578954B2 (en) | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
US8796436B2 (en) | 2003-04-17 | 2014-08-05 | Alnylam Pharmaceuticals, Inc. | Modified iRNA agents |
JP2005035945A (ja) | 2003-07-16 | 2005-02-10 | Cardio Corp | 組織再生複合療法 |
AU2004264320A1 (en) * | 2003-08-04 | 2005-02-24 | Alza Corporation | Method and device for enhancing transdermal agent flux |
US8353861B2 (en) | 2003-09-18 | 2013-01-15 | Texmac, Inc. | Applicator for applying functional substances into human skin |
KR20060120156A (ko) | 2003-10-28 | 2006-11-24 | 알자 코포레이션 | 담배의 이용빈도를 감소시키기 위한 방법 및 장치 |
WO2005044364A1 (en) | 2003-11-10 | 2005-05-19 | Agency For Science, Technology And Research | Microneedles and microneedle fabrication |
JP2007511318A (ja) * | 2003-11-18 | 2007-05-10 | ナノ パス テクノロジーズ リミテッド | 改良された挿入システム及びマイクロニードルを摺動させるための方法 |
EP1713533A4 (en) | 2003-11-21 | 2008-01-23 | Univ California | METHOD AND / OR DEVICE FOR PUNKING A SURFACE FOR EXTRACTION, IN-SITU ANALYSIS AND / OR SUBSTANCE DELIVERY USING MICRONED NEEDLES |
GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
US8551391B2 (en) | 2004-02-17 | 2013-10-08 | Avery Dennison Corporation | Method of making microneedles |
CN100540086C (zh) | 2004-03-12 | 2009-09-16 | 新加坡科技研究局 | 用来制造侧开口微型针的方法及模具 |
US7591806B2 (en) | 2004-05-18 | 2009-09-22 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
US7315758B2 (en) | 2004-06-03 | 2008-01-01 | Lynntech, Inc. | Transdermal delivery of therapeutic agent |
WO2006022933A2 (en) | 2004-08-05 | 2006-03-02 | Apogee Technologies, Inc. | System and method for drug delivery and microfluidic applications using microneedles |
ES2463818T3 (es) | 2004-08-16 | 2014-05-29 | Functional Microstructures Limited | Dispositivo que se aplicará a una barrera biológica |
US7316665B2 (en) | 2004-08-25 | 2008-01-08 | Becton, Dickinson And Company | Method and device for the delivery of a substance including a covering |
US7132054B1 (en) | 2004-09-08 | 2006-11-07 | Sandia Corporation | Method to fabricate hollow microneedle arrays |
JP4927751B2 (ja) | 2004-11-18 | 2012-05-09 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイのコーティング方法 |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
AU2005306372B2 (en) | 2004-11-18 | 2011-01-06 | Kindeva Drug Delivery L.P. | Method of contact coating a microneedle array |
WO2006055795A1 (en) | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
CN102358015A (zh) | 2004-12-07 | 2012-02-22 | 3M创新有限公司 | 模制微型针的方法 |
US20080262444A1 (en) * | 2005-01-31 | 2008-10-23 | Bioserentach Co., Ltd. | Percutaneously Absorbable Preparation, Percutaneously Absorbable Preparation Holding Sheet, and Percutaneously Absorbable Preparation Holding Equipment |
US20080213461A1 (en) * | 2005-06-17 | 2008-09-04 | Georgia Tech Research Corporation | Coated Microstructures and Methods of Manufacture Thereof |
US8376984B2 (en) | 2005-07-14 | 2013-02-19 | Terry L. James | Apparatus, system, and method to deliver optimal elements in order to enhance the aesthetic appearance of the skin |
EP3461406A1 (en) | 2005-09-30 | 2019-04-03 | Intuity Medical, Inc. | Multi-site body fluid sampling and analysis cartridge |
US8784860B2 (en) | 2005-10-27 | 2014-07-22 | Cordis Corporation | Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease |
US8554317B2 (en) | 2005-11-30 | 2013-10-08 | 3M Innovative Properties Company | Microneedle arrays and methods of use thereof |
US7658728B2 (en) * | 2006-01-10 | 2010-02-09 | Yuzhakov Vadim V | Microneedle array, patch, and applicator for transdermal drug delivery |
ATE532553T1 (de) | 2006-02-10 | 2011-11-15 | Hisamitsu Pharmaceutical Co | Transdermales arzneiverabreichungsgerät mit mikronadeln |
US7699819B2 (en) | 2006-02-21 | 2010-04-20 | The Hong Kong University Of Science And Technology | Molecular sieve and zeolite microneedles and preparation thereof |
EP2007423A2 (en) * | 2006-04-05 | 2008-12-31 | Pfizer Products Incorporated | Ctla4 antibody combination therapy |
WO2007127976A2 (en) * | 2006-05-01 | 2007-11-08 | Georgia Tech Research Corporation | Particle based molding |
US7918814B2 (en) * | 2006-05-02 | 2011-04-05 | Georgia Tech Research Corporation | Method for drug delivery to ocular tissue using microneedle |
TW200744534A (en) | 2006-06-09 | 2007-12-16 | Univ Nat Chiao Tung | Microprobe array structure and manufacturing method thereof |
DE102006028781A1 (de) | 2006-06-23 | 2007-12-27 | Robert Bosch Gmbh | Verfahren zur Herstellung von porösen Mikronadeln und ihre Verwendung |
US8250729B2 (en) | 2006-07-12 | 2012-08-28 | University Of Utah Research Foundation | 3D fabrication of needle tip geometry and knife blade |
KR100781702B1 (ko) | 2006-07-21 | 2007-12-03 | 연세대학교 산학협력단 | 중공형 마이크로니들 및 이의 제조방법 |
EP2062612A4 (en) | 2006-08-18 | 2010-01-06 | Toppan Printing Co Ltd | MICRO NEEDLE AND MICRO NEEDLE STAMP |
EP2060950A4 (en) | 2006-08-18 | 2014-06-25 | Toppan Printing Co Ltd | METHOD FOR PRODUCING AN ORGINAL PLATE, METHOD FOR PRODUCING A MICRONADEL PATCH, MICRONADEL PATCH AND EXPOSURE DEVICE |
DE102006040642A1 (de) | 2006-08-30 | 2008-03-13 | Robert Bosch Gmbh | Mikronadeln zur Platzierung in der Haut zwecks transdermaler Applikation von Pharmazeutika |
WO2008064306A2 (en) | 2006-11-22 | 2008-05-29 | Curedm, Inc. | Methods and compositions relating to islet cell neogenesis |
US7785301B2 (en) | 2006-11-28 | 2010-08-31 | Vadim V Yuzhakov | Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection |
JP2008142183A (ja) | 2006-12-07 | 2008-06-26 | Fujifilm Corp | マイクロニードルシート及びその製造方法 |
TW200829215A (en) | 2007-01-03 | 2008-07-16 | Univ Nat Chiao Tung | Micro probe array and manufacturing method of the trans-print mold thereof |
EP2121111B1 (en) * | 2007-01-22 | 2018-03-14 | Corium International, Inc. | Applicators for microneedle arrays |
US8560059B2 (en) | 2007-03-09 | 2013-10-15 | Covidien Lp | System and methods for optical sensing and drug delivery using microneedles |
AU2008241470B2 (en) * | 2007-04-16 | 2013-11-07 | Corium Pharma Solutions, Inc. | Solvent-cast microneedle arrays containing active |
WO2008139648A1 (ja) | 2007-05-15 | 2008-11-20 | Hisamitsu Pharmaceutical Co., Inc. | マイクロニードルのコーティング方法 |
JP2008284318A (ja) | 2007-05-15 | 2008-11-27 | Kosumedei Seiyaku Kk | 生体由来物質からなる投薬用微細針 |
WO2008157592A1 (en) | 2007-06-20 | 2008-12-24 | 3M Innovative Properties Company | Ultrasonic injection molding on a web |
EP3456357A1 (en) * | 2007-06-29 | 2019-03-20 | Stelic Institute Of Regenerative Medicine, Stelic Institute & Co. | Method of fixing and expressing physiologically active substance |
US20090016935A1 (en) * | 2007-07-09 | 2009-01-15 | Andrianov Alexander K | Coating formulations including polyphosphazene polyelectrolytes and biologically active agents and asperities coated with such formulations |
AU2008280755B9 (en) | 2007-07-26 | 2014-09-25 | Sanofi Pasteur Limited | Antigen-adjuvant compositions and methods |
AU2008283896A1 (en) | 2007-08-06 | 2009-02-12 | Transderm, Inc. | Microneedle arrays formed from polymer films |
EP2194864B1 (en) | 2007-09-14 | 2018-08-29 | Medtronic Monitoring, Inc. | System and methods for wireless body fluid monitoring |
EP2194847A1 (en) | 2007-09-14 | 2010-06-16 | Corventis, Inc. | Adherent device with multiple physiological sensors |
WO2009040548A1 (en) | 2007-09-28 | 2009-04-02 | The Queen's University Of Belfast | Delivery device and method |
GB0719577D0 (en) * | 2007-10-08 | 2007-11-14 | Kirby Andrew J | Microimplant devices and methods of making and use thereof |
WO2009066763A1 (ja) | 2007-11-21 | 2009-05-28 | Bioserentach Co., Ltd. | 体表適用製剤、並びに、体表適用製剤保持シート |
MX2010006699A (es) * | 2007-12-17 | 2010-11-30 | New World Pharmaceuticals Llc | Sistema integrado de entrega, diagnostico y comunicacion intradermicos. |
GB0725018D0 (en) * | 2007-12-21 | 2008-01-30 | Univ Cardiff | Monitoring system for microneedle delivery |
WO2009105564A2 (en) * | 2008-02-19 | 2009-08-27 | Xvasive, Inc. | Acupuncture and acupressure therapies |
EP2100850A1 (en) | 2008-03-11 | 2009-09-16 | Stichting Voor De Technische Wetenschappen | Microneedle array and a method for manufacturing microneedles |
NL2001718C2 (nl) * | 2008-06-24 | 2009-12-28 | Needle Holding B V U | Micronaald, micronaaldarray en fabricagewerkwijze daarvoor. |
US8795259B2 (en) | 2008-08-01 | 2014-08-05 | Wisconsin Alumni Research Foundation | Drug delivery platform incorporating hydrogel pumping mechanism with guided fluid flow |
EP2320991B1 (en) * | 2008-08-21 | 2020-05-20 | Kibur Medical, Inc. | Device for drug evaluation and local treatment |
CN101347652B (zh) | 2008-09-09 | 2011-01-12 | 南京大学 | 一种空心微针阵列注射器的制备方法 |
JP5063544B2 (ja) * | 2008-09-22 | 2012-10-31 | 富士フイルム株式会社 | 経皮吸収シート及びその製造方法 |
US8731842B2 (en) | 2008-10-31 | 2014-05-20 | The Invention Science Fund I, Llc | Compositions and methods for biological remodeling with frozen particle compositions |
US8788211B2 (en) | 2008-10-31 | 2014-07-22 | The Invention Science Fund I, Llc | Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition |
US8798932B2 (en) | 2008-10-31 | 2014-08-05 | The Invention Science Fund I, Llc | Frozen compositions and methods for piercing a substrate |
US8793075B2 (en) | 2008-10-31 | 2014-07-29 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
WO2010071918A1 (en) * | 2008-12-22 | 2010-07-01 | The University Of Queensland | Patch production |
JP5709137B2 (ja) | 2009-02-23 | 2015-04-30 | 株式会社 メドレックス | 剣山型マイクロニードルのアプリケーター |
US8798722B2 (en) | 2009-02-27 | 2014-08-05 | Virginia Tech Intellectual Properties, Inc. | Fiber array for optical imaging and therapeutics |
KR101142730B1 (ko) * | 2009-03-16 | 2012-05-04 | 가천의과학대학교 산학협력단 | 상자성-이노시톨 포스페이트 복합체를 이용한 자기공명영상용 조영제 |
JP2010233673A (ja) * | 2009-03-30 | 2010-10-21 | Fujifilm Corp | 経皮吸収シート及びその製造方法 |
US9517023B2 (en) | 2009-06-01 | 2016-12-13 | Profusa, Inc. | Method and system for directing a localized biological response to an implant |
JP5615814B2 (ja) | 2009-06-10 | 2014-10-29 | 久光製薬株式会社 | マイクロニードルデバイス |
KR101213223B1 (ko) | 2009-07-07 | 2013-01-09 | 한국전자통신연구원 | 할로우를 가지는 미세 바늘 및 미세 바늘 구조체의 제조 방법 |
KR101686692B1 (ko) | 2009-07-23 | 2016-12-14 | 히사미쓰 세이야꾸 가부시키가이샤 | 마이크로니들 어레이 |
US8790259B2 (en) | 2009-10-22 | 2014-07-29 | Corventis, Inc. | Method and apparatus for remote detection and monitoring of functional chronotropic incompetence |
US8834423B2 (en) * | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
US8439896B2 (en) | 2009-11-13 | 2013-05-14 | The Invention Science Fund I, Llc | Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject |
US9078863B2 (en) | 2009-11-13 | 2015-07-14 | The Invention Science Fund I, Llc | Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject |
US8321012B2 (en) | 2009-12-22 | 2012-11-27 | The Invention Science Fund I, Llc | Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject |
EP2338557A1 (en) * | 2009-12-23 | 2011-06-29 | Debiotech S.A. | Soluble microneedle |
US8328757B2 (en) | 2010-01-08 | 2012-12-11 | Wisconsin Alumni Research Foundation | Bladder arrangement for microneedle-based drug delivery device |
USD619245S1 (en) | 2010-01-08 | 2010-07-06 | Ratio, Inc. | Drug delivery device |
USD638534S1 (en) | 2010-01-08 | 2011-05-24 | Ratio, Inc. | Drug delivery device |
JP2011224332A (ja) | 2010-03-29 | 2011-11-10 | Fujifilm Corp | 経皮吸収シート及びその製造方法 |
US8545741B2 (en) | 2010-04-01 | 2013-10-01 | Nurim Wellness Co. Ltd. | Method of manufacturing microstructure |
US9943673B2 (en) * | 2010-07-14 | 2018-04-17 | Vaxxas Pty Limited | Patch applying apparatus |
US8784373B2 (en) | 2010-09-02 | 2014-07-22 | California Institute Of Technology | Drug delivery by carbon nanotube arrays |
JP5770055B2 (ja) | 2010-09-29 | 2015-08-26 | 富士フイルム株式会社 | 針状アレイ経皮吸収シートの製造方法 |
US10933173B2 (en) | 2010-10-19 | 2021-03-02 | Trustees Of Tufts College | Silk fibroin-based microneedles and methods of making the same |
CN103201386A (zh) | 2010-11-09 | 2013-07-10 | 加利福尼亚大学董事会 | 皮肤穿透及细胞进入(space)肽及其使用方法 |
US8784383B2 (en) | 2010-11-30 | 2014-07-22 | Becton, Dickinson And Company | Insulin pump dermal infusion set having partially integrated mechanized cannula insertion with disposable activation portion |
US8795234B2 (en) | 2010-11-30 | 2014-08-05 | Becton, Dickinson And Company | Integrated spring-activated ballistic insertion for drug infusion device |
US8795230B2 (en) | 2010-11-30 | 2014-08-05 | Becton, Dickinson And Company | Adjustable height needle infusion device |
CN103384672B (zh) | 2011-02-25 | 2016-09-28 | 武田药品工业株式会社 | N-取代的噁嗪并喋啶和噁嗪并喋啶酮 |
US8696637B2 (en) | 2011-02-28 | 2014-04-15 | Kimberly-Clark Worldwide | Transdermal patch containing microneedles |
BR112013022955A2 (pt) * | 2011-03-07 | 2016-12-06 | 3M Innovative Properties Co | dispositivo e métodos de microagulha |
GB201107642D0 (en) * | 2011-05-09 | 2011-06-22 | Univ Cork | Method |
US8636696B2 (en) | 2011-06-10 | 2014-01-28 | Kimberly-Clark Worldwide, Inc. | Transdermal device containing microneedles |
WO2013002331A1 (ja) * | 2011-06-28 | 2013-01-03 | 株式会社バイオセレンタック | 皮膚治療用微細針集積型製剤 |
CN103301092B (zh) * | 2012-03-06 | 2014-12-03 | 中国科学院理化技术研究所 | 聚合物微针阵列芯片及其制备方法和应用 |
CA3077452C (en) | 2012-05-01 | 2022-08-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Tip-loaded microneedle arrays for transdermal insertion |
US9526884B2 (en) | 2012-11-16 | 2016-12-27 | City University Of Hong Kong | Mechanically robust fast-dissolving microneedles for transdermal drug and vaccine delivery |
-
2013
- 2013-05-01 CA CA3077452A patent/CA3077452C/en active Active
- 2013-05-01 IN IN10161DEN2014 patent/IN2014DN10161A/en unknown
- 2013-05-01 AU AU2013256348A patent/AU2013256348B2/en active Active
- 2013-05-01 EP EP13784192.0A patent/EP2841147A4/en not_active Ceased
- 2013-05-01 CN CN201380031604.6A patent/CN104703651A/zh active Pending
- 2013-05-01 EP EP22192026.7A patent/EP4112112A1/en active Pending
- 2013-05-01 CN CN202110125343.0A patent/CN112933391A/zh active Pending
- 2013-05-01 MX MX2014013234A patent/MX370579B/es active IP Right Grant
- 2013-05-01 JP JP2015510434A patent/JP2015515886A/ja active Pending
- 2013-05-01 BR BR112014027242A patent/BR112014027242A2/pt not_active Application Discontinuation
- 2013-05-01 WO PCT/US2013/039084 patent/WO2013166162A1/en active Application Filing
- 2013-05-01 CA CA2871770A patent/CA2871770C/en active Active
- 2013-05-01 US US14/398,375 patent/US9944019B2/en active Active
-
2015
- 2015-10-20 HK HK15110288.3A patent/HK1209658A1/xx unknown
-
2017
- 2017-04-11 JP JP2017078229A patent/JP6712963B2/ja active Active
- 2017-09-08 AU AU2017225155A patent/AU2017225155B2/en active Active
-
2018
- 2018-03-26 US US15/936,228 patent/US20180272621A1/en not_active Abandoned
- 2018-03-27 JP JP2018059652A patent/JP2018114321A/ja active Pending
-
2019
- 2019-09-04 AU AU2019226165A patent/AU2019226165A1/en not_active Abandoned
-
2020
- 2020-03-16 JP JP2020045714A patent/JP2020110626A/ja not_active Withdrawn
-
2021
- 2021-03-02 AU AU2021201365A patent/AU2021201365B2/en active Active
- 2021-09-13 JP JP2021148376A patent/JP2021191488A/ja active Pending
-
2022
- 2022-01-21 JP JP2022007864A patent/JP2022046821A/ja active Pending
- 2022-12-22 AU AU2022291555A patent/AU2022291555A1/en active Pending
-
2023
- 2023-03-08 US US18/119,197 patent/US20230311426A1/en active Pending
- 2023-10-10 JP JP2023175104A patent/JP2023175969A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX370579B (es) | Arreglos de microagujas cargadas en la punta para insercion transdermica. | |
HK1254835A1 (zh) | 葡萄糖攝取抑制劑 | |
ZA201503160B (en) | Agricultural row unit systems, methods and apparatus | |
EP2881785A4 (en) | NETWORK SUBSTRATE, METHOD FOR MANUFACTURING SAME, AND DISPLAY APPARATUS | |
EP2812344A4 (en) | SUBSTRATE, PEPTIDARRAYS AND METHOD | |
EP2900318A4 (en) | SYSTEMS, DEVICES AND METHODS FOR SELECTIVE LOCATION OF IMPLANTABLE DEVICES | |
EP2660651A4 (en) | MATRIX SUBSTRATE, METHOD FOR MANUFACTURING SAME, AND DISPLAY DEVICE | |
EP2702610A4 (en) | SEMICONDUCTOR DEVICE WITH SEVERAL LAYERS AND METHOD THEREFOR | |
EP3041048A4 (en) | NETWORK SUBSTRATE AND METHOD FOR MANUFACTURING SAME, AND DISPLAY DEVICE | |
MX2017005820A (es) | Arreglos de microagujas para aplicaciones en terapias para cancer. | |
EP2912987A4 (en) | INSERTION SYSTEM, INSERTION ASSISTING DEVICE, INSERTION SUPPORT METHOD, AND PROGRAM | |
ZA201704917B (en) | A plate-shaped structure, a reservoir and a method | |
EP2975642A4 (en) | ARRAY SUBSTRATE AND MANUFACTURING METHOD THEREFOR AND DISPLAY DEVICE | |
DK3211074T3 (da) | Lipasevarianter og polynukleotider, som koder for dem | |
IL233315A0 (en) | Integrated antenna, antenna array and method for using the antenna array | |
GB2548759B (en) | Array substrate, display panel, and manufacturing method for array substrate | |
EP2822030A4 (en) | MANUFACTURING METHOD FOR NETWORK SUBSTRATE, NETWORK SUBSTRATE, AND DISPLAY SCREEN | |
BR112014032838A2 (pt) | método , e aparelho. | |
GB201516801D0 (en) | Method, array and use thereof | |
EP2791966A4 (en) | MOLDING METHOD, EMBOSSING DEVICE AND ARTICLE MANUFACTURING METHOD THEREWITH | |
EP2993698A4 (en) | MATRIX SUBSTRATE AND METHOD FOR MANUFACTURING SAME, AND DISPLAY DEVICE COMPRISING THE MATRIX SUBSTRATE | |
EP2868648A4 (en) | (METH) ACRYLIC ACID MANUFACTURING METHOD AND RESIN METHOD FOR HYDROPHILIC RESIN | |
GB2533046B (en) | Active matrix display, scanning driven circuit and the method thereof | |
EP2919267A4 (en) | NETWORK SUBSTRATE, METHOD FOR MANUFACTURING THE SAME, AND DISPLAY DEVICE | |
EP2876609A4 (en) | SHAPE DATA GENERATION PROGRAM, SHAPE DATA GENERATION METHOD, AND SHAPE DATA GENERATION DEVICE |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |