MX353710B - Polipeptidos que tienen actividad de lisozima y polinucleotidos que los codifican. - Google Patents
Polipeptidos que tienen actividad de lisozima y polinucleotidos que los codifican.Info
- Publication number
- MX353710B MX353710B MX2014006216A MX2014006216A MX353710B MX 353710 B MX353710 B MX 353710B MX 2014006216 A MX2014006216 A MX 2014006216A MX 2014006216 A MX2014006216 A MX 2014006216A MX 353710 B MX353710 B MX 353710B
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptides
- polynucleotides encoding
- lysozyme activity
- encoding same
- relates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/184—Hormones
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/20—Shaping or working-up of animal feeding-stuffs by moulding, e.g. making cakes or briquettes
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/25—Shaping or working-up of animal feeding-stuffs by extrusion
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
- C11B1/102—Production of fats or fatty oils from raw materials by extracting in counter-current; utilisation of an equipment wherein the material is conveyed by a screw
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38636—Preparations containing enzymes, e.g. protease or amylase containing enzymes other than protease, amylase, lipase, cellulase, oxidase or reductase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/06—Lysis of microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Animal Husbandry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Insects & Arthropods (AREA)
- Marine Sciences & Fisheries (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
Abstract
La presente invención se refiere a polipéptidos aislados que tienen actividad de lisozima, y a polinucleótidos que codifican los polipéptidos. La invención además se refiere a construcciones de ácido nucleico, vectores y células hospederas que comprenden los polinucleótidos, al igual que a métodos para la producción y el uso de los polipéptidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11190690 | 2011-11-25 | ||
PCT/EP2012/073493 WO2013076259A2 (en) | 2011-11-25 | 2012-11-23 | Polypeptides having lysozyme activity and polynucleotides encoding same |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014006216A MX2014006216A (es) | 2014-08-21 |
MX353710B true MX353710B (es) | 2018-01-25 |
Family
ID=47226164
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014006216A MX353710B (es) | 2011-11-25 | 2012-11-23 | Polipeptidos que tienen actividad de lisozima y polinucleotidos que los codifican. |
MX2014006155A MX351916B (es) | 2011-11-25 | 2012-11-23 | Polipeptidos que tienen actividad de lisozima y polinucleotdos que los codifican. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014006155A MX351916B (es) | 2011-11-25 | 2012-11-23 | Polipeptidos que tienen actividad de lisozima y polinucleotdos que los codifican. |
Country Status (18)
Country | Link |
---|---|
US (7) | US9701952B2 (es) |
EP (2) | EP2782593B1 (es) |
JP (1) | JP6105615B2 (es) |
CN (2) | CN103957929B (es) |
AR (2) | AR088976A1 (es) |
AU (1) | AU2012342456B2 (es) |
BR (2) | BR112014012170A2 (es) |
CA (1) | CA2856593C (es) |
CL (1) | CL2014001317A1 (es) |
DK (1) | DK2782592T3 (es) |
ES (2) | ES2624531T3 (es) |
IN (1) | IN2014CN04586A (es) |
MX (2) | MX353710B (es) |
PE (1) | PE20151745A1 (es) |
PL (1) | PL2782592T3 (es) |
RU (1) | RU2619051C2 (es) |
WO (2) | WO2013076253A1 (es) |
ZA (1) | ZA201403761B (es) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
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BR112014012170A2 (pt) | 2011-11-25 | 2020-06-23 | Novozymes A/S | polipetídeo isolado, composição, aditivo de ração animal, uso de um polipetídeo, métodos de isolamento de dna de bastérias, e de produção de um poliptídeo, polinucleotídeo isolado, constructo de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, e, planta, parte de planta ou célula de planta |
MX2016012260A (es) * | 2014-03-28 | 2017-01-06 | Novozymes As | Resolubilizacion de cristales de proteina a bajo ph. |
US20160030528A1 (en) * | 2014-07-01 | 2016-02-04 | Vanderbilt University | Antimicrobial muramidase |
CA2958034A1 (en) | 2014-08-28 | 2016-03-03 | Renescience A/S | Solubilization of msw with blend enzymes |
EP3970506A1 (en) | 2015-07-02 | 2022-03-23 | Novozymes A/S | Animal feed compositions comprising gh25 lysozyme and ec 3.1.3.26 phytase and uses thereof |
AU2016288515B2 (en) * | 2015-07-02 | 2020-09-10 | Dsm Ip Assets B.V. | Methods of improving animal performance |
AU2016286612B2 (en) * | 2015-07-02 | 2021-01-28 | Novozymes A/S | Animal feed compositions and uses thereof |
WO2017064092A1 (en) * | 2015-10-13 | 2017-04-20 | Dsm Ip Assets B.V. | Feed additives for aquatic animals comprising essential oils and lysozyme |
WO2017094818A1 (ja) * | 2015-12-02 | 2017-06-08 | 日清オイリオグループ株式会社 | 被覆用油脂組成物 |
WO2017140807A1 (en) | 2016-02-16 | 2017-08-24 | Monaghan Mushrooms Group | Fungal polypeptides having lysozyme activity |
US11130800B2 (en) | 2016-05-20 | 2021-09-28 | Novobind Livestock Therapeutics Inc. | Antibodies against microorganisms and uses thereof |
CN105861468B (zh) * | 2016-06-07 | 2019-12-06 | 江南大学 | 一种n端融合hlh功能域提高猪溶菌酶抗菌性能的方法 |
CN106046173B (zh) * | 2016-06-07 | 2019-05-10 | 江南大学 | 一种n端融合多聚六肽提高猪溶菌酶抗菌性能的方法 |
CN106701373A (zh) * | 2016-12-11 | 2017-05-24 | 深圳市美益洁生物科技有限公司 | 茶具生物酶除菌清洗剂及其制备方法和应用 |
US11896033B2 (en) | 2016-12-21 | 2024-02-13 | Novozymes A/S | Polypeptides having lysozyme activity, polynucleotides encoding same and uses and compositions thereof |
US10986850B2 (en) | 2016-12-21 | 2021-04-27 | Novozymes A/S | Polypeptides having lysozyme activity, polynucleotides encoding same and uses and compositions thereof |
BR112019013574A2 (pt) * | 2017-01-04 | 2020-06-23 | Novozymes A/S | Lisozima microbiana ou uma composição, método de prevenção, alívio ou tratamento da síndrome do intestino irritável ou doença inflamatória intestinal, e, método de melhora da saúde intestinal em seres humanos. |
US20200109388A1 (en) | 2017-04-03 | 2020-04-09 | Novozymes A/S | Recovery Process |
EP3621452A1 (en) | 2017-05-09 | 2020-03-18 | Novozymes A/S | Animal chew toy with dental care composition |
BR112019023329A2 (pt) * | 2017-05-12 | 2020-06-16 | Novozymes A/S | Composição, grânulo, aditivo de ração animal, ração animal, formulação líquida, métodos para aprimorar um ou mais parâmetros de desempenho de um animal, para preparar uma ração animal e para produzir o polipeptídeo, uso da composição, polipeptídeo isolado, polinucleotídeo, construto ou vetor de expressão de ácido nucleico, e, célula hospedeira recombinante |
US11554190B2 (en) | 2017-08-18 | 2023-01-17 | President And Fellows Of Harvard College | Nanocarriers for the delivery of active ingredients |
CA3074655A1 (en) * | 2017-09-05 | 2019-03-14 | Adaptive Phage Therapeutics, Inc. | Methods to determine the sensitivity profile of a bacterial strain to a therapeutic composition |
CN108251440B (zh) * | 2017-12-18 | 2021-04-13 | 宁波大学 | 缢蛏溶菌酶基因、编码蛋白及重组缢蛏溶菌酶基因工程菌的构建方法和应用 |
BR112020012498A2 (pt) * | 2017-12-20 | 2020-11-24 | Dsm Ip Assets B.V. | composições de ração animal e usos das mesmas |
WO2019121938A1 (en) | 2017-12-20 | 2019-06-27 | Dsm Ip Assets B.V. | Animal feed compositions comprising muramidase and uses thereof |
CN110115776A (zh) * | 2018-02-07 | 2019-08-13 | 沈阳药科大学 | 一种具有抗菌活性的可吸收淀粉微球止血粉及其应用 |
BR112020018166A2 (pt) | 2018-03-05 | 2021-02-02 | Novozymes A/S | composição de ração para ruminantes compreendendo uma muramidase |
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WO2020053276A1 (en) | 2018-09-11 | 2020-03-19 | Dsm Ip Assets B.V. | Animal feed composition and use thereof |
BR112021004688A2 (pt) * | 2018-09-11 | 2021-06-22 | Novozymes A/S | grânulos estáveis para composições de rações |
AU2019339736A1 (en) | 2018-09-11 | 2021-03-04 | Dsm Ip Assets B.V. | Animal feed composition and use thereof |
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AU2019339615A1 (en) | 2018-09-11 | 2021-03-04 | Dsm Ip Assets B.V. | Animal feed composition comprising muramidase and use thereof |
US20220046954A1 (en) | 2018-09-11 | 2022-02-17 | Dsm Ip Assets B.V. | Animal feed composition and use thereof |
CA3108945A1 (en) | 2018-09-17 | 2020-03-26 | Dsm Ip Assets B.V. | Animal feed composition and use thereof |
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US20220054600A1 (en) | 2018-09-17 | 2022-02-24 | Dsm Ip Assets B.V. | Animal feed compositions and uses thereof |
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FI3898985T3 (fi) * | 2018-12-21 | 2023-05-05 | Novozymes As | Proteiinien tandemekspressio |
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MX2021015818A (es) * | 2019-08-06 | 2022-02-03 | Novozymes As | Proteinas de fusion para mejorar la expresion de enzimas. |
WO2021074287A1 (en) * | 2019-10-17 | 2021-04-22 | Dsm Ip Assets B.V. | Animal feed compositions and uses thereof |
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CN111378635B (zh) * | 2020-05-29 | 2020-10-16 | 中国农业科学院北京畜牧兽医研究所 | 一种共表达溶菌酶和木聚糖酶的方法、及制备作为替代抗生素的饲料添加剂的方法 |
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2017
- 2017-04-24 US US15/495,031 patent/US10039300B2/en active Active
- 2017-05-26 US US15/606,031 patent/US10119130B2/en active Active
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2018
- 2018-06-29 US US16/023,129 patent/US10829750B2/en active Active
- 2018-09-24 AR ARP180102743A patent/AR113177A2/es unknown
- 2018-09-25 US US16/140,941 patent/US10829751B2/en active Active
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2020
- 2020-08-20 US US16/998,066 patent/US20200399625A1/en not_active Abandoned
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