MX352641B - Vacuna contra pcv2 basada en peptidos de diseño. - Google Patents
Vacuna contra pcv2 basada en peptidos de diseño.Info
- Publication number
- MX352641B MX352641B MX2013000316A MX2013000316A MX352641B MX 352641 B MX352641 B MX 352641B MX 2013000316 A MX2013000316 A MX 2013000316A MX 2013000316 A MX2013000316 A MX 2013000316A MX 352641 B MX352641 B MX 352641B
- Authority
- MX
- Mexico
- Prior art keywords
- pcv2
- peptide antigen
- vaccine
- pcv2 vaccine
- amino acid
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a composiciones de vacunas de circovirus porcino (PCV2) que comprenden un antígeno peptídico derivado de una proteína de la cápside de PCV2. En diversas modalidades, el antígeno peptídico contiene aminoácidos de la proteína de la cápside de aproximadamente el aminoácido 47 a aproximadamente el aminoácido 202. En algunas modalidades, el antígeno peptídico se enlaza opcionalmente a un epítopo de célula T cooperadora artificial y/o se mezcla con epítopos de célula T cooperadora derivados de las proteínas del ORF1 y ORF3 del PCV2. Los métodos para utilizar composiciones de vacunas de PCV2 también se describen. En diversas modalidades, una composición de vacuna se utiliza en animales para la prevención de la infección por PCV2. En otras modalidades, una composición de vacuna de PCV2 se utiliza como antígeno para diagnosticar la infección por PCV2.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2010/041406 WO2012005732A1 (en) | 2010-07-08 | 2010-07-08 | Designer peptide-based pcv2 vaccine |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013000316A MX2013000316A (es) | 2013-02-26 |
MX352641B true MX352641B (es) | 2017-12-01 |
Family
ID=45441469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013000316A MX352641B (es) | 2010-07-08 | 2010-07-08 | Vacuna contra pcv2 basada en peptidos de diseño. |
Country Status (11)
Country | Link |
---|---|
US (1) | US9932372B2 (es) |
EP (1) | EP2590673A4 (es) |
JP (1) | JP5902160B2 (es) |
KR (1) | KR101675185B1 (es) |
CN (1) | CN103108653B (es) |
AU (2) | AU2010357208A1 (es) |
BR (1) | BR112013001231A2 (es) |
CA (1) | CA2804604C (es) |
MX (1) | MX352641B (es) |
TW (1) | TWI508740B (es) |
WO (1) | WO2012005732A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101675185B1 (ko) * | 2010-07-08 | 2016-11-10 | 유나이티드 바이오메디칼 인크. | 디자이너(designer) 펩티드-기반 pcv2 백신 |
KR20220083861A (ko) | 2013-10-02 | 2022-06-20 | 베링거 인겔하임 애니멀 헬스 유에스에이 인크. | Pcv2 orf2 단백질 변이체 및 이로 이루어진 바이러스 유사 입자 |
CN103805573A (zh) * | 2013-12-31 | 2014-05-21 | 广东大华农动物保健品股份有限公司 | 一种重组腺病毒rAd-ORF2-TCE及其应用 |
EP3277315A2 (en) | 2015-03-30 | 2018-02-07 | Boehringer Ingelheim Vetmedica, Inc. | Pcv2 orf2 carrier platform |
CN105175550B (zh) * | 2015-07-01 | 2019-04-02 | 重庆市格晟生物技术有限责任公司 | 一种抗猪圆环病毒合成肽疫苗及其用途 |
CN105175551B (zh) * | 2015-07-01 | 2019-04-02 | 重庆市格晟生物技术有限责任公司 | 一种抗伪狂犬病毒合成肽疫苗及其用途 |
CN105175552B (zh) * | 2015-07-01 | 2019-04-02 | 重庆市格晟生物技术有限责任公司 | 一种刺激滤泡辅助型cd4t细胞应答的表位组合及其用途 |
CN105004856A (zh) * | 2015-07-10 | 2015-10-28 | 青岛易邦生物工程有限公司 | 猪圆环病毒2型抗体检测elisa试剂盒 |
CN105541976B (zh) * | 2015-12-25 | 2019-07-09 | 华南农业大学 | 猪圆环病毒2型Cap基因修饰改造重组抗原及其应用 |
CN107190012A (zh) * | 2016-03-14 | 2017-09-22 | 苏州派动生物技术有限公司 | 重组改构猪圆环病毒衣壳蛋白 |
CN110144001B (zh) * | 2016-08-29 | 2021-02-09 | 中牧实业股份有限公司 | 制备猪圆环合成肽疫苗的抗原多肽及应用 |
CN107056897B (zh) * | 2017-01-22 | 2020-08-25 | 中牧实业股份有限公司 | 猪圆环合成肽疫苗及其制备方法和应用 |
EP4007601A4 (en) * | 2019-07-26 | 2023-08-09 | NDSU Research Foundation | PORCINE CIRCOVIRUS TYPE 2 (PCV2) VACCINE |
CN112010949B (zh) * | 2020-08-03 | 2021-07-27 | 山东绿都生物科技有限公司 | 一种重组pcv2病毒样颗粒蜂胶疫苗及其制备方法 |
CN114805501B (zh) * | 2022-03-24 | 2024-06-25 | 中牧实业股份有限公司 | 一种猪圆环病毒2型抗原组合物及其在抗原定量方法中的应用 |
CN115947794A (zh) * | 2022-07-19 | 2023-04-11 | 沈阳农业大学 | 一种pcv2 orf3特异性多肽及应用 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
US6410022B1 (en) | 1995-05-01 | 2002-06-25 | Avant Immunotherapeutics, Inc. | Modulation of cholesteryl ester transfer protein (CETP) activity |
DE69837934T2 (de) * | 1997-12-11 | 2008-02-21 | University Of Saskatchewan, Saskatoon | Multisystemisches kümmerwuchssyndrom durch viren in schweinen |
US6107021A (en) | 1998-06-20 | 2000-08-22 | United Biomedical, Inc. | Synthetic peptide vaccines for foot-and-mouth disease |
TWI229679B (en) * | 1998-06-20 | 2005-03-21 | United Biomedical Inc | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens |
US6025468A (en) | 1998-06-20 | 2000-02-15 | United Biomedical, Inc. | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
CN1137727C (zh) | 1998-06-25 | 2004-02-11 | 四川远大蜀阳药业有限公司 | 无保护剂双重病毒灭活制备静注免疫球蛋白工艺 |
US6906169B2 (en) | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
US7279166B2 (en) | 2001-12-12 | 2007-10-09 | Virginia Tech Intellectual Properties, Inc. | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof |
US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
WO2005009462A2 (en) * | 2003-07-24 | 2005-02-03 | Merial Limited | Vaccine formulations comprising an oil-in-water emulsion |
CN1602962A (zh) | 2004-08-04 | 2005-04-06 | 任兆钧 | ***全病毒基因工程疫苗及其制备方法 |
US7833707B2 (en) | 2004-12-30 | 2010-11-16 | Boehringer Ingelheim Vetmedica, Inc. | Methods of overexpression and recovery of porcine circovirus type 2 ORF2 |
AU2006289102C1 (en) | 2005-09-09 | 2017-11-30 | Intervet International B.V. | PCV-2 vaccine |
PL2371382T3 (pl) | 2005-12-29 | 2016-08-31 | Boehringer Ingelheim Vetmedica Inc | Zastosowanie kompozycji immunogennej PCV2 do zmniejszania objawów klinicznych u świń |
US20100129397A1 (en) | 2006-12-11 | 2010-05-27 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
MX2009006066A (es) * | 2006-12-15 | 2009-06-17 | Boehringer Ingelheim Vetmed | Tratamiento de cerdos con el antigeno pcv. |
EP1958644A1 (en) * | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
GB0712160D0 (en) * | 2007-06-22 | 2007-08-01 | Univ Ghent | Methods and compositions in the treatment of procine circoviral infection |
US20090017064A1 (en) * | 2007-07-10 | 2009-01-15 | Wyeth | Methods and Compositions for Immunizing Pigs Against Porcine Circovirus |
FR2922767B1 (fr) * | 2007-10-24 | 2009-12-18 | Seppic Sa | Procede de preparation d'une composition vaccinale comprenant au moins un antigene et au moins un adjuvant. |
BRPI0821286A8 (pt) * | 2007-12-21 | 2017-08-15 | Wyeth Llc | Métodos e composições para imunizar porcos contra circovirus suino |
KR101675185B1 (ko) * | 2010-07-08 | 2016-11-10 | 유나이티드 바이오메디칼 인크. | 디자이너(designer) 펩티드-기반 pcv2 백신 |
-
2010
- 2010-07-08 KR KR1020137003210A patent/KR101675185B1/ko active IP Right Grant
- 2010-07-08 EP EP10854531.0A patent/EP2590673A4/en active Pending
- 2010-07-08 AU AU2010357208A patent/AU2010357208A1/en not_active Abandoned
- 2010-07-08 WO PCT/US2010/041406 patent/WO2012005732A1/en active Application Filing
- 2010-07-08 CN CN201080068977.7A patent/CN103108653B/zh active Active
- 2010-07-08 MX MX2013000316A patent/MX352641B/es active IP Right Grant
- 2010-07-08 JP JP2013518361A patent/JP5902160B2/ja not_active Expired - Fee Related
- 2010-07-08 BR BR112013001231A patent/BR112013001231A2/pt not_active Application Discontinuation
- 2010-07-08 US US13/808,974 patent/US9932372B2/en active Active
- 2010-07-08 CA CA2804604A patent/CA2804604C/en active Active
-
2011
- 2011-07-04 TW TW100123478A patent/TWI508740B/zh active
-
2016
- 2016-08-29 AU AU2016219738A patent/AU2016219738B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2013531673A (ja) | 2013-08-08 |
AU2016219738B2 (en) | 2018-07-05 |
EP2590673A4 (en) | 2016-03-30 |
CN103108653A (zh) | 2013-05-15 |
AU2010357208A1 (en) | 2013-02-21 |
CN103108653B (zh) | 2015-07-22 |
BR112013001231A2 (pt) | 2016-06-07 |
US9932372B2 (en) | 2018-04-03 |
JP5902160B2 (ja) | 2016-04-13 |
WO2012005732A1 (en) | 2012-01-12 |
KR101675185B1 (ko) | 2016-11-10 |
CA2804604C (en) | 2023-10-03 |
CA2804604A1 (en) | 2012-01-12 |
TW201201833A (en) | 2012-01-16 |
US20130236487A1 (en) | 2013-09-12 |
AU2016219738A1 (en) | 2016-09-15 |
EP2590673A1 (en) | 2013-05-15 |
KR20130041185A (ko) | 2013-04-24 |
MX2013000316A (es) | 2013-02-26 |
TWI508740B (zh) | 2015-11-21 |
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