EA201071365A1 - Моноклональные антитела, имеющие гомоподтип кросс-нейтрализующих свойств против вируса гриппа а подтипа н1 - Google Patents
Моноклональные антитела, имеющие гомоподтип кросс-нейтрализующих свойств против вируса гриппа а подтипа н1Info
- Publication number
- EA201071365A1 EA201071365A1 EA201071365A EA201071365A EA201071365A1 EA 201071365 A1 EA201071365 A1 EA 201071365A1 EA 201071365 A EA201071365 A EA 201071365A EA 201071365 A EA201071365 A EA 201071365A EA 201071365 A1 EA201071365 A1 EA 201071365A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- monoclonal antibody
- influenza
- virus
- homopodype
- cross
- Prior art date
Links
- 241000712461 unidentified influenza virus Species 0.000 title 1
- 241000712431 Influenza A virus Species 0.000 abstract 3
- 101710154606 Hemagglutinin Proteins 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 abstract 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 abstract 2
- 101710176177 Protein A56 Proteins 0.000 abstract 2
- 239000000185 hemagglutinin Substances 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Описано моноклональное антитело, направленное против вируса гриппа А, которое способно связывать человеческие и животные изоляты вируса гриппа А, экспрессирующие гемагглютинин подтипа HI. Предпочтительным вариантом осуществления является антитело, названное Fab49, которое демонстрирует нейтрализующую активность против множества изолятов вируса гриппа А, экспрессирующих гемагглютинин подтипа HI, включая изоляты, полученные из животных. Кроме того, описаны антиидиотипические антитела, направленные против моноклонального антитела по изобретению, иммуногенные или вакцинные композиции, содержащие моноклональное антитело по изобретению, а также терапевтическое, профилактическое и диагностическое применение моноклонального антитела по изобретению. Моноклональное антитело по изобретению может также быть использовано для тестирования препаратов антител для применения в качестве вакцин.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000398A ITTO20080398A1 (it) | 2008-05-27 | 2008-05-27 | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
PCT/IB2009/052212 WO2009144667A1 (en) | 2008-05-27 | 2009-05-27 | Monoclonal antibodies having homosubtype cross -neutralization properties against influenza a viruses subtype h1 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201071365A1 true EA201071365A1 (ru) | 2011-08-30 |
EA022855B1 EA022855B1 (ru) | 2016-03-31 |
Family
ID=40303127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201071365A EA022855B1 (ru) | 2008-05-27 | 2009-05-27 | Моноклональные антитела, имеющие гомоподтип кросс-нейтрализующих свойств против вируса гриппа а подтипа н1 |
Country Status (17)
Country | Link |
---|---|
US (1) | US9243054B2 (ru) |
EP (1) | EP2294084B2 (ru) |
JP (1) | JP5792060B2 (ru) |
KR (1) | KR101665146B1 (ru) |
CN (1) | CN102124028B (ru) |
AU (1) | AU2009252758B2 (ru) |
BR (1) | BRPI0912285A2 (ru) |
CA (1) | CA2725627C (ru) |
EA (1) | EA022855B1 (ru) |
ES (1) | ES2555486T5 (ru) |
IL (1) | IL209499A (ru) |
IT (1) | ITTO20080398A1 (ru) |
MX (1) | MX2010012974A (ru) |
NZ (1) | NZ590115A (ru) |
SG (1) | SG191610A1 (ru) |
WO (1) | WO2009144667A1 (ru) |
ZA (1) | ZA201009273B (ru) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITTO20070066A1 (it) | 2007-01-30 | 2008-07-31 | Pomona Biotechnologies Llc | Anticorpi monoclonali anti-idiotipo mimotopi dell'antigene gp 120 di hiv |
ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
ITTO20080964A1 (it) | 2008-12-22 | 2010-06-23 | Natimab Therapeutics S R L | Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv |
IT1395961B1 (it) * | 2009-06-01 | 2012-11-02 | Pomona Biotechnologies Llc | Anticorpi monoclonali come medicamento per il trattamento terapeutico e/o profilattico delle infezioni da virus influenzale a (h1n1) di origine suina (s-oiv) |
ITTO20110067A1 (it) * | 2011-01-26 | 2012-07-27 | Pomona Ricerca Srl | Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale |
WO2011117848A1 (en) * | 2010-03-26 | 2011-09-29 | Pomona Ricerca S.R.L. | Full-length immunoglobulins of the igg isotvpe capable of recognizing a heterosubtvpe neutralizing epitope on the hemagglutinin stem region and their use as anti-influenza medicament |
CN102241768B (zh) * | 2010-05-14 | 2013-12-25 | 中国科学院上海生命科学研究院 | 一种抗甲型h1n1流感病毒血凝素蛋白的抗体 |
CA2807664A1 (en) * | 2010-08-12 | 2012-02-16 | Theraclone Sciences, Inc. | Anti-hemagglutinin antibody compositions and methods of use thereof |
CN101988050B (zh) * | 2010-12-09 | 2012-06-27 | 湖南出入境检验检疫局检验检疫技术中心 | 抗h1n1猪流感病毒血凝素蛋白单克隆抗体,杂交瘤细胞株及抗原捕获elisa试剂盒 |
RU2457243C1 (ru) * | 2011-01-11 | 2012-07-27 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт вирусологии им. Д.И. Ивановского" Министерства здравоохранения и социального развития Российской Федерации | ШТАММ ГИБРИДНЫХ КУЛЬТИВИРУЕМЫХ КЛЕТОК МЫШИ Mus. Musculus - 1E7, ПРОДУЦИРУЮЩИЙ МОНОКЛОНАЛЬНОЕ АНТИТЕЛО, ИММУНОРЕАКТИВНОЕ С БЕЛКОМ ГЕМАГГЛЮТИНИНА ПАНДЕМИЧЕСКОГО ВИРУСА ГРИППА А/IIV-Moscow/01/09(H1N1)sw1 |
US20140031418A1 (en) | 2011-04-20 | 2014-01-30 | The Trustees Of The University Of Pennsylvania | Regimens and Compositions for AAV-Mediated Passive Immunization of Airborne Pathogens |
WO2013119793A1 (en) * | 2012-02-07 | 2013-08-15 | University Of Kansas | Chemiluminescent nanoparticles and uses thereof |
US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
CN113667012B (zh) | 2013-10-02 | 2024-07-12 | 免疫医疗有限责任公司 | 中和抗甲型流感抗体及其用途 |
KR101628331B1 (ko) * | 2014-03-28 | 2016-06-08 | 주식회사 녹십자엠에스 | 인플루엔자 a 바이러스 특이적 단클론 항체 및 이를 이용한 인플루엔자 감염 치료 및 진단 방법 |
PE20170261A1 (es) | 2014-05-13 | 2017-04-12 | Univ Pennsylvania | Composiciones que comprenden virus adenoasociado (aav) que expresa constructos de anticuerpos duales y sus usos |
WO2016011035A2 (en) | 2014-07-15 | 2016-01-21 | Medlmmune, Llc | Neutralizing anti-influenza b antibodies and uses thereof |
TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
MA48852A (fr) | 2015-05-13 | 2020-04-01 | Univ Pennsylvania | Expression médiée par aav d'anticorps anti-grippaux et leurs procédés d'utilisation |
RS62446B1 (sr) | 2015-06-01 | 2021-11-30 | Medimmune Llc | Neutrališući vezujući molekuli protiv gripa i njihova primena |
EP3374390A1 (en) | 2015-11-13 | 2018-09-19 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
EP3402513A4 (en) | 2016-01-13 | 2019-10-23 | Medlmmune, LLC | METHOD OF TREATING A FLU |
KR20190132639A (ko) | 2017-02-28 | 2019-11-28 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 아데노-연관 바이러스(aav) 클레이드 f 벡터 및 이의 용도 |
TW201837170A (zh) | 2017-02-28 | 2018-10-16 | 賓州大學委員會 | 新穎aav媒介的流感疫苗 |
JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
KR101972238B1 (ko) * | 2017-11-22 | 2019-04-24 | 한국생명공학연구원 | 인플루엔자 a 바이러스 특이적 항체 또는 그의 항원 결합 단편 |
JP2022521819A (ja) | 2019-03-25 | 2022-04-12 | ビステラ, インコーポレイテッド | インフルエンザを処置および予防するための組成物および方法 |
IL303236A (en) | 2020-12-01 | 2023-07-01 | Univ Pennsylvania | New compounds with specific tissue-targeting motifs and preparations containing them |
IL308404A (en) | 2021-04-27 | 2024-01-01 | Generation Bio Co | Non-viral DNA vectors expressing therapeutic antibodies and uses thereof |
WO2023177655A1 (en) | 2022-03-14 | 2023-09-21 | Generation Bio Co. | Heterologous prime boost vaccine compositions and methods of use |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA836080B (en) | 1982-08-23 | 1984-04-25 | Scripps Clinic Res | Broad spectrum influenza antisera |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US6812024B2 (en) * | 1987-03-16 | 2004-11-02 | Mcgready Roland Keith | Anti-paratopic antibody as an immunogen |
US5245015A (en) | 1991-04-26 | 1993-09-14 | Tanox Biosystems, Inc. | Monoclonal antibodies which neutralize HIV-1 through reaction with a conformational epitope in vitro |
WO1992015885A1 (en) | 1991-03-11 | 1992-09-17 | Idec Pharmaceuticals Corporation | Methods for selecting antibody reagents; anti-idiotype antibodies; and aids vaccine formulations |
WO1993017694A1 (en) * | 1992-03-09 | 1993-09-16 | San Diego Regional Cancer Center | An anti-idiotypic antibody and its use in diagnosis and in therapy in hiv-related disease |
EP0621339B1 (en) | 1992-09-17 | 2001-10-24 | Takara Shuzo Co. Ltd. | Immunogenic human influenza A virus haemagglutinin polypeptides |
JP3061960B2 (ja) * | 1992-09-17 | 2000-07-10 | 寳酒造株式会社 | 抗ヒトインフルエンザウイルス抗体 |
GB9221654D0 (en) | 1992-10-15 | 1992-11-25 | Scotgen Ltd | Recombinant human anti-cytomegalovirus antibodies |
JP2996864B2 (ja) * | 1994-03-30 | 2000-01-11 | 寳酒造株式会社 | 抗体可変領域dna |
US6057421A (en) * | 1994-11-30 | 2000-05-02 | Immpheron, Inc. | Variable heavy and light chain regions of murine monoclonal antibody 1F7 |
WO2000005266A1 (en) | 1998-07-21 | 2000-02-03 | Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh | Anti hepatitis c virus antibody and uses thereof |
AU2002243259B2 (en) | 2000-12-01 | 2008-02-07 | The Government Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Monoclonal antibodies specific for the E2 glycoprotein of hepatitis C virus and their use in the diagnosis, treatment, and prevention of hepatitis C |
FR2817869B1 (fr) | 2000-12-07 | 2005-01-14 | Technopharm | Anticorps monoclonal humain dirige contre le virus influenza ou un fragment de celui-ci |
US6768004B2 (en) * | 2001-01-11 | 2004-07-27 | Mueller Sybille | Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies |
US6964199B2 (en) * | 2001-11-02 | 2005-11-15 | Cantocor, Inc. | Methods and compositions for enhanced protein expression and/or growth of cultured cells using co-transcription of a Bcl2 encoding nucleic acid |
CA2473163C (en) * | 2002-01-17 | 2011-12-06 | Polymun Scientific Immunbiologische Forschung Gmbh | Anti-idiotypic antibody inducing hiv-1 neutralizing antibodies |
ITRM20020049A1 (it) | 2002-01-30 | 2003-07-30 | Biostrands S R L | Frammenti fab di anticorpi monoclonali umani diretti contro la glicoproteina e2 di hcv e dotati di potere neutralizzante in vitro. |
EP2522678A1 (en) | 2006-05-15 | 2012-11-14 | Sea Lane Biotechnologies, LLC | Neutralizing antibodies to influenza viruses |
WO2008028946A2 (en) † | 2006-09-07 | 2008-03-13 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof |
WO2008033159A1 (en) | 2006-09-15 | 2008-03-20 | Fraunhofer Usa, Inc. | Influenza antibodies, compositions, and related methods |
ITTO20070066A1 (it) | 2007-01-30 | 2008-07-31 | Pomona Biotechnologies Llc | Anticorpi monoclonali anti-idiotipo mimotopi dell'antigene gp 120 di hiv |
US20100316563A1 (en) | 2007-09-20 | 2010-12-16 | Bracco Imaging S.P.A. | Method For The Preparation Of New Oligoclonal Antibodies |
ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
ITTO20080964A1 (it) | 2008-12-22 | 2010-06-23 | Natimab Therapeutics S R L | Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv |
IT1395961B1 (it) | 2009-06-01 | 2012-11-02 | Pomona Biotechnologies Llc | Anticorpi monoclonali come medicamento per il trattamento terapeutico e/o profilattico delle infezioni da virus influenzale a (h1n1) di origine suina (s-oiv) |
WO2011117848A1 (en) | 2010-03-26 | 2011-09-29 | Pomona Ricerca S.R.L. | Full-length immunoglobulins of the igg isotvpe capable of recognizing a heterosubtvpe neutralizing epitope on the hemagglutinin stem region and their use as anti-influenza medicament |
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2008
- 2008-05-27 IT IT000398A patent/ITTO20080398A1/it unknown
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2009
- 2009-05-27 US US12/994,746 patent/US9243054B2/en active Active
- 2009-05-27 JP JP2011511147A patent/JP5792060B2/ja active Active
- 2009-05-27 CA CA2725627A patent/CA2725627C/en active Active
- 2009-05-27 BR BRPI0912285A patent/BRPI0912285A2/pt not_active Application Discontinuation
- 2009-05-27 MX MX2010012974A patent/MX2010012974A/es active IP Right Grant
- 2009-05-27 ES ES09754293T patent/ES2555486T5/es active Active
- 2009-05-27 AU AU2009252758A patent/AU2009252758B2/en not_active Ceased
- 2009-05-27 SG SG2013040647A patent/SG191610A1/en unknown
- 2009-05-27 WO PCT/IB2009/052212 patent/WO2009144667A1/en active Application Filing
- 2009-05-27 EA EA201071365A patent/EA022855B1/ru not_active IP Right Cessation
- 2009-05-27 NZ NZ590115A patent/NZ590115A/xx not_active IP Right Cessation
- 2009-05-27 CN CN200980130479.8A patent/CN102124028B/zh active Active
- 2009-05-27 KR KR1020107029309A patent/KR101665146B1/ko active IP Right Grant
- 2009-05-27 EP EP09754293.0A patent/EP2294084B2/en active Active
-
2010
- 2010-11-22 IL IL209499A patent/IL209499A/en active IP Right Grant
- 2010-12-23 ZA ZA2010/09273A patent/ZA201009273B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2725627A1 (en) | 2009-12-03 |
WO2009144667A1 (en) | 2009-12-03 |
ES2555486T3 (es) | 2016-01-04 |
MX2010012974A (es) | 2011-01-21 |
US20110076265A1 (en) | 2011-03-31 |
EP2294084A1 (en) | 2011-03-16 |
US9243054B2 (en) | 2016-01-26 |
ZA201009273B (en) | 2012-05-01 |
ES2555486T5 (es) | 2019-02-15 |
ITTO20080398A1 (it) | 2009-11-28 |
JP2011524161A (ja) | 2011-09-01 |
CN102124028A (zh) | 2011-07-13 |
IL209499A (en) | 2016-10-31 |
IL209499A0 (en) | 2011-01-31 |
AU2009252758A1 (en) | 2009-12-03 |
AU2009252758B2 (en) | 2014-07-31 |
CN102124028B (zh) | 2015-05-20 |
NZ590115A (en) | 2012-08-31 |
CA2725627C (en) | 2019-08-06 |
EP2294084B1 (en) | 2015-09-09 |
BRPI0912285A2 (pt) | 2015-10-20 |
EP2294084B2 (en) | 2018-09-05 |
EA022855B1 (ru) | 2016-03-31 |
KR20110020865A (ko) | 2011-03-03 |
KR101665146B1 (ko) | 2016-10-11 |
JP5792060B2 (ja) | 2015-10-07 |
SG191610A1 (en) | 2013-07-31 |
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