MX351104B - Nuevos glucosaminoglucanos con baja actividad anticoagulante. - Google Patents
Nuevos glucosaminoglucanos con baja actividad anticoagulante.Info
- Publication number
- MX351104B MX351104B MX2014007122A MX2014007122A MX351104B MX 351104 B MX351104 B MX 351104B MX 2014007122 A MX2014007122 A MX 2014007122A MX 2014007122 A MX2014007122 A MX 2014007122A MX 351104 B MX351104 B MX 351104B
- Authority
- MX
- Mexico
- Prior art keywords
- coagulative
- glycosaminoglycans
- medical use
- disaccharide unit
- repeating disaccharide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a un glucosaminoglucano químicamente modificado con una actividad antifactor II de menos de 10 UI/mg, una actividad antifactor Xa de menos de 10 UI/mg y un peso molecular promedio (promedio en peso, Mw) de desde aproximadamente 4,6 hasta 6,9 kDa. También se divulga un procedimiento de preparación del glucosaminoglucano modificado y sus usos médicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161577223P | 2011-12-19 | 2011-12-19 | |
PCT/SE2012/051433 WO2013095279A1 (en) | 2011-12-19 | 2012-12-19 | Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014007122A MX2014007122A (es) | 2015-03-05 |
MX351104B true MX351104B (es) | 2017-10-02 |
Family
ID=48668970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014007122A MX351104B (es) | 2011-12-19 | 2012-12-19 | Nuevos glucosaminoglucanos con baja actividad anticoagulante. |
Country Status (28)
Country | Link |
---|---|
US (1) | US9475888B2 (es) |
EP (1) | EP2794665B1 (es) |
JP (2) | JP6543467B2 (es) |
KR (1) | KR102135485B1 (es) |
CN (1) | CN104144950B (es) |
AU (1) | AU2012354229B2 (es) |
BR (1) | BR112014014454B1 (es) |
CA (1) | CA2856492C (es) |
CL (1) | CL2014001651A1 (es) |
CO (1) | CO7061069A2 (es) |
CY (1) | CY1119899T1 (es) |
DK (1) | DK2794665T3 (es) |
ES (1) | ES2656613T3 (es) |
HK (1) | HK1202883A1 (es) |
HR (1) | HRP20180124T1 (es) |
HU (1) | HUE036523T2 (es) |
IL (1) | IL232905A (es) |
LT (1) | LT2794665T (es) |
ME (1) | ME02994B (es) |
MX (1) | MX351104B (es) |
NO (1) | NO2904345T3 (es) |
PL (1) | PL2794665T3 (es) |
PT (1) | PT2794665T (es) |
RS (1) | RS56874B1 (es) |
RU (1) | RU2617764C2 (es) |
SI (1) | SI2794665T1 (es) |
WO (1) | WO2013095279A1 (es) |
ZA (1) | ZA201403640B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
MX2014011451A (es) * | 2012-03-26 | 2014-11-10 | Dilafor Ab | Procedimiento de tratamiento de la interrupcion del parto. |
WO2013147689A1 (en) * | 2012-03-26 | 2013-10-03 | Dilafor Ab | Combination treatment comprising sulphated glycosaminoglycans for inducing labor |
UA117912C2 (uk) * | 2012-05-08 | 2018-10-25 | Ділафор Аб | Застосування гепарину або гепарансульфату для лікування післяпологової кровотечі (ппк) |
GB2515315A (en) | 2013-06-19 | 2014-12-24 | Dilafor Ab | New Processes |
CN103788222B (zh) * | 2014-01-08 | 2016-08-31 | 中国科学院昆明植物研究所 | Fuc3S4S取代的低聚糖胺聚糖及其制备方法 |
AU2015253870B2 (en) * | 2014-04-30 | 2019-08-22 | Agency For Science, Technology And Research | Heparan sulphates |
CN108424474B (zh) * | 2017-02-15 | 2023-07-25 | 清华大学 | 去抗凝肝素衍生物及其用于炎症性肠病的治疗 |
WO2021165240A1 (en) | 2020-02-17 | 2021-08-26 | Dilafor Ab | Tafoxiparin for the treatment of preeclampsia |
EP4272749A1 (en) | 2022-05-03 | 2023-11-08 | Dilafor AB | New medical use of tafoxiparin |
WO2023213788A1 (en) | 2022-05-03 | 2023-11-09 | Dilafor Ab | New medical use of tafoxiparin |
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CA1136620A (en) | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
JPS63246396A (ja) * | 1987-03-31 | 1988-10-13 | Shiseido Co Ltd | モノクロ−ナル抗体 |
FR2614026B1 (fr) * | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
SE9002550D0 (sv) | 1990-08-01 | 1990-08-01 | Kabivitrum Ab | Heparinfragment |
SE9003181D0 (sv) | 1990-10-04 | 1990-10-04 | Kabivitrum Ab | Use of heparin fraction |
US5280016A (en) | 1991-03-29 | 1994-01-18 | Glycomed Incorporated | Non-anticoagulant heparin derivatives |
US5250519A (en) | 1991-03-29 | 1993-10-05 | Glycomed Incorporated | Non-anticoagulant heparin derivatives |
JPH0532703A (ja) * | 1991-07-26 | 1993-02-09 | Terumo Corp | 低分子量ヘパリン誘導体の製造法 |
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US5527785A (en) | 1993-05-14 | 1996-06-18 | The Regents Of The University Of California | Selectin receptor modulating compositions |
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DE69623840D1 (de) * | 1995-03-31 | 2002-10-31 | Hamilton Civic Hospitals Res | Zusammensetzung zur Hemmung der Thromboseentstehung |
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US5767269A (en) * | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
JP4203611B2 (ja) | 1996-10-15 | 2009-01-07 | 生化学工業株式会社 | 子宮頸管熟化剤 |
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US6498246B1 (en) | 1998-02-26 | 2002-12-24 | Seikagaku Corporation | Glycosaminoglycan derivatives and processes for preparing same |
US6028061A (en) | 1998-06-18 | 2000-02-22 | Children's Medical Center Corp | Angiogenesis inhibitors and use thereof |
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MXPA02000142A (es) * | 1999-06-30 | 2003-07-21 | Hamilton Civic Hospitals Res | Composiciones de heparina que inhiben los factores de coagulacion asociados con el coagulo. |
JP4897991B2 (ja) * | 1999-07-23 | 2012-03-14 | ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ | 超低分子量ヘパリン組成物 |
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WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
WO2013147689A1 (en) | 2012-03-26 | 2013-10-03 | Dilafor Ab | Combination treatment comprising sulphated glycosaminoglycans for inducing labor |
MX2014011451A (es) | 2012-03-26 | 2014-11-10 | Dilafor Ab | Procedimiento de tratamiento de la interrupcion del parto. |
-
2012
- 2012-12-19 US US14/366,624 patent/US9475888B2/en active Active
- 2012-12-19 MX MX2014007122A patent/MX351104B/es active IP Right Grant
- 2012-12-19 PT PT128588092T patent/PT2794665T/pt unknown
- 2012-12-19 PL PL12858809T patent/PL2794665T3/pl unknown
- 2012-12-19 KR KR1020147016676A patent/KR102135485B1/ko active IP Right Grant
- 2012-12-19 CA CA2856492A patent/CA2856492C/en active Active
- 2012-12-19 HU HUE12858809A patent/HUE036523T2/hu unknown
- 2012-12-19 RU RU2014129816A patent/RU2617764C2/ru active
- 2012-12-19 BR BR112014014454-0A patent/BR112014014454B1/pt active IP Right Grant
- 2012-12-19 DK DK12858809.2T patent/DK2794665T3/da active
- 2012-12-19 ME MEP-2018-14A patent/ME02994B/me unknown
- 2012-12-19 AU AU2012354229A patent/AU2012354229B2/en active Active
- 2012-12-19 WO PCT/SE2012/051433 patent/WO2013095279A1/en active Application Filing
- 2012-12-19 CN CN201280062050.1A patent/CN104144950B/zh active Active
- 2012-12-19 RS RS20180155A patent/RS56874B1/sr unknown
- 2012-12-19 LT LTEP12858809.2T patent/LT2794665T/lt unknown
- 2012-12-19 EP EP12858809.2A patent/EP2794665B1/en active Active
- 2012-12-19 ES ES12858809.2T patent/ES2656613T3/es active Active
- 2012-12-19 SI SI201231138T patent/SI2794665T1/en unknown
- 2012-12-19 JP JP2014547146A patent/JP6543467B2/ja active Active
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2013
- 2013-09-27 NO NO13771071A patent/NO2904345T3/no unknown
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2014
- 2014-05-20 ZA ZA2014/03640A patent/ZA201403640B/en unknown
- 2014-06-01 IL IL232905A patent/IL232905A/en active IP Right Grant
- 2014-06-16 CO CO14129964A patent/CO7061069A2/es unknown
- 2014-06-19 CL CL2014001651A patent/CL2014001651A1/es unknown
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2015
- 2015-04-08 HK HK15103428.9A patent/HK1202883A1/xx unknown
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2018
- 2018-01-23 HR HRP20180124TT patent/HRP20180124T1/hr unknown
- 2018-02-09 CY CY20181100162T patent/CY1119899T1/el unknown
- 2018-02-28 JP JP2018034714A patent/JP2018111825A/ja active Pending
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