MX349622B - Metodos para evaluar e identificar o evolucionar proteinas terapeuticas condicionalmente activas. - Google Patents
Metodos para evaluar e identificar o evolucionar proteinas terapeuticas condicionalmente activas.Info
- Publication number
- MX349622B MX349622B MX2013002679A MX2013002679A MX349622B MX 349622 B MX349622 B MX 349622B MX 2013002679 A MX2013002679 A MX 2013002679A MX 2013002679 A MX2013002679 A MX 2013002679A MX 349622 B MX349622 B MX 349622B
- Authority
- MX
- Mexico
- Prior art keywords
- activity
- therapeutic proteins
- conditionally active
- methods
- protein
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
Abstract
La presente invención se refiere a un método in vitro para identificar/seleccionar una proteína terapéutica modificada que es una proteína antitumor que trata tumores y que tiene una mayor actividad en un microambiente de tumor en un sujeto comparado con un ambiente sin tumor en el sujeto, caracterizado porque comprende: i) probar la actividad de unión de una pluralidad de proteínas terapéuticas anti-tumor modificadas al objetivo de las proteínas terapéuticas anti-tumor bajo las condiciones a) y bajo las condiciones b), en donde: las proteínas terapéuticas anti-tumor son anticuerpos o porciones de unión al antígeno de los mismos; la condiciones en a) comprende pH bajo que está entre 5.8 y 6.8, y suero humano; las condiciones en b) comprende pH que está entre 7.2 y 7.8, y suero humano en la misma concentración que en a); la concentración de suero en ambas condiciones es la misma y es 15-35% en volumen; opcionalmente, las condiciones en a) en comparación con las condiciones en b) comprenden una o más propiedades adicionales a pH reducido seleccionadas de entre hipoxia, concentración de lactato incrementada y concentración de piruvato incrementada; el resto de las condiciones en a) y b) son las mismas; la actividad probada es la unión a la proteína objetivo de la proteína terapéutica; cada proteína terapéutica modificada contiene reemplazo de aminoácido, inserción y/o eliminación de un residuo o residuos de aminoácido comparados con la forma no modificada de la proteína terapéutica; y cada proteína modifica se prueba en cada una de las condiciones de a) y b); ii) comparar la actividad de unión de las proteínas terapéuticas modificadas en a) con la actividad de unión en b); y iii) seleccionar/identificar una proteína terapéutica modificada que tiene mayor actividad de unión para la proteína objetivo en a) comparada con b), de este modo identificando un anticuerpo terapéutico modificado o porción de unión al antígeno del mismo que es condicionalmente activo tal que tiene mayor actividad de unión en las condiciones de pH bajas de un microambiente de tumor comparado con las condiciones de pH de un ambiente sin tumor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40297910P | 2010-09-08 | 2010-09-08 | |
| PCT/US2011/050891 WO2012033953A1 (en) | 2010-09-08 | 2011-09-08 | Methods for assessing and identifying or evolving conditionally active therapeutic proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013002679A MX2013002679A (es) | 2013-06-18 |
| MX349622B true MX349622B (es) | 2017-08-07 |
Family
ID=44906358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013002679A MX349622B (es) | 2010-09-08 | 2011-09-08 | Metodos para evaluar e identificar o evolucionar proteinas terapeuticas condicionalmente activas. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9683985B2 (es) |
| EP (1) | EP2614086A1 (es) |
| JP (2) | JP6121904B2 (es) |
| KR (1) | KR20130096731A (es) |
| CN (1) | CN103201293B (es) |
| CA (1) | CA2810668A1 (es) |
| IL (1) | IL224983A (es) |
| MX (1) | MX349622B (es) |
| WO (1) | WO2012033953A1 (es) |
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2011
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- 2011-09-08 MX MX2013002679A patent/MX349622B/es active IP Right Grant
- 2011-09-08 CN CN201180053564.6A patent/CN103201293B/zh not_active Expired - Fee Related
- 2011-09-08 KR KR1020137008951A patent/KR20130096731A/ko active IP Right Grant
- 2011-09-08 WO PCT/US2011/050891 patent/WO2012033953A1/en active Application Filing
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| JP2016166875A (ja) | 2016-09-15 |
| CA2810668A1 (en) | 2012-03-15 |
| CN103201293A (zh) | 2013-07-10 |
| JP6121904B2 (ja) | 2017-04-26 |
| US9683985B2 (en) | 2017-06-20 |
| MX2013002679A (es) | 2013-06-18 |
| IL224983A (en) | 2017-10-31 |
| JP2013541940A (ja) | 2013-11-21 |
| WO2012033953A1 (en) | 2012-03-15 |
| KR20130096731A (ko) | 2013-08-30 |
| US20120108455A1 (en) | 2012-05-03 |
| EP2614086A1 (en) | 2013-07-17 |
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