MX347257B - Solido de gamma-carbolinas fusionadas con heterociclos substituidos. - Google Patents

Solido de gamma-carbolinas fusionadas con heterociclos substituidos.

Info

Publication number
MX347257B
MX347257B MX2014007104A MX2014007104A MX347257B MX 347257 B MX347257 B MX 347257B MX 2014007104 A MX2014007104 A MX 2014007104A MX 2014007104 A MX2014007104 A MX 2014007104A MX 347257 B MX347257 B MX 347257B
Authority
MX
Mexico
Prior art keywords
carbolines
substituted heterocycle
solid
heterocycle fused
fused gamma
Prior art date
Application number
MX2014007104A
Other languages
English (en)
Inventor
P Wennogle Lawrence
Tomesch John
Original Assignee
Intra-Cellular Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41065729&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX347257(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intra-Cellular Therapies Inc filed Critical Intra-Cellular Therapies Inc
Publication of MX347257B publication Critical patent/MX347257B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente invención se refiere a cristales de sal de adición de ácido toluenosulfónico de gamma-carbolinas fusionadas con heterociclos substituidos específicos, el método para hacer y usar tales cristales.
MX2014007104A 2008-03-12 2009-03-12 Solido de gamma-carbolinas fusionadas con heterociclos substituidos. MX347257B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3606908P 2008-03-12 2008-03-12
PCT/US2009/001608 WO2009114181A2 (en) 2008-03-12 2009-03-12 Substituted heterocycle fused gamma-carbolines solid

Publications (1)

Publication Number Publication Date
MX347257B true MX347257B (es) 2017-04-20

Family

ID=41065729

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2010010024A MX2010010024A (es) 2008-03-12 2009-03-12 Solido de gamma-carbolinas fusionadas con heterociclos substituidos.
MX2014007104A MX347257B (es) 2008-03-12 2009-03-12 Solido de gamma-carbolinas fusionadas con heterociclos substituidos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2010010024A MX2010010024A (es) 2008-03-12 2009-03-12 Solido de gamma-carbolinas fusionadas con heterociclos substituidos.

Country Status (17)

Country Link
US (4) US8648077B2 (es)
EP (1) EP2262505B1 (es)
JP (1) JP5611846B2 (es)
KR (2) KR20150140418A (es)
CN (2) CN102046175B (es)
AU (1) AU2009223701B2 (es)
CA (1) CA2716730C (es)
DK (1) DK2262505T3 (es)
ES (1) ES2530090T3 (es)
HK (1) HK1152231A1 (es)
HR (1) HRP20141178T1 (es)
IL (3) IL207772A0 (es)
MX (2) MX2010010024A (es)
PL (1) PL2262505T3 (es)
PT (1) PT2262505E (es)
SI (1) SI2262505T1 (es)
WO (1) WO2009114181A2 (es)

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CN102105059B (zh) 2008-05-27 2015-09-30 细胞内治疗公司 用于睡眠障碍和其他疾病的方法和组合物
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US11053245B2 (en) 2012-04-14 2021-07-06 Intra-Cellular Therapies, Inc. Methods
PT2968320T (pt) 2013-03-15 2021-01-28 Intra Cellular Therapies Inc Compostos orgânicos
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EP3125893B1 (en) 2014-04-04 2023-09-20 Intra-Cellular Therapies, Inc. Deuterated heterocycle fused gamma-carbolines as antagonists of 5-ht2a receptors
EP3125892A4 (en) 2014-04-04 2017-12-27 Intra-Cellular Therapies, Inc. Organic compounds
TWI714567B (zh) 2015-04-03 2021-01-01 美商英塞特公司 作為lsd1抑制劑之雜環化合物
MY189367A (en) 2015-08-12 2022-02-08 Incyte Corp Salts of an lsd1 inhibitor
EP3407888B1 (en) 2016-01-26 2020-12-30 Intra-Cellular Therapies, Inc. Pyridopyrroloquinoxaline compounds, their compositions and uses
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JP2019510039A (ja) 2016-03-28 2019-04-11 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規組成物および方法
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JP7013454B2 (ja) * 2016-10-12 2022-02-15 イントラ－セルラー・セラピーズ・インコーポレイテッド アモルファス固体分散体
WO2018126143A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
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MX2021013640A (es) 2017-03-24 2022-08-31 Intra Cellular Therapies Inc Composiciones novedosas y metodos.
JP2020513023A (ja) 2017-04-10 2020-04-30 ドクター・レディーズ・ラボラトリーズ・リミテッド ルマテペロンｐ−トシラートの非晶質形態および固体分散体
JP7224333B2 (ja) 2017-07-26 2023-02-17 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
CA3071119A1 (en) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. Organic compounds
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EP3717484A4 (en) * 2017-11-27 2021-08-04 Egis Gyógyszergyár Zrt. PROCESS FOR THE PRODUCTION OF LUMATEPERON AND ITS SALT
CN109867674A (zh) * 2017-12-05 2019-06-11 上海度德医药科技有限公司 一种取代的杂环稠合γ-咔啉的新盐及其制备方法和晶型
CN112040940A (zh) 2018-03-23 2020-12-04 细胞内治疗公司 有机化合物
WO2019236889A1 (en) 2018-06-06 2019-12-12 Intra-Cellular Therapies, Inc. Novel salts and crystals
EP3801527A4 (en) * 2018-06-08 2022-03-30 Intra-Cellular Therapies, Inc. NEW METHODS
WO2019241278A1 (en) 2018-06-11 2019-12-19 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
CA3108304A1 (en) 2018-06-21 2019-12-26 Aquestive Therapeutics, Inc. System and method for making personalized individual unit doses containing pharmaceutical actives
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CN102105059B (zh) 2008-05-27 2015-09-30 细胞内治疗公司 用于睡眠障碍和其他疾病的方法和组合物
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US11053245B2 (en) 2012-04-14 2021-07-06 Intra-Cellular Therapies, Inc. Methods
PT2968320T (pt) 2013-03-15 2021-01-28 Intra Cellular Therapies Inc Compostos orgânicos

Also Published As

Publication number Publication date
JP5611846B2 (ja) 2014-10-22
JP2011513485A (ja) 2011-04-28
KR20100122948A (ko) 2010-11-23
US20110112105A1 (en) 2011-05-12
WO2009114181A3 (en) 2009-12-30
IL207772A0 (en) 2010-12-30
MX2010010024A (es) 2010-11-09
PT2262505E (pt) 2014-12-16
USRE48825E1 (en) 2021-11-23
US9199995B2 (en) 2015-12-01
PL2262505T3 (pl) 2015-04-30
US9586960B2 (en) 2017-03-07
ES2530090T3 (es) 2015-02-26
HK1152231A1 (en) 2012-02-24
IL289706A (en) 2022-03-01
AU2009223701A1 (en) 2009-09-17
IL263338A (en) 2018-12-31
AU2009223701B2 (en) 2015-04-16
US20160194325A1 (en) 2016-07-07
CA2716730C (en) 2017-05-16
US20140323491A1 (en) 2014-10-30
SI2262505T1 (sl) 2015-03-31
HRP20141178T1 (hr) 2015-04-10
CN105237536A (zh) 2016-01-13
EP2262505B1 (en) 2014-09-10
CN102046175A (zh) 2011-05-04
KR101610977B1 (ko) 2016-04-08
WO2009114181A2 (en) 2009-09-17
CN102046175B (zh) 2015-08-12
EP2262505A2 (en) 2010-12-22
KR20150140418A (ko) 2015-12-15
EP2262505A4 (en) 2012-03-07
CA2716730A1 (en) 2009-09-17
US8648077B2 (en) 2014-02-11
DK2262505T3 (en) 2015-01-05

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