MX346379B - Combinacion que comprende un inhibidor de cinasa 4 dependiente de ciclina o cinasa dependiente de ciclina (cdk4/6) y un inhibidor de mtor para tratar cancer. - Google Patents
Combinacion que comprende un inhibidor de cinasa 4 dependiente de ciclina o cinasa dependiente de ciclina (cdk4/6) y un inhibidor de mtor para tratar cancer.Info
- Publication number
- MX346379B MX346379B MX2013011693A MX2013011693A MX346379B MX 346379 B MX346379 B MX 346379B MX 2013011693 A MX2013011693 A MX 2013011693A MX 2013011693 A MX2013011693 A MX 2013011693A MX 346379 B MX346379 B MX 346379B
- Authority
- MX
- Mexico
- Prior art keywords
- dependent kinase
- cyclin dependent
- inhibitor
- cdk4
- combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Una combinación de un inhibidor de CDK4/6 y un inhibidor de mTOR para el tratamiento de cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32354110P | 2010-04-13 | 2010-04-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX346379B true MX346379B (es) | 2017-03-16 |
Family
ID=44146770
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012011912A MX2012011912A (es) | 2010-04-13 | 2011-04-12 | Combinacion que comprende un inhibidor de cinasa 4 dependiente de ciclina o cinasa dependiente de ciclia (cdk4/6) y un inhibidor de mtor para tratar cancer. |
MX2013011693A MX346379B (es) | 2010-04-13 | 2012-10-12 | Combinacion que comprende un inhibidor de cinasa 4 dependiente de ciclina o cinasa dependiente de ciclina (cdk4/6) y un inhibidor de mtor para tratar cancer. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012011912A MX2012011912A (es) | 2010-04-13 | 2011-04-12 | Combinacion que comprende un inhibidor de cinasa 4 dependiente de ciclina o cinasa dependiente de ciclia (cdk4/6) y un inhibidor de mtor para tratar cancer. |
Country Status (11)
Country | Link |
---|---|
US (3) | US20130035336A1 (es) |
EP (1) | EP2558092B1 (es) |
JP (1) | JP5918214B2 (es) |
KR (1) | KR101830455B1 (es) |
CN (1) | CN102869358B (es) |
AU (1) | AU2011240735B2 (es) |
CA (1) | CA2800327A1 (es) |
ES (1) | ES2689177T3 (es) |
MX (2) | MX2012011912A (es) |
RU (1) | RU2589696C2 (es) |
WO (1) | WO2011130232A1 (es) |
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AR091876A1 (es) | 2012-07-26 | 2015-03-04 | Novartis Ag | Combinaciones farmaceuticas para el tratamiento de enfermedades proliferativas |
CA2880764C (en) | 2012-08-03 | 2022-08-30 | Foundation Medicine, Inc. | Human papilloma virus as predictor of cancer prognosis |
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CA2904054A1 (en) | 2013-03-15 | 2014-09-25 | Concert Pharmaceuticals, Inc. | Deuterated palbociclib |
PT3033086T (pt) * | 2013-08-14 | 2021-12-15 | Novartis Ag | Terapia de combinação para o tratamento de cancro |
ES2674361T3 (es) * | 2013-08-28 | 2018-06-29 | Novartis Ag | Combinación de un inhibidor de ALK y un inhibidor de CDK para el tratamiento de enfermedades celulares proliferativas |
US20150320754A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
JP6631616B2 (ja) * | 2014-07-26 | 2020-01-15 | ノース・アンド・サウス・ブラザー・ファーマシー・インベストメント・カンパニー・リミテッド | CDK阻害剤としての2−アミノ−ピリド[2,3−d]ピリミジン−7(8H)−オン誘導体及びその使用 |
CN105294737B (zh) * | 2014-07-26 | 2019-02-12 | 广东东阳光药业有限公司 | Cdk类小分子抑制剂的化合物及其用途 |
EP3778605A3 (en) * | 2015-02-13 | 2021-03-10 | Dana Farber Cancer Institute, Inc. | Lrrk2 inhibitors and methods of making and using the same |
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EP3156406A1 (en) * | 2015-10-14 | 2017-04-19 | ratiopharm GmbH | Crystalline forms of ribociclib free base |
EP4108659A1 (en) | 2016-06-07 | 2022-12-28 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
CN109803684B (zh) * | 2016-08-23 | 2022-08-23 | 卫材 R&D 管理有限公司 | 用于治疗肝细胞癌的组合疗法 |
CN110022900A (zh) | 2016-09-08 | 2019-07-16 | 蓝图药品公司 | 成纤维细胞生长因子受体4抑制剂与细胞周期蛋白依赖性激酶抑制剂的组合 |
RU2747311C2 (ru) | 2016-12-16 | 2021-05-04 | СиСТОУН ФАРМАСЬЮТИКАЛС (СУЧЖОУ) КО., ЛТД. | Ингибитор CDK4/6 |
EP3558997B1 (en) | 2016-12-20 | 2021-01-27 | AstraZeneca AB | Amino-triazolopyridine compounds and their use in treating cancer |
JP7219224B2 (ja) | 2017-03-16 | 2023-02-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 乳癌の治療のための組合せ療法 |
AU2018239542C1 (en) | 2017-03-23 | 2021-02-11 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as SHP2 inhibitors |
CN108794452B (zh) | 2017-05-05 | 2021-05-28 | 上海时莱生物技术有限公司 | 具有激酶抑制活性的化合物、其制备方法和用途 |
JP7100125B2 (ja) | 2017-10-27 | 2022-07-12 | フレゼニウス・カビ・オンコロジー・リミテッド | リボシクリブおよびその塩の改善された調製のためのプロセス |
CN112020500A (zh) | 2017-12-22 | 2020-12-01 | 拉文纳制药公司 | 作为磷脂酰肌醇磷酸激酶抑制剂的氨基吡啶衍生物 |
US10519136B2 (en) | 2017-12-29 | 2019-12-31 | Accutar Biotechnology | Dual inhibitors of PARP1 and CDK |
WO2019195959A1 (en) | 2018-04-08 | 2019-10-17 | Cothera Biosciences, Inc. | Combination therapy for cancers with braf mutation |
WO2019222524A1 (en) * | 2018-05-16 | 2019-11-21 | The University Of North Carolina At Chapel Hill | Alkyl pyrrolopyrimidines as pan-tam inhibitors and their application in cancer treatment |
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JP2022500388A (ja) * | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス, インコーポレイテッド | 組み合わせ療法 |
US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
US20220056037A1 (en) * | 2018-12-28 | 2022-02-24 | Spv Therapeutics Inc. | Cyclin-dependent kinase inhibitors |
AU2019413360A1 (en) * | 2018-12-28 | 2021-08-12 | Spv Therapeutics Inc. | Cyclin-dependent kinase inhibitors |
WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
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CN112094272A (zh) * | 2019-06-18 | 2020-12-18 | 北京睿熙生物科技有限公司 | Cdk激酶抑制剂 |
MX2022001940A (es) | 2019-08-14 | 2022-05-10 | Incyte Corp | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2. |
PE20221905A1 (es) | 2019-10-11 | 2022-12-23 | Incyte Corp | Aminas biciclicas como inhibidoras de la cdk2 |
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IL293940A (en) * | 2019-12-16 | 2022-08-01 | Lunella Biotech Inc | Selective cancer drugs cdk4/6 inhibitors |
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KR20230136625A (ko) * | 2021-01-22 | 2023-09-26 | 얀센 파마슈티카 엔브이 | 라파마이신 유사체 및 이의 용도 |
KR20220147511A (ko) | 2021-04-27 | 2022-11-03 | 재단법인 아산사회복지재단 | 사이클린 의존성 키나아제 억제용 조성물 및 이의 의학적 용도 |
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CN114957248B (zh) * | 2022-05-09 | 2023-12-29 | 南开大学 | 一种吡咯并嘧啶化合物及其制备方法、药物组合物和应用 |
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-
2011
- 2011-04-12 MX MX2012011912A patent/MX2012011912A/es active IP Right Grant
- 2011-04-12 WO PCT/US2011/032062 patent/WO2011130232A1/en active Application Filing
- 2011-04-12 KR KR1020127029596A patent/KR101830455B1/ko active IP Right Grant
- 2011-04-12 AU AU2011240735A patent/AU2011240735B2/en not_active Ceased
- 2011-04-12 RU RU2012148133/15A patent/RU2589696C2/ru not_active IP Right Cessation
- 2011-04-12 ES ES11715370.0T patent/ES2689177T3/es active Active
- 2011-04-12 CN CN201180019111.1A patent/CN102869358B/zh not_active Expired - Fee Related
- 2011-04-12 US US13/640,863 patent/US20130035336A1/en not_active Abandoned
- 2011-04-12 CA CA2800327A patent/CA2800327A1/en not_active Abandoned
- 2011-04-12 JP JP2013505045A patent/JP5918214B2/ja active Active
- 2011-04-12 EP EP11715370.0A patent/EP2558092B1/en not_active Revoked
-
2012
- 2012-10-12 MX MX2013011693A patent/MX346379B/es unknown
-
2015
- 2015-07-16 US US14/800,893 patent/US20160008367A1/en not_active Abandoned
-
2018
- 2018-03-26 US US15/935,294 patent/US20180207163A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20160008367A1 (en) | 2016-01-14 |
CN102869358B (zh) | 2016-03-23 |
CA2800327A1 (en) | 2011-10-20 |
RU2012148133A (ru) | 2014-05-20 |
WO2011130232A1 (en) | 2011-10-20 |
KR101830455B1 (ko) | 2018-02-20 |
JP5918214B2 (ja) | 2016-05-18 |
EP2558092B1 (en) | 2018-06-27 |
RU2589696C2 (ru) | 2016-07-10 |
JP2013523885A (ja) | 2013-06-17 |
CN102869358A (zh) | 2013-01-09 |
US20180207163A1 (en) | 2018-07-26 |
AU2011240735A1 (en) | 2012-11-01 |
ES2689177T3 (es) | 2018-11-08 |
EP2558092A1 (en) | 2013-02-20 |
KR20130098151A (ko) | 2013-09-04 |
US20130035336A1 (en) | 2013-02-07 |
MX2012011912A (es) | 2012-11-16 |
AU2011240735B2 (en) | 2015-01-29 |
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