MX2013000474A - Derivados de arilamida novedosos que tienen propiedades antiandrogenicas. - Google Patents
Derivados de arilamida novedosos que tienen propiedades antiandrogenicas.Info
- Publication number
- MX2013000474A MX2013000474A MX2013000474A MX2013000474A MX2013000474A MX 2013000474 A MX2013000474 A MX 2013000474A MX 2013000474 A MX2013000474 A MX 2013000474A MX 2013000474 A MX2013000474 A MX 2013000474A MX 2013000474 A MX2013000474 A MX 2013000474A
- Authority
- MX
- Mexico
- Prior art keywords
- arylamide derivatives
- antiandrogenic properties
- novel
- formula
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
La invención se refiere a derivados novedosos de arilamida que tiene la fórmula (I) (Ver Formula) y estereoisómeros y sus sales farmacéuticamente aceptables, donde R1 - R11, R', R", z y X son tal como se definieron en las reivindicaciones. Los derivados de arilamida de la fórmula (I) tienen propiedades antiandrogénicas. La invención también se refiere a compuestos de la fórmula (I) para utilizar como un medicamento y a composiciones farmacéuticas que los contienen y a su preparación.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20105806A FI20105806A0 (fi) | 2010-07-15 | 2010-07-15 | Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia |
PCT/FI2011/050655 WO2012007644A1 (en) | 2010-07-15 | 2011-07-14 | Novel arylamide derivatives having antiandrogenic properties |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013000474A true MX2013000474A (es) | 2013-05-17 |
Family
ID=42555499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013000474A MX2013000474A (es) | 2010-07-15 | 2011-07-14 | Derivados de arilamida novedosos que tienen propiedades antiandrogenicas. |
Country Status (18)
Country | Link |
---|---|
US (1) | US8816119B2 (es) |
EP (1) | EP2593424B1 (es) |
JP (1) | JP5990833B2 (es) |
KR (1) | KR101928375B1 (es) |
CN (1) | CN102985403B (es) |
AR (1) | AR082218A1 (es) |
AU (1) | AU2011278201B2 (es) |
BR (1) | BR112013000783B1 (es) |
CA (1) | CA2804765C (es) |
EA (1) | EA022619B1 (es) |
ES (1) | ES2750309T3 (es) |
FI (1) | FI20105806A0 (es) |
MX (1) | MX2013000474A (es) |
NZ (1) | NZ605636A (es) |
SG (1) | SG187049A1 (es) |
TW (1) | TWI542343B (es) |
WO (1) | WO2012007644A1 (es) |
ZA (1) | ZA201300300B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013104831A1 (en) * | 2012-01-13 | 2013-07-18 | Medeia Therapeutics Ltd | Arylamide derivatives having antiandrogenic properties |
WO2016079521A1 (en) * | 2014-11-20 | 2016-05-26 | University College Cardiff Consultants Limited | Androgen receptor modulators and their use as anti-cancer agents |
US9814698B2 (en) | 2015-04-21 | 2017-11-14 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10093613B2 (en) | 2015-04-21 | 2018-10-09 | Gtx, Inc. | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10441570B2 (en) | 2015-04-21 | 2019-10-15 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) Ligands and methods of use thereof |
US10654809B2 (en) | 2016-06-10 | 2020-05-19 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10035763B2 (en) | 2015-04-21 | 2018-07-31 | Gtx, Inc. | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US9834507B2 (en) | 2015-04-21 | 2017-12-05 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10806720B2 (en) | 2015-04-21 | 2020-10-20 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
RU2724103C2 (ru) | 2015-04-21 | 2020-06-22 | Джи Ти Икс, ИНК. | Селективные лиганды-разрушители андрогенных рецептов (sard) и способы их применения |
US10865184B2 (en) | 2015-04-21 | 2020-12-15 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10017471B2 (en) | 2015-04-21 | 2018-07-10 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US11230523B2 (en) | 2016-06-10 | 2022-01-25 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA831466B (en) * | 1982-03-23 | 1984-10-31 | Ici Plc | Heterocyclic compounds |
EP0099165A1 (en) | 1982-03-23 | 1984-01-25 | Imperial Chemical Industries Plc | Triazole and imidazole compounds, process for their preparation and their use as fungicides and plant growth regulators, and intermediates for their synthesis |
ATE28864T1 (de) | 1982-07-23 | 1987-08-15 | Ici Plc | Amide-derivate. |
WO1998053826A1 (en) * | 1997-05-30 | 1998-12-03 | The University Of Tennessee Research Corporation | Non-steroidal agonist compounds and their use in male hormone therapy |
US7741371B2 (en) * | 2002-06-17 | 2010-06-22 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
JP5373405B2 (ja) * | 2006-03-03 | 2013-12-18 | オリオン コーポレーション | 選択的アンドロゲン受容体モジュレーター |
TW200812962A (en) | 2006-07-12 | 2008-03-16 | Astrazeneca Ab | New compounds I/418 |
EP2040709A2 (en) | 2006-07-19 | 2009-04-01 | Osurf | Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof |
CN101516835A (zh) * | 2006-07-19 | 2009-08-26 | 俄亥俄州立大学研究基金会 | 选择性雄激素受体调节剂、它们的类似物和衍生物以及它们的用途 |
CA2666769A1 (en) * | 2006-10-18 | 2008-04-24 | Merck & Co., Inc. | 2-hydroxy-2-phenyl/thiophenyl propionamides as androgen receptor modulators |
DE102006061913A1 (de) * | 2006-12-21 | 2008-06-26 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
WO2009105214A2 (en) * | 2008-02-22 | 2009-08-27 | Radius Health, Inc. | Selective androgen receptor modulators |
US8741951B2 (en) * | 2009-04-10 | 2014-06-03 | CNR—Consiglio Nazionale Delle Ricerche | Non-steroidal compounds for androgen receptor modulation |
-
2010
- 2010-07-15 FI FI20105806A patent/FI20105806A0/fi not_active Application Discontinuation
-
2011
- 2011-07-14 WO PCT/FI2011/050655 patent/WO2012007644A1/en active Application Filing
- 2011-07-14 TW TW100124935A patent/TWI542343B/zh active
- 2011-07-14 AU AU2011278201A patent/AU2011278201B2/en not_active Ceased
- 2011-07-14 BR BR112013000783-4A patent/BR112013000783B1/pt active IP Right Grant
- 2011-07-14 CA CA2804765A patent/CA2804765C/en active Active
- 2011-07-14 EP EP11770471.8A patent/EP2593424B1/en active Active
- 2011-07-14 EA EA201390008A patent/EA022619B1/ru not_active IP Right Cessation
- 2011-07-14 AR ARP110102539A patent/AR082218A1/es active IP Right Grant
- 2011-07-14 MX MX2013000474A patent/MX2013000474A/es active IP Right Grant
- 2011-07-14 JP JP2013519121A patent/JP5990833B2/ja active Active
- 2011-07-14 US US13/809,787 patent/US8816119B2/en active Active
- 2011-07-14 NZ NZ605636A patent/NZ605636A/en not_active IP Right Cessation
- 2011-07-14 KR KR1020137000843A patent/KR101928375B1/ko active IP Right Grant
- 2011-07-14 CN CN201180034245.0A patent/CN102985403B/zh active Active
- 2011-07-14 SG SG2013002555A patent/SG187049A1/en unknown
- 2011-07-14 ES ES11770471T patent/ES2750309T3/es active Active
-
2013
- 2013-01-11 ZA ZA2013/00300A patent/ZA201300300B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA201390008A1 (ru) | 2013-05-30 |
AU2011278201A1 (en) | 2013-01-31 |
ZA201300300B (en) | 2013-09-25 |
TW201208669A (en) | 2012-03-01 |
CA2804765A1 (en) | 2012-01-19 |
AU2011278201B2 (en) | 2014-08-21 |
EP2593424A1 (en) | 2013-05-22 |
US20130109750A1 (en) | 2013-05-02 |
JP2013532178A (ja) | 2013-08-15 |
BR112013000783A2 (pt) | 2020-11-03 |
US8816119B2 (en) | 2014-08-26 |
NZ605636A (en) | 2014-05-30 |
BR112013000783B1 (pt) | 2022-01-25 |
KR101928375B1 (ko) | 2018-12-12 |
AR082218A1 (es) | 2012-11-21 |
JP5990833B2 (ja) | 2016-09-14 |
TWI542343B (zh) | 2016-07-21 |
EA022619B1 (ru) | 2016-02-29 |
CA2804765C (en) | 2018-08-07 |
WO2012007644A1 (en) | 2012-01-19 |
CN102985403A (zh) | 2013-03-20 |
CN102985403B (zh) | 2016-03-23 |
ES2750309T3 (es) | 2020-03-25 |
FI20105806A0 (fi) | 2010-07-15 |
KR20130079479A (ko) | 2013-07-10 |
SG187049A1 (en) | 2013-02-28 |
EP2593424B1 (en) | 2019-08-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2013000474A (es) | Derivados de arilamida novedosos que tienen propiedades antiandrogenicas. | |
MX2020003055A (es) | Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico. | |
TN2015000121A1 (en) | Gdf-8 inhibitors | |
MY149731A (en) | Compounds | |
MX2011012122A (es) | Derivados de tiofeno. | |
MX2011011661A (es) | Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750. | |
MX2009011802A (es) | Imidazoquinolinas con propiedades inmunomoduladoras. | |
NZ608116A (en) | Triazine-oxadiazoles | |
MX2013001929A (es) | Nuevos compuestos | |
TN2013000253A1 (en) | Bicyclo[3.2.1]octyl amide derivatives and uses of same | |
EP2590655A4 (en) | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | |
IN2012DN03182A (es) | ||
WO2012051988A3 (de) | Derivate von steroidbenzylaminen mit antiparasitärer, antibakterieller, antimykotischer und/oder antiviraler wirkung | |
UA104489C2 (uk) | Сполуки для лікування дисліпідемії та споріднених хвороб | |
MX2011013648A (es) | Nuevos compuestos, composiciones farmaceuticas y metodos relacionados con ellos. | |
MX2009013501A (es) | Compuestos piperidinicos y sus usos. | |
WO2009125434A3 (en) | Oxime derivatives, process for their preparation, pharmaceutical composition containing the same and medicinal use thereof | |
WO2012135615A3 (en) | Enopeptins, uses thereof, and methods of synthesis thereto | |
MX2011012643A (es) | 2,4-diaminopiridinas para el tratamiento de enfermedades caracterizadas por la proliferacion celular excesiva o anormal. | |
MX2009006010A (es) | Derivados de amina y su uso en enfermedades mediadas por el adrenoreceptor beta 2. | |
MY161749A (en) | Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use | |
IN2012DN01292A (es) | ||
TN2012000105A1 (en) | Spirolactam derivatives and uses of same | |
TN2011000531A1 (en) | 5- alkynyl - pyridines | |
MX2013003736A (es) | Novedosos agonistas del receptor de la proteina g 119. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |