MX338825B - Proteinas de enlace a objetivos multiples de antagonistas de cd86. - Google Patents

Proteinas de enlace a objetivos multiples de antagonistas de cd86.

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Publication number
MX338825B
MX338825B MX2011003611A MX2011003611A MX338825B MX 338825 B MX338825 B MX 338825B MX 2011003611 A MX2011003611 A MX 2011003611A MX 2011003611 A MX2011003611 A MX 2011003611A MX 338825 B MX338825 B MX 338825B
Authority
MX
Mexico
Prior art keywords
agonist
antagonist
specific fusion
binding proteins
target binding
Prior art date
Application number
MX2011003611A
Other languages
English (en)
Other versions
MX2011003611A (es
Inventor
Peter Armstrong Thompson
Philip Tan
Peter Robert Baum
John W Blankenship
Sateesh Kumar Natarajan
Original Assignee
Emergent Product Dev Seattle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emergent Product Dev Seattle filed Critical Emergent Product Dev Seattle
Publication of MX2011003611A publication Critical patent/MX2011003611A/es
Publication of MX338825B publication Critical patent/MX338825B/es

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    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Abstract

La presente invención se refiere a una proteína de fusión multiespecífica compuesta de un dominio de enlace al antagonista de PC86, y otro dominio de enlace que es un agonista de IL5 10, un agonista de HLA-G, un agonista de HGF, un agonista de IL-35, un agonista de PD-1, un agonista de BTLA, un antagonista de LIGHT, un antagonista de GITRL o un antagonista de CD40. La proteína de fusión multi-específica puede también incluir un dominio de intervención que separa los otros dominios. Esta descripción también proporciona los polinucleótidos que codifican para las proteínas de fusión multi-específicas, las composiciones de las proteínas de fusión, y los métodos de uso de las proteínas de fusión multi-específicas y las composiciones.
MX2011003611A 2008-10-02 2009-10-02 Proteinas de enlace a objetivos multiples de antagonistas de cd86. MX338825B (es)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US10231508P 2008-10-02 2008-10-02
US10233408P 2008-10-02 2008-10-02
US10232708P 2008-10-02 2008-10-02
US10233608P 2008-10-02 2008-10-02
US10233108P 2008-10-02 2008-10-02
US10230708P 2008-10-02 2008-10-02
US10229708P 2008-10-02 2008-10-02
US10228808P 2008-10-02 2008-10-02
US10231908P 2008-10-02 2008-10-02
PCT/US2009/059446 WO2010040105A2 (en) 2008-10-02 2009-10-02 Cd86 antagonist multi-target binding proteins

Publications (2)

Publication Number Publication Date
MX2011003611A MX2011003611A (es) 2011-05-10
MX338825B true MX338825B (es) 2016-05-03

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MX2011003611A MX338825B (es) 2008-10-02 2009-10-02 Proteinas de enlace a objetivos multiples de antagonistas de cd86.

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US (2) US9493564B2 (es)
EP (2) EP3281955A1 (es)
JP (4) JP5840494B2 (es)
KR (5) KR20170091801A (es)
CN (2) CN102227447A (es)
AU (4) AU2009298131B2 (es)
BR (1) BRPI0920749A8 (es)
CA (2) CA2739460C (es)
CY (1) CY1119874T1 (es)
DK (1) DK2344540T3 (es)
EA (1) EA024877B1 (es)
ES (1) ES2657220T3 (es)
HK (1) HK1251000A1 (es)
HR (1) HRP20180045T1 (es)
LT (1) LT2344540T (es)
MX (1) MX338825B (es)
NO (1) NO2344540T3 (es)
NZ (1) NZ592420A (es)
PL (1) PL2344540T3 (es)
PT (1) PT2344540T (es)
SI (1) SI2344540T1 (es)
WO (1) WO2010040105A2 (es)
ZA (1) ZA201102637B (es)

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US7030219B2 (en) 2000-04-28 2006-04-18 Johns Hopkins University B7-DC, Dendritic cell co-stimulatory molecules
MX2011000071A (es) * 2008-07-02 2011-05-03 Emergent Product Dev Seattle Inmunoterapeuticos de interleucina-6 (il6).
US20110152173A1 (en) * 2008-07-02 2011-06-23 Emergent Product Development Seattle ,LLC TNF-a ANTAGONIST MULTI-TARGET BINDING PROTEINS
KR20170091801A (ko) * 2008-10-02 2017-08-09 압테보 리서치 앤드 디벨롭먼트 엘엘씨 Ｃｄ86 길항제 다중-표적 결합 단백질
US20110217302A1 (en) * 2008-10-10 2011-09-08 Emergent Product Development Seattle, Llc TCR Complex Immunotherapeutics
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US9090691B2 (en) 2010-09-15 2015-07-28 Applied Molecular Transport Llc Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences
US11246915B2 (en) 2010-09-15 2022-02-15 Applied Molecular Transport Inc. Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
CN101962413B (zh) * 2010-09-21 2013-03-13 中国科学技术大学 具有透皮能力和白细胞介素-10活性的融合蛋白及其编码基因与应用
WO2012145714A2 (en) * 2011-04-22 2012-10-26 Emergent Product Development Seattle, Llc Prostate-specific membrane antigen binding proteins and related compositions and methods
US20140314712A1 (en) 2011-11-08 2014-10-23 Umc Utrecht Holding B.V. Fusion protein comprising an interleukin 4 and interleukin
BR112014025830A8 (pt) 2012-04-20 2017-10-10 Emergent Product Dev Seattle Polipeptídeos de ligação ao cd3
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