MX2023009497A - Composiciones y metodos de terapia celular para modular la se?alizacion del factor de crecimiento transformador-beta (tgf-beta). - Google Patents

Composiciones y metodos de terapia celular para modular la se?alizacion del factor de crecimiento transformador-beta (tgf-beta).

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Publication number
MX2023009497A
MX2023009497A MX2023009497A MX2023009497A MX2023009497A MX 2023009497 A MX2023009497 A MX 2023009497A MX 2023009497 A MX2023009497 A MX 2023009497A MX 2023009497 A MX2023009497 A MX 2023009497A MX 2023009497 A MX2023009497 A MX 2023009497A
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Mexico
Prior art keywords
tgfî2
methods
signaling
fragments
cell therapy
Prior art date
Application number
MX2023009497A
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English (en)
Inventor
Gary Shapiro
Chantal Kuhn
Original Assignee
Takeda Pharmaceuticals Co
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Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of MX2023009497A publication Critical patent/MX2023009497A/es

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Abstract

Se proporcionan métodos para usar polipéptidos para modular la señalización del factor de crecimiento transformante ß (TGFß) (por ejemplo, receptores del TGFß, anticuerpos o fragmentos de unión a antígeno de los mismos que se unen específicamente a TGFß o un receptor del TGFß). Se proporcionan composiciones que comprenden los anticuerpos o fragmentos de los mismos y métodos para usar los mismos para el tratamiento de enfermedades que involucran la actividad del TGFß. También se describen ácidos nucleicos, vectores de expresión recombinantes, células hospederas, fragmentos de unión a antígenos, y composiciones farmacéuticas que comprenden estos agentes de unión a antígenos y fragmentos de estos. La invención también proporciona métodos terapéuticos para usar los moduladores de señalización del TGFß que se proporcionan en la presente descripción.
MX2023009497A 2021-02-15 2022-02-15 Composiciones y metodos de terapia celular para modular la se?alizacion del factor de crecimiento transformador-beta (tgf-beta). MX2023009497A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163149628P 2021-02-15 2021-02-15
US202263306836P 2022-02-04 2022-02-04
PCT/IB2022/000063 WO2022172085A2 (en) 2021-02-15 2022-02-15 Cell therapy compositions and methods for modulating tgf-b signaling

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Publication Number Publication Date
MX2023009497A true MX2023009497A (es) 2023-08-23

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Country Status (11)

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US (1) US20240226295A9 (es)
EP (1) EP4291227A2 (es)
JP (1) JP2024506200A (es)
KR (1) KR20230146032A (es)
AU (1) AU2022219373A1 (es)
CA (1) CA3208365A1 (es)
CO (1) CO2023010473A2 (es)
IL (1) IL305181A (es)
MX (1) MX2023009497A (es)
TW (1) TW202302626A (es)
WO (1) WO2022172085A2 (es)

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CN116178567A (zh) * 2022-10-28 2023-05-30 四川大学华西医院 一种靶向TGFβRII的嵌合抗原受体及其用途

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