MX2023009497A - Composiciones y metodos de terapia celular para modular la se?alizacion del factor de crecimiento transformador-beta (tgf-beta). - Google Patents
Composiciones y metodos de terapia celular para modular la se?alizacion del factor de crecimiento transformador-beta (tgf-beta).Info
- Publication number
- MX2023009497A MX2023009497A MX2023009497A MX2023009497A MX2023009497A MX 2023009497 A MX2023009497 A MX 2023009497A MX 2023009497 A MX2023009497 A MX 2023009497A MX 2023009497 A MX2023009497 A MX 2023009497A MX 2023009497 A MX2023009497 A MX 2023009497A
- Authority
- MX
- Mexico
- Prior art keywords
- tgfî2
- methods
- signaling
- fragments
- cell therapy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000011664 signaling Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000002659 cell therapy Methods 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 4
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 239000011230 binding agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- -1 host cells Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
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Abstract
Se proporcionan métodos para usar polipéptidos para modular la señalización del factor de crecimiento transformante ß (TGFß) (por ejemplo, receptores del TGFß, anticuerpos o fragmentos de unión a antígeno de los mismos que se unen específicamente a TGFß o un receptor del TGFß). Se proporcionan composiciones que comprenden los anticuerpos o fragmentos de los mismos y métodos para usar los mismos para el tratamiento de enfermedades que involucran la actividad del TGFß. También se describen ácidos nucleicos, vectores de expresión recombinantes, células hospederas, fragmentos de unión a antígenos, y composiciones farmacéuticas que comprenden estos agentes de unión a antígenos y fragmentos de estos. La invención también proporciona métodos terapéuticos para usar los moduladores de señalización del TGFß que se proporcionan en la presente descripción.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163149628P | 2021-02-15 | 2021-02-15 | |
US202263306836P | 2022-02-04 | 2022-02-04 | |
PCT/IB2022/000063 WO2022172085A2 (en) | 2021-02-15 | 2022-02-15 | Cell therapy compositions and methods for modulating tgf-b signaling |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023009497A true MX2023009497A (es) | 2023-08-23 |
Family
ID=81585807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023009497A MX2023009497A (es) | 2021-02-15 | 2022-02-15 | Composiciones y metodos de terapia celular para modular la se?alizacion del factor de crecimiento transformador-beta (tgf-beta). |
Country Status (11)
Country | Link |
---|---|
US (1) | US20240226295A9 (es) |
EP (1) | EP4291227A2 (es) |
JP (1) | JP2024506200A (es) |
KR (1) | KR20230146032A (es) |
AU (1) | AU2022219373A1 (es) |
CA (1) | CA3208365A1 (es) |
CO (1) | CO2023010473A2 (es) |
IL (1) | IL305181A (es) |
MX (1) | MX2023009497A (es) |
TW (1) | TW202302626A (es) |
WO (1) | WO2022172085A2 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116178567A (zh) * | 2022-10-28 | 2023-05-30 | 四川大学华西医院 | 一种靶向TGFβRII的嵌合抗原受体及其用途 |
Family Cites Families (89)
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2022
- 2022-02-15 CA CA3208365A patent/CA3208365A1/en active Pending
- 2022-02-15 JP JP2023548964A patent/JP2024506200A/ja active Pending
- 2022-02-15 IL IL305181A patent/IL305181A/en unknown
- 2022-02-15 EP EP22721840.1A patent/EP4291227A2/en active Pending
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WO2022172085A3 (en) | 2022-10-13 |
US20240226295A9 (en) | 2024-07-11 |
AU2022219373A1 (en) | 2023-08-24 |
KR20230146032A (ko) | 2023-10-18 |
JP2024506200A (ja) | 2024-02-09 |
TW202302626A (zh) | 2023-01-16 |
IL305181A (en) | 2023-10-01 |
EP4291227A2 (en) | 2023-12-20 |
CA3208365A1 (en) | 2022-08-18 |
CO2023010473A2 (es) | 2023-08-28 |
US20240131158A1 (en) | 2024-04-25 |
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