MX2022014817A - Benzofurano, benzopirrol, benzotiofeno sustituidos y otros inhibidores del complemento estructuralmente relacionados. - Google Patents
Benzofurano, benzopirrol, benzotiofeno sustituidos y otros inhibidores del complemento estructuralmente relacionados.Info
- Publication number
- MX2022014817A MX2022014817A MX2022014817A MX2022014817A MX2022014817A MX 2022014817 A MX2022014817 A MX 2022014817A MX 2022014817 A MX2022014817 A MX 2022014817A MX 2022014817 A MX2022014817 A MX 2022014817A MX 2022014817 A MX2022014817 A MX 2022014817A
- Authority
- MX
- Mexico
- Prior art keywords
- benzopyrrole
- benzothiophene
- structurally related
- complement inhibitors
- substituted benzofuran
- Prior art date
Links
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical class CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 title 1
- 239000004074 complement inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000004154 complement system Effects 0.000 abstract 2
- 230000001594 aberrant effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/4164—1,3-Diazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07D209/12—Radicals substituted by oxygen atoms
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
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- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Neurology (AREA)
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- Urology & Nephrology (AREA)
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- Immunology (AREA)
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- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
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Abstract
Se describen compuestos de fórmulas I y II, y sales y profármacos farmacéuticamente aceptables de los mismos, que son inhibidores del sistema del complemento. También se proveen composiciones farmacéuticas que comprenden dicho compuesto, y métodos para usar los compuestos y composiciones en el tratamiento o prevención de una enfermedad o condición que se caracteriza por una actividad aberrante del sistema del complemento. (ver Fórmulas).
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US201862654108P | 2018-04-06 | 2018-04-06 |
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MX2022014817A true MX2022014817A (es) | 2023-01-18 |
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ID=68101457
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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MX2020010508A MX2020010508A (es) | 2018-04-06 | 2019-04-05 | Benzofurano, benzopirrol, benzotiofeno sustituidos y otros inhibidores del complemento estructuralmente relacionados. |
MX2022014817A MX2022014817A (es) | 2018-04-06 | 2020-10-05 | Benzofurano, benzopirrol, benzotiofeno sustituidos y otros inhibidores del complemento estructuralmente relacionados. |
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MX2020010508A MX2020010508A (es) | 2018-04-06 | 2019-04-05 | Benzofurano, benzopirrol, benzotiofeno sustituidos y otros inhibidores del complemento estructuralmente relacionados. |
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EP (2) | EP3939658A1 (es) |
JP (2) | JP7383635B2 (es) |
KR (1) | KR20210005619A (es) |
CN (2) | CN112272553B (es) |
AR (1) | AR115033A1 (es) |
AU (1) | AU2019247471B2 (es) |
BR (1) | BR112020019183A2 (es) |
CA (1) | CA3095628A1 (es) |
CL (2) | CL2020002578A1 (es) |
CO (1) | CO2020013840A2 (es) |
CY (1) | CY1124510T1 (es) |
DK (1) | DK3687506T3 (es) |
EA (1) | EA202092383A1 (es) |
ES (1) | ES2891123T3 (es) |
HR (1) | HRP20211405T1 (es) |
HU (1) | HUE055307T2 (es) |
IL (2) | IL277787B2 (es) |
LT (1) | LT3687506T (es) |
MA (1) | MA51627B1 (es) |
MD (1) | MD3687506T2 (es) |
MX (2) | MX2020010508A (es) |
PE (1) | PE20210398A1 (es) |
PH (1) | PH12020551589A1 (es) |
PL (1) | PL3687506T3 (es) |
PT (1) | PT3687506T (es) |
RS (1) | RS62370B1 (es) |
SG (1) | SG11202008972WA (es) |
SI (1) | SI3687506T1 (es) |
TW (1) | TW202010742A (es) |
UY (1) | UY38174A (es) |
WO (1) | WO2019195720A1 (es) |
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TW202010742A (zh) | 2018-04-06 | 2020-03-16 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
EP4003327A4 (en) * | 2019-07-31 | 2023-08-02 | Biocryst Pharmaceuticals, Inc. | DOSING REGIME FOR ORAL COMPLEMENT FACTOR-D INHIBITORS |
UY38909A (es) * | 2019-10-09 | 2021-05-31 | Biocryst Pharm Inc | Inhibidores del factor d del complemento para administración oral |
TW202128637A (zh) * | 2019-10-09 | 2021-08-01 | 美商百歐克斯製藥公司 | 口服補體因子d抑制劑 |
EP4213832A1 (en) * | 2020-09-18 | 2023-07-26 | Merck Sharp & Dohme LLC | Modified benzofuran-carboxamides as glucosylceramide synthase inhibitors |
TW202330489A (zh) * | 2021-10-21 | 2023-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合環類化合物、其製備方法及其在醫藥上的應用 |
WO2023227696A1 (en) * | 2022-05-25 | 2023-11-30 | Katholieke Universiteit Leuven | New derivatives for treating trpm3 mediated disorders |
WO2024112831A1 (en) * | 2022-11-22 | 2024-05-30 | Maze Therapeutics, Inc. | Inhibitors of solute carrier family 6a member 19 (slc6a19) and methods of use thereof |
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