MX2018005620A - Composiciones que comprenden un inhibidor de demetilasa-1 especifico de lisina. - Google Patents

Composiciones que comprenden un inhibidor de demetilasa-1 especifico de lisina.

Info

Publication number
MX2018005620A
MX2018005620A MX2018005620A MX2018005620A MX2018005620A MX 2018005620 A MX2018005620 A MX 2018005620A MX 2018005620 A MX2018005620 A MX 2018005620A MX 2018005620 A MX2018005620 A MX 2018005620A MX 2018005620 A MX2018005620 A MX 2018005620A
Authority
MX
Mexico
Prior art keywords
inhibitor
specific demethylase
lysine specific
compositions
lysine
Prior art date
Application number
MX2018005620A
Other languages
English (en)
Inventor
Alan Stafford Jeffrey
Marvin Veal James
W Kaldor Stephen
K Chen Young
Kanouni Toufike
Alessandra TAVARES-GRECO Paula
Michael Kreilein Matthew
Original Assignee
Celgene Quanticel Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Quanticel Res Inc filed Critical Celgene Quanticel Res Inc
Publication of MX2018005620A publication Critical patent/MX2018005620A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describen en la presente formas amorfas y cristalinas de sales farmacéuticamente aceptables del inhibidor de demetilasa-1 especifico de lisina, 4-[2-(4-amino-piperidin-1-i1)-5-(3-fluoro-4- metoxi-feni1)-1-metil-6-oxo-1,6-dihidro-pirimidin-4-111-2-fluorob enzonitrilo. También se describen composiciones farmacéuticas adecuadas para administración a un mamífero que incluye el inhibidor de demetilasa-1 específico de lisina, y métodos para utilizar el inhibidor de demetilasa-1 específico de lisina para tratar enfermedades o condiciones que están asociadas con la actividad de demetilasa-1 especifica de lisina.
MX2018005620A 2015-11-05 2016-11-04 Composiciones que comprenden un inhibidor de demetilasa-1 especifico de lisina. MX2018005620A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562251507P 2015-11-05 2015-11-05
PCT/US2016/060694 WO2017079670A1 (en) 2015-11-05 2016-11-04 Compositions comprising an inhibitor of lysine specific demethylase-1

Publications (1)

Publication Number Publication Date
MX2018005620A true MX2018005620A (es) 2018-08-01

Family

ID=58662888

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018005620A MX2018005620A (es) 2015-11-05 2016-11-04 Composiciones que comprenden un inhibidor de demetilasa-1 especifico de lisina.
MX2020004894A MX2020004894A (es) 2015-11-05 2016-11-04 Composiciones que comprenden un inhibidor de demetilasa-1 especifico de lisina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020004894A MX2020004894A (es) 2015-11-05 2016-11-04 Composiciones que comprenden un inhibidor de demetilasa-1 especifico de lisina.

Country Status (20)

Country Link
US (4) US9828358B2 (es)
EP (1) EP3371152B1 (es)
JP (1) JP6995043B2 (es)
CN (1) CN108473442B (es)
AR (1) AR106612A1 (es)
AU (1) AU2016349707B2 (es)
CA (1) CA3004300C (es)
CY (1) CY1124078T1 (es)
DK (1) DK3371152T3 (es)
ES (1) ES2846951T3 (es)
HR (1) HRP20210144T8 (es)
HU (1) HUE053449T2 (es)
LT (1) LT3371152T (es)
MX (2) MX2018005620A (es)
PL (1) PL3371152T3 (es)
PT (1) PT3371152T (es)
RS (1) RS61404B1 (es)
SI (1) SI3371152T1 (es)
TW (1) TW201720808A (es)
WO (1) WO2017079670A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20161438A1 (es) * 2014-05-01 2017-01-18 Celgene Quanticel Res Inc Inhibidores de desmetilasa 1 especifica a lisina
EP3371152B1 (en) * 2015-11-05 2020-12-23 Celgene Quanticel Research, Inc. Compositions comprising an inhibitor of lysine specific demethylase-1 having a pyrimidine ring and its use in the treatment of cancer
EP3535420A1 (en) 2016-11-03 2019-09-11 Oryzon Genomics, S.A. Biomarkers for determining responsiveness to lsd1 inhibitors
US20200069677A1 (en) 2016-12-09 2020-03-05 Constellation Pharmaceuticals, Inc. Markers for personalized cancer treatment with lsd1 inhibitors
BR112020000827A2 (pt) 2017-08-03 2020-07-21 Oryzon Genomics, S.A. métodos de tratamento de alterações de comportamento
US20220151998A1 (en) 2019-03-20 2022-05-19 Oryzon Genomics, S.A. Methods of treating borderline personality disorder
JP2022526755A (ja) 2019-03-20 2022-05-26 オリソン ヘノミクス，ソシエダ アノニマ 化合物バフィデムスタット（ｖａｆｉｄｅｍｓｔａｔ）などｋｄｍ１ａ阻害剤を使用した注意欠陥多動性障害の処置方法
MX2021015447A (es) * 2019-06-13 2022-04-06 Celgene Corp Métodos de tratamiento del cáncer dirigidos a tumores fríos.
US20220249528A1 (en) * 2019-06-20 2022-08-11 Celgene Corporation Azacitidine in combination with venetoclax, gilteritinib, midostaurin or other compounds for treating leukemia or myelodysplastic syndrome
JP2022546908A (ja) 2019-07-05 2022-11-10 オリゾン・ゲノミクス・ソシエダッド・アノニマ Ｋｄｍ１ａ阻害剤を使用した小細胞肺がんの個別化された処置のためのバイオマーカーおよび方法
WO2021247977A1 (en) * 2020-06-05 2021-12-09 Celgene Quanticel Research, Inc. Methods of treating prostate cancer
ES2919083R1 (es) * 2020-06-29 2022-07-26 Celgene Quanticel Res Inc Métodos de tratamiento de cáncer de próstata
WO2022214303A1 (en) 2021-04-08 2022-10-13 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors for treating myeloid cancers
WO2023217784A1 (en) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Methods of treating nf1-mutant tumors using lsd1 inhibitors
WO2023217758A1 (en) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
CA2513414A1 (en) * 2002-04-10 2003-10-16 Orchid Chemicals & Pharmaceuticals Limited Pyrimidinedione derivatives useful for the treatment of inflammation and immunological diseases
AU2003216591A1 (en) * 2002-04-10 2003-10-20 Orichid Chemicals And Pharmaceuticals Limited Amino substituted pyrimidinone derivatives useful in the treatment of inflammation and immunological
US20070270446A1 (en) * 2004-10-06 2007-11-22 Smithkline Beecham Corporation Reversed Pyrimidinone Compounds as Calcilytics
AR073760A1 (es) 2008-10-03 2010-12-01 Astrazeneca Ab Derivados heterociclicos y metodos de uso de los mismos
US10093646B2 (en) * 2014-01-17 2018-10-09 Novartis Ag 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
PE20161438A1 (es) * 2014-05-01 2017-01-18 Celgene Quanticel Res Inc Inhibidores de desmetilasa 1 especifica a lisina
EP3371152B1 (en) * 2015-11-05 2020-12-23 Celgene Quanticel Research, Inc. Compositions comprising an inhibitor of lysine specific demethylase-1 having a pyrimidine ring and its use in the treatment of cancer

Also Published As

Publication number Publication date
JP2019500323A (ja) 2019-01-10
US9828358B2 (en) 2017-11-28
CA3004300C (en) 2023-08-22
SI3371152T1 (sl) 2021-06-30
LT3371152T (lt) 2021-04-12
US20190367473A1 (en) 2019-12-05
CA3004300A1 (en) 2017-05-11
CY1124078T1 (el) 2022-05-27
AR106612A1 (es) 2018-01-31
WO2017079670A1 (en) 2017-05-11
EP3371152A1 (en) 2018-09-12
HRP20210144T1 (hr) 2021-03-05
CN108473442B (zh) 2022-03-25
EP3371152B1 (en) 2020-12-23
CN108473442A (zh) 2018-08-31
AU2016349707B2 (en) 2020-12-10
MX2020004894A (es) 2021-11-03
AU2016349707A1 (en) 2018-05-24
PT3371152T (pt) 2021-02-01
EP3371152A4 (en) 2019-07-03
US20170129871A1 (en) 2017-05-11
US20180319767A1 (en) 2018-11-08
RS61404B1 (sr) 2021-02-26
PL3371152T3 (pl) 2021-06-28
US10047069B2 (en) 2018-08-14
TW201720808A (zh) 2017-06-16
DK3371152T3 (da) 2021-02-15
JP6995043B2 (ja) 2022-02-04
HRP20210144T8 (hr) 2021-04-16
ES2846951T3 (es) 2021-07-30
WO2017079670A9 (en) 2017-06-15
US10703739B2 (en) 2020-07-07
US20180044320A1 (en) 2018-02-15
HUE053449T2 (hu) 2021-06-28
US10316016B2 (en) 2019-06-11

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