MX2022013525A - Composiciones de agentes de ácido ribonucleico de interferencia (arni) de apolipoproteína e (apoe) y métodos de uso de las mismas. - Google Patents

Composiciones de agentes de ácido ribonucleico de interferencia (arni) de apolipoproteína e (apoe) y métodos de uso de las mismas.

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Publication number
MX2022013525A
MX2022013525A MX2022013525A MX2022013525A MX2022013525A MX 2022013525 A MX2022013525 A MX 2022013525A MX 2022013525 A MX2022013525 A MX 2022013525A MX 2022013525 A MX2022013525 A MX 2022013525A MX 2022013525 A MX2022013525 A MX 2022013525A
Authority
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Mexico
Prior art keywords
apoe
methods
apolipoprotein
irna agent
agent compositions
Prior art date
Application number
MX2022013525A
Other languages
English (en)
Inventor
Mark K Schlegel
James D Mcininch
Adam Castoreno
Bret Lee Bostwick
Haiyan Peng
Original Assignee
Alnylam Pharmaceuticals Inc
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Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2022013525A publication Critical patent/MX2022013525A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/3521—Methyl
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen

Abstract

La descripción se refiere a agentes y composiciones de ácido ribonucleico de doble hebra (ARNdh) dirigidos a un gen de APOE, así como métodos para inhibir la expresión de un gen de APOE y métodos para tratar sujetos que tienen una enfermedad o trastorno neurodegenerativo asociado con APOE, por ejemplo, enfermedad de Alzheimer y enfermedad de Parkinson, usando estos agentes y composiciones de ARNdh.
MX2022013525A 2020-04-27 2021-04-26 Composiciones de agentes de ácido ribonucleico de interferencia (arni) de apolipoproteína e (apoe) y métodos de uso de las mismas. MX2022013525A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063015867P 2020-04-27 2020-04-27
PCT/US2021/029081 WO2021222065A1 (en) 2020-04-27 2021-04-26 Apolipoprotein e (apoe) irna agent compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2022013525A true MX2022013525A (es) 2023-01-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022013525A MX2022013525A (es) 2020-04-27 2021-04-26 Composiciones de agentes de ácido ribonucleico de interferencia (arni) de apolipoproteína e (apoe) y métodos de uso de las mismas.

Country Status (11)

Country Link
US (1) US20230193268A1 (es)
EP (1) EP4143319A1 (es)
JP (1) JP2023523993A (es)
KR (1) KR20230018377A (es)
CN (1) CN115955972A (es)
AU (1) AU2021263554A1 (es)
BR (1) BR112022021813A2 (es)
CA (1) CA3181400A1 (es)
IL (1) IL297702A (es)
MX (1) MX2022013525A (es)
WO (1) WO2021222065A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023078883A1 (en) * 2021-11-03 2023-05-11 F. Hoffmann-La Roche Ag Oligonucleotides for modulating apolipoprotein e4 expression
US20230242988A1 (en) * 2022-01-23 2023-08-03 Regeneron Pharmaceuticals, Inc. Methods Of Improving Health With Apolipoprotein E (APOE) Inhibitors

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