MX2022006391A - Receptores de antigeno quimerico que se unen a bcma y cd19 y usos de los mismos. - Google Patents

Receptores de antigeno quimerico que se unen a bcma y cd19 y usos de los mismos.

Info

Publication number
MX2022006391A
MX2022006391A MX2022006391A MX2022006391A MX2022006391A MX 2022006391 A MX2022006391 A MX 2022006391A MX 2022006391 A MX2022006391 A MX 2022006391A MX 2022006391 A MX2022006391 A MX 2022006391A MX 2022006391 A MX2022006391 A MX 2022006391A
Authority
MX
Mexico
Prior art keywords
chimeric antigen
antigen receptors
receptors binding
binding bcma
bcma
Prior art date
Application number
MX2022006391A
Other languages
English (en)
Inventor
Jennifer Brogdon
Glenn Dranoff
Andrew Price
Chonghui Zhang
Boris Engels
Attilio Bondanza
Lu Huang
Aida Abujoub
John Blankenship
Tony Fleming
Brian Holmberg
Connie Hong
Dexiu Bu
Louise Treanor
Olja Kodrasi
Hyungwook Lim
Akash Sohoni
Anniesha Hack
Xu Zhu
Vita Serena De
Michael R Greene
Elizabeth Dorothy Pratico
Andrew Marc Stein
Brian Walter Granda
Joni Waiee Lam
Carla Patricia Guimaraes
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2022006391A publication Critical patent/MX2022006391A/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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Abstract

La invención proporciona células efectoras inmunes (por ejemplo, células T, células NK) que expresan un receptor de antígeno quimérico (CAR), y composiciones y métodos del mismo.
MX2022006391A 2019-11-26 2020-11-25 Receptores de antigeno quimerico que se unen a bcma y cd19 y usos de los mismos. MX2022006391A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962940509P 2019-11-26 2019-11-26
PCT/US2020/062357 WO2021108661A2 (en) 2019-11-26 2020-11-25 Chimeric antigen receptors and uses thereof

Publications (1)

Publication Number Publication Date
MX2022006391A true MX2022006391A (es) 2022-06-24

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MX2022006391A MX2022006391A (es) 2019-11-26 2020-11-25 Receptores de antigeno quimerico que se unen a bcma y cd19 y usos de los mismos.

Country Status (14)

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US (1) US20210220404A1 (es)
EP (1) EP4065158A2 (es)
JP (1) JP2023503163A (es)
KR (1) KR20220105664A (es)
CN (1) CN114761037A (es)
AR (1) AR120566A1 (es)
AU (1) AU2020393912A1 (es)
BR (1) BR112022010206A2 (es)
CA (1) CA3163104A1 (es)
CL (1) CL2022001374A1 (es)
IL (1) IL293215A (es)
MX (1) MX2022006391A (es)
TW (1) TW202134264A (es)
WO (1) WO2021108661A2 (es)

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RU2708032C2 (ru) 2013-02-20 2019-12-03 Новартис Аг ЛЕЧЕНИЕ РАКА С ИСПОЛЬЗОВАНИЕМ ХИМЕРНОГО АНТИГЕНСПЕЦИФИЧЕСКОГО РЕЦЕПТОРА НА ОСНОВЕ ГУМАНИЗИРОВАННОГО АНТИТЕЛА ПРОТИВ EGFRvIII
EP2970426B1 (en) 2013-03-15 2019-08-28 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
EP3087101B1 (en) 2013-12-20 2024-06-05 Novartis AG Regulatable chimeric antigen receptor
IL280215B (en) * 2014-04-07 2022-07-01 Novartis Ag Cancer treatment using a chimeric receptor antigen (car) against cd19
CN107108744B (zh) 2014-08-19 2020-09-25 诺华股份有限公司 抗cd123嵌合抗原受体(car)用于癌症治疗
ES2948133T3 (es) 2015-04-17 2023-08-31 Novartis Ag Métodos para mejorar la eficacia y expansión de células que expresan un receptor de antígeno quimérico
WO2017027392A1 (en) 2015-08-07 2017-02-16 Novartis Ag Treatment of cancer using chimeric cd3 receptor proteins
CN116334205A (zh) 2015-09-03 2023-06-27 诺华股份有限公司 预测细胞因子释放综合征的生物标志物
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