MX2021006696A - Derivado de cicloalcano-1,3-diamina. - Google Patents
Derivado de cicloalcano-1,3-diamina.Info
- Publication number
- MX2021006696A MX2021006696A MX2021006696A MX2021006696A MX2021006696A MX 2021006696 A MX2021006696 A MX 2021006696A MX 2021006696 A MX2021006696 A MX 2021006696A MX 2021006696 A MX2021006696 A MX 2021006696A MX 2021006696 A MX2021006696 A MX 2021006696A
- Authority
- MX
- Mexico
- Prior art keywords
- mll
- leukemia
- menin
- fusion protein
- gene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
La presente invención proporciona un compuesto o una sal farmacéuticamente aceptable del mismo que tiene una acción inhibidora de la interacción entre menina y una proteína MLL; el compuesto representado por la fórmula (1) o una sal farmacéuticamente aceptable del mismo; (ver Fórmula) Fórmula 1 en donde, en la fórmula (1), el circulo punteado, R1, R2, R3, R4, R5, R6, R7, R8, el anillo Q1, W, m y n son cada uno como se define en la descripción.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018229397 | 2018-12-06 | ||
PCT/JP2019/048834 WO2020116662A1 (ja) | 2018-12-06 | 2019-12-05 | シクロアルカン−1,3−ジアミン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021006696A true MX2021006696A (es) | 2021-07-07 |
Family
ID=70974277
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021006696A MX2021006696A (es) | 2018-12-06 | 2019-12-05 | Derivado de cicloalcano-1,3-diamina. |
Country Status (16)
Country | Link |
---|---|
US (3) | US20230030720A1 (es) |
EP (1) | EP3892278B1 (es) |
JP (1) | JP7417540B2 (es) |
KR (1) | KR20210100612A (es) |
CN (1) | CN113164481A (es) |
AU (1) | AU2019395201A1 (es) |
BR (1) | BR112021007421A2 (es) |
CA (1) | CA3116141C (es) |
CO (1) | CO2021008253A2 (es) |
IL (1) | IL282905A (es) |
MX (1) | MX2021006696A (es) |
PH (1) | PH12021550869A1 (es) |
SG (1) | SG11202104243VA (es) |
TW (1) | TW202039512A (es) |
WO (1) | WO2020116662A1 (es) |
ZA (1) | ZA202102876B (es) |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003255528B2 (en) | 2002-07-10 | 2009-07-16 | Merck Serono Sa | Azolidinone-vinyl fused-benzene derivatives |
SE0301654D0 (sv) | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
JP2007507551A (ja) | 2003-10-03 | 2007-03-29 | ポートラ ファーマシューティカルズ, インコーポレイテッド | 2,4−ジオキソ−3−キナゾリニルアリールスルホニル尿素 |
AU2005240942B2 (en) | 2004-05-10 | 2010-08-05 | Banyu Pharmaceutical Co., Ltd. | Imidazopyridine compound |
US20100216798A1 (en) | 2005-07-29 | 2010-08-26 | Astellas Pharma Inc | Fused heterocycles as lck inhibitors |
EP2007707A1 (en) | 2006-04-07 | 2008-12-31 | Boehringer Ingelheim International GmbH | Compounds which modulate the cb2 receptor |
EP2438066A2 (en) | 2009-06-05 | 2012-04-11 | Cephalon, Inc. | PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a]PYRIDINE DERIVATIVES |
ES2662332T3 (es) | 2010-03-04 | 2018-04-06 | Merck Sharp & Dohme Corp. | Inhibidores de la catecol-O-metil-transferasa y su uso en el tratamiento de trastornos psicóticos |
EP2663312B1 (en) | 2011-01-10 | 2017-10-11 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
BR112014001665A2 (pt) | 2011-07-27 | 2017-02-14 | Glaxo Group Ltd | compostos de 2,3-di-hidroimidazo[1,2-c]pirimidin-5(1h)-ona utilizados como inibidores de lp-plaz |
LT2794600T (lt) | 2011-12-22 | 2018-02-26 | Novartis Ag | 2,3-dihidro-benzo[1,4]oksazino dariniai ir giminingi junginiai kaip fosfoinozitido-3 kinazės (pi3k) inhibitoriai, skirti gydymui, pavyzdžiui, reumatoidinio artrito |
WO2014049133A1 (en) | 2012-09-28 | 2014-04-03 | H. Lundbeck A/S | New positive allosteric modulators of nicotinic acetylcholine receptor |
JP2016500073A (ja) | 2012-11-19 | 2016-01-07 | ノバルティス アーゲー | 寄生虫病の処置のための化合物および組成物 |
CN104903331A (zh) | 2013-01-24 | 2015-09-09 | 山东亨利医药科技有限责任公司 | Jnk抑制剂 |
RU2737434C2 (ru) | 2013-03-13 | 2020-11-30 | Форма Терапьютикс, Инк. | Новые соединения и композиции для ингибирования fasn |
CA2904612A1 (en) * | 2013-03-13 | 2014-10-09 | The Regents Of The University Of Michigan | Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof |
SG11201608242XA (en) * | 2014-04-04 | 2016-10-28 | Syros Pharmaceuticals Inc | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
JP6673850B2 (ja) | 2014-04-14 | 2020-03-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ヘテロアリール置換されたヘテロシクリルスルホン |
AR104020A1 (es) | 2015-06-04 | 2017-06-21 | Kura Oncology Inc | Métodos y composiciones para inhibir la interacción de menina con proteínas mill |
JO3793B1 (ar) | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | مثبطات تيروزين كاينيز بروتون وأساليب استخدامها |
SG11201807834WA (en) * | 2016-03-16 | 2018-10-30 | Kura Oncology Inc | Bridged bicyclic inhibitors of menin-mll and methods of use |
JP6919977B2 (ja) | 2016-03-16 | 2021-08-18 | クラ オンコロジー,インク. | メニン−mllの置換された阻害剤及びその使用方法 |
SI3468966T1 (sl) | 2016-06-10 | 2021-03-31 | Vitae Pharmaceuticals, Llc | Zaviralci interakcije menin-MLL |
WO2018024602A1 (en) | 2016-08-04 | 2018-02-08 | Bayer Aktiengesellschaft | 2,7-diazaspiro[4.4]nonanes |
TWI757340B (zh) | 2016-09-16 | 2022-03-11 | 美商生命醫藥有限責任公司 | 梅嫩蛋白(menin)-MLL相互作用之抑制劑 |
WO2018109088A1 (en) | 2016-12-15 | 2018-06-21 | Janssen Pharmaceutica Nv | Azepane inhibitors of menin-mll interaction |
-
2019
- 2019-12-05 EP EP19893921.7A patent/EP3892278B1/en active Active
- 2019-12-05 AU AU2019395201A patent/AU2019395201A1/en not_active Abandoned
- 2019-12-05 CA CA3116141A patent/CA3116141C/en active Active
- 2019-12-05 TW TW108144586A patent/TW202039512A/zh unknown
- 2019-12-05 SG SG11202104243VA patent/SG11202104243VA/en unknown
- 2019-12-05 BR BR112021007421-0A patent/BR112021007421A2/pt unknown
- 2019-12-05 WO PCT/JP2019/048834 patent/WO2020116662A1/ja unknown
- 2019-12-05 CN CN201980080573.0A patent/CN113164481A/zh active Pending
- 2019-12-05 MX MX2021006696A patent/MX2021006696A/es unknown
- 2019-12-05 JP JP2020559333A patent/JP7417540B2/ja active Active
- 2019-12-05 US US17/289,710 patent/US20230030720A1/en active Pending
- 2019-12-05 KR KR1020217016475A patent/KR20210100612A/ko unknown
-
2021
- 2021-04-19 PH PH12021550869A patent/PH12021550869A1/en unknown
- 2021-04-28 US US17/243,360 patent/US11236106B2/en active Active
- 2021-04-29 ZA ZA2021/02876A patent/ZA202102876B/en unknown
- 2021-05-03 IL IL282905A patent/IL282905A/en unknown
- 2021-07-01 CO CONC2021/0008253A patent/CO2021008253A2/es unknown
- 2021-11-24 US US17/535,369 patent/US20230074669A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20230074669A1 (en) | 2023-03-09 |
CO2021008253A2 (es) | 2021-07-19 |
US20210269454A1 (en) | 2021-09-02 |
SG11202104243VA (en) | 2021-05-28 |
PH12021550869A1 (en) | 2021-10-18 |
IL282905A (en) | 2021-06-30 |
US11236106B2 (en) | 2022-02-01 |
WO2020116662A1 (ja) | 2020-06-11 |
JPWO2020116662A1 (ja) | 2021-10-21 |
BR112021007421A2 (pt) | 2021-08-03 |
EP3892278A1 (en) | 2021-10-13 |
JP7417540B2 (ja) | 2024-01-18 |
CN113164481A (zh) | 2021-07-23 |
KR20210100612A (ko) | 2021-08-17 |
CA3116141C (en) | 2023-09-05 |
EP3892278A4 (en) | 2022-08-24 |
EP3892278B1 (en) | 2024-02-28 |
ZA202102876B (en) | 2022-10-26 |
CA3116141A1 (en) | 2020-06-11 |
TW202039512A (zh) | 2020-11-01 |
AU2019395201A1 (en) | 2021-05-20 |
US20230030720A1 (en) | 2023-02-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Tarumoto et al. | LKB1, salt-inducible kinases, and MEF2C are linked dependencies in acute myeloid leukemia | |
Scharer et al. | Global DNA methylation remodeling accompanies CD8 T cell effector function | |
Tee et al. | Chromatin features and the epigenetic regulation of pluripotency states in ESCs | |
Fowle et al. | PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer | |
Schwartz et al. | A new world of Polycombs: unexpected partnerships and emerging functions | |
Relogio et al. | Ras-mediated deregulation of the circadian clock in cancer | |
Vázquez-Arreguín et al. | The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks | |
Shinde et al. | Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing | |
Mao et al. | Serine/threonine kinase 17A is a novel candidate for therapeutic targeting in glioblastoma | |
You et al. | SNF5 is an essential executor of epigenetic regulation during differentiation | |
Chari et al. | The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death | |
Cao et al. | ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency | |
Xu et al. | CTCF controls HOXA cluster silencing and mediates PRC2-repressive higher-order chromatin structure in NT2/D1 cells | |
Markouli et al. | Structure, activity and function of the SETDB1 protein methyltransferase | |
Kiselev et al. | Perturbations of PIP3 signalling trigger a global remodelling of mRNA landscape and reveal a transcriptional feedback loop | |
Liu et al. | A functional role for the histone demethylase UTX in normal and malignant hematopoietic cells | |
US20170313978A1 (en) | Endogenous retrovirus transcription as a marker for primate naive pluripotent stem cells | |
Cartularo et al. | Molecular mechanisms of malignant transformation by low dose cadmium in normal human bronchial epithelial cells | |
Kirtana et al. | Molecular mechanisms of KDM5A in cellular functions: Facets during development and disease | |
Kim et al. | The WTX tumor suppressor interacts with the transcriptional corepressor TRIM28 | |
Haley et al. | Altered transcriptional control networks with trans-differentiation of isogenic mutant-KRas NSCLC models | |
Basile et al. | Resistance to chemotherapy: short-term drug tolerance and stem cell-like subpopulations | |
Akpa et al. | DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations | |
Markey | Regulation of MDM4 | |
Imesch et al. | MLH1-deficient HCT116 colon tumor cells exhibit resistance to the cytostatic and cytotoxic effect of the poly (A) polymerase inhibitor cordycepin (3'-deoxyadenosine) in vitro |